Online citations, reference lists, and bibliographies.
← Back to Search

The Role Of 5-HT1a And 5-HT2a Receptors In Attention And Motor Control: A Mechanistic Study In Healthy Volunteers

M. Wingen, K. Kuypers, J. Ramaekers
Published 2006 · Psychology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
RationaleVarious studies have demonstrated a modulating role for serotonin in attention. Selective serotonin inhibitors have repeatedly been shown to impair performance in sustained attention tasks.ObjectivesTo assess the contribution of serotonin reuptake inhibition and specific blockade of the pre-synaptic 5-HT1a receptor and the 5-HT2a receptor to deficits in attention.Materials and methodsThe study was conducted according to a randomized, double-blind, placebo controlled, four-way crossover design including 16 healthy volunteers. Treatments consisted of oral administration of the selective serotonin reuptake inhibitor (SSRI) escitalopram 20 mg + placebo; escitalopram 20 mg + ketanserin (5-HT2a antagonist), 50 mg; escitalopram 20 mg + pindolol (5-HT1a antagonist) 10 mg; and placebo + placebo on four separate days. A range of performance tasks were conducted to assess the subjects’ attention and motor functions.ResultsEscitalopram administered alone impaired tracking performance in a divided attention task. The combination of escitalopram and pindolol and escitalopram and ketanserin impaired divided attention as compared to placebo. In addition, escitalopram and ketanserin impaired sustained attention. Divided attention impairment observed after combined treatments did not significantly differ from impairments after escitalopram alone. Sustained attention impairment observed after combined escitalopram and ketanserin significantly differed from escitalopram alone.Conclusions5HT1a blockade hardly affected SSRI effects on attention. Additional 5HT2a blockade, however, produced impairments of sustained attention and motor impulse control.
This paper references
Researches on the Measurement of Human Performance.
N. Mackworth (1950)
Researches on the measurement of human performance.
H. J. Eysenck (1951)
A "critical" tracking task for man-machine research related to the operator's effective delay time. I. Theory and experiments with a first-order divergent controlled element. NASA CR-616.
H. Jex (1966)
Laboratory studies of the effects of alcohol on some variables related to driving.
H. Moskowitz (1973)
The use of analogue scales in rating subjective feelings
A. Bond (1974)
Arousal, activation, and effort in the control of attention.
K. Pribram (1975)
Ketanserin, a novel 5-hydroxytryptamine antagonist: monotherapy in essential hypertension.
T. Hedner (1983)
On the ability to inhibit thought and action
G. Logan (1984)
Reconciling the role of central serotonin neurons in human and animal behavior
P. Soubrié (1986)
Dopaminergic transmission and the sleep-wakefulness continuum in man
A. Nicholson (1990)
Modulatory role of serotonin in neural information processing: implications for human psychopathology.
M. Spoont (1992)
Studies of interference in serial verbal reactions.
J. Stroop (1992)
Inhibitory Processes in Attention, Memory and Language
T. Carr (1994)
A comparative study of acute and subchronic effects of dothiepin, fluoxetine and placebo on psychomotor and actual driving performance.
J. Ramaekers (1995)
Arousal systems and attentional processes
T. Robbins (1997)
Central 5-HT depletion enhances impulsive responding without affecting the accuracy of attentional performance: interactions with dopaminergic mechanisms
A. Harrison (1997)
Venlafaxine's effects on healthy volunteers' driving, psychomotor, and vigilance performance during 15-day fixed and incremental dosing regimens.
J. O'hanlon (1998)
Psychological and Physiological Effects of MDMA (“Ecstasy”) after Pretreatment with the 5-HT2 Antagonist Ketanserin in Healthy Humans
M. Liechti (2000)
Role of Striatal Serotonin2A and Serotonin2C Receptor Subtypes in the Control of In Vivo Dopamine Outflow in the Rat Striatum
G. Lucas (2000)
Tyrosine depletion attenuates dopamine function in healthy volunteers
C.J. Harmer (2000)
The 5-HT1A receptor agonist 8-OH-DPAT reduces rats’ accuracy of attentional performance and enhances impulsive responding in a five-choice serial reaction time task: role of presynaptic 5-HT1A receptors
M. Carli (2000)
Tryptophan depletion impairs memory consolidation but improves focussed attention in healthy young volunteers
J. Schmitt (2000)
Drug action at the 5-HT(1A) receptor in vivo: autoreceptor and postsynaptic receptor occupancy examined with PET and [carbonyl-(11)C]WAY-100635.
E. Rabiner (2000)
Effects of d-amphetamine and ethanol on a measure of behavioral inhibition in humans.
H. de Wit (2000)
The 5-HT(1A) receptor agonist 8-OH-DPAT reduces rats' accuracy of attentional performance and enhances impulsive responding in a five-choice serial reaction time task: role of presynaptic 5-HT(1A) receptors.
M. Carli (2000)
Chemical neuromodulation of frontal-executive functions in humans and other animals
T. Robbins (2000)
Pindolol augmentation of selective serotonin reuptake inhibitors: PET evidence that the dose used in clinical trials is too low.
E. Rabiner (2001)
Role of 5-HT(2C) receptors in the control of central dopamine function.
V. di Matteo (2001)
Additional dopamine reuptake inhibition attenuates vigilance impairment induced by serotonin reuptake inhibition in man
J. Schmitt (2002)
Acute Administration of d-Amphetamine Decreases Impulsivity in Healthy Volunteers
H. Wit (2002)
Attenuation of the effects of fluoxetine on serotonergic neuronal activity by pindolol in rats
K. Rasmussen (2004)
Simultaneous Depletion of Serotonin and Catecholamines Impairs Sustained Attention in Healthy Female Subjects without Affecting Learning and Memory
Cathy Matrenza (2004)
Preferential 5-HT1A Autoreceptor Occupancy by Pindolol is Attenuated in Depressed Patients: Effect of Treatment or an Endophenotype of Depression?
E. Rabiner (2004)
A pharmacodynamic and pharmacokinetic comparison of pindolol 20 mg retard and a conventional tablet
W. H. Aellig (2004)
Selective Effects of Acute Serotonin and Catecholamine Depletion on Memory in Healthy Women
B. Harrison (2004)
The activation of 5‐HT2A receptors in prefrontal cortex enhances dopaminergic activity
A. Bortolozzi (2005)
Evaluation of DOI, 8-OH-DPAT, eticlopride and amphetamine on impulsive responding in a reaction time task in rats
A. Blokland (2005)
Specific serotonergic reuptake inhibition impairs vigilance performance acutely and after subchronic treatment
W. Riedel (2005)
Stimulant drugs and vigilance performance: a review
H. S. Koelega (2005)
Actual driving performance and psychomotor function in healthy subjects after acute and subchronic treatment with escitalopram, mirtazapine, and placebo: a crossover trial.
M. Wingen (2005)
Differential effects of clonidine, haloperidol, diazepam and tryptophan depletion on focused attention and attentional search
J. Coull (2005)
Serotonin-dopamine interaction as a focus of novel antidepressant drugs.
E. Esposito (2006)
Acute Effects of 3,4-Methylenedioxymethamphetamine (MDMA) on Behavioral Measures of Impulsivity: Alone and in Combination with Alcohol
J. Ramaekers (2006)

This paper is referenced by
[A new look at the genetics of neurocognitive deficits in schizophrenia].
O. Fedorenko (2020)
Neural correlates and role of medication in reactive motor impulsivity in Tourette disorder
Cyril Atkinson-Clement (2020)
Opposing Cholinergic and Serotonergic Modulation of Layer 6 in Prefrontal Cortex
D. W. Sparks (2018)
Brain endocannabinoid signaling exhibits remarkable complexity
Anna Gorzkiewicz (2018)
Controlling Prefrontal Attention Circuits: Neuromodulation of Cortical Layer 6 and its Local Outputs
Michael K Tian (2017)
PTSD, Psychotropic Medication Use, and the Risk of Dementia Among US Veterans: A Retrospective Cohort Study
Francis Mawanda (2017)
Serotonergic Suppression of Mouse Prefrontal Circuits Implicated in Task Attention
Michael K Tian (2016)
Emotion moderates the association between HTR2A (rs6313) genotype and antisaccade latency
M. Mills (2016)
Recent Insights into the Neurobiology of Impulsivity
M. Mitchell (2014)
Association between promoter polymorphism (rs10789970) in 5-hydroxytryptamine receptor 3B and poor concentration in schizophrenia
H. Park (2014)
The role of serotonin in cognitive function: evidence from recent studies and implications for understanding depression
P. Cowen (2013)
Modafinil, but not escitalopram, improves working memory and sustained attention in long-term, high-dose cocaine users
A. Kalechstein (2013)
The effect of serotonin 1A receptor polymorphism on the cognitive function of premenstrual dysphoric disorder
J. Yen (2013)
Acute serotonin 2A receptor blocking alters the processing of fearful faces in the orbitofrontal cortex and amygdala
B. Hornboll (2013)
Neuropsychological functioning in young subjects with generalized anxiety disorder with and without pharmacotherapy
D. Tempesta (2013)
The alteration of 5-HT2A and 5-HT2C receptors is involved in neuronal apoptosis of goldfish cerebellum following traumatic experience
Xueqing Hu (2012)
Contributions of serotonin in addiction vulnerability
L. Kirby (2011)
Variations in 5-HT2A Influence Spatial Cognitive Abilities and Working Memory
Pingyuan Gong (2011)
The utility of rat models of impulsivity in developing pharmacotherapies for impulse control disorders
C. Winstanley (2011)
Cognitive function is related to fronto-striatal serotonin transporter levels – a brain PET study in young healthy subjects
K. Madsen (2010)
Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMA
F. Hasler (2009)
Comparison of ketanserin, buspirone and propranolol on arousal, pupil size and autonomic function in healthy volunteers
V. Koudas (2009)
A new behavioral test for assessment of drug effects on attentional performance and its validity in cynomolgus monkeys.
A. Fujiwara (2009)
Approaches to measuring the effects of wake‐promoting drugs: a focus on cognitive function
C. Edgar (2009)
Cognitive toxicity of pharmacotherapeutic agents used in social anxiety disorder
I. Hindmarch (2009)
Differential effects of escitalopram on attention: a placebo-controlled, double-blind cross-over study
B. Drueke (2009)
Antagonism of serotonergic 5‐HT2A/2C receptors: mutual improvement of sleep, cognition and mood?
H. Landolt (2009)
The effect of Escitalopram on tonic and phasic alertness in healthy volunteers
Julia Bätz (2009)
Molecular genetic studies of cognitive deficit in schizophrenia
V. Golimbet (2008)
Molecular imaging of the 5-HT1A receptor in relation to human cognition
J. Borg (2008)
Sustained attention and serotonin: a pharmaco‐fMRI study
M. Wingen (2008)
The Effects of Acute Tryptophan Depletion on Movement, Mood, and Cognition in Patients with Parkinson’s Disease and Healthy Older Persons
J. Mace (2007)
See more
Semantic Scholar Logo Some data provided by SemanticScholar