Online citations, reference lists, and bibliographies.
← Back to Search

Effects Of Intravaginal Estriol And Pelvic Floor Rehabilitation On Urogenital Aging In Postmenopausal Women

G. Capobianco, E. Donolo, G. Borghero, F. Dessole, P. L. Cherchi, S. Dessole
Published 2011 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
PurposeTo assess the effects of the combination of pelvic floor rehabilitation and intravaginal estriol administration on stress urinary incontinence (SUI), urogenital atrophy and recurrent urinary tract infections in postmenopausal women.MethodsTwo-hundred-six postmenopausal women with urogenital aging symptoms were enrolled in this prospective randomized controlled study. Patients were randomly divided into two groups and each group consisted of 103 women. Subjects in the treatment group received intravaginal estriol ovules, such as 1 ovule (1 mg) once daily for 2 weeks and then 2 ovules once weekly for a total of 6 months as maintenance therapy plus pelvic floor rehabilitation. Subjects in the control group received only intravaginal estriol in a similar regimen. We evaluated urogenital symptomatology, urine cultures, colposcopic findings, urethral cytologic findings, urethral pressure profiles and urethrocystometry before, as well as after 6 months of treatment.ResultsAfter therapy, the symptoms and signs of urogenital atrophy significantly improved in both groups. 61/83 (73.49%) of the treated patients, and only 10/103 (9.71%) of the control patients referred a subjective improvement of their incontinence. In the patients treated by combination therapy with estriol plus pelvic floor rehabilitation, we observed significant improvements of colposcopic findings, and there were statistically significant increases in mean maximum urethral pressure (MUP), in mean urethral closure pressure (MUCP), as well as in the abdominal pressure transmission ratio to the proximal urethra (PTR).ConclusionsOur results showed that combination therapy with estriol plus pelvic floor rehabilitation was effective and should be considered as a first-line treatment for symptoms of urogenital aging in postmenopausal women.
This paper references
[Local administration of low-dose estriol and vital Lactobacillus acidophilus in postmenopause].
B. Kanne (1991)
10.1097/00006254-198205000-00022
Estrogen Receptors in the Human Female Lower Urinary Tract
C. Iosif (1982)
10.1016/0378-5122(94)90121-X
Estrogens and the urogenital tract. Studies on steroid hormone receptors and a clinical study on a new estradiol-releasing vaginal ring.
P. Smith (1993)
10.1016/0002-9378(89)90114-2
Effects of estrogen on urethral function in women with urinary incontinence.
N. Bhatia (1989)
10.1016/0378-5122(92)90246-Z
Low-dose oestradiol in the treatment of urogenital oestrogen deficiency--a pharmacokinetic and pharmacodynamic study.
K. Nilsson (1992)
10.1159/000271609
Lokale Anwendung von schwachdosiertem Östriol und lebensfähigen Döderlein-Keimen in der Postmenopause
Bodo Kanne (1991)
10.1590/S1807-59322008000400009
Single-Blind, Randomized, Controlled Trial of Pelvic Floor Muscle Training, Electrical Stimulation, Vaginal Cones, and No Active Treatment in the Management of Stress Urinary Incontinence
R. Castro (2008)
10.1111/j.1471-0528.2000.tb10408.x
Oestradiol‐releasing vaginal ring versus oestriol vaginal pessaries in the treatment of bothersome lower urinary tract symptoms
G. Lose (2000)
10.1111/j.1471-0528.1983.tb06766.x
The use of intravaginal oestrogen cream in genuine stress incontinence
P. Hilton (1983)
10.1016/S0002-9378(98)70555-1
Urogenital aging--a hidden problem.
G. Samsioe (1998)
10.1034/j.1600-0412.2000.079004293.x
Comparison of usefulness of estradiol vaginal tablets and estriol vagitories for treatment of vaginal atrophy
Randi Dugal (2000)
10.1046/J.1464-410X.1998.00730.X
Conservative treatment of stress urinary incontinence in women: a systematic review of randomized clinical trials.
L. Berghmans (1998)
Conservative treatment if stress urinary incontinence in women : a systematic review of randomized clinical trials
Berghmans LCM (1998)
10.3109/13697137.2010.522875
Recommendations for the management of postmenopausal vaginal atrophy
D. Sturdee (2010)
10.1016/0378-5122(85)90057-X
Occurrence, nature and treatment of urinary incontinence in a 70-year-old female population.
G. Samsioe (1985)
10.3109/09513599109028436
Estriol: a weak estrogen or a different hormone?
G. Esposito (1991)
10.1097/01.JU.0000080708.87092.CC
Duloxetine Versus Placebo for the Treatment of North American Women With Stress Urinary Incontinence
R. Dmochowski (2003)
A study of European women’s experience of the problems of urogenital ageing and its management
DH Barlow (1997)
10.1007/BF02718372
Effects of protracted administration of estriol on the lower genito urinary tract in postmenopausal women
C. Iosif (2007)
10.1097/01.OGX.0000116046.42679.18
Duloxetine versus placebo for the treatment of North American women with stress urinary incontinence.
R. Dmochowski (2003)
10.1016/S0378-5122(97)00047-9
A study of European womens' experience of the problems of urogenital ageing and its management.
D. Barlow (1997)
10.1111/j.1532-5415.1993.tb06953.x
The Menopause: Health Implications and Clinical Management
G. Greendale (1993)
10.1016/S1166-7087(10)70004-X
Recommandations pour la prise en charge rééducative de l’incontinence urinaire non neurologique de la femme
B. Leriche (2010)
10.1016/0378-5122(92)90112-H
Effects of vaginally-administered oestriol on post-menopausal urogenital disorders: a cytohormonal study.
G. Heimer (1992)
10.1056/NEJM199309093291102
A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract infections.
R. Raz (1993)
Evaluation of endocrinologic condition by exfoliative cytology
GL Wied (1975)
Evaluation of endocrinologic condition by exfoliative cytology. In: Gold JJ (ed) Textbook of gynaecologic endocrinology
GL Wied (1975)
10.1007/BF00451721
Health-related quality of life measures for women with urinary incontinence: the Incontinence Impact Questionnaire and the Urogenital Distress Inventory
S. Shumaker (2004)
Estrogen Therapy in the Management of Urinary Incontinence in Postmenopausal Women: A Meta-Analysis. First Report of the Hormones and Urogenital Therapy Committee
J. A. Fantl (1994)
10.1016/0378-5122(91)90092-5
Efficacy of sustained-release vaginal oestriol in alleviating urogenital and systemic climacteric complaints.
J. Foidart (1991)
10.1016/0378-5122(93)90059-Q
Oestradiol-releasing vaginal ring for treatment of postmenopausal urogenital atrophy.
P. Smith (1993)
10.1016/0378-5122(95)00943-F
Transvaginal estriol administration in postmenopausal women: a double blind comparative study of two different doses.
F. Bottiglione (1995)
10.1097/01.GME.0000077620.13164.62
Efficacy of low-dose intravaginal estriol on urogenital aging in postmenopausal women
S. Dessole (2004)
Menopause: Physiology and Pharmacology
D. Mishell (1986)
10.1016/0002-9378(94)90074-4
A comparative multicenter study of the effects of continuous low-dose estradiol released from a new vaginal ring versus estriol vaginal pessaries in postmenopausal women with symptoms and signs of urogenital atrophy.
L. Henriksson (1994)
10.1016/S0029-7844(98)00175-6
META‐ANALYSIS OF ESTROGEN THERAPY IN THE MANAGEMENT OF UROGENITAL ATROPHY IN POSTMENOPAUSAL WOMEN: SECOND REPORT OF THE HORMONES AND UROGENITAL THERAPY COMMITTEE
L. Cardozo (1998)
Hormone replacement therapy plus pelvic floor muscle exercise for postmenopausal stress incontinence. A randomized, controlled trial.
O. Ishiko (2001)
10.1016/S0301-2115(96)02612-7
Continuous low dose estradiol released from a vaginal ring versus estriol vaginal cream for urogenital atrophy.
R. Barentsen (1997)
10.1016/0028-2243(93)90187-H
The effect of estriol on the cytology of urethra and vagina in postmenopausal women with genito-urinary symptoms.
M. C. van der Linden (1993)
10.1016/S1166-7087(10)70004-X
[Guidelines for rehabilitation management of non-neurological urinary incontinence in women].
Béatrice Leriche (2010)
[Effect of vaginal estrogen therapy on urinary incontinence in postmenopause].
G. Schaer (1995)
10.1097/gme.0b013e3181a95581
Efficacy and tolerability of local estrogen therapy for urogenital atrophy
D. Archer (2010)
10.3109/00016349309156514
Estrogens and the urogenital tract
P. Smith (1993)



This paper is referenced by
LCMS Saliva Steroid & Steroid Synthesis Inhibitor Profile | ZRT Laboratory
(2019)
10.5306/wjco.v5.i4.693
Caring for the breast cancer survivor's health and well-being.
P. Casey (2014)
10.1097/AOG.0000000000000526
Vaginal Estrogen for Genitourinary Syndrome of Menopause: A Systematic Review
David D. Rahn (2014)
Efeito da terapêutica com estrogéneos na incontinência urinária
Gisela Lage (2013)
10.1016/J.MATURITAS.2019.03.002
Pelvic floor muscle training as a treatment for genitourinary syndrome of menopause: A single-arm feasibility study.
J. Mercier (2019)
10.7326/M13-2410
Nonsurgical management of urinary incontinence in women: a clinical practice guideline from the American College of Physicians.
A. Qaseem (2014)
10.1007/s11884-019-00536-5
Hormone Replacement for Pelvic Floor Disorders
Joseph Panza (2019)
10.1002/14651858.CD010551.pub3
Pelvic floor muscle training added to another active treatment versus the same active treatment alone for urinary incontinence in women.
Reuben Olugbenga Ayeleke (2015)
10.1097/GME.0b013e3182a122c2
Management of symptomatic vulvovaginal atrophy: 2013 position statement of The North American Menopause Society
G. Bachman (2013)
10.1080/13697137.2018.1527306
What should guide our patient management of vulvovaginal atrophy?
M. Shapiro (2019)
10.1097/GME.0000000000000278
Do stages of menopause affect the outcomes of pelvic floor muscle training?
Ö. Tosun (2015)
NINETY DAY CHEMICAL STABILITY OF COMPOUNDED ESTRADIOL, ESTRONE, AND ESTRIOL COMBINATION AND BEYOND - USE - DATE
A. B. Sarkar (2012)
10.1016/j.maturitas.2016.04.017
Benefits of physical exercise in postmenopausal women.
N. Mendoza (2016)
10.7326/M18-3227
Pharmacologic and Nonpharmacologic Treatments for Urinary Incontinence in Women
E. Balk (2019)
Effects of vaginal prolapse surgery and ageing on vaginal vascularization
Maaike A. Weber (2016)
Managing postmenopausal dyspareunia : An update
Susan Hoff (2018)
10.1007/s00404-013-3030-6
Triple therapy with Lactobacilli acidophili, estriol plus pelvic floor rehabilitation for symptoms of urogenital aging in postmenopausal women
G. Capobianco (2013)
10.1007/s11606-019-05028-0
Adverse Events Associated with Nonsurgical Treatments for Urinary Incontinence in Women: a Systematic Review
Ethan M. Balk (2019)
10.1159/000381989
Low-Dose Intravaginal Estriol and Pelvic Floor Rehabilitation in Post-Menopausal Stress Urinary Incontinence
Daniele Castellani (2015)
10.1002/nau.22885
Stress urinary incontinence and endogenous sex steroids in postmenopausal women
A. Augoulea (2017)
Adult conservative management
C. Dumoulin (2017)
10.1371/journal.pone.0136265
Local Oestrogen for Pelvic Floor Disorders: A Systematic Review
M. A. Weber (2015)
10.1016/j.maturitas.2020.09.005
Management of urinary incontinence in postmenopausal women: An EMAS clinical guide.
E. Russo (2020)
10.1016/j.maturitas.2017.12.008
Management of female stress urinary incontinence: A care pathway and update.
G. Capobianco (2018)
10.1007/978-1-4939-3100-2_28
Female Sexual Dysfunction and Premature Menopause with Focus on Women’s Wording
Alessandra Graziottin (2016)
10.23970/AHRQEPCCER212
Nonsurgical Treatments for Urinary Incontinence in Women: A Systematic Review Update
E. Balk (2018)
10.1097/GME.0000000000001121
Management of genitourinary syndrome of menopause in women with or at high risk for breast cancer: consensus recommendations from The North American Menopause Society and The International Society for the Study of Women's Sexual Health
S. Faubion (2018)
10.1002/14651858.CD001405.pub3
Oestrogen therapy for urinary incontinence in post-menopausal women.
June D Cody (2012)
10.1097/gme.0000000000001609
The 2020 genitourinary syndrome of menopause position statement of The North American Menopause Society.
(2020)
10.14200/JRM.2013.2.0103
Estriol; the ‘Good’ Estrogen Advances and Updates in its Clinical Uses
E. Lommen (2013)
Pelvic floor muscle training in the treatment of postmenopausal urinary incontinence – a review of studies
M. Weber-Rajek (2015)
10.1007/978-3-030-13936-0_9
Management of Female Stress Urinary Incontinence
Giampiero Capobianco (2019)
See more
Semantic Scholar Logo Some data provided by SemanticScholar