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Glutamate Receptors, Neurotoxicity And Neurodegeneration
A. Lau, M. Tymianski
Published 2010 · Biology, Medicine
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Time to take this seriously.
Glutamate excitotoxicity is a hypothesis that states excessive glutamate causes neuronal dysfunction and degeneration. As glutamate is a major excitatory neurotransmitter in the central nervous system (CNS), the implications of glutamate excitotoxicity are many and far-reaching. Acute CNS insults such as ischaemia and traumatic brain injury have traditionally been the focus of excitotoxicity research. However, glutamate excitotoxicity has also been linked to chronic neurodegenerative disorders such as amyotrophic lateral sclerosis, multiple sclerosis, Parkinson’s disease and others. Despite the continued research into the mechanisms of excitotoxicity, there are currently no pharmacological interventions capable of providing significant neuroprotection in the clinical setting of brain ischaemia or injury. This review addresses the current state of excitotoxic research, focusing on the structure and physiology of glutamate receptors; molecular mechanisms underlying excitotoxic cell death pathways and their interactions with each other; the evidence for glutamate excitotoxicity in acute neurologic diseases; laboratory and clinical attempts at modulating excitotoxicity; and emerging targets for excitotoxicity research.
This paper references
Effect of the NMDA Antagonist MK-801 on Local Cerebral Blood Flow in Focal Cerebral Ischaemia in the Rat
C. K. Park (1989)
mu-calpain activation and calpain-mediated cytoskeletal proteolysis following traumatic brain injury.
A. Kampfl (1996)
Effects of L-NAME and 7-NI on NOS catalytic activity and behavioral outcome after traumatic brain injury in the rat.
K. Wada (1999)
Ischemia-Induced Brain Damage Depends on Specific Gap-Junctional Coupling
M. Frantseva (2002)
Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.
V. Dawson (1991)
NXY-059 for acute ischemic stroke.
V. Serebruany (2006)
MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.
W. Koek (1988)
Glutamate neurotoxicity in cortical cell culture is calcium dependent
D. Choi (1985)
Sequential Activation of Poly(ADP-Ribose) Polymerase 1, Calpains, and Bax Is Essential in Apoptosis-Inducing Factor-Mediated Programmed Necrosis
R. Moubarak (2007)
p38 Activation Is Required Upstream of Potassium Current Enhancement and Caspase Cleavage in Thiol Oxidant-Induced Neuronal Apoptosis
B. McLaughlin (2001)
Neuroprotective Effects of a Novel Nitrone, NXY-059, after Transient Focal Cerebral Ischemia in the Rat
S. Kuroda (1999)
LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability
M. Nadler (2001)
Anti‐ischaemic efficacy of a nitric oxide synthase inhibitor and a N‐methyl‐d‐aspartate receptor antagonist in models of transient and permanent focal cerebral ischaemia
D. A. Dawson (1994)
Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes.
N. Burnashev (1995)
Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons
S. Traynelis (1990)
A critical role of TRPM2 in neuronal cell death by hydrogen peroxide.
S. Kaneko (2006)
Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide.
R. Radi (1991)
Femtomolar Sensitivity of Metalloregulatory Proteins Controlling Zinc Homeostasis
C. E. Outten (2001)
Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS
J.R.P. Geiger (1995)
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding
M. Hara (2005)
Reduced Neuronal Injury after Treatment with NG-nitro-L-arginine methyl ester (L-NAME) or 2-sulfo-phenyl-N-tert-butyl nitrone (S-PBN) Following Experimental Brain Contusion
C. Gahm (2005)
Effects of the Nitrone Radical Scavengers PBN and S-PBN on In vivo Trapping of Reactive Oxygen Species after Traumatic Brain Injury in Rats
N. Marklund (2001)
ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology
Anne-Laure Perraud (2001)
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
Y. Lazebnik (1994)
Inhibition of nitric oxide synthesis does not reduce infarct volume in a rat model of focal cerebral ischaemia
D. A. Dawson (1992)
Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions
M. Aarts (2002)
Inactivation of Human Manganese-superoxide Dismutase by Peroxynitrite Is Caused by Exclusive Nitration of Tyrosine 34 to 3-Nitrotyrosine*
F. Yamakura (1998)
Effectiveness of PSD95 Inhibitors in Permanent and Transient Focal Ischemia in the Rat
H. Sun (2008)
Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons
M. Tymianski (1993)
Lamotrigine protects hippocampal CA1 neurons from ischemic damage after cardiac arrest.
R. Crumrine (1997)
The polyamine spermine has multiple actions on N-methyl-D-aspartate receptor single-channel currents in cultured cortical neurons.
D. M. Rock (1992)
Activation of Calpain I Converts Excitotoxic Neuron Death into a Caspase-independent Cell Death*
S. Lankiewicz (2000)
Accumulation of Zinc in Degenerating Hippocampal Neurons of ZnT3-Null Mice after Seizures: Evidence against Synaptic Vesicle Origin
J. Lee (2000)
Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice
V. Dawson (1996)
Effects of lazaroids and a peroxynitrite scavenger in a cell model of peroxynitrite toxicity.
G. Fici (1997)
Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-aspartate neurotoxicity
C. Ikonomidou (1989)
Riluzole attenuates cortical lesion size, but not hippocampal neuronal loss, following traumatic brain injury in the rat
C. Zhang (1998)
Sequestration of glutamate-induced Ca2+ loads by mitochondria in cultured rat hippocampal neurons.
G. J. Wang (1996)
Molecular characterization of mitochondrial apoptosis-inducing factor
S. Susin (1999)
The critical role of calpain versus caspase activation in excitotoxic injury induced by nitric oxide
C. Volbracht (2005)
Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death
S. Rothman (1984)
Brain Lesions in an Infant Rhesus Monkey Treated with Monosodium Glutamate
J. Olney (1969)
Inhibition of Caspase-Mediated Apoptosis by Peroxynitrite in Traumatic Brain Injury
A. Lau (2006)
SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models.
T. Matsuda (2001)
Aptiganel hydrochloride in acute ischemic stroke: a randomized controlled trial.
G. Albers (2001)
Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage.
H. Hara (1997)
Preferential Zn2+ influx through Ca2+-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production.
S. Sensi (1999)
Crosstalk between Nitric Oxide and Zinc Pathways to Neuronal Cell Death Involving Mitochondrial Dysfunction and p38-Activated K+ Channels
E. Bossy-Wetzel (2004)
Delayed AMPA receptor blockade reduces cerebral infarction induced by focal ischemia.
A. Buchan (1991)
Preferential Zn 2 1 influx through Ca 2 1-permeable AMPA y kainate channels triggers prolonged mitochondrial superoxide production
S. Sensi (1999)
The molecular basis of NMDA receptor subtypes: native receptor diversity is predicted by subunit composition
A. Buller (1994)
Intra-ischemic extracellular release of dopamine and glutamate is associated with striatal vulnerability to ischemia
M. Globus (1988)
Inhibition of mitochondrial electron transport by peroxynitrite.
R. Radi (1994)
Neuronal nitric oxide synthase isoforms alpha and mu are closely related calpain-sensitive proteins.
R. Laine (1998)
The glutamate AMPA receptor antagonist, YM872, attenuates cortical tissue loss, regional cerebral edema, and neurological motor deficits after experimental brain injury in rats
古川 哲也 (2004)
Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND).
R. Miller (2000)
Nonsteroidal lazaroid U78517F in models of focal and global ischemia.
E. Hall (1990)
Intranuclear localization of apoptosis‐inducing factor (AIF) and large scale dna fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite
X. Zhang (2002)
Voltage-dependent Anion Channels Control the Release of the Superoxide Anion from Mitochondria to Cytosol*
D. Han (2003)
The role of excitatory amino acids and NMDA receptors in traumatic brain injury.
A. Faden (1989)
DNA Damage and Oxidation of Thiols Peroxynitrite Causes in Rat Thymocytes
M. G. Salgo (1995)
Zinc-induced Neurotoxicity Mediated by Transient Receptor Potential Melastatin 7 Channels*
K. Inoue (2010)
Blockade of Gap Junctions In Vivo Provides Neuroprotection After Perinatal Global Ischemia
M. H. De Pina-Benabou (2005)
Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase.
H. Ischiropoulos (1992)
Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group.
T. Yamaguchi (1998)
Specific proteolysis of the NR2 subunit at multiple sites by calpain
R. Guttmann (2001)
Changes in Cortical Extracellular Levels of Energy-Related Metabolites and Amino Acids following Concussive Brain Injury in Rats
P. Nilsson (1990)
The neuroprotective efficacy of ebselen (a glutathione peroxidase mimic) on brain damage induced by transient focal cerebral ischaemia in the rat
D. A. Dawson (1995)
Coupling between NMDA Receptor and Acid-Sensing Ion Channel Contributes to Ischemic Neuronal Death
Jun Gao (2005)
Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor
S. Yu (2002)
Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein.
R. Sattler (1999)
Double-blind, randomized, vehicle-controlled study of high-dose tirilazad mesylate in women with aneurysmal subarachnoid hemorrhage. Part II. A cooperative study in North America.
G. Lanzino (1999)
Effect of riluzole on focal cerebral ischemia in rats.
F. Wahl (1993)
The nitrone free radical scavenger NXY-059 is neuroprotective when administered after traumatic brain injury in the rat.
F. Clausen (2008)
Cleavage of the plasma membraneNa/Ca exchanger in excitotoxicity
D Bano (2005)
The action of zinc on synaptic transmission and neuronal excitability in cultures of mouse hippocampus.
M. Mayer (1989)
Measurement of Intracellular Free Zinc in Living Cortical Neurons: Routes of Entry
S. Sensi (1997)
Glycine potentiates the NMDA response in cultured mouse brain neurons
J. Johnson (1987)
Sequestration of glutamateinduced Ca 2 + loads by mitochondria in cultured rat hippocampal neurons
GJ Wang (1996)
Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia
H. Sun (2009)
Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons.
Y. Du (1997)
The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells
P. Chavis (1994)
Presynaptic kainate receptors at hippocampal mossy fiber synapses
D. Schmitz (2001)
Pharmacological Studies on Lamotrigine, A Novel Potential Antiepileptic Drug
M. Leach (1986)
Neuroprotective effects of phenyl-t-butyl-nitrone in gerbil global brain ischemia and in cultured rat cerebellar neurons
T. Yue (1992)
Memantine reduces functional and morphological consequences induced by global ischemia in rats
F. Block (1996)
Peroxynitrite-mediated protein nitration and lipid peroxidation in a mouse model of traumatic brain injury.
E. Hall (2004)
Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: a randomised controlled trial
K. Lees (2000)
Interactions of polyamines with ion channels.
K. Williams (1997)
The TRPM7 channel is inactivated by PIP2 hydrolysis
L. Runnels (2002)
Zn2+ inhibits alpha-ketoglutarate-stimulated mitochondrial respiration and the isolated alpha-ketoglutarate dehydrogenase complex.
A. M. Brown (2000)
A multicenter trial on the efficacy of using tirilazad mesylate in cases of head injury.
L. Marshall (1998)
Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition
M. Hollmann (1991)
S-nitrosation of glutathione by nitric oxide, peroxynitrite, and (*)NO/O(2)(*-).
A. Schrammel (2003)
Inhibition of glutamate‐induced delayed calcium deregulation by 2‐APB and La3+ in cultured cortical neurones
C. Chinopoulos (2004)
NXY-059 for the treatment of acute ischemic stroke.
A. Shuaib (2007)
Ebselen in Acute Middle Cerebral Artery Occlusion: A Placebo-Controlled, Double-Blind Clinical Trial
A. Ogawa (1999)
Regulation of glutamate release by presynaptic kainate receptors in the hippocampus
R. Chittajallu (1996)
Peroxynitrite causes DNA nicks in plasmid pBR322.
M. G. Salgo (1995)
Riluzole reduces brain lesions and improves neurological function in rats after a traumatic brain injury
F. Wahl (1997)
Differential contribution of plasmalemmal Na+/Ca2+ exchange isoforms to sodium‐dependent calcium influx and NMDA excitotoxicity in depolarized neurons
L. Kiedrowski (2004)
Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia.
G. Pignataro (2007)
Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate
J. Olney (1969)
Tirilazad Reduces Cortical Infarction After Transient but Not Permanent Focal Cerebral Ischemia in Rats
D. Xue (1992)
Zinc neurotoxicity in cortical cell culture
D. Choi (1988)
Peroxynitrite-mediated DNA strand breakage activates poly-adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide.
B. Zingarelli (1996)
Multiple effects of spermine on N‐methyl‐D‐aspartic acid receptor responses of rat cultured hippocampal neurones.
M. Benveniste (1993)
Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis
N. Sen (2008)
Neuroprotective Actions of Novel and Potent Ligands of Group I and Group II Metabotropic Glutamate Receptors
A. Kingston (1999)
Reversible inactivation of calpain isoforms by nitric oxide.
M. Michetti (1995)
Neuroprotective effects of 7-nitroindazole in the gerbil model of global cerebral ischaemia.
M. O'Neill (1996)
Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons
P. E. Castillo (1997)
Ionic dependence of glutamate neurotoxicity
D. Choi (1987)
Memantine in Moderate-to-severe Alzheimer's Disease
M. Riepe (2006)
Nitric Oxide Inhibits Caspase Activation and Apoptotic Morphology but Does Not Rescue Neuronal Death
P. Zhou (2005)
Regulation of N-Methyl-D-aspartate Receptors by Calpain in Cortical Neurons*
H. Wu (2005)
In Vivo Calpain/Caspase Cross-talk during 3-Nitropropionic Acid-induced Striatal Degeneration
N. Bizat (2003)
Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation.
L. M. Molina y Vedia (1992)
The Role of NADPH Oxidase and Neuronal Nitric Oxide Synthase in Zinc-Induced Poly(ADP-ribose) Polymerase Activation and Cell Death in Cortical Culture
Y. Kim (2002)
Free radical scavenger posttreatment improves functional and morphological outcome after fluid percussion injury in the rat.
N. Marklund (2001)
Neuroprotective efficacy of ebselen, an anti‐oxidant with anti‐inflammatory actions, in a rodent model of permanent middle cerebral artery occlusion
T. Takasago (1997)
Activation of the Cation Channel Long Transient Receptor Potential Channel 2 (LTRPC2) by Hydrogen Peroxide
E. Wehage (2002)
Effects of the N-methyl-D-aspartate receptor blocker MK-801 on neurologic function after experimental brain injury.
T. Mcintosh (1989)
NMDA-dependent superoxide production and neurotoxicity
M. Lafon-Cazal (1993)
Instrumental role of Na+ in NMDA excitotoxicity in glucose‐deprived and depolarized cerebellar granule cells
Aneta Czyż (2002)
Selfotel in acute ischemic stroke : possible neurotoxic effects of an NMDA antagonist.
S. Davis (2000)
Neuronal Vacuolization and Necrosis Induced by the Noncompetitive N-methyl-d-aspartate (NMDA) Antagonist MK(+)801 (Dizocilpine Maleate): A Light and Electron Microscopic Evaluation of the Rat Retrosplenial Cortex
A. Fix (1993)
Memantine for dementia.
S. A. Areosa (2005)
Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4
Y. Tanabe (1993)
Critical Role of Calpain I in Mitochondrial Release of Apoptosis-Inducing Factor in Ischemic Neuronal Injury
G. Cao (2007)
Molecular actions of ebselen--an antiinflammatory antioxidant.
T. Schewe (1995)
Epilepsy-Related Ligand/Receptor Complex LGI1 and ADAM22 Regulate Synaptic Transmission
Y. Fukata (2006)
In Vitro Neurotoxicity of Methylisothiazolinone, a Commonly Used Industrial and Household Biocide, Proceeds via a Zinc and Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase-Dependent Pathway
S. Du (2002)
Protective Effect of the Glutamate Antagonist, MK-801 in Focal Cerebral Ischemia in the Cat
E. Ozyurt (1988)
Modulation of mitochondrial function by endogenous Zn2+ pools
S. Sensi (2003)
Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells
V. Bruno (1995)
GOSPEL: A Neuroprotective Protein that Binds to GAPDH upon S-Nitrosylation
N. Sen (2009)
Apoptosis and Necrosis in Cerebrovascular Disease
B. Snider (1999)
Functional modification of cytochrome c by peroxynitrite in an electron transfer reaction.
D. Nakagawa (2001)
The free radical trapping agent N-tert.-butyl-alpha-phenylnitrone (PBN) attenuates cerebral ischaemic injury in gerbils.
C. Clough-Helfman (1991)
Metaanalysis of Tirilazad Mesylate in Patients with Aneurysmal Subarachnoid Hemorrhage
Y. G. Jang (2009)
Tirilazad for acute ischaemic stroke.
P. Bath (2001)
Inhibition of nitric oxide synthase activity by Zn 2 + ion
A Persechini (1995)
Manganese Superoxide Dismutase Protects nNOS Neurons from NMDA and Nitric Oxide-Mediated Neurotoxicity
M. Gonzalez-Zulueta (1998)
Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia
A. Buchan (1990)
Zinc-Induced Cortical Neuronal Death: Contribution of Energy Failure Attributable to Loss of NAD+ and Inhibition of Glycolysis
C. Sheline (2000)
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
M. Mayer (1984)
The novel 21-aminosteroid U74006F attenuates cerebral edema and improves survival after brain injury in the rat.
T. Mcintosh (1992)
Global Ischemia-Induced Increases in the Gap Junctional Proteins Connexin 32 (Cx32) and Cx36 in Hippocampus and Enhanced Vulnerability of Cx32 Knock-Out Mice
K. Oguro (2001)
Alterations in metabolism and gap junction expression may determine the role of astrocytes as “good samaritans” or executioners
R. Farahani (2005)
The toxic effect of sodium L-glutamate on the inner layers of the retina.
Daniel Lucas (1957)
S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.
J. Stamler (1992)
Excitatory amino acids in cerebrospinal fluid following traumatic brain injury in humans.
A. Baker (1993)
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia.
M. Sheardown (1990)
Calpain Activation Contributes to Dendritic Remodeling after Brief Excitotoxic Injury In Vitro
B. Faddis (1997)
Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation
I. Reynolds (1995)
L-Arginine Infusion Promotes Nitric Oxide-Dependent Vasodilation, Increases Regional Cerebral Blood Flow, and Reduces Infarction Volume in the Rat
E. Md (1994)
The N-methyl-d-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils
C. Boast (1988)
GLUTAMATE‐INDUCED CALCIUM LOADS: EFFECTS ON ENERGY METABOLISM AND NEURONAL VIABILITY
S. Thayer (1995)
Distinct Influx Pathways, Not Calcium Load, Determine Neuronal Vulnerability to Calcium Neurotoxicity
R. Sattler (1998)
Dynamics of Extracellular Metabolites in the Striatum after Middle Cerebral Artery Occlusion in the Rat Monitored by Intracerebral Microdialysis
L. Hillered (1989)
A Key Role for TRPM7 Channels in Anoxic Neuronal Death
M. Aarts (2003)
Memantine for dementia.
S. A. Areosa (2005)
Ischemia induces release of glutamate in regions spared from histopathologic damage in the rat.
M. Globus (1990)
Failure of the competitive N-methyl-D-aspartate antagonist Selfotel (CGS 19755) in the treatment of severe head injury: results of two phase III clinical trials. The Selfotel Investigators.
G. F. Morris (1999)
Cerebroprotective Effect of the Nitric Oxide Synthase Inhibitors, 1-(2-Trifluoromethylphenyl) Imidazole and 7-Nitro Indazole, after Transient Focal Cerebral Ischemia in the Rat
K. J. Escott (1998)
Induction of Neuronal Apoptosis by Thiol Oxidation
E. Aizenman (2000)
Calpain activation is not required for AIF translocation in PARP‐1‐dependent cell death (parthanatos)
Y. Wang (2009)
Neuroprotection With a Calpain Inhibitor in a Model of Focal Cerebral Ischemia
S. C. Hong (1994)
The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia
J. Koh (1996)
Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies
S. R. Bradley (1996)
The reaction of no with superoxide.
R. E. Huie (1993)
Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke.
Elaine Besancon (2008)
Selective neuron loss after cerebral ischemia in the rat: Possible role of transmitter glutamate
M. B. Jørgensen (1982)
Ischemia Opens Neuronal Gap Junction Hemichannels
R. Thompson (2006)
L-arginine decreases infarct size caused by middle cerebral arterial occlusion in SHR.
E. Morikawa (1992)
The synaptic activation of kainate receptors
M. Vignes (1997)
Neuroprotective effect of memantine demonstrated in vivo and in vitro.
M. Seif el Nasr (1990)
Protons Open Acid-Sensing Ion Channels by Catalyzing Relief of Ca2+ Blockade
D. Immke (2003)
Kinetics of Peroxynitrite Reaction with Amino Acids and Human Serum Albumin*
B. Álvarez (1999)
Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.
E. Bonfoco (1995)
Translocation of zinc may contribute to seizure-induced death of neurons
C. Frederickson (1989)
Cleavage of the Plasma Membrane Na+/Ca2+ Exchanger in Excitotoxicity
D. Bano (2005)
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
M. Enari (1998)
Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite.
J. Beckman (1992)
Antioxidant ebselen reduces oxidative damage in focal cerebral ischemia.
H. Imai (2003)
Nitrosylation The Prototypic Redox-Based Signaling Mechanism
J. Stamler (2001)
TRPC channels promote cerebellar granule neuron survival
Yichang Jia (2007)
Relationship between excitatory amino acid release and outcome after severe human head injury.
S. Koura (1998)
Neuroprotection in Ischemia Blocking Calcium-Permeable Acid-Sensing Ion Channels
Z. Xiong (2004)
Inhibition of caspase-3 by S-nitrosation and oxidation caused by nitric oxide.
S. Mohr (1997)
Formation of S-Nitrosothiols via Direct Nucleophilic Nitrosation of Thiols by Peroxynitrite with Elimination of Hydrogen Peroxide*
A. van der Vliet (1998)
Attenuation of Delayed Neuronal Death after Mild Focal Ischemia in Mice by Inhibition of the Caspase Family
M. Endres (1998)
Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation.
J. Li (1997)
Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.
T. Abe (1992)
Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons
R. D. Randall (1992)
Gap-junction-mediated propagation and amplification of cell injury
J. Lin (1998)
Kainate Receptors Depress Excitatory Synaptic Transmission at CA3→CA1 Synapses in the Hippocampus via a Direct Presynaptic Action
M. Frerking (2001)
Glutamate mobilizes [Zn2+]i through Ca2+‐dependent reactive oxygen species accumulation
K. Dineley (2008)
μ‐Calpain Activation and Calpain‐Mediated Cytoskeletal Proteolysis Following Traumatic Brain Injury
A. Kampfl (1996)
Isolated Cerebral and Cerebellar Mitochondria Produce Free Radicals when Exposed to Elevated Ca2+ and Na+: Implications for Neurodegeneration
J. Dykens (1994)
Kynurenate is neuroprotective following experimental brain injury in the rat
R. Hicks (1994)
YM872, a novel selective alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, reduces brain damage after permanent focal cerebral ischemia in cats.
M. Takahashi (1998)
Cooperative Modulation of [3H]MK‐801 Binding to the N‐Methyl‐d‐Aspartate Receptor‐Ion Channel Complex by l‐Glutamate, Glycine, and Polyamines
R. Ransom (1988)
Activation of Class II or III Metabotropic Glutamate Receptors Protects Cultured Cortical Neurons Against Excitotoxic Degeneration
V. Bruno (1995)
Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?
C. Ikonomidou (2002)
Evidence that synaptically-released zinc contributes to neuronal injury after traumatic brain injury
S. W. Suh (2000)
Activation of CPP32-Like Caspases Contributes to Neuronal Apoptosis and Neurological Dysfunction after Traumatic Brain Injury
A. Yakovlev (1997)
Neurobiology of zinc and zinc-containing neurons.
C. J. Frederickson (1989)
Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists.
K. Muir (2006)
Role of Caspases in N‐Methyl‐d‐Aspartate‐Induced Apoptosis in Cerebrocortical Neurons
L. Tenneti (1998)
Involvement of Activated Caspase‐3‐Like Proteases in N‐Methyl‐D‐Aspartate‐Induced Apoptosis in Cerebrocortical Neurons
L. Tenneti (2000)
Brief exposure to zinc is toxic to cortical neurons
M. Yokoyama (1986)
Improved Therapeutic Window for Treatment of Histotoxic Hypoxia with a Free Radical Spin Trap
J. Schulz (1995)
Inhibition of nitric oxide synthase activity by Zn2+ ion.
A. Persechini (1995)
Phase II Clinical Trial of Sipatrigine (619C89) by Continuous Infusion in Acute Stroke
K. Muir (2000)
Effects of the 21-aminosteroid U74006F on experimental head injury in mice.
E. Hall (1988)
Non‐NMDA and NMDA receptor‐mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: Further evidence for an apoptosis‐necrosis continuum
C. Portera-Cailliau (1997)
G-protein-independent signaling mediated by metabotropic glutamate receptors
C. Heuss (1999)
Safety, Tolerability, and Pharmacokinetics of the N-Methyl-d-Aspartate Antagonist Dextrorphan in Patients With Acute Stroke
G. Albers (1995)
Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluRl, in transfected CHO cells
I. Aramori (1992)
Delayed antagonism of calpain reduces excitotoxicity in cultured neurons.
J. Brorson (1995)
Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate
L. Dugan (1995)
Zinc-positive boutons in the cerebral cortex of lizards show glutamate immunoreactivity
F. J. Martínez-Guijarro (1991)
Dose escalation study of the NMDA glycine-site antagonist licostinel in acute ischemic stroke.
G. Albers (1999)
Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.
R. Radi (1991)
Peroxynitrite causes DNA damage and oxidation of thiols in rat thymocytes [corrected].
M. G. Salgo (1995)
Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death
S. Yu (2006)
Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity.
J. Zhang (1994)
Mechanism of Kainate Toxicity to Cerebellar Neurons In Vitro Is Analogous to Reperfusion Tissue Injury
James A. Dykens (1987)
Evidence for a protective role played by the Na+/Ca2+ exchanger in cerebral ischemia induced by middle cerebral artery occlusion in male rats
G. Pignataro (2004)
LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death.
Y. Hara (2002)
Anticonvulsant Lamotrigine Administered on Reperfusion Fails To Improve Experimental Stroke Outcomes
R. Traystman (2001)
Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex
H. Ohishi (1994)
Dextromethorphan protects against cerebral injury following transient focal ischemia in rabbits.
G. Steinberg (1988)
Identification and Characterization of Heterogeneous Neuronal Injury and Death in Regions of Diffuse Brain Injury: Evidence for Multiple Independent Injury Phenotypes
R. H. Singleton (2004)
Peroxynitrite-Induced Neuronal Apoptosis Is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation
Yumin Zhang (2004)
Zn2+ Inhibits α-Ketoglutarate-stimulated Mitochondrial Respiration and the Isolated α-Ketoglutarate Dehydrogenase Complex*
A. Brown (2000)
Induction and Activation by Zinc of NADPH Oxidase in Cultured Cortical Neurons and Astrocytes
K. Noh (2000)
Calpain I Induces Cleavage and Release of Apoptosis-inducing Factor from Isolated Mitochondria*
B. Polster (2005)
Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits
J. Chatterton (2002)
Inhibition of nonphosphorylating electron transfer by zinc. The problem of delineating interaction sites.
P. Nicholls (1968)
Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat
N. Tønder (1990)
Double-blind, randomized, vehicle-controlled study of high-dose tirilazad mesylate in women with aneurysmal subarachnoid hemorrhage. Part I. A cooperative study in Europe, Australia, New Zealand, and South Africa.
G. Lanzino (1999)
This paper is referenced by
Microarray Expression Analysis for the Paradoxical Roles of Acanthopanax senticosus Harms in Treating α‐Synucleinopathies
X. Li (2016)
Mystixin-7 mini-peptide protects ionotropic glutamatergic mechanisms against oxygen–glucose deprivation in vitro
A. A. Mokrushin (2016)
Nitric Oxide in Human Health and Disease
S. Paolo (2013)
Interleukin-10 prevents the hypoxia-induced decreases in expressions of AMPA receptor subunit GluA1 and alpha subunit of Ca2+/calmodulin-dependent protein kinase II in hippocampal neurons
T. Savina (2013)
Luteolin protects the hippocampus against neuron impairments induced by kainic acid in rats.
Tzu Lin (2016)
Reasonably activating Nrf2: A long-term, effective and controllable strategy for neurodegenerative diseases.
Q. Li (2019)
The Role of Cyclo(His-Pro) in Neurodegeneration
S. Grottelli (2016)
Restoration of the striatal circuitry: from developmental aspects toward clinical applications
Marie-Christin Pauly (2012)
Matrine regulates glutamate-related excitotoxic factors in experimental autoimmune encephalomyelitis
Quan-cheng Kan (2014)
Fission and Fusion of the Neuronal Endoplasmic Reticulum
K. Kucharz (2013)
Modulation of NMDAR Subunit Expression by TRPM2 Channels Regulates Neuronal Vulnerability to Ischemic Cell Death
I. Alim (2013)
Associação entre alterações cognitivas e comportamentais com processos inflamatórios e neuroquímicos em modelo experimental de Malária
Aline Silva de Miranda (2011)
Studies with selected antagonists of the N-methyl-D-aspartate receptor in an in-vitro blood-brain barrier model of ischemia
Sebastian Membier (2015)
Redox binding partners of the hBCAT proteins and their distribution and expression in control and disease human brains: Implications in protein folding in neurodegeneration
Christopher Lee (2017)
C-Phycocyanin protects SH-SY5Y cells from oxidative injury, rat retina from transient ischemia and rat brain mitochondria from Ca2+/phosphate-induced impairment
Javier Marín-Prida (2012)
Protective Effect of Safranal, a Constituent of Crocus sativus, on Quinolinic Acid-induced Oxidative Damage in Rat Hippocampus
H. R. Sadeghnia (2013)
Evaluation of the Effects of Charged Amino Acids on Uncontrolled Seizures
H. Ebrahimi (2015)
A single fraction from Uncaria sinensis exerts neuroprotective effects against glutamate-induced neurotoxicity in primary cultured cortical neurons
H. Kim (2015)
Sorting mRNA Molecules for Cytoplasmic Transport and Localization
Nathalie Nériec (2018)
Expression and localization of diacylglycerol kinase ζ in guinea pig cochlea and its functional implication under noise-exposure stress conditions
Chikako Shinkawa (2019)
Cortical Glutamate/GABA Imbalance after Combined Radiation Exposure: Relevance to Human Deep-Space Missions
V. Kokhan (2019)
Necroptosis, a Potential Therapeutic Target for Neurological Disorders
Jing Chen (2014)
Molecular Mechanisms of Acute Brain Injury and Ensuing Neurodegeneration
F. Ortega (2012)
Effect of Forced and Voluntary Exercise on Neural Plasticity Mediated by Astrocytes
C. Bernardi (2015)
Identification of Brain Damage after Seizures Using an MR-Based Electrical Conductivity Imaging Method
Sanga Kim (2021)
Brain Damage - Bridging Between Basic Research and Clinics
A. González-Quevedo (2012)
Rotating and Neurochemical Activity of Rats Lesioned with Quinolinic Acid and Transplanted with Bone Marrow Mononuclear Cells.
T. Sánchez (2018)
DGKζ is degraded through the cytoplasmic ubiquitin-proteasome system under excitotoxic conditions, which causes neuronal apoptosis because of aberrant cell cycle reentry.
M. Okada (2012)
Estudo dos mecanismos associados à disfunção cognitiva em modelo murino de malária cerebral
A. S. Miranda (2015)
Enriquecimento ambiental como estratégia neuroprotetora em ratos submetidos à hipóxia-isquemia neonatal
J. J. Rojas (2015)
Antioxidant effects of JM-20 on rat brain mitochondria and synaptosomes: Mitoprotection against Ca2+-induced mitochondrial impairment
Y. Nuñez-Figueredo (2014)
Transient alteration of the vestibular calyceal junction and synapse in response to chronic ototoxic insult in rats
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