Online citations, reference lists, and bibliographies.

Peritoneal Carcinomatosis From Adenocarcinoma Of The Colon

Paul H Sugarbaker, Monique E. T. Schellinx, David Chang, Patricia Koslowe, Maarten von Meyerfeldt
Published 1996 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
Peritoneal carcinomatosis is a major cause of surgical treatment failure in patients with colorectal cancer. In the past patients with this condition have had a lethal outcome. In this study, 64 consecutive patients were treated by the cytoreductive approach, which involved surgery to maximally resect all cancer in the abdomen and pelvis, early postoperative intraperitoneal chemotherapy with 5-fluorouracil (5-FU) and mitomycin C, and three cycles of adjuvant intraperitoneal 5-FU with systemic mitomycin C. The clinical features that may affect prognosis were assessed and critically analyzed statistically. Peritoneal implant size of < 5 cm present in the abdomen and pelvis at the time of exploration correlated with a good prognosis (p < 0.0001), as did complete cytoreduction with tumor removed to nodules < 2.5 mm (p < 0.0001). Involvement of only one or two of the five abdominopelvic regions, compared to three or more regions, was a significant determinant of prognosis (p < 0.0001). Finally, a mucinous histologic type correlated adversely with prognosis when compared to intestinal-type adenocarcinomas (p < 0.001). These data suggest that patients with small-volume peritoneal seeding from colon cancer should be treated with cytoreductive surgery and aggressive regional and systemic chemotherapy in an attempt to achieve long-term disease-free survival.
This paper references
10.1002/1097-0142(19900401)65:7<1495::AID-CNCR2820650708>3.0.CO;2-1
Histologic changes induced by intraperitoneal chemotherapy with 5-fluorouracil and mitomycin C in patients with peritoneal carcinomatosis from cystadenocarcinoma of the colon or appendix.
Paul H Sugarbaker (1990)
Gastrointestinal fistula following cy - toreductive procedures for peritoneal carcinomatosis : incidence and outcome
E. Moreno (1993)
10.1007/978-1-4613-1247-5_20
Treatment of peritoneal carcinomatosis from colon or appendiceal cancer with induction intraperitoneal chemotherapy.
Paul H Sugarbaker (1993)
10.1002/1097-0142(19900101)65:1<65::AID-CNCR2820650115>3.0.CO;2-L
Continuous hyperthermic peritoneal perfusion for the treatment of peritoneal dissemination in gastric cancers and subsequent second-look operation.
Taku Fujimura (1990)
Diagnosis and management of postoperative gastrointestinal fistula : a kinetic analysis
V. Fernandez-Trigo (1994)
10.1007/978-1-4613-1247-5_6
Observations concerning cancer spread within the peritoneal cavity and concepts supporting an ordered pathophysiology.
Paul H Sugarbaker (1996)
10.1007/978-2-8178-0782-9_59
Technical aspects of adjuvant intraperitoneal chemotherapy
J. Vidal-Jove (1991)
A novel treatment for the peritoneal dissemination of gastric cancer : peritonectomy and hyperthermo - chemotherapy
Y. Yonemura
10.1097/00000658-198807000-00005
Intraperitoneal Hyperthermic Perfusion Combined with Surgery Effective for Gastric Cancer Patients with Peritoneal Seeding
Shigeru Fujimoto (1988)
10.1097/00000658-199502000-00002
Prognostic Features of 51 Colorectal and 130 Appendiceal Cancer Patients with Peritoneal Carcinomatosis Treated by Cytoreductive Surgery and Intraperitoneal Chemotherapy
Paul H Sugarbaker (1995)
10.1097/00000658-199402000-00001
Pseudomyxoma peritonei. A cancer whose biology is characterized by a redistribution phenomenon.
Paul H Sugarbaker (1994)
10.1007/BF02053933
Peritoneal carcinomatosis from appendiceal cancer: Results in 69 patients treated by cytoreductive surgery and intraperitoneal chemotherapy
Paul H Sugarbaker (1993)
Early postoperative intraperitoneal chemotherapy as an adjuvant therapy to surgery for peritoneal carcinomatosis from gastrointestinal cancer: pharmacological studies.
Paul H Sugarbaker (1990)
Surgical treatment of peritoneal carcinomatosis: 1988 Du Pont lecture.
Paul H Sugarbaker (1989)
Limited penetration of methotrexate into human osteosarcoma spheroids as a proposed model for solid tumor resistance to adjuvant chemotherapy.
Gary W. West (1980)
10.1002/jso.2930560409
Dissection by electrocautery with a ball tip.
Paul H Sugarbaker (1994)
10.1007/978-2-8178-0782-9_67
Rationale for integrating early postoperative intraperitoneal chemotherapy into the surgical treatment of gastrointestinal cancer.
Paul H Sugarbaker (1989)
Recurrent intraabdominal cancer causing intestinal destruction : management of 42 patients by surgery and intraperitoneal chemotherapy
A. M. Averback (1995)
Pharmacokinetics of adriamycin and tissue penetration in murine ovarian cancer.
Robert F. Ozols (1979)
Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of patterns of recurrence.
Kevin S Hughes (1986)
Evaluation of computer tomography in patients with peritoneal carcinomatosis
P. Jacquet (1993)
10.1002/1097-0142(19930901)72:5<1631::AID-CNCR2820720523>3.0.CO;2-I
Evaluation of computed tomography in patients with peritoneal carcinomatosis.
P Jacquet (1993)
Portal levels and hepatic clearance of 5-fluorouracil after intraperitoneal administration in humans.
James L. Speyer (1981)
10.1007/BF02253499
Intraperitoneal hyperthermic treatment for peritoneal dissemination of colorectal cancers
Ayano Yamaguchi (1992)
Chemotherapy of ovarian cancer.
Robert F. Ozols (1991)
The effect of hyperthermo-chemotherapy in gastric cancer patients with peritoneal dissemination
Y. Yonemura (1996)
10.3862/jcoloproctology.47.324
Mucinous Carcinoma of the Colon and Rectum
Kazuhiro Toyota (1994)
10.1007/BF02554625
Malignant pseudomyxoma peritonei of colonic origin
Paul H Sugarbaker (1987)
10.2307/j.ctt1t897jc.83
[Colon Cancer].
E Carbonetto (1958)
Cytoreductive surgery and intraperitoneal chemotherapy with peritoneal spread of cystadenocarcinoma.
Paul H Sugarbaker (1991)
Prospective, randomized trial of intravenous versus intraperitoneal 5-fluorouracil in patients with advanced primary colon or rectal cancer.
Paul H Sugarbaker (1985)



This paper is referenced by
10.1016/j.jviscsurg.2018.01.002
Preoperative assessment of peritoneal carcinomatosis of colorectal origin.
Anthony Dohan (2018)
10.1007/978-1-4614-9022-7_5
Carcinomatosis: Cytoreduction and Heated Intraperitoneal Chemotherapy (HIPEC) Versus Palliation
Björn L.D.M. Brücher (2014)
10.1245/ASO.2003.11.005
Intraperitoneal Photodynamic Therapy Causes a Capillary-Leak Syndrome
Robert J. Canter (2003)
10.1007/S11888-010-0050-5
Curative Approach for Stage IV Colorectal Cancer with Multiorgan Involvement: What Makes Sense and What Doesn’t?
Polina Khrizman (2010)
10.1016/J.CIRESP.2017.11.006
Cirugía de second look más HIPEC en pacientes sin evidencia de recidiva con alto riesgo de desarrollar carcinomatosis tras resección de cáncer colorrectal
Ángel Serrano del Moral (2018)
10.1007/978-3-642-57282-1_85
Regional Therapy of Cancer
Douglas L. Fraker (2001)
10.1097/SLA.0b013e31818a15b5
Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy for Isolated Colorectal Peritoneal Carcinomatosis: Experimental Therapy or Standard of Care?
Tristan D. Yan (2008)
10.1007/DCR.0b013e3181dcadbc
Metastasectomy for Stage IV Colorectal Cancer
Najjia N. Mahmoud (2010)
10.1097/DCR.0b013e3182a62d9d
Incidence, Prognosis, and Treatment Options for Patients With Synchronous Peritoneal Carcinomatosis and Liver Metastases from Colorectal Origin
Irene Thomassen (2013)
10.21037/tgh.2016.08.05
A critical analysis of the cytoreductive surgery with hyperthermic intraperitoneal chemotherapy combo in the clinical management of advanced gastric cancer: an effective multimodality approach with scope for improvement.
Maneesh Kumarsing Beeharry (2016)
10.1080/15419060390262561
ICAM-1 Mediated Tumor-Mesothelial Cell Adhesion is Modulated by IL-6 and TNF-α: A Potential Mechanism by Which Surgical Trauma Increases Peritoneal Metastases
Paul Ziprin (2003)
10.1007/978-981-10-7053-2_17
Clinical Trials in CRS and HIPEC: Ongoing Trials and Future Directives
William F. Morano (2018)
10.1038/sj.bjc.6601586
Improved survival in patients with peritoneal metastases from colorectal cancer: a preliminary study
Haile Mahteme (2004)
10.1007/978-3-319-28773-7_12
Cytoreductive Surgery and “Hyperthermic Intraperitoneal Chemotherapy (HIPEC)”
Markus Hirschburger (2016)
10.1016/J.JCHIRV.2017.08.016
Exploration préopératoire de la carcinose péritonéale d’origine colorectale
Anthony Dohan (2018)
10.2486/indhealth.2014-0025
Evaluation of oxaliplatin exposure of healthcare workers during heated intraperitoneal perioperative chemotherapy (HIPEC)
Antoine F Villa (2015)
10.1080/10463356.2005.11883244
Cytoreductive Surgery and Intraperitoneal Hyperthermic Chemotherapy for Colorectal Cancer: Limitations and Calls for More Research
Vijay P. Khatri (2005)
10.1245/s10434-013-3145-9
Cytoreduction and HIPEC in The Netherlands: Nationwide Long-term Outcome Following the Dutch Protocol
Anke M. J. Kuijpers (2013)
10.1007/978-981-10-7053-2_5
Early Postoperative Intraperitoneal Chemotherapy: Current Role and Future Perspectives
Thomas Douchy (2018)
10.1007/978-88-470-5711-1_13
Patient Selection for Treatment
Paolo Sammartino (2015)
10.1016/j.jss.2017.08.002
Abdominal wall reconstruction after cytoreduction surgery-hyperthermic intraperitoneal chemotherapy.
Anthony J Scholer (2018)
10.1016/S1282-9129(12)63390-X
Tratamiento quirúrgico con fines curativos de las carcinomatosis peritoneales
Dominique Élias (2012)
10.1002/jso.21369
Comparison of optimally resected hepatectomy and peritonectomy patients with colorectal cancer metastasis.
Christopher Q Cao (2009)
10.1016/j.ejso.2008.10.006
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis from colorectal and gastrointestinal origin shows acceptable morbidity and high survival.
Jeroen Hagendoorn (2009)
10.1080/00015458.2006.11679897
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Colorectal Peritoneal Carcinomatosis: Higher Complication Rate for Oxaliplatin Compared to Mitomycin C
A Rouers (2006)
10.1016/J.CIRENG.2017.11.011
Systematic Second-look Surgery Plus HIPEC in Patients Without Evidence of Recurrence, at High Risk of Carcinomatosis After Colorectal Cancer Resection
Ángel Serrano del Moral (2018)
10.1111/ans.12306
Cure for peritoneal metastases? An evidence-based review.
Lawson Ung (2013)
10.1016/j.ejso.2015.08.162
Cytoreduction and hyperthermic intraperitoneal chemotherapy: The learning curve reassessed.
Anke M. J. Kuijpers (2016)
Management of colorectal cancer patients at high risk of peritoneal metastases.
Umar S Shariff (2015)
10.1016/j.anchir.2004.09.016
Pseudomyxome péritonéal ou maladie gélatineuse du péritoine : nouveaux concepts et nouvelle prise en charge thérapeutique
Rasmy Loungnarath (2005)
10.1097/PPO.0b013e3181a58f1d
Cytoreductive Surgery Plus Intraperitoneal Chemohyperthermia in Patients With Colorectal Cancer at High Risk for Local-Regional Recurrence
Jérémie H. Lefevre (2009)
Peritoneal carcinomatosis of gastro-intestinal origin
Irene Thomassen (2014)
See more
Semantic Scholar Logo Some data provided by SemanticScholar