← Back to Search
The Functional Role Of Peroxiredoxin 3 In Reactive Oxygen Species, Apoptosis, And Chemoresistance Of Cancer Cells
Lianqin Li, Ai-Qun Yu
Published 2015 · Biology, Medicine
Save to my Library
Download via 🐼 PaperPanda Download via oaDOI Download via OAB Download via LibKey Download via Google Google ScholarAnalyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
PurposeThe mammalian peroxiredoxin (PRX) family contains six members that provide antioxidant defense in different cell types by removing reactive oxygen species (ROS) through conserved active cysteines. Different from other members, PRX3 is predominantly located in mitochondria, a major apoptosis mediator. The purpose of this review is to summarize the findings on PRX3 concerning its role in ROS removal, apoptosis, and chemoresistance of cancer cells.MethodsThe relevant literature from PubMed and Medline databases is reviewed in this article (1994-2014).Results Because of fast growth and relatively low supply of oxygen in cancer cells, ROS production from mitochondria is exaggerated to an extent that overwhelms cellular antioxidant defenses resulting in oxidative stress. As an active responder to oxidative stress, PRX3 is accordingly up-regulated in cancer cells to remove cellular ROS and inhibit apoptosis, which provides a favorable microenvironment for cell proliferation. ConclusionSince most of chemotherapy or radiotherapy for cancers is through ROS increase and apoptotic induction, PRX3 might be involved in the chemotherapeutic resistance of cancers.
This paper references
Abrin and Ricin: New Anti-tumour Substances
Jung-Yaw Lin (1970)
2004a) a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria
TS Chang (1984)
Cloning of a housekeeping-type gene (MERS) preferentially expressed in murine erythroleukemia cells
Yamamoto Tohru (1989)
Cloning of a housekeeping-type gene (MER5) preferentially expressed in murine erythroleukemia cells.
T. Yamamoto (1989)
Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes.
H. Z. Chae (1994)
Mammalian antioxidant protein complements alkylhydroperoxide reductase (ahpC) mutation in Escherichia coli.
K. Tsuji (1995)
SP-22 is a thioredoxin-dependent peroxide reductase in mitochondria.
S. Watabe (1997)
Human T cell cyclophilin18 binds to thiol-specific antioxidant protein Aop1 and stimulates its activity.
A. Jäschke (1998)
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.
H. Zhong (1999)
Characterization of three isoforms of mammalian peroxiredoxin that reduce peroxides in the presence of thioredoxin.
H. Chae (1999)
Antioxidant Function of the Mitochondrial Protein SP-22 in the Cardiovascular System*
M. Araki (1999)
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
K. Talks (2000)
The mitochondrial thioredoxin system.
A. Miranda-Vizuete (2000)
Identification of c-myc responsive genes using rat cDNA microarray.
Q. Guo (2000)
The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
Kate L. Talks (2000)
The mitochondrial antioxidant defence system and its response to oxidative stress
T. Rabilloud (2001)
Abrin Triggers Cell Death by Inactivating a Thiol-specific Antioxidant Protein*
S. Shih (2001)
Cyclophilin A Binds to Peroxiredoxins and Activates Its Peroxidase Activity*
S. Lee (2001)
Overexpression of peroxiredoxin in human breast cancer.
D. Y. Noh (2001)
Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling
E. Smaele (2001)
The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation
D. Wonsey (2002)
Overexpression of peroxiredoxins I, II, III, V, and VI in malignant mesothelioma
V. Kinnula (2002)
Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas.
J. H. Choi (2002)
A QSPR-Approach to the Estimation of the pKHB of Six-Membered Nitrogen-Heterocycles using Quantum Mechanically Derived Descriptors
M. Hennemann (2002)
Nonredundant Antioxidant Defense by Multiple Two-Cysteine Peroxiredoxins in Human Prostate Cancer Cells
C. Shen (2002)
Pag, a Putative Tumor Suppressor, Interacts with the Myc Box II Domain of c-Myc and Selectively Alters Its Biological Function and Target Gene Expression*
Z. M. Mu (2002)
Peroxiredoxins in breast carcinoma.
P. Karihtala (2003)
Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis.
L. Nonn (2003)
Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically.
M. Masaki (2003)
Inhibition of Constitutive NF-κB Activation in Mantle Cell Lymphoma B Cells Leads to Induction of Cell Cycle Arrest and Apoptosis1
L. Pham (2003)
Peroxiredoxin III, a Mitochondrion-specific Peroxidase, Regulates Apoptotic Signaling by Mitochondria*
T. Chang (2004)
Characterization of Mammalian Sulfiredoxin and Its Reactivation of Hyperoxidized Peroxiredoxin through Reduction of Cysteine Sulfinic Acid in the Active Site to Cysteine*
T. Chang (2004)
Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells
P. Srinivas (2004)
Multiple RNA surveillance pathways limit aberrant expression of iron uptake mRNAs and prevent iron toxicity in S. cerevisiae.
A. Lee (2005)
The antioxidant function of the p53 tumor suppressor
A. Sablina (2005)
RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains.
L. Liu (2005)
HIF-1α and p53: the ODD couple?
D. Fels (2005)
HIF-1alpha and p53: the ODD couple?
D. Fels (2005)
Reduction of Cysteine Sulfinic Acid by Sulfiredoxin Is Specific to 2-Cys Peroxiredoxins*
H. Woo (2005)
Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel‐induced cancer cell death both in vitro and in vivo
J. Alexandre (2006)
Expression of peroxiredoxin and thioredoxin in human lung cancer and paired normal lung
J. Park (2006)
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity.
H. Zhang (2007)
Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology.
Yun-Jeong Kim (2007)
Hydrogen peroxide induces apoptosis in HeLa cells through mitochondrial pathway.
Mayank Singh (2007)
Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells.
C. Marzano (2007)
Silencing of peroxiredoxin 3 and peroxiredoxin 5 reveals the role of mitochondrial peroxiredoxins in the protection of human neuroblastoma SH-SY5Y cells toward MPP+
S. Simoni (2008)
The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation.
A. G. Cox (2008)
Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates.
Kristin K. Brown (2008)
FOXO3A Regulates Peroxiredoxin III Expression in Human Cardiac Fibroblasts*
Calin B Chiribau (2008)
Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis.
Andrew G. Cox (2008)
cancer : consistent upregulation of PRDX 3 and PRDX 4
KK Brown (2008)
Peroxiredoxins, a novel target in cancer radiotherapy.
B. Zhang (2009)
Downregulation of the c‐MYC target gene, peroxiredoxin III, contributes to arsenic trioxide‐induced apoptosis in acute promyelocytic leukemia
P. Vivas-Mejía (2009)
Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis.
Kiyoon Kim (2009)
Induction of sulfiredoxin via an Nrf2-dependent pathway and hyperoxidation of peroxiredoxin III in the lungs of mice exposed to hyperoxia.
Soo Han Bae (2009)
Transcriptional up‐regulation of FoxM1 in response to hypoxia is mediated by HIF‐1
L. Xia (2009)
Sulfiredoxin Translocation into Mitochondria Plays a Crucial Role in Reducing Hyperoxidized Peroxiredoxin III*
Y. H. Noh (2009)
The role of enoyl‐CoA hydratase short chain 1 and peroxiredoxin 3 in PP2‐induced apoptosis in human breast cancer MCF‐7 cells
X. Liu (2010)
Peroxiredoxins in colorectal neoplasms.
X. Wu (2010)
Respiration-dependent H2O2 Removal in Brain Mitochondria via the Thioredoxin/Peroxiredoxin System*
Derek A. Drechsel (2010)
Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer.
Pei-Jou Chua (2010)
Thiazole antibiotics against breast cancer
M. Halasi (2010)
Both Thioredoxin 2 and Glutaredoxin 2 Contribute to the Reduction of the Mitochondrial 2-Cys Peroxiredoxin Prx3*
E. Hanschmann (2010)
Mitochondrial respiratory chain involvement in peroxiredoxin 3 oxidation by phenethyl isothiocyanate and auranofin
Kristin K. Brown (2010)
Downregulation of c-MYC protein levels contributes to cancer cell survival under dual deficiency of oxygen and glucose.
H. Okuyama (2010)
Regulation of reactive oxygen species by p53: implications for nitric oxide-mediated apoptosis.
D. Popowich (2010)
Thiazole antibiotics against breast cancer. Cell Cycle
M Halasi (2010)
Differential expression of peroxiredoxins in prostate cancer: Consistent upregulation of PRDX3 and PRDX4
Anamika Basu (2011)
Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway.
N. Miyamoto (2011)
FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function
Kim Steen Jensen (2011)
Nuclear factor E2-related factor 2 Dependent Overexpression of Sulfiredoxin and Peroxiredoxin III in Human Lung Cancer
Y. Kim (2011)
Mitochondrial Peroxiredoxin III is a Potential Target for Cancer Therapy
I. Song (2011)
Upregulation of Peroxiredeoxin III in the Hippocampus of Acute Immobilization Stress Model Rats and the Foxo3a-Dependent Expression in PC12 Cells
H. J. Jeong (2011)
Differential expression of perox - iredoxins in
A Basu (2011)
Physiological roles of mitochondrial reactive oxygen species.
Laura A. Sena (2012)
Expression and prognostic significance of human peroxiredoxin isoforms in endometrial cancer.
Seulhee Han (2012)
Peroxiredoxin 3 Is a Redox-Dependent Target of Thiostrepton in Malignant Mesothelioma Cells
Kheng Newick (2012)
Peroxiredoxin III and sulfiredoxin together protect mice from pyrazole-induced oxidative liver injury.
Soo Han Bae (2012)
The biological activity of auranofin: implications for novel treatment of diseases
J. Madeira (2012)
Detection and identification of peroxiredoxin 3 as a biomarker in hepatocellular carcinoma by a proteomic approach.
B. Qiao (2012)
Myc posttranscriptionally induces HIF1 protein and target gene expression in normal and cancer cells.
Megan R. Doe (2012)
FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression
E. C. Ferber (2012)
MicroRNA‐23b downregulates peroxiredoxin III in human prostate cancer
H. He (2012)
Expression of Peroxiredoxin 1, 2, 3, and 6 Genes in Cancer Cells during Drug Resistance Formation
E. Kalinina (2012)
Expression and prognostic significance
S Han (2012)
siRNA targeting of PRDX3 enhances cisplatin‑induced apoptosis in ovarian cancer cells through the suppression of the NF‑κB signaling pathway.
J. Duan (2013)
Anti-apoptotic role of peroxiredoxin III in cervical cancer cells☆
Lianqin Li (2013)
Peroxiredoxin III protein expression is associated with platinum resistance in epithelial ovarian cancer
Xin-yan Wang (2013)
Peroxiredoxin 3 is a novel marker for cell proliferation in cervical cancer.
Jing-xia Hu (2013)
c-Myc enhances colon cancer cell-mediated angiogenesis through the regulation of HIF-1α.
Cheng Chen (2013)
Peroxiredoxin Overexpression in MCF-7 Breast Cancer Cells and Regulation by Cell Proliferation and Oxidative Stress
Lauren Tehan (2013)
Mitochondrial‐targeted nitroxides disrupt mitochondrial architecture and inhibit expression of peroxiredoxin 3 and FOXM1 in malignant mesothelioma cells
B. Cunniff (2013)
Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress
H. Whitaker (2013)
Peroxiredoxin 3 is resistant to oxidation-induced apoptosis of Hep-3b cells
Y-G Wang (2013)
MiR‐383 is Downregulated in Medulloblastoma and Targets Peroxiredoxin 3 (PRDX3)
K. Li (2013)
Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses
Joanna Obacz (2013)
Peroxiredoxin proteins protect MCF-7 breast cancer cells from doxorubicin-induced toxicity.
C. McDonald (2014)
2013) siRNA targeting of PRDX3 enhances cisplatin—induced apoptosis in ovarian cancer cells through the suppression of the NF–κB signaling pathway
Rhee SG (2004a) a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria
This paper is referenced by
Targeting Mitochondrial Oncometabolites: A New Approach to Overcome Drug Resistance in Cancer
Martina Godel (2021)
Modulation of Mitochondrial Metabolic Reprogramming and Oxidative Stress to Overcome Chemoresistance in Cancer
R. Avolio (2020)
Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression
T. Ismail (2019)
The Expression and Prognostic Role of Peroxiredoxins in Lung Cancer
B. Li (2019)
The Role of Peroxiredoxin Family in Cancer Signaling
Yosup Kim (2019)
SALL4 suppresses reactive oxygen species in pancreatic ductal adenocarcinoma phenotype via FoxM1/Prx III axis.
D. Huynh (2018)
Tanshinone l exhibits anticancer effects in human endometrial carcinoma HEC-1-A cells via mitochondrial mediated apoptosis, cell cycle arrest and inhibition of JAK/STAT signalling pathway.
Q. Li (2018)
Spontaneous Unexplained Preterm Labor with Intact Membrane: Finding Protein Biomarkers through Placenta Proteome
N. J. Tan (2018)
Modulating ROS to overcome multidrug resistance in cancer.
Qingbin Cui (2018)
Interaction of High Molecular Weight Compounds with a, β-Unsaturated Carbonyl Moiety with Mammalian and Drosophila Melanogaster Thioredoxin Reductase
Anupama Tuladhar (2018)
Transforming Growth Factor-β Drives the Transendothelial Migration of Hepatocellular Carcinoma Cells
Petra Koudelková (2017)
New Challenges to Study Heterogeneity in Cancer Redox Metabolism
R. Benfeitas (2017)
Characterization and Expression Analysis of Peroxiredoxin Genes in NNK-induced V 79 Cells *
Shiyue Qin (2017)
Characterization and Expression Analysis of Peroxiredoxin Genes in NNK-induced V79 Cells.
G. Q. Shi (2017)
The role of peroxiredoxins in cancer
A. Nicolussi (2017)
Roles of the Translationally Controlled Tumor Protein (TCTP) in Plant Development.
Léo Betsch (2017)
Mitochondrial peroxiredoxins are essential in regulating the relationship between Drosophila immunity and aging.
O. Odnokoz (2017)
Mitochondrial transcription factor A contributes to cisplatin resistance in patients with estrogen receptor‑positive breast cancer.
W. Gao (2016)
Peroxiredoxin-3 Is Involved in Bactericidal Activity through the Regulation of Mitochondrial Reactive Oxygen Species
S. Lee (2016)
Structures of Human Peroxiredoxin 3 Suggest Self-Chaperoning Assembly that Maintains Catalytic State.
N. A. Yewdall (2016)
Solution Conformations of Peroxiredoxins Visualised by Volta Phase Plates
M. Radjainia (2016)
Molecular Basis of Hydroperoxide Specificity in Peroxiredoxins: The Case of AhpE from Mycobacterium tuberculosis.
Ari Zeida (2015)