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Prevalence Of Arterial Hypertension, Hemodynamic Phenotypes, And Left Ventricular Hypertrophy In Children After Coarctation Repair: A Multicenter Cross-sectional Study

Skaiste Sendzikaite, R. Sudikienė, V. Tarutis, Inguna Lubaua, Pauls Sīlis, A. Rybak, A. Jankauskiene, M. Litwin
Published 2020 · Medicine

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Background This study aimed to evaluate hemodynamic phenotypes and prevalence of left ventricular hypertrophy in children after coarctation repair with right arm and leg blood pressure difference < 20 mmHg. Secondary objectives were analysis of effects of age at intervention, residual gradient across the descending aorta, and type of correction. Methods Blood pressure status and left ventricular hypertrophy were diagnosed according to European Society of Hypertension 2016 guidelines. Results Of 90 patients with a median age 12.5 (8.9–15.8) years, 8.5 (6.0–11.8) years after coarctation repair who were included, 42 (46.7%) were hypertensive. Isolated systolic hypertension dominated among 29 hypertensive patients with uncontrolled or masked hypertension (25 of 29; 86.2%). Of the 48 patients with office normotension, 14.6% (7) had masked hypertension, 8.3% (4) had ambulatory prehypertension, and 54.2% (26) were truly normotensive. Left ventricular hypertrophy was diagnosed in 29 patients (32.2%), including 14 of 42 (33.3%) hypertensive and 15 of 48 (31.3%) normotensive patients. The peak systolic gradient across the descending aorta was greater in hypertensive subjects (33.3 ± 12.7 mmHg) compared with normotensive subjects (25 ± 8.2 mmHg, p = 0.0008). Surgical correction was performed earlier than percutaneous intervention ( p < 0.0001) and dominated in 40 of 48 (83.3%) normotensive versus 24 of 42 (57.1%) hypertensive patients ( p = 0.006). Conclusions Arterial hypertension with isolated systolic hypertension as the dominant phenotype and left ventricular hypertrophy are prevalent even after successful coarctation repair. Coarctation correction from the age of 9 years and older was associated with a higher prevalence of hypertension.
This paper references
10.1016/0735-1097(94)00540-7
Effect of growth on variability of left ventricular mass: assessment of allometric signals in adults and children and their capacity to predict cardiovascular risk.
G. de Simone (1995)
10.1536/JHJ.41.49
Ambulatory blood pressure monitoring after successful repair of coarctation of the aorta at mid-term follow-up.
A. Eroğlu (2000)
10.1097/00126097-200006000-00004
Arterial hypertension in children and adolescents after surgical repair of aortic coarctation defined by ambulatory blood pressure monitoring
M. Bald (2000)
10.1016/S0002-9149(01)02293-7
Long-term follow-up of patients after coarctation of the aorta repair.
Olga H Toro-Salazar (2002)
10.1016/S0735-1097(02)01886-7
The incidence of congenital heart disease.
J. Hoffman (2002)
10.1067/MPD.2002.125228
Isolated systolic hypertension, obesity, and hyperkinetic hemodynamic states in children.
J. Sorof (2002)
10.25060/residpediatr-2018.v8n1-12
The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents.
Isabel Rey Madeira (2004)
10.1542/PEDS.114.2.S2.555
The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents
B. Falkner (2004)
10.1007/BF00794187
Ambulatory blood pressure in patients with occult recurrent coarctation of the aorta
M. Parrish (2004)
10.1161/01.HYP.0000153793.84859.B8
Aortic diameter, aortic stiffness, and wave reflection increase with age and isolated systolic hypertension.
M. O'Rourke (2005)
10.1093/EURHEARTJ/EHI004
Predictive value of mild, residual descending aortic narrowing for blood pressure and vascular damage in patients after repair of aortic coarctation.
J. Vriend (2005)
10.1016/J.IJCARD.2004.03.056
Late complications in patients after repair of aortic coarctation: implications for management.
J. Vriend (2005)
10.1016/J.ATHEROSCLEROSIS.2005.01.030
Evidence of vascular dysfunction in young patients with successfully repaired coarctation of aorta.
S. Brili (2005)
10.1016/J.JACC.2005.10.063
The results of catheter-based therapy compared with surgical repair of adult aortic coarctation.
J. A. Carr (2006)
10.1016/J.JACC.2006.10.057
Vascular remodeling after "successful" repair of coarctation: impact of aortic arch geometry.
P. Ou (2007)
10.1016/J.JTCVS.2007.04.027
Coarctation Long-term Assessment (COALA): significance of arterial hypertension in a cohort of 404 patients up to 27 years after surgical repair of isolated coarctation of the aorta, even in the absence of restenosis and prosthetic material.
A. Hager (2007)
10.1016/j.echo.2009.03.003
Age-specific reference intervals for indexed left ventricular mass in children.
P. Khoury (2009)
10.1002/9781444306309
Echocardiography in pediatric and congenital heart disease
W. Lai (2009)
10.1007/s11906-010-0140-4
Masked Hypertension: Evidence of the Need to Treat
G. Ogedegbe (2010)
10.1038/nrcardio.2009.231
Assessment and management of hypertension in children and adolescents
B. McCrindle (2010)
10.1007/s00431-010-1329-x
Polish 2010 growth references for school-aged children and adolescents
Z. Kułaga (2010)
10.1038/jhh.2010.118
Masked hypertension in young patients after successful aortic coarctation repair: impact on left ventricular geometry and function
G. Salvo (2011)
10.1038/hr.2011.22
Hypertension and coarctation of the aorta: an inevitable consequence of developmental pathophysiology
D. Kenny (2011)
10.1016/j.jacc.2013.06.016
Coarctation of the aorta: lifelong surveillance is mandatory following surgical repair.
M. Brown (2013)
10.1016/j.amjcard.2012.09.037
Correlation of exercise response in repaired coarctation of the aorta to left ventricular mass and geometry.
E. Krieger (2013)
10.1016/j.ijcard.2012.09.084
Hypertension after repair of aortic coarctation--a systematic review.
C. Canniffe (2013)
10.1016/j.jcin.2012.10.009
Systemic blood pressure after stent management for arch coarctation implications for clinical care.
G. Morgan (2013)
10.1161/HYP.0000000000000007
Update: Ambulatory Blood Pressure Monitoring in Children and Adolescents A Scientific Statement From the American Heart Association
J. Flynn (2014)
10.1002/9781118742440
Echocardiography in Pediatric and Congenital Heart Disease: From Fetus to Adult
P. Noonan-Walsh (2015)
10.1016/j.athoracsur.2015.03.099
High Prevalence of Hypertension and End-Organ Damage Late After Coarctation Repair in Normal Arches.
Melissa G Y Lee (2015)
10.1136/heartjnl-2014-307035
Late outcomes in adults with coarctation of the aorta
P. Choudhary (2015)
10.4330/wjc.v7.i11.765
Coarctation of the aorta: Management from infancy to adulthood.
Rachel D. Torok (2015)
10.1016/j.ijcard.2016.05.033
Left ventricular hypertrophy in adults with previous repair of coarctation of the aorta; association with systolic blood pressure in the high normal range.
Daniel Rinnström (2016)
10.1016/j.ijcard.2016.08.295
A systematic review and meta-analysis of outcomes of transcatheter stent implantation for the primary treatment of native coarctation.
L. Yang (2016)
10.1097/HJH.0000000000001039
2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents.
E. Lurbe (2016)
European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents
E Lurbe (2016)
10.1016/j.ijcard.2016.11.164
Survival and cardiovascular events after coarctation-repair in long-term follow-up (COAFU): Predictive value of clinical variables.
P. Bambul Heck (2017)
10.1007/s00246-017-1739-x
Hypertension in Coarctation of the Aorta: Challenges in Diagnosis in Children
T. Vigneswaran (2017)
10.1093/eurheartj/ehw502
Masked hypertension: understanding its complexity.
S. Franklin (2017)
Survival and cardiovascular events after coarctationrepair in long-term follow-up (COAFU): Predictive value of clinical Pediatr Nephrol variables
P Bambul Heck (2017)
Survival and cardiovascular events after coarctationrepair in long-term follow-up (COAFU): Predictive value of clinical 2154 Pediatr Nephrol
P Bambul Heck (2017)
10.28942/EJCS.V1I4.35
Late Coarctation Presenters Suffer Chronic Hypertension Resisting to Medicine Treatment
A. Petropoulos (2018)
10.1097/HJH.0000000000001726
Isolated systolic hypertension in the young: a position paper endorsed by the European Society of Hypertension
P. Palatini (2018)
Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations
s The pediatric cardiology handbook. Fifth edn
M K Park



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