Sensing Lorazepam With A Glassy Carbon Electrode Coated With An Electropolymerized-imprinted Polymer Modified With Multiwalled Carbon Nanotubes And Gold Nanoparticles
B. Rezaei, O. Rahmanian, A. A. Ensafi
Published 2012 · Chemistry
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AbstractWe report on an electrode for the amperometric determination of lorazepam. A glassy carbon electrode was coated with a molecular imprint made by electropolymerization of ortho-phenylenediamine and filled with multiwalled carbon nanotubes and gold nanoparticles, which enhances the transmission of electrons. The sensor was studied with respect to its response to hexacyanoferrate (III) as a probe and by electrochemical impedance spectroscopy, cyclic voltammetry and square wave voltammetry. The linear response range to Lorazepam is from 0.5 nM to 1.0 nM and from 1.0 nM to 10.0 nM, with a detection limit of 0.2 nM (at an S/N of 3). The electrode was successfully applied to determine Lorazepam in spiked human serum. Figure 1The preparation of schematic of the AuNP/MIP/f−MWCNT/GCE electrode
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