Online citations, reference lists, and bibliographies.
← Back to Search

Antimicrobial P(HEMA/IA)/PVP Semi-interpenetrating Network Hydrogels

Bojana D. Krezović, Suzana Dimitrijević, J. Filipović, R. Nikolić, Simonida Lj. Tomić
Published 2012 · Materials Science

Save to my Library
Download PDF
Analyze on Scholarcy
New semi-interpenetrating networks (semi-IPNHs) (P(HEMA/IA)/PVP) were prepared by free radical crosslinking copolymerization of 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA, 5 mol%), in the presence of poly(vinyl pyrrolidone) (PVP, 2, 5, and 10 mol%), as an interpenetrating agent. The structure of the semi-IPNHs was confirmed by Fourier transform infrared spectroscopy, and morphology study was performed by scanning electron microscopy, which revealed the characteristic porous morphology. The results obtained by dynamic mechanical analysis showed the improvement of mechanical properties with increasing PVP content in semi-IPNs. The maximum swelling was observed for all studied systems at a slightly acidic media (around pH 6), so it can be said that the content of PVP has no influence on the swelling behavior, in the PVP range investigated. Along with the pH sensitivity, which was expected due to the presence of IA, semi-IPNHs showed temperature-sensitive swelling properties, with the lower critical solution temperature value around 41 °C, which is in the physiologically interesting interval. The antimicrobial activity of the samples was tested using E. coli, S. aureus, and C. albicans pathogens. It was noticed that the antimicrobial potential depends on type of microbes, time of exposure, and PVP content in the samples. Due to their good antimicrobial and mechanical properties these stimuli-sensitive semi-IPNHs have potential to be used as biomaterials for the applications in medicine and pharmacy.
This paper references
Thermal properties of crosslinked poly(N-isopropylacrylamide) [P(NIPAAm)], poly(methacrylic acid) [P(MAA)], their random copolymers [P(NIPAAm-co-MAA)] and sequential IPNs
E Diez-Pena (2002)
Hydrogels in regenerative medicine.
B. V. Slaughter (2009)
The copolymerization of N-vinyl-2-pyrrolidone with 2-hydroxyethyl methacrylate
Magdy M. Faragalla (2002)
Interpenetrating Polymer Networks and Related Materials
L. Sperling (1981)
Synthesis and physical properties of pH-sensitive semi-IPN hydrogels based on poly(dimethylaminoethyl methacrylate-co-PEG dimethacrylate) and poly(acrylic acid)
G. M. Kim (2006)
Suljovrujić EH (2010) Smart poly(2-hydroxyethylmethacrylate/itaconic acid) hydrogels for biomedical application
SLj Tomić (2010)
Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid
Simonida Lj. Tomić (2006)
Transparent semi- and full-IPNHs based on uralkylpolymethyl methacrylate
A Vilas (2000)
Evaluation of a bi-layer wound dressing for burn care I. Cooling and wound healing properties.
L. Martineau (2006)
Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology†
N. Peppas (2006)
Swelling and drug release behavior of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels obtained by gamma irradiation
S. Tomić (2007)
Hydrogels as smart biomaterials
J. Kopeček (2007)
Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application
Simonida Lj. Tomić (2010)
Mechanical properties of a ph sensitive hydrogel, session on biologically inspire synthesis and properties
BD Johnson (2002)
Biomaterials Science: An Introduction to Materials in Medicine
B. Ratner (1996)
Porous alginate-Ca2+ hydrogels interpenetrated with PNIPAAm networks: Interrelationship between compressive stress and pore morphology
M. Moura (2005)
Evaluation of the first 60 cases of poly HEMA posterior chamber lenses implanted in the sulcus
R. Menapace (1989)
Synthesis and characterization of pH-sensitivity semi-IPN hydrogel based on hydrogen bond between poly(N-vinylpyrrolidone) and poly(acrylic acid)
S. Jin (2006)
Cytotoxicity study of homopolymers and copolymers of 2-hydroxyethyl methacrylate and some alkyl acrylates for potential use as temporary skin substitutes
M. Prasitsilp (2003)
Biomimetic strain hardening in interpenetrating polymer network hydrogels
D. Myung (2007)
Molecularly engineered hydrogels for implant biocompatibility
S. Abraham (2004)
Thermal properties of crosslinked poly(N-isopropylacrylamide) [P(NIPAAm)], poly(methacrylic acid) [P(MAA)], their random copolymers [P(NIPAAm-co-MAA)] and sequential IPNs
E Diez-Pena (2002)
Evaluation of a bi-layer wound dressing for burn care. II. In vitro and in vivo bactericidal properties.
L. Martineau (2006)
Transparent semi- and full-interpenetrating polymer networks based on uralkyd–polymethyl methacrylate
V. Athawale (2000)
Poly(1-vinyl-2-pyrrolidinone) hydrogels as vitreous substitutes: histopathological evaluation in the animal eye.
S. Vijayasekaran (1996)
Preparation and antibacterial effects of PVA‐PVP hydrogels containing silver nanoparticles
Haijun Yu (2007)
Measurement of the swelling force in ionic polymer networks. III. Swelling force of interpolymer complexes
C. L. Bell (1995)
1258–1266 818 Polym
L Yin (2013)
Mechanical Properties of a pH Sensitive Hydrogel
B. Johnson (2002)
Antimicrobial/Anti-Infective Materials : Principles and Applications
S. Sawan (1999)
Preparation and characterization of sodium carboxymethylcellulose/poly(N-isopropylacrylamide)/clay semi-IPN nanocomposite hydrogels
J. Ma (2007)
Handbook of Chemistry and Physics. Von R. C. Weast. The Chemical Rubber Co., Cleveland, Ohio/USA 1972. 52. Aufl., XXVII, 2313 S., geb. DM 99.80
H. Grünewald (1972)
In vitro tests and ethnopharmacological investigations: wound healing as an example.
P. Houghton (2005)
Thermal properties of cross-linked poly(N-isopropylacrylamide) [P(N-iPAAm)], poly(methacrylic acid) [P(MAA)], their random copolymers [P(N-iPAAm-co-MAA)], and sequential interpenetrating polymer networks (IPNs)
E. Díez-Peña (2002)
Handbook of Chemistry and Physics
D. Lide (1992)
Analysis of Fickian and non-Fickian drug release from polymers.
N. Peppas (1985)
Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels
Simonida Lj. Tomić (2010)
Structural and mechanical properties of UV-photo-cross-linked poly(N-vinyl-2-pyrrolidone) hydrogels.
G. D'Errico (2008)
wound healing as an example
PJ Houghton (2013)
Synthesis of poly(ethylene glycol)-tethered poly(propylene fumarate) and its modification with GRGD peptide
Seongbong Jo (2000)
Progress in the development of interpenetrating polymer network hydrogels.
D. Myung (2008)
Superporous hydrogels containing poly(acrylic acid-co-acrylamide)/O-carboxymethyl chitosan interpenetrating polymer networks.
Lichen Yin (2007)
Clinical results of hydrogel lens implantation
G. Barrett (1986)
Molecularly engineered p(HEMA)-based hydrogels for implant biochip biocompatibility.
Sheena Abraham (2005)

This paper is referenced by
Phosphorylation of chitosan/HEMA interpenetrating polymer network prepared by γ-radiation for metal ions removal from aqueous solutions.
A. Elbarbary (2017)
Amphipathic Substrates Based on Crosslinker-Free Poly(ε-Caprolactone):Poly(2-Hydroxyethyl Methacrylate) Semi-Interpenetrated Networks Promote Serum Protein Adsorption
G. Vilariño-Feltrer (2020)
Grafting of poly (2-Hydroxyethyl Methacrylate) onto chitin beads
D. Mohammed (2014)
Interpenetrating polymeric hydrogels as favorable materials for hygienic applications
A. M. Khalil (2020)
Iodine-responsive poly (HEMA–PVP) hydrogel for self-regulating burst-free extended release
J. Xu (2017)
Adsorption of methylene blue in aqueous solution using hydrogels based on 2-hydroxyethyl methacrylate copolymerized with itaconic acid or acrylic acid
Estefanía Oyarce (2020)
Effects of antimicrobial agents on the thermal and mechanical properties of acrylate hydrogel matrices
Pierrick Paillot (2016)
Modification chimique, greffage et dispersion d'agents fonctionnels pour des applications antimicrobiennes
Pierrick Paillot (2016)
Miniaturized Passive Hydrogel Check Valve for Hydrocephalus Treatment
H. Schwerdt (2014)
Interpenetrating Polymer Network Composite Hydrogels and Their Applications in Separation Processes
E. Dragan (2014)
Interpenetrating Polymer Networks (IPNs): Hydrophillic and Hydrophobic System Applications
Sudipta Goswami (2015)
Features of Structure and Properties of pHEMA-gr-PVP Block Copolymers, Obtained in the Presence of Fe2+
O. Grytsenko (2020)
Compression Modulus and Equilibrium Swelling Studies of Poly(2-Hydroxyethyl Methacrylate) Hydrogels Formed at Various Polymer Concentrations
Burcu Kizmaz (2014)
Design and applications of interpenetrating polymer network hydrogels. A review
E. Dragan (2014)
Oxaprozin/poly(2-hydroxyethyl acrylate/itaconic acid) hydrogels: morphological, thermal, swelling, drug release and antibacterial properties
M. Babić (2014)
Effect of CaCO₃/HCl pretreatment on the surface modification of chitin gel beads via graft copolymerization of 2-hydroxy ethyl methacrylate and 4-vinylpyridine.
Z. Yalinca (2016)
Microscopy of IPNs
R. Adhikari (2016)
Antimicrobial materials based on poly(ethylene‐co‐vinyl alcohol) and silver acetate produced by reactive extrusion
Pierrick Paillot (2019)
Structural, thermal, mechanical, swelling, drug release, antibacterial and cytotoxic properties of P(HEA/IA)/PVP semi-IPN hydrogels
Bojana D. Krezović (2017)
Investigation on pH-switchable (itaconic acid/ethylene glycol/acrylic acid) based polymeric biocompatible hydrogel
M. Sakthivel (2016)
Semantic Scholar Logo Some data provided by SemanticScholar