Online citations, reference lists, and bibliographies.

Properties And Applications Of Undecylprodigiosin And Other Bacterial Prodigiosins

N. Stanković, L. Šenerović, T. Ilić-Tomić, B. Vasiljević, J. Nikodinovic-Runic
Published 2014 · Medicine, Biology

Cite This
Download PDF
Analyze on Scholarcy
Share
The growing demand to fulfill the needs of present-day medicine in terms of novel effective molecules has lead to reexamining some of the old and known bacterial secondary metabolites. Bacterial prodigiosins (prodiginines) have a long history of being re markable multipurpose compounds, best examined for their anticancer and antimalarial activities. Production of prodigiosin in the most common producer strain Serratia marcescens has been described in great detail. However, few reports have discussed the ecophysiological roles of these molecules in the producing strains, as well as their antibiotic and UV-protective properties. This review describes recent advances in the production process, biosynthesis, properties, and applications of bacterial prodigiosins. Special emphasis is put on undecylprodigiosin which has generally been a less studied member of the prodigiosin family. In addition, it has been suggested that proteins involved in undecylprodigiosin synthesis, RedG and RedH, could be a useful addition to the biocatalytic toolbox being able to mediate regio- and stereoselective oxidative cyclization. Judging by the number of recent references (216 for the 2007–2013 period), it has become clear that undecylprodigiosin and other bacterial prodigiosins still hold surprises in terms of valuable properties and applicative potential to medical and other industrial fields and that they still deserve continuing research curiosity.
This paper references
10.1002/1439-7633(20010903)2:9<706::AID-CBIC706>3.0.CO;2-J
Studies on DNA Cleavage by Cytotoxic Pyrrole Alkaloids Reveal the Distinctly Different Behavior of Roseophilin and Prodigiosin Derivatives
A. Fürstner (2001)
10.1002/CHIN.200343231
Chemistry and Biology of Roseophilin and the Prodigiosin Alkaloids: A Survey of the Last 2500 Years.
A. Fürstner (2003)
10.5860/choice.30-4151
Encyclopedia of microbiology
M. Schaechter (2009)
10.1093/nar/gkp1063
Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability
D. Schild (2010)
10.7324/japs.2012.2823
Enhanced Production of Prodigiosin Production in Serratia Marcescens
K. Poornima (2012)
10.1099/mic.0.055780-0
The stationary phase sigma factor, RpoS, regulates the production of a carbapenem antibiotic, a bioactive prodigiosin and virulence in the enterobacterial pathogen Serratia sp. ATCC 39006.
Nabil M. Wilf (2012)
10.1016/j.bmcl.2012.05.115
CoMSIA and POM analyses of anti-malarial activity of synthetic prodiginines.
D. T. Mahajan (2012)
10.1016/j.chembiol.2007.11.015
Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis.
S. Mo (2008)
10.1126/science.1209855
H2S: A Universal Defense Against Antibiotics in Bacteria
Konstantin Shatalin (2011)
10.1021/jm00313a005
Antimicrobial properties of pyrrole derivatives.
A. Castro (1967)
10.7164/antibiotics.43.1293
Selective immunosuppression of prodigiosin 25-C and FK506 in the murine immune system.
R. Tsuji (1990)
Studies on pigmentation of serratia marcescens. III. The characteristics of an orange variant.
Green Ja (1956)
10.1007/PL00013038
Synergistic Antifungal Activity of Chitinolytic Enzymes and Prodigiosin Produced by Biocontrol Bacterium, Serratia marcescens Strain B2 against Gray Mold Pathogen, Botrytis cinerea
N. Someya (2001)
10.3389/fmicb.2012.00255
Viscosity dictates metabolic activity of Vibrio ruber
Maja Borić (2012)
10.1007/978-3-642-24520-6
Application of Bacterial Pigments as Colorant: The Malaysian Perspective
W. Ahmad (2012)
10.1016/J.JTICE.2010.05.009
Response surface optimization of microbial prodigiosin production from Serratia marcescens
Wen-Ta Su (2011)
10.1007/s00044-012-0223-7
Integrating GUSAR and QSAR analyses for antimalarial activity of synthetic prodiginines against multi drug resistant strain
D. T. Mahajan (2012)
Optimization of prodigiosin production by Serratia marcescens SU10 and evaluation of its bioactivity
A Samrot (2011)
10.1111/J.1574-6968.2007.00950.X
Pseudovibrio denitrificans strain Z143-1, a heptylprodigiosin-producing bacterium isolated from a Philippine tunicate.
Alice A Sertan-de Guzman (2007)
Microbial Pigments
V. Joshi (2011)
10.1186/1471-2180-4-11
A novel medium for the enhanced cell growth and production of prodigiosin from Serratia marcescens isolated from soil
A. V. Giri (2003)
10.7164/antibiotics.38.128
Identification of a red pigment from Streptomyces coelicolor A3(2) as a mixture of prodigiosin derivatives.
S. W. Tsao (1985)
10.1080/10826068.2012.721850
MUTANT BREEDING OF Serratia marcescens STRAIN FOR ENHANCING PRODIGIOSIN PRODUCTION AND APPLICATION TO TEXTILES
Xiaoxia Liu (2013)
10.1371/journal.pone.0057634
A Serratia marcescens PigP Homolog Controls Prodigiosin Biosynthesis, Swarming Motility and Hemolysis and Is Regulated by cAMP-CRP and HexS
R. Shanks (2013)
10.1128/mBio.00407-12
Crp Is a Global Regulator of Antibiotic Production in Streptomyces
Chan Gao (2012)
10.1128/AEM.01986-10
Exceptional Production of both Prodigiosin and Cycloprodigiosin as Major Metabolic Constituents by a Novel Marine Bacterium, Zooshikella rubidus S1-1 †
J. Lee (2011)
10.1128/AAC.46.4.1112-1113.2002
Potent In Vitro Antimalarial Activity of Metacycloprodigiosin Isolated from Streptomycesspectabilis BCC 4785
M. Isaka (2002)
10.1128/CMR.00017-11
Serratia Infections: from Military Experiments to Current Practice
Steven D. Mahlen (2011)
10.1007/s00253-011-3581-z
Inactivation of phosphomannose isomerase gene abolishes sporulation and antibiotic production in Streptomyces coelicolor
Thangamani Rajesh (2011)
10.1007/s10529-010-0401-y
Streptomyces coelicolor increases the production of undecylprodigiosin when interacted with Bacillus subtilis
Khalid Jaber Kadhum Luti (2010)
10.1023/A:1014940632674
Synergistic Effects Induced by Cycloprodigiosin Hydrochloride and Epirubicin on Human Breast Cancer Cells
D. Yamamoto (2004)
10.1021/jo00242a013
Total synthesis of prodigiosin, prodigiosene, and desmethoxyprodigiosin: Diels-Alder reactions of heterocyclic azadienes and development of an effective palladium(II)-promoted 2,2'-bipyrrole coupling procedure
D. Boger (1988)
10.1016/J.PROCBIO.2013.06.006
Bacterial pigments and their applications
C. K. Venil (2013)
10.1128/aem.30.5.807-810.1975
Prodiginine (prodigiosin-like) pigments from Streptoverticillium rubrireticuli, an organism that causes pink staining of polyvinyl chloride.
N. Gerber (1975)
10.1099/MIC.0.27222-0
The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation.
A. K. Harris (2004)
10.1038/nrmicro1531
The biosynthesis and regulation of bacterial prodiginines
N. Williamson (2006)
10.1073/pnas.0709443104
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
M. Nguyễn (2007)
10.1263/JBB.100.466
Enhanced undecylprodigiosin production from Serratia marcescens SS-1 by medium formulation and amino-acid supplementation.
Yu-Hong Wei (2005)
1975b) Prodigiosin-like pigments
NN Gerber (1975)
10.1007/s00203-004-0669-1
Differential production of two antibiotics of Streptomyces coelicolor A3(2), actinorhodin and undecylprodigiosin, upon salt stress conditions
B. Ševčíková (2004)
10.1128/aem.49.1.173-178.1985
Influence of Serratia marcescens Pigmentation on Cell Concentrations in Aerosols Produced by Bursting Bubbles.
L. Syzdek (1985)
10.1021/np7007494
A prodigiosin from the roseophilin producer Streptomyces griseoviridis.
T. Kawasaki (2008)
10.1111/j.1365-2672.2006.03172.x
Biosynthesis of antibiotic prodiginines in the marine bacterium Hahella chejuensis KCTC 2396
D. Kim (2007)
10.1016/S1074-5521(01)00054-0
Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2): new mechanisms for chain initiation and termination in modular multienzymes.
A. M. Cerdeño (2001)
10.1016/0378-1119(90)90141-D
Cloning and expression in a heterologous host of the complete set of genes for biosynthesis of the Streptomyces coelicolor antibiotic undecylprodigiosin.
F. Malpartida (1990)
Effect of salt stress on pigment production of Serratia rubidaea N-1: a potential indicator strain for screening quorum sensing inhib
G Treat 721–10 Yamazaki (2006)
10.1155/2011/670349
Bioactive Pigments from Marine Bacteria: Applications and Physiological Roles
A. B. Soliev (2011)
10.1134/S0006297912080123
Role of prodigiosin and chitinases in antagonistic activity of the bacterium Serratia marcescens against the fungus Didymella applanata
A. B. Duzhak (2012)
10.1093/TOXSCI/KFI149
DNA interaction and dual topoisomerase I and II inhibition properties of the anti-tumor drug prodigiosin.
B. Montaner (2005)
10.1021/JM001003P
Synthesis and immunosuppressive activity of novel prodigiosin derivatives.
R. D'Alessio (2000)
10.1016/J.TAAP.2007.08.007
Undecylprodigiosin selectively induces apoptosis in human breast carcinoma cells independent of p53.
T. Ho (2007)
10.1016/J.BEJ.2013.02.001
Enhancing production of prodigiosin from Serratia marcescens C3 by statistical experimental design and porous carrier addition strategy
W. Chen (2013)
10.1016/0378-1119(92)90533-U
Molecular genetic analysis of proline and tryptophan biosynthesis in Streptomyces coelicolor A3(2): interaction between primary and secondary metabolism--a review.
D. Hood (1992)
Heptyl prodigiosin, a bacterial metabolite, is antimalarial in vivo and non-mutagenic in vitro.
J. E. Lazaro (2002)
10.1016/j.resmic.2009.12.004
Cyclic AMP negatively regulates prodigiosin production by Serratia marcescens.
Eric J. Kalivoda (2010)
10.1021/jm200543y
Antimalarial activity of natural and synthetic prodiginines.
Kancharla Papireddy (2011)
10.1093/nar/gki1016
Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent
Haeyoung Jeong (2005)
Potent in vitro anticancer activity of metacycloprodigiosin and undecylprodigiosin from a sponge-derived actinomycete Saccharopolyspora sp. nov
R Liu (2005)
10.1038/sj.onc.1210421
MAP kinase signalling pathways in cancer
A. S. Dhillon (2007)
10.1007/s12275-009-0118-6
Isolation and characterization of marine pigmented bacteria from Norwegian coastal waters and screening for carotenoids with UVA-blue light absorbing properties
M. Stafsnes (2009)
10.1263/JBB.99.616
Enhanced production of prodigiosin-like pigment from Serratia marcescens SMdeltaR by medium improvement and oil-supplementation strategies.
Yu-Hong Wei (2005)
10.1007/s10482-012-9772-5
Overproduction and biological activity of prodigiosin-like pigments from recombinant fusant of endophytic marine Streptomyces species
Ahmed Mohamed Ahmed El-Bondkly (2012)
10.1128/JB.00909-08
Kinetic analysis of growth rate, ATP, and pigmentation suggests an energy-spilling function for the pigment prodigiosin of Serratia marcescens.
P. Haddix (2008)
10.1016/S0041-1345(01)02390-9
PNU156804 inhibits Jak3 tyrosine kinase and rat heart allograft rejection.
S. Stepkowski (2001)
10.1089/dna.2010.1020
Psychrotrophic strain of Janthinobacterium lividum from a cold Alaskan soil produces prodigiosin.
P. Schloss (2010)
Different effect of acidic pH shock on the prodiginine production in Streptomyces coelicolor M511 and SJM1 mutant
SJ Mo (2013)
A (2000a) Cycloprodigiosin hydrochloride, a H+/Cl- symporter, induces apoptosis in human breast cancer cell lines
D Yamamoto (2000)
10.1007/S10156-005-0376-0
Evaluation of the anti-Trichophyton activity of a prodigiosin analogue produced by γ-proteobacterium, using stratum corneum epidermis of the Yucatan micropig
T. Nakashima (2005)
10.1139/m76-097
Prodiginine (prodigiosin-like) pigments from Streptomyces and other aerobic Actinomycetes.
N. Gerber (1976)
10.2217/17460913.2.6.605
Anticancer and immunosuppressive properties of bacterial prodiginines.
N. Williamson (2007)
10.1021/ja400473v
Modular access to complex prodiginines: total synthesis of (+)-roseophilin via its 2-azafulvene prototropisomer.
James H Frederich (2013)
Red to red - the marine bacterium Hahella chejuensis and its product prodigiosin for mitigation of harmful algal blooms.
D. Kim (2008)
Cloning and expression in a heterologous host of the complete set of
F Malpartida (1990)
10.1016/j.chembiol.2012.06.013
Chemical perturbation of secondary metabolism demonstrates important links to primary metabolism.
A. Craney (2012)
10.1128/JB.00040-13
Positive feedback regulation of stgR expression for secondary metabolism in Streptomyces coelicolor.
X. Mao (2013)
10.1111/j.1758-2229.2010.00140.x
Engineering of new prodigiosin-based biosensors of Serratia for facile detection of short-chain N-acyl homoserine lactone quorum-sensing molecules.
Simon Poulter (2010)
10.1016/S0041-1345(00)02794-9
Inhibition of Jak3 tyrosine kinase by PNU156804 blocks rat heart allograft rejection.
M. Wang (2001)
10.1021/OL027165S
Zinc and copper complexes of prodigiosin: implications for copper-mediated double-strand DNA cleavage.
Gyungse Park (2003)
10.1016/J.TET.2013.07.067
Synthesis of 2,2′-bipyrrole-5-carboxaldehydes and their application in the synthesis of B-ring functionalized prodiginines and tambjamines
P. Kancharla (2013)
10.1099/00221287-136-11-2291
PIGMENTED ANTIBIOTIC PRODUCTION BY STREPTOMYCES COELICOLOR A3(2) : KINETICS AND THE INFLUENCE OF NUTRIENTS
Glyn Hobbs (1990)
10.1007/s00253-010-3032-2
Elicitation of Streptomyces coelicolor with dead cells of Bacillus subtilis and Staphylococcus aureus in a bioreactor increases production of undecylprodigiosin
Khalid Jaber Kadhum Luti (2010)
10.2174/1568009033333772
The prodigiosins: a new family of anticancer drugs.
B. Montaner (2003)
10.1186/1471-2164-11-10
The dynamic architecture of the metabolic switch in Streptomyces coelicolor
K. Nieselt (2009)
Algicidal activity of prodigiosin against harmful algae.
Liu Bo-ya (2010)
10.4014/JMB.1307.07067
Different effects of acidic pH shock on the prodiginine production in Streptomyces coelicolor M511 and SJM1 mutants.
SangJoon Mo (2013)
10.1271/bbb.110984
Cytotoxic Prodigiosin Family Pigments from Pseudoalteromonas sp. 1020R Isolated from the Pacific Coast of Japan
Y. Wang (2012)
10.1128/JB.02191-12
The ROK family regulator Rok7B7 pleiotropically affects xylose utilization, carbon catabolite repression, and antibiotic production in streptomyces coelicolor.
Magdalena A. Światek (2013)
10.1016/S0065-2164(00)47000-0
Seeing red: the story of prodigiosin.
J. W. Bennett (2000)
10.1158/1535-7163.MCT-06-0266
Prodigiosin induces the proapoptotic gene NAG-1 via glycogen synthase kinase-3β activity in human breast cancer cells
V. Soto-Cerrato (2007)
10.1134/S1068162012060040
Bacterial pigment prodigiosin and its genotoxic effect
I. D. Guryanov (2012)
10.1111/j.1462-2920.2011.02665.x
Characterization and localization of prodiginines from Streptomyces lividans suppressing Verticillium dahliae in the absence or presence of Arabidopsis thaliana.
Holger Meschke (2012)
10.2174/15734099113099990020
QSAR and pharmacophore modeling of natural and synthetic antimalarial prodiginines.
B. Singh (2013)
10.1371/journal.pone.0065381
Undecylprodigiosin Induced Apoptosis in P388 Cancer Cells Is Associated with Its Binding to Ribosome
Ping Liu (2013)
Overexpression of RAD 51 suppresses recombination defects : a possible mechanism to reverse genomic instabil
D Schild (2010)
10.2323/JGAM.52.113
Effect of salt stress on pigment production of Serratia rubidaea N-1: a potential indicator strain for screening quorum sensing inhibitors from marine microbes.
G. Yamazaki (2006)
10.1007/s004320050032
Cycloprodigiosin hydrochloride, a H+/Cl− symporter, induces apoptosis in human breast cancer cell lines
D. Yamamoto (2000)
10.1039/B609556A
Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis.
A. Stanley (2006)
10.1002/1097-0215(20001001)88:1<121::AID-IJC19>3.0.CO;2-C
Cycloprodigiosin hydrochloride, H+/CL– symporter, induces apoptosis and differentiation in HL‐60 cells
D. Yamamoto (2000)
10.1038/cdd.2013.45
Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes
F. Basit (2013)
10.1139/m69-122
The chitinase of Serratia marcescens.
J. Monreal (1969)
10.1007/s10637-006-7774-8
Proteomic analysis of prodigiosin-induced apoptosis in a breast cancer mitoxantrone-resistant (MCF-7 MR) cell line
M. Monge (2006)
10.1007/s12257-012-0210-3
Selection of extraction solvent and temperature effect on stability of the algicidal agent prodigiosin
Heeyong Park (2012)
10.1016/J.JCLEPRO.2013.03.031
Recent advancements in natural dye applications: a review
Mohammad Shahid (2013)
10.1016/S0024-3205(01)01002-5
Prodigiosin-induced apoptosis in human colon cancer cells.
B. Montaner (2001)
10.1039/b801677a
Role and substrate specificity of the Streptomyces coelicolor RedH enzyme in undecylprodiginine biosynthesis.
Stuart W. Haynes (2008)
10.1021/JO990944A
DNA Binding by 4-Methoxypyrrolic Natural Products. Preference for Intercalation at AT Sites by Tambjamine E and Prodigiosin.
M. Melvin (1999)
10.1016/S0192-0561(97)00062-3
T-cell specific immunosuppression by prodigiosin isolated from Serratia marcescens.
S. Han (1998)
10.1016/S0006-2952(03)00496-9
The prodigiosins, proapoptotic drugs with anticancer properties.
R. Pérez-Tomás (2003)
10.1007/s00253-011-3644-1
The PII protein GlnK is a pleiotropic regulator for morphological differentiation and secondary metabolism in Streptomyces coelicolor
Eva Waldvogel (2011)
Studies on pigmentation of Serratia marcescens. I. Spectral and paper chromatographic properties of prodigiosin.
R. Williams (1956)
10.1007/s12275-008-0037-y
Mutant selection of Hahella chejuensis KCTC 2396 and statistical optimization of medium components for prodigiosin yield-up
S. Kim (2008)
10.4161/bioe.21371
Engineering of N-acetylglucosamine metabolism for improved antibiotic production in Streptomyces coelicolor A3(2) and an unsuspected role of NagA in glucosamine metabolism
Magdalena A. Światek (2012)
10.1126/science.1175439
Endogenous Nitric Oxide Protects Bacteria Against a Wide Spectrum of Antibiotics
I. Gusarov (2009)
10.1016/j.toxlet.2012.05.002
Prodigiosin-induced cytotoxicity involves RAD51 down-regulation through the JNK and p38 MAPK pathways in human breast carcinoma cell lines.
Chien-Hsing Lu (2012)
Algicidal agent containing prodigiosin and prodigiosin biosynthetic gene cluster
HY Jeong (2007)
10.1128/jb.118.2.756-757.1974
Isolation and purification of prodigiosin from Vibrio psychroerythrus.
J. D'aoust (1974)
10.3109/10408417509108758
Prodigiosin-like pigments.
N. Gerber (1975)
Prodigiosin from marine bacterium: production, characterization and application as dye in textile industry
GJ Krishna (2011)
10.1046/J.1365-2958.2003.03295.X
Phosphate availability regulates biosynthesis of two antibiotics, prodigiosin and carbapenem, in Serratia via both quorum-sensing-dependent and -independent pathways.
H. Slater (2003)
10.1007/978-1-4020-9942-7
Biotechnology for Agro-Industrial-Residues-Utilisation
P. Nigam (2009)
10.1182/blood-2012-04-425033
Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia.
K. Urtishak (2013)
10.1016/j.exppara.2007.11.015
Leishmania (Leishmania) chagasi interactions with Serratia marcescens: ultrastructural studies, lysis and carbohydrate effects.
C. S. Moraes (2008)
10.1074/jbc.M110.213512
Structure and Function of the RedJ Protein, a Thioesterase from the Prodiginine Biosynthetic Pathway in Streptomyces coelicolor*
J. R. Whicher (2011)
10.1007/s00248-011-9857-0
Prodigiosin from Vibrio sp. DSM 14379; A New UV-Protective Pigment
Maja Borić (2011)
10.1016/0014-4894(53)90009-5
In vitro effects of prodigiosin and other antibiotics on Trypanosoma cruzi
W. L. Mcrary (1953)
Shternshis MV (2012) Role of prodigiosin and chitinases in antagonistic activity of the bacterium Serratia marcescens against the fungus
AB Duzhak (2012)
Characterization of the new immunosuppressive drug undecylprodigiosin in human lymphocytes: retinoblastoma protein, cyclin-dependent kinase-2, and cyclin-dependent kinase-4 as molecular targets.
S. Songia (1997)
10.1186/1471-2180-4-1
Restricted changes in major surface protein-2 (msp2) transcription after prolonged in vitro passage of Anaplasma phagocytophilum
D. Scorpio (2003)
10.1111/J.1348-0421.2006.TB03833.X
Transcriptional downregulator hexS controlling prodigiosin and serrawettin W1 biosynthesis in Serratia marcescens.
Taichiro Tanikawa (2006)
10.1016/j.taap.2012.08.034
Prodigiosin activates endoplasmic reticulum stress cell death pathway in human breast carcinoma cell lines.
Mu-Yun Pan (2012)
10.1111/j.1348-0421.1989.tb01975.x
A protein associated with prodigiosin formation in Serratia marcescens.
N. Kobayashi (1989)
10.1002/btpr.346
Mutation of bacterium Vibrio gazogenes for selective preparation of colorants
Farzaneh Alihosseini (2010)
10.3967/0895-3988.2013.02.009
Isolation and characterization of an algicidal bacterium indigenous to lake Taihu with a red pigment able to lyse microcystis aeruginosa.
F. Yang (2013)
10.1128/jb.172.1.326-333.1990
Nucleotide sequence and transcriptional analysis of the redD locus of Streptomyces coelicolor A3(2).
K. E. Narva (1990)
10.7164/antibiotics.49.86
Effect of metacycloprodigiosin, an inhibitor of killer T cells on murine skin and heart transplants.
J. Magae (1996)
10.1099/00222615-46-11-903
Serratia marcescens.
A. Hejazi (1997)
10.5897/AJB11.846
Marine bacterial prodigiosin as dye for rubber latex, polymethyl methacrylate sheets and paper
Jissa G. Krishna (2013)
10.1007/s00436-011-2365-9
Prodigiosin produced by Serratia marcescens NMCC46 as a mosquito larvicidal agent against Aedes aegypti and Anopheles stephensi
C. Patil (2011)
10.1002/cbic.200700714
Polarity of Major Grooves Explored by Using an Isosteric Emissive Nucleoside
Renatus W. Sinkeldam (2008)
10.1016/j.biotechadv.2010.11.006
Unexpected applications of secondary metabolites.
P. Vaishnav (2011)
10.1007/s00248-010-9671-0
Vibrio sp. DSM 14379 Pigment Production—A Competitive Advantage in the Environment?
Nejc Starič (2010)
10.1111/j.1365-2958.2012.08126.x
Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor.
Zhenyu Yu (2012)
10.1089/dna.2012.1902
The anticancer agent prodigiosin is not a multidrug resistance protein substrate.
F. Elahian (2013)
10.7164/antibiotics.28.194
A new prodiginine (prodigiosin-like) pigment from Streptomyces. antimalarial activity of several prodiginines.
N. Gerber (1975)
The reversal of glucose repressed prodigiosin production in Serratia marcescens by the cyclic 3′5′-adenosine
S Clements-Jewery (1976)
10.1039/c3cp44058c
An investigation of the photophysical properties of minor groove bound and intercalated DAPI through quantum-mechanical and spectroscopic tools.
A. Biancardi (2013)
10.1128/aem.50.2.487-490.1985
Droplet enrichment factors of pigmented and nonpigmented Serratia marcescens: possible selective function for prodigiosin.
S. Burger (1985)
10.1038/nchem.1024
Regio and Stereodivergent Antibiotic Oxidative Carbocyclizations Catalyzed by Rieske Oxygenase-Like Enzymes
P. K. Sydor (2011)
10.7164/antibiotics.39.1155
Selective suppression by prodigiosin of the mitogenic response of murine splenocytes.
A. Nakamura (1986)
10.1371/journal.pone.0043801
Life History Trade-Offs and Relaxed Selection Can Decrease Bacterial Virulence in Environmental Reservoirs
L. Mikonranta (2012)
10.1021/JA0000798
Double-Strand DNA Cleavage by Copper·Prodigiosin
M. Melvin (2000)
10.3390/molecules15106931
Prodigiosin Production by Serratia marcescens UCP 1549 Using Renewable-Resources as a Low Cost Substrate
H. W. C. de Araújo (2010)
10.1002/CHIN.201049269
Carbon Source Regulation of Antibiotic Production
S. Sánchez (2010)
10.1016/J.EJPHAR.2007.06.054
Mechanisms of prodigiosin cytotoxicity in human neuroblastoma cell lines.
R. Francisco (2007)
10.1016/j.jphotobiol.2011.08.006
Response of pigmented Serratia marcescens to the illumination.
Irina N. Ryazantseva (2012)
10.1016/J.FEMSEC.2004.08.008
Role of pigmentation in protecting Bacillus sp. endospores against environmental UV radiation.
R. Moeller (2005)
10.1002/chem.201101547
Synthetic prodiginine obatoclax (GX15-070) and related analogues: anion binding, transmembrane transport, and cytotoxicity properties.
Borja Díaz de Greñu (2011)
10.1016/J.BCP.2004.05.056
Mitochondria-mediated apoptosis operating irrespective of multidrug resistance in breast cancer cells by the anticancer agent prodigiosin.
V. Soto-Cerrato (2004)
10.1038/213903a0
Antimalarial Activity of Prodigiosin
A. Castro (1967)
10.1007/978-81-322-1087-0_2
Antifouling Activity of Prodigiosin from Estuarine Isolate of Serratia marcescens CMST 07
Kumutha Priya (2013)
10.1007/s00253-006-0507-2
Producing mechanism of an algicidal compound against red tide phytoplankton in a marine bacterium γ-proteobacterium
T. Nakashima (2006)
10.4028/www.scientific.net/AMR.779-780.156
Kinetics and Thermodynamics Studies of Prodigiosin Dyeing on Polyester
Jia Jia Shen (2013)
10.1111/J.1365-2958.2005.04602.X
Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2-methyl-3-n-amyl-pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodigiosin biosynthesis in Streptomyces.
N. Williamson (2005)
10.1128/JB.179.3.627-633.1997
bldA dependence of undecylprodigiosin production in Streptomyces coelicolor A3(2) involves a pathway-specific regulatory cascade.
J. White (1997)
10.1002/j.1460-2075.1986.tb04235.x
Isolation and characterization of genes encoding two chitinase enzymes from Serratia marcescens
J. D. Jones (1986)
New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kappa B and AP-1 activation.
A. Mortellaro (1999)
10.1007/BF01920771
The reversal of glucose repressed prodigiosin production inSerratia marcescens by the cyclic 3′5′-adenosine monophosphate inhibitor theophylline
S. Clements-Jewery (2005)
10.1099/00221287-132-4-865
Extracellular Vesicle Formation and Biosurfactant Production by Serratia marcescens
T. Matsuyama (1986)
10.2174/092986710791331103
New insights on the antitumoral properties of prodiginines.
R. Pérez-Tomás (2010)
10.1016/J.CHEMBIOL.2004.11.006
Production of branched-chain alkylprodiginines in S. coelicolor by replacement of the 3-ketoacyl ACP synthase III initiation enzyme, RedP.
S. Mo (2005)
10.1128/JB.06370-11
Functional analysis of the N-acetylglucosamine metabolic genes of Streptomyces coelicolor and role in control of development and antibiotic production.
Magdalena A. Światek (2012)
10.3109/10520299509108199
DAPI: a DNA-specific fluorescent probe.
J. Kapuściński (1995)
10.1371/journal.pone.0057562
Molecular Interactions of Prodiginines with the BH3 Domain of Anti-Apoptotic Bcl-2 Family Members
A. Hosseini (2013)
10.1038/bjc.2012.21
A phase I trial of pan-Bcl-2 antagonist obatoclax administered as a 3-h or a 24-h infusion in combination with carboplatin and etoposide in patients with extensive-stage small cell lung cancer
A. Chiappori (2012)
10.1021/bp070481r
Antibacterial Colorants: Characterization of Prodiginines and Their Applications on Textile Materials
Farzaneh Alihosseini (2008)
10.1007/s12010-011-9415-8
Characterization and Enhanced Production of Prodigiosin from the Spoiled Coconut
R. Siva (2011)
10.1111/J.1749-6632.2002.TB04642.X
Prodigiosin induces caspase-9 and caspase-8 activation and cytochrome C release in Jurkat T cells.
B. Montaner (2002)
10.1046/J.1365-2958.2000.01872.X
Biosynthesis of carbapenem antibiotic and prodigiosin pigment in Serratia is under quorum sensing control.
N. Thomson (2000)
10.1186/1756-3305-4-66
Mitochondrial dysfunction in Trypanosoma cruzi: the role of Serratia marcescens prodigiosin in the alternative treatment of Chagas disease
Carlos Genes (2011)
10.1016/J.EXPPARA.2004.04.007
Isolation of Serratia marcescens in the midgut of Rhodnius prolixus: impact on the establishment of the parasite Trypanosoma cruzi in the vector.
P. Azambuja (2004)
10.1074/mcp.M111.013797
Metabolic Switches and Adaptations Deduced from the Proteomes of Streptomyces coelicolor Wild Type and phoP Mutant Grown in Batch Culture*
L. Thomas (2011)
10.1016/j.mimet.2013.02.012
Use of red autofluorescence for monitoring prodiginine biosynthesis.
Elodie Tenconi (2013)
10.1099/00222615-46-11-913
The use of RAPD-PCR as a typing method for Serratia marcescens.
A. Hejazi (1997)
10.3389/fmicb.2012.00413
Direct interaction studies between Aspergillus fumigatus and human immune cells; what have we learned about pathogenicity and host immunity?
C. O. Morton (2012)
10.1196/ANNALS.1299.030
Prodigiosin induces apoptosis by acting on mitochondria in human lung cancer cells.
E. Llagostera (2003)
10.1111/j.1472-765X.2010.02993.x
Inhibition of quorum sensing in Chromobacterium violaceum by pigments extracted from Auricularia auricular.
H. Zhu (2011)
10.1007/s00253-012-4237-3
Streptomyces sp. JS520 produces exceptionally high quantities of undecylprodigiosin with antibacterial, antioxidative, and UV-protective properties
N. Stanković (2012)
10.1016/j.jbiosc.2010.12.026
Development of natural anti-tumor drugs by microorganisms.
Chia-Che Chang (2011)
10.1016/B978-0-12-394291-3.00002-2
Oxidative tailoring reactions catalyzed by nonheme iron-dependent enzymes: streptorubin B biosynthesis as an example.
P. K. Sydor (2012)
10.1074/jbc.273.34.21455
Prodigiosins as a New Group of H+/Cl−Symporters That Uncouple Proton Translocators*
T. Sato (1998)
10.1093/OXFORDJOURNALS.JBCHEM.A022147
Prodigiosins uncouple mitochondrial and bacterial F-ATPases: evidence for their H+/Cl- symport activity.
H. Konno (1998)



This paper is referenced by
10.1021/acsomega.9b04322
An Indonesian Marine Bacterium, Pseudoalteromonas rubra, Produces Antimicrobial Prodiginine Pigments
Edi Setiyono (2020)
10.15421/022019
In vitro synergy testing of prodigiosin in combination with inhibitors of cell wall synthesis against Mycobacterium smegmatis
D. A. Ivanchenko (2020)
10.1021/acs.chemrev.6b00478
Oxidative Cyclization in Natural Product Biosynthesis.
Mancheng Tang (2017)
10.1099/ijsem.0.002155
Vibrio palustris sp. nov. and Vibrio spartinae sp. nov., two novel members of the Gazogenes clade, isolated from salt-marsh plants (Arthrocnemum macrostachyum and Spartina maritima).
T. Lucena (2017)
10.1039/c5cp01498k
Optical properties of prodigiosin and obatoclax: action spectroscopy and theoretical calculations.
Evangeline Drink (2015)
10.1590/s2175-97902019000217819
Effect of prodigiosin on the alleviation of the intestinal inflammation of weaned rats based on 1H-NMR spectroscopy study and biochemistry indexes
Peizhou Yang (2019)
10.3389/fmicb.2020.02056
Spartinivicinus ruber gen. nov., sp. nov., a Novel Marine Gammaproteobacterium Producing Heptylprodigiosin and Cycloheptylprodigiosin as Major Red Pigments
Zhaobin Huang (2020)
10.1007/s00253-018-09611-z
Recent advancements in high-level synthesis of the promising clinical drug, prodigiosin
Chee-Hoo Yip (2018)
10.1007/s00253-018-9520-5
Biosurfactants produced by Serratia species: Classification, biosynthesis, production and application
Teresa Clements (2018)
10.1038/nchembio.2471
Oxidative cyclization of prodigiosin by an alkylglycerol monooxygenase-like enzyme
Tristan de Rond (2017)
10.1016/J.BEJ.2018.01.034
Characterization of a prodigiosin synthetase PigC from Serratia marcescens jx-1 and its application in prodigiosin analogue synthesis
Zhongyu You (2018)
10.1021/acssynbio.7b00099
New Prodigiosin Derivatives Obtained by Mutasynthesis in Pseudomonas putida.
A. S. Klein (2017)
10.1016/j.jhazmat.2019.121530
Physiological response and morphological changes of Heterosigma akashiwo to an algicidal compound prodigiosin.
Su Zhang (2019)
10.1016/j.jip.2016.03.011
The red pigment prodigiosin is not an essential virulence factor in entomopathogenic Serratia marcescens.
W. Zhou (2016)
Serratia liquefaciens from IMO: Antibacterial and Chitinolytic Potentials
Paolo Antonio Saministrado-Fudalan (2017)
10.1038/s41429-017-0011-1
Prodigiosin R2, a new prodigiosin from the roseophilin producer Streptomyces griseoviridis 2464-S5
Shoko Kimata (2017)
10.3389/fmicb.2018.01742
Production of Prodiginines Is Part of a Programmed Cell Death Process in Streptomyces coelicolor
Elodie Tenconi (2018)
10.3389/fmicb.2018.01495
Microbial Production of Violacein and Process Optimization for Dyeing Polyamide Fabrics With Acquired Antimicrobial Properties
Maria C. Kanelli (2018)
10.3389/fmicb.2015.00972
Efficient recombinant production of prodigiosin in Pseudomonas putida
A. Domröse (2015)
10.1080/10826068.2017.1421965
Enhancement of prodigiosin synthetase (PigC) production from recombinant Escherichia coli through optimization of induction strategy and media
Zhongyu You (2018)
10.1097/IPC.0000000000000360
Marvelous but Morbid: Infective Endocarditis Due to Serratia marcescens
V. Phadke (2016)
10.1002/EJIC.201601179
Synthesis, Structure and Properties of First Examples of Hexacoordinated Sn(IV) Complexes of Pyrrolyl Dipyrrins
Mangalampalli Ravikanth (2016)
10.22207/jpam.12.4.11
Mixture Design of Experiments for the Optimization of Carbon Source for Promoting Undecylprodigiosin and Actinorhodin Production
Khalid Jaber Kadhum Luti (2018)
10.3389/fmicb.2016.00027
Prodigiosin Induces Autolysins in Actively Grown Bacillus subtilis Cells
Tjaša Danevčič (2016)
10.1016/j.jbiosc.2018.06.010
Construction and co-cultivation of two mutant strains harboring key precursor genes to produce prodigiosin.
Wei-Chuan Chen (2018)
10.3390/ijms20215458
Targeted Delivery Prodigiosin to Choriocarcinoma by Peptide-Guided Dendrigraft Poly-l-lysines Nanoparticles
Kai Zhao (2019)
10.1128/AEM.02889-16
Large-Scale Transposition Mutagenesis of Streptomyces coelicolor Identifies Hundreds of Genes Influencing Antibiotic Biosynthesis
Z. Xu (2017)
10.1007/s00792-020-01180-2
Pigment production by cold-adapted bacteria and fungi: colorful tale of cryosphere with wide range applications
Wasim Sajjad (2020)
10.1016/j.jbiotec.2014.07.451
New Stetter reactions catalyzed by thiamine diphosphate dependent MenD from E. coli.
M. Beigi (2014)
10.1590/1678-9199-JVATITD-2019-0001
Using prodigiosin against some gram-positive and gram-negative bacteria and Trypanosoma cruzi
Rocío Herráez (2019)
10.3390/molecules25122744
Production and Potential Applications of Bioconversion of Chitin and Protein-Containing Fishery Byproducts into Prodigiosin: A Review
S. Wang (2020)
10.1007/s00253-015-7242-5
Antiviral activity and specific modes of action of bacterial prodigiosin against Bombyx mori nucleopolyhedrovirus in vitro
W. Zhou (2015)
See more
Semantic Scholar Logo Some data provided by SemanticScholar