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Age-associated Prevalence And Risk Factors Of Lewy Body Pathology In A General Population: The Hisayama Study

Y. Wakisaka, A. Furuta, Y. Tanizaki, Y. Kiyohara, M. Iida, T. Iwaki
Published 2003 · Medicine

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In dementia with Lewy bodies (DLB), the Lewy bodies (LBs) are an essential substrate. Although LB pathology has gained increasing attention as one of the major causes of dementia, little is known about the exact prevalence of LB pathology in the general population. In addition, the pathology of Alzheimer-type dementia (ATD) is frequently associated with DLB. To investigate the prevalence of LB pathology in a community-based population and to evaluate the relationship between LB and ATD pathology, we performed an analysis of 102 consecutive autopsy cases. The survey extended over 2.5 years and autopsy rate was 70.5%. LB pathology was detected using α-synuclein immunohistochemistry and was assessed based on consensus guidelines for DLB. ATD pathology was evaluated by both CERAD and NIA-RI criteria. Twenty-nine subjects were clinically demented. LB pathology was present in 23 (22.5%) of 102 cases, and in 12 (41.4%) of the demented subjects. The LB score was not significantly different between DLB cases and non-demented subjects with LB pathology (nd-LB), while the Braak stages were significantly different between the two groups. Prevalence of LB pathology constantly increased with age. DLB cases accompanying severe ATD pathology showed more rapid increase of LB scores than did DLB cases without severe ATD pathology. Moreover, DLB cases with severe ATD pathology had poorer prognoses than those without severe ATD pathology. Our results suggested that aging and severe ATD pathology have a strong effect on the evolution of LB pathology.
This paper references
10.1007/BF00308809
Neuropathological stageing of Alzheimer-related changes
H. Braak (2004)
10.1007/s004010051025
Numerous and widespread α-synuclein-negative Lewy bodies in an asymptomatic patient
S. V. van Duinen (1999)
10.1016/S0197-4580(97)00057-2
Consensus recommendations for the postmortem diagnosis of Alzheimer's disease
M. Ball (1997)
10.1111/j.1750-3639.2000.tb00269.x
Lewy Bodies in Alzheimer's Disease: A Neuropathological Review of 145 Cases Using α‐Synuclein Immunohistochemistry
R. Hamilton (2000)
Regional Distribution of α‐Synuclein Pathology in Unimpaired Aging and Alzheimer Disease
L. Parkkinen (2003)
10.1016/0197-4580(92)90298-C
Neuropathological stageing of Alzheimer related changes correlates with psychometrically assessed intellectual status: H. Braak, C. Duyckaerts, E. Braak and F. Piette. Depts of Anatomy and Neuropathology, Goethe University and Hopital de la Salpetriere, Frankfurt, Germany and Paris, France
(1992)
10.1212/WNL.41.4.479
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
S. S. Mirra (1991)
10.1093/JNEN/61.5.413
Where Does Parkinson Disease Pathology Begin in the Brain?
K. Del Tredici (2002)
10.3233/JAD-2006-9S347
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop.
I. McKeith (1996)
10.1016/0022-510X(90)90037-N
Lewy body prevalence in the aging brain: relationship to neuropsychiatric disorders, Alzheimer-type pathology and catecholaminergic nuclei
R. Perry (1990)
10.1001/ARCHNEUR.59.1.43
Research evaluation and prospective diagnosis of dementia with Lewy bodies.
O. Lopez (2002)
10.1038/42166
α-Synuclein in Lewy bodies
M. Spillantini (1997)
The frequency of Lewy bodies in a consecutive autopsy series.
K. Jellinger (1999)
10.1161/01.STR.31.11.2616
Incidence and Risk Factors for Subtypes of Cerebral Infarction in a General Population: The Hisayama Study
Y. Tanizaki (2000)
10.1046/j.1440-1789.2000.00269.x
Clinicopathological studies on diffuse Lewy body disease
K. Kosaka (2000)
10.1136/jnnp.51.6.745
The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.
W. Gibb (1988)
10.1093/CERCOR/1.1.103
The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease.
S. E. Arnold (1991)
10.1016/S0079-6123(08)64226-0
Epidemiological and clinicopathological study on cerebrovascular disease in Japan.
S. Katsuki (1966)
10.1212/WNL.34.7.939
Clinical diagnosis of Alzheimer's disease
G. Mckhann (1984)
10.1001/ARCHNEUR.57.8.1145
Contribution of Lewy body inclusions to dementia in patients with and without Alzheimer disease neuropathological conditions.
V. Haroutunian (2000)
The frequency of Lewy bodies in a consecutive autopsy series.
Lindboe Cf (1998)
10.1212/WNL.43.2.250
Vascular dementia
G. Román (1993)
10.1212/WNL.53.5.902
Report of the second dementia with Lewy body international workshop
I. McKeith (1999)
10.1016/S0140-6736(00)03589-3
Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales
M. Esiri (2001)
10.1007/PL00007419
α-Synuclein is expressed in a variety of brain tumors showing neuronal differentiation
M. Kawashima (2000)
10.1007/s007020200027
Impact of coexistent Alzheimer pathology on the natural history of Parkinson's disease
K. Jellinger (2002)
10.1001/ARCHNEUR.1993.00540020018011
A clinicopathologic study of 100 cases of Parkinson's disease.
A. Hughes (1993)
The topographical distribution of neurofibrillary tangles and neuritic plaque in the cerebral cortex of patients with Alzheimer ’ s disease
H Baba (1991)
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.
M. Baba (1998)
10.1097/00005072-199311000-00012
Plaque‐Only Alzheimer Disease is Usually the Lewy Body Variant, and Vice Versa
L. Hansen (1993)
10.1212/WNL.47.5.1113
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB)
I. McKeith (1996)
10.1212/WNL.52.9.1839
Comparison of Lewy body variant of Alzheimer’s disease with pure Alzheimer’s disease
A. Heyman (1999)
10.1212/WNL.45.6.1161
Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population
T. Yoshitake (1995)
10.1212/WNL.53.6.1284
Clinical and quantitative pathologic correlates of dementia with Lewy bodies
E. Gómez-Tortosa (1999)
10.1097/00005072-199904000-00008
Alzheimer neuropathologic alterations in aged cognitively normal subjects.
D. Davis (1999)
10.1159/000106940
Neuropathological diagnoses in elderly patients in Oslo: Alzheimer's disease, Lewy body disease, vascular lesions.
P. Ince (1995)
10.1016/S0002-9440(10)65722-7
Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes.
C. F. Lippa (1998)
10.1097/00005072-199710000-00002
Editorial on Consensus Recommendations for the Postmortem Diagnosis of Alzheimer Disease from the National Institute on Aging and the Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer Disease
B. Hyman (1997)
10.1212/WNL.51.2.351
Cognitive decline is faster in Lewy body variant than in Alzheimer's disease
J. Olichney (1998)
10.1093/JNEN/59.7.585
α‐Synuclein Inclusions in Amygdala in the Brains of Patients with the Parkinsonism‐Dementia Complex of Guam
M. Yamazaki (2000)
Patho - logical correlates of late - onset dementia in a multicentre , communitybased population in England and Wales
JM Olichney (2001)
10.1159/000213625
Changing patterns in the prevalence of dementia in a Japanese community: the Hisayama study.
Y. Kiyohara (1994)
10.1111/j.1750-3639.1998.tb00156.x
Dementia with Lewy Bodies. A Distinct Non‐Alzheimer Dementia Syndrome?
P. Ince (1998)
Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease.
T. Iwatsubo (1996)
10.1093/JNEN/62.4.363
Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease.
L. Parkkinen (2003)
10.1002/ANA.410260107
Dementia in Parkinson's disease is related to neuronal loss in the medial substantia nigra
Juha O. Rinne (1989)
10.1046/j.0305-1846.2001.00342.x
α‐Synuclein pathology is highly dependent on the case selection
L. Parkkinen (2001)



This paper is referenced by
10.1002/ana.21541
A critical evaluation of the Braak staging scheme for Parkinson's disease
R. Burke (2008)
10.1002/mds.27867
Pathological Influences on Clinical Heterogeneity in Lewy Body Diseases
David G Coughlin (2019)
10.1002/acn3.772
α‐synuclein RT‐QuIC in cerebrospinal fluid of LRRK2‐linked Parkinson's disease
A. Garrido (2019)
10.1212/01.wnl.0000306697.48738.b6
Patterns and stages of &agr;-synucleinopathy: Relevance in a population-based cohort
J. Zaccai (2008)
10.1111/j.1750-3639.2008.00169.x
Clinicopathological Outline of Dementia with Lewy Bodies Applying the Revised Criteria: The Hisayama Study
Kouhei Fujimi (2008)
10.1016/J.EURGER.2010.07.012
Multiple brain pathologies in dementia are common
M. Woodward (2010)
10.1038/nrneurol.2013.105
Dementia in the oldest old
Z. Yang (2013)
10.1007/978-1-4614-7264-3_33
Chapter 33 Alpha-Synucleinopathy and Neuropsychological Symptoms in a Population-Based Cohort of the Elderly
Julia Zaccai (2013)
10.1016/j.neuint.2008.08.004
α-Synuclein enhances secretion and toxicity of amyloid beta peptides in PC12 cells
A. Kaźmierczak (2008)
10.1016/j.bbadis.2008.07.006
A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders.
K. Jellinger (2009)
10.1093/BRAIN/AWH725
What best differentiates Lewy body from Alzheimer's disease in early-stage dementia?
P. Tiraboschi (2006)
10.1007/978-3-211-45295-0_16
Critical appraisal of brain pathology staging related to presymptomatic and symptomatic cases of sporadic Parkinson's disease.
G. Halliday (2006)
10.1038/s12276-020-00494-7
Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer's disease.
Seong Su Kang (2020)
10.1212/01.wnl.0000306697.48738.b6
Patterns and stages of α-synucleinopathy
Julia Zaccai (2008)
10.1037/neu0000282
Temporal course of neurodegenerative effects on cognition in old age.
R. Wilson (2016)
10.1136/jnnp-2020-325668
Sex differences for phenotype in pathologically defined dementia with Lewy bodies
Ece Bayram (2021)
10.1001/jamanetworkopen.2019.16439
Association of Longitudinal β-Amyloid Accumulation Determined by Positron Emission Tomography With Clinical and Cognitive Decline in Adults With Probable Lewy Body Dementia
Z. Nedelska (2019)
10.1371/journal.pmed.1002267
Neuropathological diagnoses and clinical correlates in older adults in Brazil: A cross-sectional study
C. Suemoto (2017)
10.1007/s00406-013-0472-6
Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders
S. Nagao (2013)
10.1016/j.neulet.2004.08.076
Progressive changes in regulation of apolipoproteins E and J in glial cultures during postnatal development and aging
N. Patel (2004)
10.1159/000095641
The Role of 123I-Metaiodobenzylguanidine Myocardial Scintigraphy in the Diagnosis of Lewy Body Disease in Patients with Dementia in a Memory Clinic
H. Hanyu (2006)
10.1016/j.jns.2008.06.008
Age and apoE associations with complex pathologic features in Alzheimer's disease
G. Jicha (2008)
10.1186/1471-2377-6-2
Population-based neuropathological studies of dementia: design, methods and areas of investigation – a systematic review
J. Zaccai (2006)
10.1002/mds.23795
Neuropathology of sporadic Parkinson's disease: Evaluation and changes of concepts
K. Jellinger (2012)
Impact of α-Synuclein Pathology on Aging
L. Parkkinen (2005)
10.1007/s00702-015-1405-5
Neuropathobiology of non-motor symptoms in Parkinson disease
K. Jellinger (2015)
10.1016/j.mad.2005.09.014
Pathophysiology of synuclein aggregation in Lewy body disease
E. Mukaetova-Ladinska (2006)
10.1002/mds.26666
Predicting Survival in Dementia With Lewy Bodies With Hippocampal Volumetry
Jonathan Graff-Radford (2016)
10.1111/neup.12691
Where and how alpha‐synuclein pathology spreads in Parkinson’s disease:
K. Wakabayashi (2020)
10.1186/s13195-014-0082-1
Prevalence of mixed pathologies in the aging brain
Jasmin Rahimi (2014)
10.1007/978-1-4614-0785-0_28
Chapter 28 Alpha-Synucleinopathy and Neuropsychological Symptoms in a Population-Based Cohort of the Elderly
J. Zaccai (2012)
10.1007/978-3-319-08046-8_2
Neuropathology of Parkinson’s Disease
K. Jellinger (2014)
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