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Micronutrient Status, Cognition And Behavioral Problems In Childhood

David Benton, Ilsi Europe a.i.s.b.l.
Published 2008 · Biology, Medicine
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It is widely accepted that the rapid rate of growth of the brain during the last third of gestation and the early postnatal stage makes it vulnerable to an inadequate diet, although brain development continues into adulthood and micronutrient status can influence functioning beyond infancy. A deficiency of various micro-nutrients in developing countries has been found to have long-term implication for cognitive development. Vitamin A plays a critical role in visual perception and a deficiency is the leading cause of childhood blindness. A lack of iodine during a critical period in brain development is associated with reduced intellectual ability. Iron shortage is a widespread problem in the developing world but also in industrialized countries. There is evidence that iron deficiency in early life adversely effects brain development. In addition in industrialized countries a role for folate in the prevention of neural tube defects is well established and in a few individuals impaired cognitive functioning is associated with the inadequate provision of vitamin B12. The controversial suggestions that sub-clinical deficiencies of micronutrients may in industrialized societies influence anti-social behavior and intelligence are also discussed.
This paper references
10.1093/ajcn/60.5.782
Relation of maternal zinc nutriture to pregnancy outcome and infant development in an Egyptian village.
Avanelle Kirksey (1994)
10.1136/bmj.1.5687.16
Reduction of Incidence of Prematurity by Folic Acid Supplementation in Pregnancy
Naomi Baumslag (1970)
National diet and nutrition survey: young people aged 4-18 years, Vol. 2 - Report of the oral health survey
Alison Walker (2004)
10.1111/j.1651-2227.2003.tb00662.x
Potential effects of supplementation with amino acids, choline or sialic acid on cognitive development in young infants.
Jean P. Colombo (2003)
Adverse effects on infant development associated with maternal folic acid deficiency
RL Gross (1974)
10.1177/15648265030244S104
Vitamin A Deficiency Disorders in Children and Women
Keith P West (2003)
10.1016/0140-6736(90)91694-6
Vitamin/mineral supplementation and intelligence
Iain K Crombie (1990)
10.1002/jtra.10042
Zinc is essential for brain development and function
Harold H. Sandstead (2003)
10.1093/ajcn/73.3.586
Serum retinol distributions in residents of the United States: third National Health and Nutrition Examination Survey, 1988-1994.
Carol Ballew (2001)
The devastating consequence of iodine deficiency.
Ma Tai (1997)
10.1093/ajcn/84.6.1261
Iron supplementation in early childhood: health benefits and risks.
Lora L Iannotti (2006)
10.1542/peds.108.3.823
Screening for iron deficiency anemia by dietary history in a high-risk population.
Debra L Bogen (2000)
10.1093/jn/45.1.153
Effect of diet on maze learning in second generation rats; folic acid deficiency.
J R Whitley (1951)
10.1007/BF01646863
Influence of B vitamins on binding properties of serotonin receptors in the CNS of rats
Krishnamurti Dakshinamurti (2005)
The impact of diet on anti-social behaviour
D Benton (2007)
10.1016/S0022-3476(05)81897-9
Long-term neurologic consequences of nutritional vitamin B12 deficiency in infants.
Stephen M Graham (1992)
10.1111/j.1753-4887.1993.tb03102.x
Vitamin B6 and cognitive development: recent research findings from human and animal studies.
Tomás R. Guilarte (1993)
10.1016/S0140-6736(08)60133-6
Effect of maternal multiple micronutrient supplementation on fetal loss and infant death in Indonesia: a double-blind cluster-randomised trial.
Anuraj H. Shankar (2008)
10.1097/00003081-200606000-00009
Adult consequences of fetal growth restriction.
David J. P. Barker (2006)
Micronutrient deficiencies. Hohenheim consensus conference
HK Biesalski (2003)
10.1093/ajcn/85.2.614S
Nutrition and the developing brain: nutrient priorities and measurement.
Michael K. Georgieff (2007)
10.1016/S0031-9384(97)88988-3
Elevated Blood Copper/Zinc Ratios in Assaultive Young Males
William J. Walsh (1997)
10.1097/00005176-199307000-00015
Zinc supplementation in very-low-birth-weight infants.
James Friel (1990)
10.1079/PHN2004677
Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials.
Harshpal S Sachdev (2005)
10.1136/adc.77.2.137
Persistence of neurological damage induced by dietary vitamin B-12 deficiency in infancy
U von Schenck (1997)
10.6133/apjcn.2007.16.1.12
Impact of vitamin A supplementation on health status and absenteeism of school children in Sri Lanka.
Sanath Thushara Chamakara Mahawithanage (2007)
10.1089/thy.2006.16.949
Iodine supplementation for pregnancy and lactation-United States and Canada: recommendations of the American Thyroid Association.
David V. Becker (2006)
10.1093/jn/31.3.283
Mental response to added thiamine.
R F Harrell (1946)
10.1001/archneur.64.12.1706
Functional implication of the vitamin A signaling pathway in the brain.
Mehdi Tafti (2007)
10.6133/apjcn.2007.16.3.16
Multiple micronutrient fortification of salt and its effect on cognition in Chennai school children.
Malavika Vinod Kumar (2007)
10.1210/jc.2004-0571
Attention deficit and hyperactivity disorders in the offspring of mothers exposed to mild-moderate iodine deficiency: a possible novel iodine deficiency disorder in developed countries.
Francesco Vermiglio (2004)
10.1016/S0306-4522(02)00423-2
Vitamin A deficiency produces spatial learning and memory impairment in rats
Stefania Cocco (2002)
10.1049/BJN2000305
Effect of micronutrient supplementation on linear growth of children.
Nita Bhandari (2001)
10.1089/cap.2005.15.619
Zinc in attention-deficit/hyperactivity disorder.
L. Eugene Arnold (2005)
10.1093/ajcn/82.6.1269
Anemia, iron deficiency, and iron deficiency anemia in 12-36-mo-old children from low-income families.
Julie M Schneider (2005)
10.1177/026010600101500413
Vitamin a during Pregnancy
Ram Reifen (2001)
Improvement in hearing among otherwise normal schoolchildren in iodine-deficient areas of Guizhou, China, following use of iodized salt.
Yan Yan Wang (1985)
10.1080/07315724.1997.10718684
A preliminary report: effects of zinc and micronutrient repletion on growth and neuropsychological function of urban Chinese children.
James G. Penland (1997)
10.1093/jn/125.suppl_8.2263S
Developmental zinc deficiency and behavior.
Mari S. Golub (1995)
10.1192/bjp.181.1.22
Influence of supplementary vitamins, minerals and essential fatty acids on the antisocial behaviour of young adult prisoners. Randomised, placebo-controlled trial.
C. Bernard Gesch (2002)
10.1002/14651858.CD003497.pub2
Combined vitamin B6-magnesium treatment in autism spectrum disorder.
Christine Nye (2005)
10.1093/ajcn/72.3.762
Signs of impaired cognitive function in adolescents with marginal cobalamin status.
Marieke W. J. Louwman (2000)
10.1177/000992288302200503
Review and Recommendations
R A Turetsky (1983)
Effect of zinc supplementation on observed activity in low socioeconomic Indian preschool children.
Sudha Sazawal (1996)
10.1093/ajcn/31.8.1409
Zinc nutrition and growth in a childhood population.
Gerald P. Butrimovitz (1978)
10.1530/acta.0.1290501
Impairment of neuromotor and cognitive development in iodine-deficient schoolchildren with normal physical growth.
Fereidoun Azizi (1993)
10.1177/15648265070284S409
Iron Deficiency and Child Development
Betsy Lozoff (2007)
10.1093/ajcn/56.2.365
Maternal serum folate and zinc concentrations and their relationships to pregnancy outcome.
Tsunenobu Tamura (1992)
10.1016/j.bbr.2007.11.003
Effect of perinatal iron deficiency on myelination and associated behaviors in rat pups
Ling-ling Wu (2008)
10.1177/156482650602700110
Micronutrient fortification: WFP experiences and ways forward.
(2006)
10.5860/choice.30-3254
Nutritional Biochemistry of the Vitamins
David A. Bender (2003)
10.1146/annurev.nutr.23.020102.075739
Iron status and neural functioning.
John L. Beard (2003)
10.1093/jn/117.4.636
Analysis of vitamin A data from the health and nutrition examination surveys.
Shira Pilch (1987)
10.1093/ajcn/49.6.1266
A growth-limiting, mild zinc-deficiency syndrome in some southern Ontario boys with low height percentiles.
Rosalind Gibson (1989)
10.1016/j.jpeds.2006.06.065
The fetal origins of memory: the role of dietary choline in optimal brain development.
Steven H Zeisel (2006)
B-vitamin status and intake in European adolescents. A review of the literature.
J. Al-Tahan (2006)
10.1002/ajpa.1330530110
Effects of iodine deficiency on mental and psychomotor abilities.
N. Bleichrodt (1980)
10.1007/s002130050163
Thiamine supplementation mood and cognitive functioning
David Benton (1997)
10.1097/00006254-200104000-00003
Perinatal Iron Deficiency Decreases Cytochrome c Oxidase (CytOx) Activity in Selected Regions of Neonatal Rat Brain
Marissa deUngria (2001)
10.1089/acm.2000.6.7
The effect of vitamin-mineral supplementation on juvenile delinquency among American schoolchildren: a randomized, double-blind placebo-controlled trial.
Stephen J. Schoenthaler (2000)
10.1542/peds.2004-2189
Folate Status of Mothers During Pregnancy and Mental and Psychomotor Development of Their Children at Five Years of Age
Tsunenobu Tamura (2005)
10.1146/annurev.nutr.26.061505.111156
Choline: critical role during fetal development and dietary requirements in adults.
Steven H Zeisel (2006)
sible roles of zinc nutriture in the foetal origins of disease
W Maret (2007)
The vitamin status of young British adults.
David Benton (1997)
10.1093/ajcn/68.2.464S
Zinc deficiency and child development.
Maureen M Black (1998)
10.1016/S1474-4422(06)70598-1
Vitamin B12, folic acid, and the nervous system
Edward Reynolds (2006)
10.1111/j.1753-4887.2006.tb00202.x
Perinatal choline influences brain structure and function.
Steven H Zeisel (2006)
10.1016/0031-9384(78)90313-X
Effects of prenatal nutritional deficiency on affiliation and aggression in rats
Douglas P. Peters (1978)
10.1097/00006254-200208000-00008
Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age
Tsunenobu Tamura (2002)
10.1002/14651858.CD000228.pub2
Vitamin D supplementation in pregnancy.
Kassam Mahomed (2000)
10.1080/13590849762475
The Effect of Randomized Vitamin± Mineral Supplementation on Violent and Non-violent Antisocial Behavior Among Incarcerated Juveniles
Stephen J. Schoenthaler (1997)
Brain MR spectroscopy findings in neonates with hypothyroidism born to mothers living in iodine-deficient areas.
Ayşehan Akıncı (2006)
Nutrition and development: other micronutrients' effect on growth and cognition.
Emorn Wasantwisut (1997)
10.1093/ajcn/83.1.108
Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: a randomized, controlled, double-blind study.
Michael Zimmermann (2006)
10.1093/ajcn/60.2.238
Modulation of behavioral performance of prepubertal monkeys by moderate dietary zinc deprivation.
Mari S. Golub (1994)
10.1016/j.neubiorev.2005.12.003
An overview of evidence for a causal relationship between dietary availability of choline during development and cognitive function in offspring
Joyce C. McCann (2006)
Nutritional Blindness: Xerophthalmia and Keratomalacia
Alfred W. Sommer (1982)
Supplementation with Multiple Micronutrients Intervention Trial
Group Study (2008)
10.1111/j.1753-4887.2006.tb00228.x
Regulation of the NMDA receptor: implications for neuropsychological development.
Cathy W. Levenson (2006)
10.1016/j.exger.2007.10.005
Possible roles of zinc nutriture in the fetal origins of disease
Wolfgang Maret (2008)
10.1093/ajcn/85.1.285S
Folate and neural tube defects.
Roy M. Pitkin (2007)
10.1037/0003-066X.56.1.5
Developmental science and the media. Early brain development.
Ross A Thompson (2001)
10.1089/thy.2007.0108
The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: a review.
Michael Zimmermann (2007)
10.1111/j.1365-2265.1984.tb03468.x
Maternal thyroid hormone levels in pregnancy and the subsequent cognitive and motor performance of the children.
Pod Pharoah (1984)
10.1016/S0149-7634(01)00015-X
Micro-nutrient supplementation and the intelligence of children
David Benton (2001)
10.1203/00006450-199511000-00018
Low Vitamin B6 Status Associated with Slow Growth in Healthy Breast-Fed Infants
Kaarina Heiskanen (1995)
10.1093/ajcn/86.4.1082
Effect of a 12-mo micronutrient intervention on learning and memory in well-nourished and marginally nourished school-aged children: 2 parallel, randomized, placebo-controlled studies in Australia and Indonesia.
Saskia J M Osendarp (2007)
10.1016/S0022-3476(76)80250-8
Iron deficiency and behavior.
Ernesto Pollitt (1976)
10.1016/j.nut.2004.07.021
Effect of micronutrient supplement on health and nutritional status of schoolchildren: mental function.
Shahnaz Vazir (2006)
10.1093/ajcn/63.6.997
The role of nutrition in the development of normal cognition.
Norman Kretchmer (1996)
10.1079/PNS19920043
Vitamin-mineral supplements and intelligence.
David Benton (1992)
10.1089/thy.1994.4.107
The disorders induced by iodine deficiency.
François M. Delange (1994)
10.1093/jn/134.1.162
Folic acid deficiency during late gestation decreases progenitor cell proliferation and increases apoptosis in fetal mouse brain.
Corneliu N. Craciunescu (2004)
10.1080/07853890701704683
Nutrition, child growth, and chronic disease prevention
Ricardo Uauy (2008)
10.1089/cap.2005.15.628
Serum zinc correlates with parent- and teacher- rated inattention in children with attention-deficit/hyperactivity disorder.
L. Eugene Arnold (2005)
10.1016/S0140-6736(88)92720-1
EFFECT OF VITAMIN AND MINERAL SUPPLEMENTATION ON INTELLIGENCE OF A SAMPLE OF SCHOOLCHILDREN
David Benton (1988)
10.1182/blood.V34.4.452.452
Isolated defect of folic acid absorption associated with mental retardation and cerebral calcification.
Philip Lanzkowsky (1969)
10.1001/archpedi.1979.02130030091017
The nonhematologic manifestations of iron deficiency.
Frank A. Oski (1979)
10.1093/ajcn/51.6.1067
Vitamin B-6 status of Egyptian mothers: relation to infant behavior and maternal-infant interactions.
Ann Louise McCullough (1990)
10.1016/S0140-6736(96)02341-0
Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls
Ann Bruner (1996)
10.1136/adc.62.2.213
Treatment with iron increases weight gain and psychomotor development.
Joanna Poulton (1987)



This paper is referenced by
10.1080/03004279.2015.1078573
Parents’/carers’ perceptions and experiences of growing, preparing and eating their own fruit and vegetables as part of the ‘Field to Fork’ project
Diana Burton (2016)
10.19082/7314
Association between clusters of anxiety and psychosomatic disorder with lifestyle habits in children and adolescents: the CASPIAN-V study
Seyde Shahrbanoo Daniali (2018)
10.20546/ijcmas.2018.705.281
Evaluation of Micronutrients in Fenugreek (Trigonella foenum-graecum L.): A Viable Alternative for Micronutrient Supplementation
Naveen Pant (2018)
10.18502/kls.v4i10.3737
Association Between Birth Weight and Other Factors with the Intelligence Quotient (IQ) of the Student of SMP Negeri 200 Jakarta in 2013
K Abadini (2019)
10.1016/j.semcdb.2011.05.005
B12 in fetal development.
M. Reese Pepper (2011)
Health Economics and Nutrition: Over- and Undernutrition Editors
Jacob C. Seidell (2015)
10.1017/S1368980019004622
Body iron and lead status in early childhood and its effects on development and cognition: a longitudinal study from urban Vellore.
Beena Koshy (2020)
10.1016/j.earlhumdev.2010.12.006
Effects of iron deficiency on neonatal behavior at different stages of pregnancy.
Carmen Hernández-Martínez (2011)
10.1179/1476830511Y.0000000012
Omega-3 polyunsaturated fatty acids and cognition throughout the lifespan: A review
Justin E Karr (2011)
10.1016/j.mehy.2012.09.011
The connection between maternal thiamine shortcoming and offspring cognitive damage and poverty perpetuation in underprivileged communities across the world.
Fernando Machado Vilhena Dias (2013)
The Effect of Nutrition on the Microbiome in Pregnant Women and the Use of Micronutrient Supplemented Probiotic Yogurt to Improve Outcomes
Megan K. Enos (2014)
10.1007/s12035-017-0534-2
Maternal Folic Acid Supplementation During Pregnancy Improves Neurobehavioral Development in Rat Offspring
Xinyan Wang (2017)
The possible effect of food supplements in the early grades on intelligence scores
Carla Feenstra (2012)
10.3402/fnr.v56i0.17231
Diet and behavioral problems at school in Norwegian adolescents
Nina Cecilie Øverby (2012)
10.1016/j.neuro.2019.02.018
Residential exposure to urban traffic is associated with the poorer neurobehavioral health of Ecuadorian schoolchildren.
Khalid M Khan (2019)
10.1007/BF03347103
The size of the community rather than its geographical location better defines the risk of iodine deficiency: Results of an extensive survey in Southern Italy
Fabrizio Aghini-Lombardi (2013)
Current evidence suggests that food fortification is a cost-effective means of addressing iron deficiency at the population level, particularly in infants and young children
Patrick Detzel (2015)
Explaining the relationship between paternal incarceration and family well-being: a mediating model using food insecurity
Christian King (2015)
10.1097/MCO.0b013e32835e8d0b
Micronutrient supply and health outcomes in children.
Anura V Kurpad (2013)
10.1016/C2011-0-07466-5
Bioactive Food as Dietary Interventions for the Aging Population
Ronald Ross Watson (2013)
10.1159/000334490
The Effect of Iron on Cognitive Development and Function in Infants, Children and Adolescents: A Systematic Review
Maria Hermoso (2011)
The Urbanization of Poverty in Latin America and Maternal Depression: Prevalence, Correlates, and Relationship to Child Development
Brieanne Kidd Kohrt (2013)
10.1017/S000711451300189X
Effects of a multi-micronutrient-fortified beverage, with and without sugar, on growth and cognition in South African schoolchildren: a randomised, double-blind, controlled intervention.
Christine Taljaard (2013)
DESEMPENHO ACADÊMICO DE UNIVERSITÁRIOS: ASSOCIAÇÃO ENTRE ESTADO NUTRICIONAL, INGESTÃO DIETÉTICA DE FERRO ALIMENTAR E CONCENTRAÇÕES DE HEMOGLOBINA
Amanda Marreiro Barbosa (2013)
Factors prenatals materns que afecten el comportament del nadó: el paper de l'ansietat, l'exposició a la nicotina i l'estat en ferro
Carmen Dolores Hernández Martínez (2011)
10.3389/fphys.2019.00463
Iron Metabolism and Brain Development in Premature Infants
Yafeng Wang (2019)
10.21149/8581
Child dietary intake of folate and vitamin B12 and their neurodevelopment at 24 and 30 months of age.
Giovanna Gatica-Domínguez (2018)
10.1007/978-3-030-14895-9_28
Nutrition in Neurocognition and Mental Health
Melanie Katrinak (2019)
10.18999/forids.46.2
Malnutrition Expectations and Precautionary Demand for Children: Evidence from Vietnam
Eric T. Stuen (2015)
10.1007/s00394-013-0560-4
Nutrition and neurodevelopment in children: focus on NUTRIMENTHE project
Tânia Gomes Anjos (2013)
10.18203/2394-6040.ijcmph20190191
Levels of childhood nutritional status among the Muslims of char areas in Barpeta district, Assam
Gulrukh Begum (2019)
10.1155/2018/6067283
Household Food Insecurity and Psychosocial Dysfunction in Ecuadorian Elementary Schoolchildren
M Margaret Weigel (2018)
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