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Application Of The P9NORM Correction Method To Timed Neuropsychological Tests In Parkinson’s Disease And Multiple System Atrophy

Teresa Costabile, Chiara Pane, Luisa Aurisicchio, Adriana Salvati, Maria Chiara Di Lieto, Silvio Peluso, A. Z. Reia, Natascia De Lucia, Anna De Rosa, Alessandro Filla, Giuseppe De Michele, Francesco Saccà
Published 2020 · Medicine
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Objective Timed neuropsychological tests do not take into account physical impairment during scoring procedures. Dysarthria and upper limb impairment can be easily measured with the PATA rate test (PRT) and the nine-hole pegboard test (9HPT). We recently validated a normalization method for timed neuropsychological tests using the PRT and 9HPT (p9NORM). We now validate the p9NORM in Parkinson’s disease (Yarnall et al. Neurology 82(4):308–316; 2014 ) and multiple system atrophy (MSA). Methods We enrolled twenty-six patients with PD, eighteen patients with MSA, and fifteen healthy controls (HC). p9NORM was applied to patients with abnormal PRT and/or 9HPT. All subjects were tested with a comprehensive neuropsychological battery. Results No differences emerged in demographics across groups: (PD: mean age ± SD 66 ± 8; education 9 ± 4 years; MSA: age 60 ± 8; education 10 ± 4 years; HC: age 61 ± 12; education 9 ± 4 years). In MSA patients, the scores on the trail making test (TMT-A p = 0.003; TMT-B p = 0.018), attentional matrices (AM; p = 0.042), and symbol digit modalities test (SDMT p = 0.027) significantly differed following application of p9NORM. In PD patients, the TMT-A ( p < 0.001), TMT-B ( p = 0.001), and AM ( p = 0.001) differed after correction. PD and MSA showed cognitive impairment relative to HC performance. When comparing MSA with PD, the SDMT, AM, and fluencies were similar. TMT-A and -B raw scores were different between groups ( p = 0.006; p = 0.034), but these differences lost significance after p9NORM corrections ( p = 0.100; p = 0.186). Conclusions We confirm that the p9NORM can be successfully used in both PD and MSA patients, as it mitigates the impact of disability on timed tests, resulting in a more accurate analysis of cognitive domains.
This paper references
10.1212/WNL.0000000000000066
Characterizing mild cognitive impairment in incident Parkinson disease
Alison J. Yarnall (2014)
Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis
D Aarsland (2010)
10.1055/s-0028-1086654
Second consensus statement on the diagnosis of multiple system atrophy
Sid Gilman (2008)
10.1002/mds.10473
The Unified Parkinson's Disease Rating Scale (UPDRS): status and recommendations.
(2003)
10.1111/jnp.12125
Normalization of timed neuropsychological tests with the PATA rate and nine‐hole pegboard tests
Francesco Saccà (2018)
10.1212/01.wnl.0000324863.76290.19
SCA Functional Index
Tanja Schmitz-Hübsch (2008)
10.1007/s10072-014-1995-y
Normative data for the Montreal Cognitive Assessment in an Italian population sample
Gabriella Santangelo (2014)
10.1002/mds.20255
Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS).
Gregor K. Wenning (2004)
10.1007/s10072-006-0717-5
Italian neuropsychological instruments to assess memory, attention and frontal functions for developmental age
Paola Scarpa (2006)
10.1159/000117297
The Mental Deterioration Battery: normative data, diagnostic reliability and qualitative analyses of cognitive impairment. The Group for the Standardization of the Mental Deterioration Battery.
Giovanni A. Carlesimo (1996)
10.1007/s00415-018-8820-0
Adult normative values for the PATA Rate Test
Chiara Pane (2018)
10.1007/s10072-013-1520-8
Standardization and normative data obtained in the Italian population for a new verbal fluency instrument, the phonemic/semantic alternate fluency test
Alberto Costa (2013)
10.1007/s00702-003-0011-0
Differentiation of parkinsonian syndromes according to differences in executive functions
K Lange (2003)
Standardizazione e taratura italiana di test neuropsicologici
Henri Spinnler (1987)
10.1001/archneur.55.3.372
Cognitive dysfunction and impaired organization of complex motility in degenerative parkinsonian syndromes.
Daniela Monza (1998)
Raven's coloured progressive matrices: normative values on 305 adult normal controls.
Anna Basso (1987)
10.1016/S1474-4422(14)70321-7
Biological and clinical characteristics of the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS) cohort: a cross-sectional analysis of baseline data
Kathrin Reetz (2015)
10.1016/S1474-4422(10)70212-X
Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease
Angie A. Kehagia (2010)
10.1016/j.nbd.2012.03.029
Cognitive impairment and dementia in Parkinson's disease
Javier Pagonabarraga (2012)
10.1212/WNL.0b013e3181f39d0e
Mild cognitive impairment in Parkinson disease
Dag Aarsland (2010)
10.1093/brain/122.9.1637
Frontal, midbrain and striatal dopaminergic function in early and advanced Parkinson's disease A 3D [(18)F]dopa-PET study.
J S Rakshi (1999)
10.1007/s00415-015-7671-1
Speech disorders reflect differing pathophysiology in Parkinson’s disease, progressive supranuclear palsy and multiple system atrophy
Jan Rusz (2015)
The Symbol Digit Modalities Test - Oral version: Italian normative data.
Ugo Nocentini (2006)
10.3233/JPD-140372
Non-motor symptoms profile and burden in drug naïve versus long-term Parkinson's disease patients.
Panagiotis Zis (2014)
Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations
Destee A (2003) Executive function differences in multiple system atrophy and Parkinson’s disease
K Dujardin (2003)
10.1016/S1353-8020(02)00050-0
Executive function differences in multiple system atrophy and Parkinson's disease.
Kathy Dujardin (2003)
10.1002/mds.23260
Factors influencing the cognitive function in patients with multiple system atrophy.
K. Kawamura (2010)
10.3758/BF03195471
Word naming times and psycholinguistic norms for Italian nouns
Laura Barca (2002)
10.1007/s10072-017-2919-4
Edinburgh Cognitive and Behavioural ALS Screen (ECAS)-Italian version: regression based norms and equivalent scores
Mattia Siciliano (2017)
10.1136/jnnp.2009.204446
Cognitive dysfunction in lower motor neuron disease: executive and memory deficits in progressive muscular atrophy
Joost Raaphorst (2010)
10.1002/ana.20463
Very late onset in ataxia oculomotor apraxia type I.
C Criscuolo (2005)
10.1002/ana.10078
Dopaminergic modulation of cortical function in patients with Parkinson's disease.
Venkata S. Mattay (2002)
10.1002/mds.870120203
Multiple system atrophy: a review of 203 pathologically proven cases.
Gregor K. Wenning (1997)
10.1007/s10072-012-1130-x
Forward and backward span for verbal and visuo-spatial data: standardization and normative data from an Italian adult population
Marco Di Monaco (2012)
10.1007/s10072-014-2019-7
Erratum to: Forward and backward span for verbal and visuo-spatial data: standardization and normative data from an Italian adult population
Marco Di Monaco (2014)
10.1002/acn3.555
Cognitive and functional connectivity alterations in Friedreich's ataxia
Sirio Cocozza (2018)
10.1002/mds.26424
MDS clinical diagnostic criteria for Parkinson's disease.
Ronald B. Postuma (2015)
10.1212/01.wnl.0000310413.04462.6a
Cognitive impairments in multiple system atrophy
Yoshiko Kawai (2008)
10.1007/s00415-018-9038-x
Comparative cognitive and neuropsychiatric profiles between Parkinson’s disease, multiple system atrophy and progressive supranuclear palsy
Gabriella Santangelo (2018)
A (2018)Normalization of timed neuropsychological tests with the PATA rate and ninehole pegboard tests
F Sacca (2018)
10.1002/mds.24893
Diagnostic criteria for mild cognitive impairment in Parkinson's disease: Movement Disorder Society Task Force guidelines.
Irene Litvan (2012)
10.1093/brain/awn065
Clinical outcomes of progressive supranuclear palsy and multiple system atrophy.
Sean S. O’Sullivan (2008)
10.1159/000341998
Cognitive Impairment in Parkinson's Disease: The Dual Syndrome Hypothesis
Angie A. Kehagia (2012)
10.1007/s00702-013-0997-x
A cross-sectional multicenter study of cognitive and behavioural features in multiple system atrophy patients of the parkinsonian and cerebellar type
Chiara Siri (2013)
10.1016/S0028-3932(99)00146-3
Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS)
Sharon Abrahams (2000)
10.5014/ajot.57.5.570
Adult norms for a commercially available Nine Hole Peg Test for finger dexterity.
Kimatha Oxford Grice (2003)
10.1007/s00415-012-6655-7
A randomized clinical trial of lithium in multiple system atrophy
Francesco Saccà (2012)
10.1007/s10072-018-3673-y
Regression-based normative data and equivalent scores for Trail Making Test (TMT): an updated Italian normative study
Mattia Siciliano (2018)
10.1097/WAD.0b013e3181b5065d
Cognitive and Neuropsychiatric Profile of the Synucleinopathies: Parkinson Disease, Dementia With Lewy Bodies, and Multiple System Atrophy
Aimee W. Kao (2009)



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