Online citations, reference lists, and bibliographies.

Pediatric Papillary Thyroid Carcinoma: Outcomes And Survival Predictors In 2504 Surgical Patients

Samuel Golpanian, Eduardo Perez, Jun Tashiro, John I Lew, Juan Antonio Estévez Sola, Anthony Richard Hogan
Published 2015 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
ObjectiveTo evaluate outcomes and predictors of survival of pediatric thyroid carcinoma, specifically papillary thyroid carcinoma.MethodsSEER was searched for surgical pediatric cases (≤20 years old) of papillary thyroid carcinoma diagnosed between 1973 and 2011. Demographics, clinical characteristics, and survival outcomes were analyzed using standard statistical methods. All papillary types, including follicular variant, were included.ResultsA total of 2504 cases were identified. Overall incidence was 0.483/100,000 persons per year with a significant annual percent change (APC) in occurrence of 2.07 % from baseline (P < 0.05). Mean age at diagnosis was 16 years and highest incidence was found in white, female patients ages 15–19. Patients with tumor sizes <1 cm more likely received lobectomies/isthmusectomies versus subtotal/total thyroidectomies [OR = 3.03 (2.12, 4.32); P < 0.001]. Patients with tumors ≥1 cm and lymph node-positive statuses [OR = 99.0 (12.5, 783); P < 0.001] more likely underwent subtotal/total thyroidectomy compared to lobectomy/isthmusectomy. Tumors ≥1 cm were more likely lymph node-positive [OR = 39.4 (16.6, 93.7); p < 0.001]. Mortality did not differ between procedures. Mean survival was 38.6 years and higher in those with regional disease. Disease-specific 30-year survival ranged from 99 to 100 %, regardless of tumor size or procedure. Lymph node sampling did not affect survival.ConclusionsThe incidence of pediatric papillary thyroid cancer is increasing. Females have a higher incidence, but similar survival to males. Tumors ≥1 cm were likely to be lymph node-positive. Although tumors ≥1 cm were more likely to be resected by subtotal/total thyroidectomy, survival was high and did not differ based on procedure.
This paper references
10.1016/0002-9343(94)90321-2
Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer.
Ernest L. Mazzaferri (1994)
Cancer incidence and mortality in the United States, 1973-77.
John Lum Young (1981)
10.1007/PL00012284
Selective Treatment of Differentiated Thyroid Carcinoma
Ernst Gemsenjaeger (1997)
10.1007/s00383-013-3261-4
Primary pediatric cardiac malignancies: the SEER experience
James S. Davis (2013)
10.1016/j.jss.2013.03.020
An analysis of 73 cases of pediatric malignant tumors of the thymus.
Bassan J. Allan (2013)
10.1002/pbc.20474
Papillary thyroid carcinoma of childhood and adolescence: a 30-year experience at the Istituto Nazionale Tumori in Milan.
Paola Collini (2006)
10.1016/j.jpedsurg.2013.02.017
Predictors of survival in pediatric adrenocortical carcinoma: a Surveillance, Epidemiology, and End Results (SEER) program study.
Jarod P Mcateer (2013)
10.1155/2012/125389
Surgical and Pathological Characteristics of Papillary Thyroid Cancer in Children and Adolescents
Davor Džepina (2012)
Longterm results of treatment of 283 patients with lung and bone metastases from differentiated thyroid carcinoma
M Schlumberger (1986)
10.1016/j.jpedsurg.2011.06.006
Primary gastrointestinal tract lymphoma in the pediatric patient: review of 265 patients from the SEER registry.
Noor Kassira (2011)
10.1053/jpsu.2000.6935
Differentiated thyroid cancer: clinical characteristics, treatment, and outcome in patients under 21 years of age who present with distant metastases. A report from the Surgical Discipline Committee of the Children's Cancer Group.
Michael La Quaglia (2000)
10.1097/CCO.0b013e3282f30220
Differentiated thyroid cancer in children: diagnosis and management
Catherine A. Dinauer (2008)
Therapeutic radiation at a young age is linked to secondary thyroid cancer. The Late Effects Study Group.
Margaret A Tucker (1991)
10.1097/00000658-198012000-00001
Surgical Management of Papillary and Follicular Carcinoma of the Thyroid
William Blair Farrar (1980)
Differentiated thyroid cancer: clinical characteristics, treatment, and outcome in patients under 21 years of age who present with Pediatr Surg Int (2016
MP La Quaglia (2000)
10.1007/s00268-002-6612-1
Papillary Thyroid Carcinoma Managed at the Mayo Clinic during Six Decades (1940–1999): Temporal Trends in Initial Therapy and Long-term Outcome in 2444 Consecutively Treated Patients
Ian D. Hay (2002)
10.1210/jcem-63-4-960
Long-term results of treatment of 283 patients with lung and bone metastases from differentiated thyroid carcinoma.
Martin Jean Schlumberger (1986)
10.1067/msy.2000.109728
Papillary thyroid cancer with pulmonary metastases in children: long-term prognosis.
Jeromy S. Brink (2000)
10.1111/hpb.12112
Predictors of survival and incidence of hepatoblastoma in the paediatric population.
Bassan J. Allan (2013)
10.1016/j.jpedsurg.2004.06.016
Surgical therapy of the thyroid papillary carcinoma in children: experience with 56 patients < or =16 years old.
Claud Spinelli (2004)
10.1002/pbc.20438
Conservative surgical approach for thyroid and lymph-node involvement in papillary thyroid carcinoma of childhood and adolescence.
Maura Massimino (2006)
Repeat surgery for recurrent thyroid cancer in children
Demidchik IuE (2003)
10.1097/01.pas.0000213264.07597.9a
Papillary Carcinoma of the Thyroid Gland of Childhood and Adolescence: Morphologic Subtypes, Biologic Behavior and Prognosis: A Clinicopathologic Study of 42 Sporadic Cases Treated at a Single Institution During a 30-Year Period
Paola Collini (2006)
Some factors influencing the survival of patients with less advanced stages of differentiated thyroid cancer.
Jan Němec (1986)
10.1016/j.jpedsurg.2008.10.039
Malignant pancreatic tumors: incidence and outcome in 58 pediatric patients.
Eduardo Perez (2009)
10.1016/j.jss.2008.12.003
Primary solid tumors of the colon and rectum in the pediatric patient: a review of 270 cases.
Relin Yang (2010)
10.3978/j.issn.2227-684X.2013.10.10
The pros and cons of routine central compartment neck dissection for clinically nodal negative (cN0) papillary thyroid cancer.
Ai Chen Chan (2013)
10.1200/JCO.2011.29.15_SUPPL.E20507
The Royal Marsden Hospital experience of trabectedin in patients with advanced soft tissue sarcoma (STS): Toxicity and efficacy in a nonselected group.
Susana N Banerjee (2011)
10.1089/ve.2014.0026
Extent of Surgery for Papillary Thyroid Cancer Is Not Associated with Survival: An Analysis of 61,775 Patients
SosaJulie Ann (2014)
10.1002/cncr.10725
Childhood and adolescent thyroid carcinoma.
Perry Grigsby (2002)
in childhood : management strategy , including dosimetry and long - term results
M Luster (2007)
10.5555/uri:pii:0039606093903214
Predicting outcome in papillary thyroid carcinoma: development of a reliable prognostic scoring system in a cohort of 1779 patients surgically treated at one institution during 1940 through 1989.
Ian D. Hay (1993)
Management of thyroid nodules in children and adolescents.
Wilmar M. Wiersinga (2007)
10.1097/00000658-199804000-00014
Differentiated thyroid cancer: determinants of disease progression in patients <21 years of age at diagnosis: a report from the Surgical Discipline Committee of the Children's Cancer Group.
Kurt D. Newman (1998)
10.1016/j.jss.2009.03.098
Pediatric thyroid carcinoma: incidence and outcomes in 1753 patients.
Anthony Richard Hogan (2009)
10.1016/S0959-8049(99)00281-6
Thyroid cancer in children: the Royal Marsden Hospital experience.
Daryl Landau (2000)
Recurrence and morbidity in differentiated thyroid carcinoma in children.
Michael La Quaglia (1988)
10.1016/S0039-6060(98)70034-0
Presidential address: beyond risk groups--a new look at differentiated thyroid cancer.
Blake Cady (1998)
10.1053/j.sempedsurg.2011.10.004
Pediatric thyroid cancer.
Diana Diesen (2012)
Papillary thyroid carcinoma in children and adults: long-term follow-up of 1039 patients conservatively treated at one institution during three decades.
Dean W. Zimmerman (1988)
10.1007/s00383-007-1933-7
Markedly improving survival of neuroblastoma: a 30-year analysis of 1,646 patients
Juan C. Gutiérrez (2007)
Long-term outcome in 215 children and adolescents with papillary thyroid cancer
ID Hay (2010)
10.1007/978-3-319-00233-0_5
Cancer Incidence and Mortality
Amelie G Ramirez (2013)
10.1001/archsurg.1971.01350040040008
Childhood thyroid carcinoma.
Jay K. Harness (1971)
10.1007/s00268-009-0364-0
Long-Term Outcome in 215 Children and Adolescents with Papillary Thyroid Cancer Treated During 1940 Through 2008
Ian D. Hay (2009)
10.1007/s00268-004-7605-z
Current Strategies for Surgical Management and Adjuvant Treatment of Childhood Papillary Thyroid Carcinoma
Geoffrey Thompson (2004)
10.1634/theoncologist.2012-0240
Lymph node ratio predicts recurrence in papillary thyroid cancer.
David F. Schneider (2013)
10.1038/bjc.1995.410
Childhood thyroid cancer in England and Wales.
H. Rubén Harach (1995)
10.1016/j.jpedsurg.2013.09.050
A review of 218 pediatric cases of hepatocellular carcinoma.
Bassan J. Allan (2014)
Managing patients with papillary thyroid carcinoma: insights gained from the Mayo Clinic's experience of treating 2,512 consecutive patients during 1940 through 2000.
Ian D. Hay (2002)
[Repeat surgery for recurrent thyroid cancer in children].
Iu E Demidchik (2003)
10.14310/horm.2002.1111023
Thyroid cancer in childhood: management strategy, including dosimetry and long-term results.
Markus Luster (2007)
10.1097/00006231-200108000-00006
Clinical features of differentiated thyroid carcinoma in children and adolescents from a sub-Himalayan iodine-deficient endemic zone
Chandra Sekhar Bal (2001)



This paper is referenced by
10.1016/j.ijporl.2020.110000
Pediatric thyroid cancer: Risk factors for central lymph node metastasis in patients with cN0 papillary carcinoma.
Duy Quoc Ngo (2020)
10.1089/THY.2016.0302
Prognostic Factors for Early and Long-Term Remission in Pediatric Differentiated Thyroid Carcinoma: The Role of Sex, Age, Clinical Presentation, and the Newly Proposed American Thyroid Association Risk Stratification System.
Bárbara Pereira Pires (2016)
10.1007/978-3-319-54493-9_10
Pediatric Thyroid Cancer
Melanie Goldfarb (2017)
Thyroid Health Monitoring After Nuclear Accidents : IARC Expert Group on Thyroid Health Monitoring After Nuclear Accidents
Joachim Schüz (2018)
10.1111/his.13285
Paediatric follicular thyroid carcinoma – indolent cancer with low prevalence of RAS mutations and absence of PAX8–PPARG fusion in a Japanese population
Huy Gia Vuong (2017)
10.1002/cncy.22104
Incidence and malignancy rates of indeterminate pediatric thyroid nodules
Huiying Wang (2019)
10.1007/s12149-016-1142-3
18F-FDG PET/CT to differentiate malignant necrotic lymph node from benign cystic lesions in the neck
Peymaneh Abadi (2016)
10.1177/1093526619866584
Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features in Children: An Institutional Experience and Literature Review
Huiying Wang (2019)
10.1515/jpem-2016-0327
Pediatric differentiated thyroid carcinoma: trends in practice and outcomes over 40 years at a single tertiary care institution
Courtney L Olmsted (2017)
10.1210/jc.2017-02698
DICER1 Mutations Are Frequent in Adolescent-Onset Papillary Thyroid Carcinoma
Jonathan D Wasserman (2018)
10.1515/jpem-2018-0233
Treatment outcomes in pediatric differentiated thyroid carcinoma
Nisha Bhavani (2018)
10.1002/cncr.32125
Trends in pediatric thyroid cancer incidence in the United States, 1998-2013.
Marie-Odile Bernier (2019)
10.1007/s00268-018-4487-z
Cervical Lymph Node Metastases of Papillary Thyroid Carcinoma, in the Central and Lateral Compartments, in Children and Adolescents: Predictive Factors
Claudio Spinelli (2018)
10.4174/astr.2018.95.4.222
Usefulness of dynamic risk stratification in pediatric patients with differentiated thyroid carcinoma
KwangSoon Kim (2018)
10.1097/RLU.0000000000002978
FASpecT/CT, A New SPECT/CT Acquisition With Higher Sensitivity and Efficiency in Radioiodine Thyroid Cancer Imaging
William T. Phillips (2020)
10.1016/j.jpedsurg.2019.02.033
The relationships of surgeon volume and specialty with outcomes following pediatric thyroidectomy.
Joseph D Drews (2019)
10.1530/ERC-19-0463
Pulmonary and overall healthcare utilization after childhood and young adult thyroid cancer.
Giancarlo Di Giuseppe (2020)
10.1016/j.jss.2019.12.002
Recurrence and Complications in Pediatric and Adolescent Papillary Thyroid Cancer in a High-Volume Practice.
Jill C Rubinstein (2020)
10.1016/S1470-2045(18)30680-6
Long-term strategies for thyroid health monitoring after nuclear accidents: recommendations from an Expert Group convened by IARC.
Kayo Togawa (2018)
10.1007/978-3-319-91725-2_21
Pediatric Differentiated Thyroid Carcinoma
Steven G. Waguespack (2018)
10.1159/000495040
Thyroid Sequelae of Pediatric Cancer Therapy
Steven G. Waguespack (2018)
10.15381/anales.v80i4.16349
Patologia quirúrgica de la glándula tiroides en pacientes pediátricos
Juan Oré (2019)
10.1080/17446651.2017.1365597
Risk prediction in children and adults less than 45 years old with papillary thyroid cancer
Agathoklis Konstantinidis (2017)
10.1002/jum.14593
Ultrasound and the Evaluation of Pediatric Thyroid Malignancy: Current Recommendations for Diagnosis and Follow‐up
Sarah B. Ogle (2018)
10.1016/j.jpedsurg.2016.10.033
Predictors of nodal metastasis in pediatric differentiated thyroid cancer.
Jina Kim (2017)
10.1002/cncr.32124
Children and thyroid cancer: Interpreting troubling trends.
Amy Y. Chen (2019)
10.4103/wjnm.WJNM_15_19
Differentiated thyroid carcinoma in children: Clinical characteristics and long-term follow-up
Muge Oner Tamam (2020)
10.1002/cncr.32123
We cannot ignore the real component of the rise in thyroid cancer incidence.
David Goldenberg (2019)
Semantic Scholar Logo Some data provided by SemanticScholar