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Effect Of Supplementation Of Low-molecular-weight Chitosan Oligosaccharide, GO2KA1, On Postprandial Blood Glucose Levels In Healthy Individuals Following Bread Consumption

Yu-Ri Kang, Hwang-Yong Choi, J. Lee, Soo-In Jang, Jung-Bae Oh, J. Kim, J. Lee, S. Jo, Kyoung-Soo Ha, Mee-Sook Lee, Young-Cheul Kim, E. Apostolidis, Y. Kwon
Published 2016 · Chemistry, Medicine

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The effect of chitosan oligosaccharide (GO2KA1) administration on postprandial blood glucose levels of subjects with normal blood glucose levels was evaluated following bread consumption. Postprandial blood glucose levels were determined for 2 h after bread ingestion with or without 500 mg of GO2KA1. GO2KA1 significantly lowered the mean, maximum, and minimum levels of postprandial blood glucose at 30 min after the meal. Postprandial blood glucose levels were decreased by about 25% (from 155.11±13.06 to 138.50±13.59, p<0.01) at 30 min when compared to control. Furthermore, we observed that the area under the concentration-time curve (AUCt) was decreased by about 6% (from 255.46±15.43 to 240.15±14.22, p<0.05) and the peak concentration of blood glucose (Cmax) was decreased by about 11% (from 157.94±10.90 to 140.61±12.52, p<0.01) when compared to control. However, postprandial the time to reach Cmax (Tmax) levels were the same as those found in control. Our findings suggest that GO2KA1 limits the increase in postprandial blood glucose levels following bread consumption.
This paper references
Action of low molecular weight chitosan in genetically obese diabetic KK - A y Mice
H Koji (2002)
10.1016/J.CARBPOL.2008.05.003
Antioxidant properties of chitosan from crab shells
Ming-Tsung Yen (2008)
10.1016/S0140-6736(12)60283-9
Prediabetes: a high-risk state for diabetes development
Á. Tabák (2012)
10.2337/dc08-9025
Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy
D. Nathan (2009)
10.1016/S0168-1605(01)00717-6
Antibacterial activity of chitosans and chitosan oligomers with different molecular weights.
H. K. No (2002)
10.1093/JN/130.11.2753
Cholesterol reduction by glucomannan and chitosan is mediated by changes in cholesterol absorption and bile acid and fat excretion in rats.
C. Gallaher (2000)
10.5114/aoms.2012.31621
α-Glucosidase inhibitors and their use in clinical practice
G. Derosa (2012)
10.1007/s10068-014-0131-3
The reduction effect of low molecular weight chitosan oligosaccharide (GO2KA1) on postprandial blood glucose levels in healthy individuals
S. Jo (2014)
10.1016/S0141-8130(02)00064-8
Enzymic preparation of water-soluble chitosan and their antitumor activity.
Caiqin Qin (2002)
10.1016/J.BMCL.2006.05.078
In vivo antitumor activity of chitosan nanoparticles.
Lifeng Qi (2006)
10.1186/1478-7954-8-29
Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence
J. P. Boyle (2010)
10.2337/dc11-S062
Diagnosis and Classification of Diabetes Mellitus
Vittorio Basevi (2011)
10.1248/BPB.26.1100
Antidiabetic effects of chitosan oligosaccharides in neonatal streptozotocin-induced noninsulin-dependent diabetes mellitus in rats.
Hyean-Woo Lee (2003)
10.1248/BPB.25.188
Antidiabetic action of low molecular weight chitosan in genetically obese diabetic KK-Ay mice.
K. Hayashi (2002)
10.3390/ijms140714214
Molecular Weight Dependent Glucose Lowering Effect of Low Molecular Weight Chitosan Oligosaccharide (GO2KA1) on Postprandial Blood Glucose Level in SD Rats Model
S. Jo (2013)
Action of low molecular weight chitosan in genetically obese diabetic KK-A Mice
H Koji (2002)
10.1007/S00217-006-0439-1
Preparation of chitosan oligomers and their antioxidant activity
Tao Sun (2007)
10.1007/s00125-006-0316-2
Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy
D. Nathan (2006)



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