Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Effect Of Apomorphine On Cortical Inhibition In Parkinson's Disease Patients: A Transcranial Magnetic Stimulation Study

M. Pierantozzi, M. Palmieri, M. Marciani, G. Bernardi, P. Giacomini, P. Stanzione
Published 2001 · Psychology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Abstract. In this study, transcranial magnetic stimulation (TMS) of the primary motor hand area was used to test cortical excitability in Parkinson's disease (PD) patients. Motor evoked potentials (MEPs) to TMS were studied at rest by utilising distinct paired-pulse TMS protocols. Out of 29 untreated PD patients and 29 healthy subjects, early cortical inhibition (1–6 ms) was studied in a first subgroup of 17 PD patients and 15 healthy subjects, whereas late cortical inhibition (20–200 ms) was studied in a second subgroup of 21 PD patients and 19 healthy subjects. In all PD patients the same TMS protocols were performed before and after 3 h of apomorphine infusion. In comparison to healthy subjects, untreated PD patients showed a significant reduction of both early and late cortical inhibition, which was maximal at 2–3 ms, and at 80–100 ms, respectively. Apomorphine administration consistently reversed all the MEP abnormalities found in PD patients. The lack of TMS effects on the Hoffman's reflex (HR), at those intervals revealing the reduced inhibition in PD patients, is compatible with a supraspinal origin of the observed MEP abnormalities. Our data suggest that the cortical and/or subcortical loss of dopaminergic transmission in PD patients is associated with impaired motor cortical inhibitory mechanisms, as tested by a decreased early and late MEP inhibition.
This paper references
10.1113/jphysiol.1994.sp020124
Separate activation of fast and slow inhibitory postsynaptic potentials in rat neocortex in vitro.
L. Benardo (1994)
10.1111/j.1468-1331.1997.tb00296.x
SEPs N30 amplitude in Parkinson's disease and in pharmacologically induced rigidity: relationship with the clinical status
P. Stanzione (1997)
10.1113/jphysiol.1993.sp019732
Silent period evoked by transcranial stimulation of the human cortex and cervicomedullary junction.
M. Inghilleri (1993)
10.1016/0006-8993(76)90952-5
Short latency EPSPs of pyramidal tract cells evoked by stimulation of the centrum medianum-parafascicular complex and the nucleus ventralis anterior of the thalamus
T. Araki (1976)
10.1111/j.1469-7793.1998.301br.x
Role of spinal premotoneurones in mediating corticospinal input to forearm motoneurones in man
V. Pauvert (1998)
10.1016/0168-5597(92)90048-G
Human motor evoked responses to paired transcranial magnetic stimuli.
J. Valls-Solé (1992)
10.1016/S0140-6736(87)91660-6
SUBCUTANEOUS INFUSION OF APOMORPHINE AND LISURIDE IN THE TREATMENT OF PARKINSONIAN ON-OFF FLUCTUATIONS
C. Stibe (1987)
10.1016/0006-8993(76)90500-X
Spontaneous firing rate of neurones in the prefrontal cortex of the rat: evidence for a dopaminergic inhibition
F. Mora (1976)
10.1016/0022-510X(92)90066-T
Corticospinal conduction studied with magnetic double stimulation in the intact human
D. Claus (1992)
10.1016/0006-8993(82)90809-5
Responses of intracellularly recorded cortical neurons to the iontophoretic application of dopamine
G. Bernardi (1982)
10.1113/jphysiol.1996.sp021734
Interaction between intracortical inhibition and facilitation in human motor cortex.
U. Ziemann (1996)
10.1038/35018000
Transcranial magnetic stimulation and the human brain
M. Hallett (2000)
10.1093/BRAIN/117.4.877
The functions of the basal ganglia and the paradox of stereotaxic surgery in Parkinson's disease.
C. Marsden (1994)
10.1113/jphysiol.1995.sp020898
The effect of voluntary contraction on cortico‐cortical inhibition in human motor cortex.
M. Ridding (1995)
10.1016/0006-8993(87)90509-9
Excitation of rat prefrontal cortical neurons by dopamine: An in vitro electrophysiological study
J. Penit-Soria (1987)
10.1152/JN.1989.62.5.1018
GABA as an inhibitory neurotransmitter in human cerebral cortex.
D. McCormick (1989)
10.1002/ANA.410370208
Changes in excitability of motor cortical circuitry in patients with parkinson's disease
M. C. Ridding (1995)
stimulation in healthy subjects and patients with multiple sclerosis
R Cantello (1991)
10.1212/WNL.42.10.1951
Magnetic brain stimulation: the silent period after the motor evoked potential.
R. Cantello (1992)
10.1212/WNL.41.9.1449
Parkinson's disease rigidity
R. Cantello (1991)
10.1152/JN.1994.71.2.550
Corticocortical and thalamocortical responses of neurons in the monkey primary motor cortex and their relation to a trained motor task.
H. Aizawa (1994)
10.1152/JN.1989.61.4.747
Horizontal spread of synchronized activity in neocortex and its control by GABA-mediated inhibition.
Y. Chagnac-Amitai (1989)
10.1016/0006-8993(86)90385-9
Dopamine modulates neuronal activities related to motor performance in the monkey prefrontal cortex
T. Sawaguchi (1986)
10.1093/BRAIN/119.1.71
Cortical inhibition in Parkinson's disease. A study with paired magnetic stimulation.
A. Berardelli (1996)
10.1212/WNL.17.5.427
Parkinsonism: onset, progression, and mortality
M. Hoehn (1967)
10.1002/SYN.890110408
Differential modulation by dopamine of responses evoked by excitatory amino acids in human cortex
C. Cepeda (1992)
10.1113/jphysiol.1988.sp017390
Two inhibitory postsynaptic potentials, and GABAA and GABAB receptor‐mediated responses in neocortex of rat and cat.
B. Connors (1988)
10.1523/JNEUROSCI.16-08-02767.1996
Spatiotemporal properties of short-term plasticity sensorimotor thalamocortical pathways of the rat
M. Castro-Alamancos (1996)
10.1016/0166-2236(89)90074-X
The functional anatomy of basal ganglia disorders
R. Albin (1989)
10.1111/j.1469-7793.1998.625bq.x
Effects of voluntary contraction on descending volleys evoked by transcranial stimulation in conscious humans
V. Lazzaro (1998)
10.1212/WNL.43.12.2615
Facilitation of magnetic motor evoked potential; during the cortical stimulation silent period
W. J. Triggs (1993)
Study of central motor functions using magnetic stimulation in Parkinson's disease.
P. Diószeghy (1999)
10.1111/j.1460-9568.1995.tb00331.x
The Effects of Dopamine on the Subthreshold Electrophysiological Responses of Rat Prefrontal Cortex Neurons In Vitro
E. Geijo-Barrientos (1995)
10.1002/ANA.410400306
Effects of antiepileptic drugs on motor cortex excitability in humans: A transcranial magnetic stimulation study
U. Ziemann (1996)
10.1016/S0165-0173(97)00061-1
Salient features of synaptic organisation in the cerebral cortex
P. Somogyi (1998)
10.1152/JN.1989.62.5.1149
Synchronized excitation and inhibition driven by intrinsically bursting neurons in neocortex.
Y. Chagnac-Amitai (1989)
10.1016/0304-3940(95)12031-X
Intracortical facilitation and inhibition after paired magnetic stimulation in humans under anesthesia
H. Nakamura (1995)
10.1016/S0924-980X(96)96517-0
Motor evoked responses to paired cortical magnetic stimulation in Parkinson's disease.
F. Valzania (1997)
10.1111/j.1469-7793.1998.181bi.x
Demonstration of facilitatory I wave interaction in the human motor cortex by paired transcranial magnetic stimulation
U. Ziemann (1998)
10.1212/WNL.45.8.1613
Long-duration response to levodopa
J. Nutt (1995)
10.1152/JN.1992.67.1.227
Differential activation of GABAA and GABAB receptors by spontaneously released transmitter.
T. Otis (1992)
10.1016/0306-4522(92)90362-6
Inhibitory effects of ventral tegmental area stimulation on the activity of prefrontal cortical neurons: Evidence for the involvement of both dopaminergic and GABAergic components
S. Pirot (1992)
10.1152/JN.1992.68.3.692
GABAergic inhibition of neuronal activity in the primate motor and premotor cortex during voluntary movement.
M. Matsumura (1992)
10.1016/S0924-980X(98)00023-X
Pharmacological control of facilitatory I-wave interaction in the human motor cortex. A paired transcranial magnetic stimulation study.
U. Ziemann (1998)
10.1016/S1388-2457(00)00316-3
Effects of chronic levodopa and pergolide treatment on cortical excitability in patients with Parkinson's disease: a transcranial magnetic stimulation study
A. Strafella (2000)
10.1097/00004691-199201000-00014
Optimal Focal Transcranial Magnetic Activation of the Human Motor Cortex: Effects of Coil Orientation, Shape of the Induced Current Pulse, and Stimulus Intensity
J. Brasil-Neto (1992)
10.1016/0168-5597(91)90011-L
Spinal motor neuron excitability during the silent period after cortical stimulation.
P. Fuhr (1991)
10.1212/WNL.44.4.735
Abnormal facilitation of the response to transcranial magnetic stimulation in patients with Parkinson's disease
J. Valls-Solé (1994)
10.1093/BRAIN/117.2.317
Motor cortical inhibition and the dopaminergic system. Pharmacological changes in the silent period after transcranial brain stimulation in normal subjects, patients with Parkinson's disease and drug-induced parkinsonism.
A. Priori (1994)
10.1093/BRAIN/114.1.643
Responses of single spinal motoneurons to magnetic brain stimulation in healthy subjects and patients with multiple sclerosis.
S. Boniface (1991)
10.1016/0166-2236(90)90110-V
Primate models of movement disorders of basal ganglia origin
M. Delong (1990)
10.1113/jphysiol.1997.sp021905
Intracortical facilitation and inhibition after transcranial magnetic stimulation in conscious humans.
H. Nakamura (1997)
10.1007/s002210050878
Mechanism of the silent period following transcranial magnetic stimulation Evidence from epidural recordings
R. Chen (1999)
10.1002/ANA.410420217
Long‐duration response to levodopa influences the pharmacodynamics of short‐duration response in Parkinson's disease
M. Zappia (1997)
10.1016/0306-4522(84)90014-9
Responses of striatal neurons in the behaving monkey. 3. Effects of iontophoretically applied dopamine on normal responsiveness
E. Rolls (1984)
10.1016/0304-3940(93)90464-V
Spinal and supraspinal mechanisms contribute to the silent period in the contracting soleus muscle after transcranial magnetic stimulation of human motor cortex
U. Ziemann (1993)
10.1002/ANA.410300308
Alterations of dopaminergic and noradrenergic innervations in motor cortex in parkinson's disease
P. Gaspar (1991)
10.1152/JN.1997.77.6.3134
Recruitment of GABAergic inhibition and synchronization of inhibitory interneurons in rat neocortex.
L. Benardo (1997)
10.1016/0140-6736(90)91531-E
Apomorphine test to predict dopaminergic responsiveness in parkinsonian syndromes
A. Hughes (1990)
10.1016/0006-8993(79)90598-5
A comparative study of ventrolateral and recurrent excitatory postsynaptic potentials in large pyramidal tract cells in the cat
M. Descheˆnes (1979)
H , T , masseter , and other reflexes
J Kimura (1989)
10.1113/jphysiol.1993.sp019912
Corticocortical inhibition in human motor cortex.
T. Kujirai (1993)
10.1007/s002210050694
Effects of dopamine agonists and antagonists on optical responses evoked in rat frontal cortex slices after stimulation of the subcortical white matter
H. Kita (1999)
10.1523/JNEUROSCI.16-20-06567.1996
Properties of Convergent Thalamocortical and Intracortical Synaptic Potentials in Single Neurons of Neocortex
Z. Gil (1996)
10.1016/S0924-980X(97)00050-7
Changes in human motor cortex excitability induced by dopaminergic and anti-dopaminergic drugs.
U. Ziemann (1997)
10.1152/JN.1985.54.4.782
Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex.
D. McCormick (1985)
10.1016/b0-44-306557-8/50234-3
Unified Parkinson's Disease Rating Scale
S. Fahn (1987)
Members of the UPDRS Development Committee. Unified Parkinson's Disease Rating Scale
S. Fahn (1987)
10.1016/0168-5597(94)90034-5
Pattern of motor evoked response to repetitive transcranial magnetic stimulation.
F. Valzania (1994)



This paper is referenced by
10.1016/j.brainresbull.2017.10.002
Follow up study: The influence of rTMS with high and low frequency stimulation on motor and executive function in Parkinson’s disease
J. Málly (2017)
10.1515/REVNEURO.2010.21.4.289
Dopaminergic Impact on Cortical Excitability in Humans
M. Nitsche (2010)
10.1007/s40261-018-0619-3
Pharmacological Insights into the Use of Apomorphine in Parkinson’s Disease: Clinical Relevance
Manon Auffret (2018)
10.1016/j.neuroscience.2007.08.033
Cortical inhibition in Parkinson’s disease: New insights from early, untreated patients
R. Cantello (2007)
10.1016/S1567-4231(09)70174-1
Chapter 26 Diseases and treatments: Parkinson's disease
J. Rothwell (2003)
10.1212/01.wnl.0000278109.76607.0a
Sensorimotor integration is abnormal in asymptomatic Parkin mutation carriers
T. Bäumer (2007)
Historia badania ruchowych potencjałów wywołanych drażnieniem zmiennym polem magnetycznym przez powierzchnię czaszki. Pionierzy i kontynuatorzy The history of motor evoked potentials by using transcranial magnetic stimulation. Pioneers and continuators
Jacek BoJakowski A-G (2015)
10.1016/j.neuroimage.2006.11.047
Role of hyperactive cerebellum and motor cortex in Parkinson's disease
Hong Yu (2007)
10.3233/NRE-182638
Acute kinematic and neurophysiological effects of treadmill and overground walking in Parkinson's disease.
Helena Fernández-Lago (2019)
10.1080/14660820410020600
Neurophysiological measures in amyotrophic lateral sclerosis: Markers of progression in clinical trials
M. de Carvalho (2005)
10.3389/fnhum.2013.00146
An investigation of semantic similarity judgments about action and non-action verbs in Parkinson's disease: implications for the Embodied Cognition Framework
D. Kemmerer (2013)
10.1016/j.arcmed.2013.03.003
Novel mechanisms underlying inhibitory and facilitatory transcranial magnetic stimulation abnormalities in Parkinson's disease.
F. E. León-Sarmiento (2013)
10.1016/j.brs.2008.06.005
Consensus paper on short-interval intracortical inhibition and other transcranial magnetic stimulation intracortical paradigms in movement disorders
A. Berardelli (2008)
10.1113/jphysiol.2002.018937
Excitability changes in human peripheral nerve axons in a paradigm mimicking paired‐pulse transcranial magnetic stimulation
Jane H L Chan (2002)
10.1038/sj.npp.1301122
Modulation of Human Motor Cortex Excitability by Single Doses of Amantadine
J. Reis (2006)
10.1093/BRAIN/AWH321
Abnormal excitability of premotor-motor connections in de novo Parkinson's disease.
C. Buhmann (2004)
10.3389/fneur.2020.00127
Cerebellar Contribution to Motor and Non-motor Functions in Parkinson's Disease: A Meta-Analysis of fMRI Findings
Linda Solstrand Dahlberg (2020)
10.1093/brain/awn179
Subthalamic nucleus stimulation-induced regional blood flow responses correlate with improvement of motor signs in Parkinson disease.
M. Karimi (2008)
10.1016/S1388-2457(01)00694-0
Deep brain stimulation of both subthalamic nucleus and internal globus pallidus restores intracortical inhibition in Parkinson's disease paralleling apomorphine effects: a paired magnetic stimulation study
M. Pierantozzi (2002)
10.3389/fnhum.2017.00309
Effects of More-Affected vs. Less-Affected Motor Cortex tDCS in Parkinson’s Disease
G. Cosentino (2017)
10.1007/s00221-009-1997-9
Interactions between short latency afferent inhibition and long interval intracortical inhibition
K. Udupa (2009)
10.1002/mds.23378
A motor cortex excitability and gait analysis on Parkinsonian patients
F. Vacherot (2010)
10.1212/01.wnl.0000343881.27524.e8
Impaired presynaptic inhibition in the motor cortex in Parkinson disease
J. Chu (2009)
10.1016/j.arcmed.2012.06.003
WITHDRAWN: Mechanisms Underlying Inhibitory and Facilitatory Transcranial Magnetic Stimulation Abnormalities in a Large Sample of Patients with Parkinson's Disease.
F. E. León-Sarmiento (2012)
10.1016/j.neubiorev.2013.09.008
Critical involvement of the motor cortex in the pathophysiology and treatment of Parkinson's disease
D. Lindenbach (2013)
10.5772/25841
Combination of Transcranial Magnetic Stimulation with Electromyography and Electroencephalography: Application in Diagnosis of Neuropsychiatric Disorders
F. Farzan (2012)
10.1016/j.parkreldis.2013.01.007
Safety of transcranial magnetic stimulation in Parkinson's disease: a review of the literature.
Matthew Vonloh (2013)
10.1007/s00221-007-1121-y
Motor intracortical inhibition in PD: L-DOPA modulation of high-frequency rTMS effects
B. Fierro (2007)
10.1016/j.parkreldis.2014.03.018
Therapeutic applications of repetitive transcranial magnetic stimulation (rTMS) in movement disorders: a review.
Nitish Kamble (2014)
10.1007/0-387-28066-9_38
Biochemical Markers of DBS-Induced Transition from “Off” to “On” State in Parkinsonian Patients
S. Galati (2005)
Degenerative diseases Mild cognitive impairment: diagnosing Alzheimer's in the pre-dementia stage Related review: Mild cognitive impairment
Pp (2002)
10.1007/s00415-010-5533-4
Motor cortex excitability correlates with novelty seeking in social anxiety: a transcranial magnetic stimulation investigation
S. Pallanti (2010)
See more
Semantic Scholar Logo Some data provided by SemanticScholar