Properties And Applications Of Undecylprodigiosin And Other Bacterial Prodigiosins
N. Stanković, L. Šenerović, T. Ilić-Tomić, B. Vasiljević, J. Nikodinovic-Runic
Published 2014 · Medicine, Biology
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The growing demand to fulfill the needs of present-day medicine in terms of novel effective molecules has lead to reexamining some of the old and known bacterial secondary metabolites. Bacterial prodigiosins (prodiginines) have a long history of being re markable multipurpose compounds, best examined for their anticancer and antimalarial activities. Production of prodigiosin in the most common producer strain Serratia marcescens has been described in great detail. However, few reports have discussed the ecophysiological roles of these molecules in the producing strains, as well as their antibiotic and UV-protective properties. This review describes recent advances in the production process, biosynthesis, properties, and applications of bacterial prodigiosins. Special emphasis is put on undecylprodigiosin which has generally been a less studied member of the prodigiosin family. In addition, it has been suggested that proteins involved in undecylprodigiosin synthesis, RedG and RedH, could be a useful addition to the biocatalytic toolbox being able to mediate regio- and stereoselective oxidative cyclization. Judging by the number of recent references (216 for the 2007–2013 period), it has become clear that undecylprodigiosin and other bacterial prodigiosins still hold surprises in terms of valuable properties and applicative potential to medical and other industrial fields and that they still deserve continuing research curiosity.
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Construction and co-cultivation of two mutant strains harboring key precursor genes to produce prodigiosin.
Wei-Chuan Chen (2018)
Targeted Delivery Prodigiosin to Choriocarcinoma by Peptide-Guided Dendrigraft Poly-l-lysines Nanoparticles
Kai Zhao (2019)
Large-Scale Transposition Mutagenesis of Streptomyces coelicolor Identifies Hundreds of Genes Influencing Antibiotic Biosynthesis
Z. Xu (2017)
Pigment production by cold-adapted bacteria and fungi: colorful tale of cryosphere with wide range applications
Wasim Sajjad (2020)
New Stetter reactions catalyzed by thiamine diphosphate dependent MenD from E. coli.
M. Beigi (2014)
Using prodigiosin against some gram-positive and gram-negative bacteria and Trypanosoma cruzi
Rocío Herráez (2019)
Production and Potential Applications of Bioconversion of Chitin and Protein-Containing Fishery Byproducts into Prodigiosin: A Review
S. Wang (2020)
Antiviral activity and specific modes of action of bacterial prodigiosin against Bombyx mori nucleopolyhedrovirus in vitro
W. Zhou (2015)See more