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Evaluation Of Compressive Strength Index Of The Femoral Neck In Caucasians And Chinese

N. Yu, Y. Liu, Yu-Fang Pei, L. Zhang, S. Lei, Niraj R. Kothari, Ding-You Li, C. Papasian, J. Hamilton, Jiqun Cai, H. Deng
Published 2010 · Medicine

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Compressive strength index (CSI) of the femoral neck is a parameter that integrates the information of bone mineral density (BMD), femoral neck width (FNW), and body weight. CSI is considered to have the potential to improve the performance of assessment for hip fracture risk. However, studies on CSI have been rare. In particular, few studies have evaluated the performance of CSI, in comparison with BMD, FNW, and bending geometry, for assessment of hip fracture risk. We studied two large populations, including 1683 unrelated U.S. Caucasians and 2758 unrelated Chinese adults. For all the study subjects, CSI, femoral neck BMD (FN_BMD), FNW, and bending geometry (section modulus [Z]) of the samples were obtained from dual-energy X-ray absorptiometry scans. We investigated the age-related trends of these bone phenotypes and potential sex and ethnic differences. We further evaluated the performance of these four phenotypes for assessment of hip fracture risk by logistic regression models. Chinese had significantly lower FN_BMD, FNW, and Z, but higher CSI than sex-matched Caucasians. Logistic regression analysis showed that higher CSI was significantly associated with lower risk of hip fracture, and the significance remained after adjusting for covariates of age, sex, and height. Each standard deviation (SD) increment in CSI was associated with odds ratios of 0.765 (95% confidence interval, 0.634, 0.992) and 0.724 (95% confidence interval, 0.569, 0.921) for hip fracture risk in Caucasians and Chinese, respectively. The higher CSI in Chinese may partially help explain the lower incidence of hip fractures in this population compared to Caucasians. Further studies in larger cohorts and/or longitudinal observations are necessary to confirm our findings.
This paper references
A Comparison Study of the Reference Curves of Bone Mineral Density at Different Skeletal Sites in Native Chinese, Japanese, and American Caucasian Women
X. Wu (2003)
Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs.
S. Cummings (2002)
Femoral Bone Mineral Density, Neck-Shaft Angle and Mean Femoral Neck Width as Predictors of Hip Fracture in Men and Women
C. Alonso (2000)
Structural and Biomechanical Basis of Sexual Dimorphism in Femoral Neck Fragility Has Its Origins in Growth and Aging
Y. Duan (2003)
Proximal Femoral Structure and the Prediction of Hip Fracture in Men: A Large Prospective Study Using QCT
D. Black (2008)
Program package for Mendelian analysis of pedigree data (MAN, version 6 technical report)
I Malkin (2003)
Prediction of Incident Hip Fracture Risk by Femur Geometry Variables Measured by Hip Structural Analysis in the Study of Osteoporotic Fractures
S. Kaptoge (2008)
Bone Health of Immigrant Chinese Women Living in New York City
Rajeev Babbar (2005)
Risk Factors for Osteoporosis Related to their Outcome: Fractures
D. V. D. van der Voort (2001)
Differences in bone mineral in young Asian and Caucasian Americans may reflect differences in bone size
G. S. Bhudhikanok (1996)
Weight change over three decades and the risk of osteoporosis in men: the Norwegian Epidemiological Osteoporosis Studies (NOREPOS).
H. Meyer (2008)
Fracture Site‐Specific Deficits in Bone Size and Volumetric Density in Men with Spine or Hip Fractures
E. Seeman (2001)
Hip fracture risk assessment using composite indices of femoral neck strength: the Rancho Bernardo study
A. Karlamangla (2004)
The Influence of an Insulin‐Like Growth Factor I Gene Promoter Polymorphism on Hip Bone Geometry and the Risk of Nonvertebral Fracture in the Elderly: The Rotterdam Study
F. Rivadeneira (2004)
BMD at Multiple Sites and Risk of Fracture of Multiple Types: Long‐Term Results From the Study of Osteoporotic Fractures
K. Stone (2003)
Hip geometry and its role in fracture: What do we know so far?
R. Brownbill (2003)
A reference standard for the description of osteoporosis.
J. Kanis (2008)
Femoral neck geometry and radiographic signs of osteoporosis as predictors of hip fracture.
K. Karlsson (1996)
Femoral Neck Length and Hip Fracture Risk
J. Michelotti (1999)
Universal standardization for dual X‐ray absorptiometry: Patient and phantom cross‐calibration results
H. Genant (1994)
Femoral neck fragility in women has its structural and biomechanical basis established by periosteal modeling during growth and endocortical remodeling during aging
S. Filardi (2003)
Poor correlation of mid-femoral measurements by CT and hip measurements by DXA in the elderly
D. Taaffe (2003)
Robust and Comprehensive Analysis of 20 Osteoporosis Candidate Genes by Very High‐Density Single‐Nucleotide Polymorphism Screen Among 405 White Nuclear Families Identified Significant Association and Gene–Gene Interaction
Dong-hai Xiong (2006)
Sources of interracial variation in bone mineral density
T. Cundy (1995)
Comparison of femoral geometry among cases with and without hip fractures.
H. T. Çaliş (2004)
Modelling of age-related bone loss using cross-sectional data
I. Malkin (2002)
Bone mineral density thresholds for pharmacological intervention to prevent fractures.
E. Siris (2004)
Areal and volumetric bone density in Hong Kong Chinese: a comparison with Caucasians living in the United States
E. Lau (2003)
Genomic Regions Identified for BMD in a Large Sample Including Epistatic Interactions and Gender‐Specific Effects
P. Xiao (2006)
Differences in peak bone mass in women of European and South Asian origin can be explained by differences in body size
D. Roy (2005)
Tests of Linkage and/or Association of Genes for Vitamin D Receptor, Osteocalcin, and Parathyroid Hormone With Bone Mineral Density
H. Deng (2002)
Simple measurement of femoral geometry predicts hip fracture: The study of osteoporotic fractures
K. Faulkner (1993)
Weight loss and distal forearm fractures in postmenopausal women
T. Omsland (2009)
Femoral Neck BMD Is a Strong Predictor of Hip Fracture Susceptibility in Elderly Men and Women Because It Detects Cortical Bone Instability: The Rotterdam Study
F. Rivadeneira (2007)
Hip Fracture Risk and Proximal Femur Geometry from DXA Scans
C. Bergot (2002)
Femoral Bone Mineral Density, Neck-Shaft Angle and Mean Femoral Neck Width as Predictors of Hip Fracture in Men and Women
C. Gómez Alonso (2000)
Hip fractures. Epidemiology, risk factors, falls, energy absorption, hip protectors, and prevention.
J. Lauritzen (1997)

This paper is referenced by
Insulin Resistance and Bone Strength: Findings From the Study of Midlife in the United States
P. Srikanthan (2014)
C‐Reactive Protein, Bone Strength, and Nine‐Year Fracture Risk: Data From the Study of Women's Health Across the Nation (SWAN)
S. Ishii (2013)
Decreased Composite Indices of Femoral Neck Strength in Young Obese Women
A. Berro (2018)
Epidemiology and structural basis of racial differences in fragility fractures in Chinese and Caucasians
Xiufeng Wang (2011)
Association between obesity and femoral neck strength according to age, sex, and fat distribution
H. Kim (2017)
Composite Indices of Femoral Neck Strength in Middle-Aged Inactive Subjects Vs Former Football Players.
B. Finianos (2020)
Influence of Physical Activity Level on Composite Indices of Femoral Neck Strength in a Group of Young Overweight Men.
Eddy Zakhem (2020)
The Chinese skeleton: insights into microstructure that help to explain the epidemiology of fracture
E. Cong (2014)
Physical activity as determinant of femoral neck strength relative to load in adult women: findings from the hip strength across the menopause transition study
T. Mōri (2013)
Complementary and Traditional Chinese Medicine Methods in the Treatment of Gynecological Diseases
W. Wuttke (2013)
Combining areal DXA bone mineral density and vertebrae postero-anterior width improves the prediction of vertebral strength
G. Tatoń (2013)
Maximal Oxygen Consumption and Composite Indices of Femoral Neck Strength in a Group of Young Women
A. Berro (2017)
Bivariate genome-wide association study suggests fatty acid desaturase genes and cadherin DCHS2 for variation of both compressive strength index and appendicular lean mass in males.
Y. Han (2012)
New advances in imaging osteoporosis and its complications
J. Griffith (2012)
The positive association of total protein intake with femoral neck strength (KNHANES IV)
B. Kim (2018)
Trajectories of femoral neck strength in relation to the final menstrual period in a multi-ethnic cohort
S. Ishii (2013)
Higher serum ferritin level and lower femur neck strength in women at the stage of bone loss (≥ 45 years of age): The Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV)
S. H. Ahn (2016)
The Association of Vitamin D With Femoral Neck Strength: An Additional Evidence of Vitamin D on Bone Health.
H. Kim (2015)
Maximal Oxygen Consumption and Composite Indices of Femoral Neck Strength in a Group of Young Overweight and Obese Men.
Georges El Khoury (2018)
Prediction of hip osteoporotic fractures from composite indices of femoral neck strength
Guan-wu Li (2012)
Adult bone strength of children from single-parent families: the Midlife in the United States Study
C. Crandall (2014)
Low skeletal muscle mass associates with low femoral neck strength, especially in older Korean women: the Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV)
B. Kim (2014)
Diabetes and femoral neck strength: findings from the Hip Strength Across the Menopausal Transition Study.
S. Ishii (2012)
Childhood socioeconomic status and adult femoral neck bone strength: findings from the Midlife in the United States Study.
A. Karlamangla (2013)
Gender differences in a reference database of age-related femoral neck geometric parameters for Chinese population and their association with femoral neck fractures.
Y. Shen (2016)
Decreased Composite Indices of Femoral Neck Strength in Young Obese Men.
C. El Khoury (2017)
Proximal femur geometry assessed by hip structural analysis in hip fracture in women
G. Iolascon (2015)
Vitamin D Level and Composite Indices of Femoral Neck Strength in a Group of Young Lebanese Men.
A. Alwan (2016)
Differential association of dietary fat intake with DXA-based estimates of bone strength according to sex in the KNHANES IV population
H. Kim (2020)
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