Please confirm you are human (Sign Up for free to never see this)
← Back to Search
Multi-Dimensional Nanostructures For Microfluidic Screening Of Biomarkers: From Molecular Separation To Cancer Cell Detection
E. Ng, Kaina Chen, A. Hang, A. Syed, J. Zhang
Published 2015 · Computer Science, Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
Rapid screening of biomarkers, with high specificity and accuracy, is critical for many point-of-care diagnostics. Microfluidics, the use of microscale channels to manipulate small liquid samples and carry reactions in parallel, offers tremendous opportunities to address fundamental questions in biology and provide a fast growing set of clinical tools for medicine. Emerging multi-dimensional nanostructures, when coupled with microfluidics, enable effective and efficient screening with high specificity and sensitivity, both of which are important aspects of biological detection systems. In this review, we provide an overview of current research and technologies that utilize nanostructures to facilitate biological separation in microfluidic channels. Various important physical parameters and theoretical equations that characterize and govern flow in nanostructure-integrated microfluidic channels will be introduced and discussed. The application of multi-dimensional nanostructures, including nanoparticles, nanopillars, and nanoporous layers, integrated with microfluidic channels in molecular and cellular separation will also be reviewed. Finally, we will close with insights on the future of nanostructure-integrated microfluidic platforms and their role in biological and biomedical applications.
This paper references
Low molecular weight protamine-functionalized nanoparticles for drug delivery to the brain after intranasal administration.
H. Xia (2011)
DNA-Directed Synthesis of Binary Nanoparticle Network Materials
R. C. Mucic (1998)
Self-assembled inorganic/organic hybrid nanoparticles with multi-functionalized surfaces for active targeting drug delivery.
P. Liang (2013)
Mesoporous Thin Films: Properties and Applications
P. Innocenzi (2013)
Peptide functionalized nanoparticles for nonviral gene delivery
Rachel M. Levine (2013)
Nanoporous anti-fouling silicon membranes for biosensor applications.
T. Desai (2000)
Photopatterned free-standing polyacrylamide gels for microfluidic protein electrophoresis.
T. Duncombe (2013)
Magnetic force-based multiplexed immunoassay using superparamagnetic nanoparticles in microfluidic channel.
Kyu Sung Kim (2005)
Enhanced microcontact printing of proteins on nanoporous silica surface.
Ellen Blinka (2010)
Arrangement of a nanostructure array to control equilibrium and nonequilibrium transports of macromolecules.
T. Yasui (2015)
Hydrodynamic filtration for on-chip particle concentration and classification utilizing microfluidics.
Masumi Yamada (2005)
Targeting cancer cells with biotin-dendrimer conjugates.
W. Yang (2009)
Proteolysis in microfluidic droplets: an approach to interface protein separation and peptide mass spectrometry.
Ji Ji (2012)
Application of Microfluidic Devices to Proteomics Research
J. Li (2002)
Monolithic integrated microfluidic DNA amplification and capillary electrophoresis analysis system
E. Lagally (2000)
Gold nanoparticle-enhanced microchip capillary electrophoresis.
M. Pumera (2001)
Charge- and size-based separation of macromolecules using ultrathin silicon membranes
C. C. Striemer (2007)
Isolation of circulating tumor cells using a microvortex-generating herringbone-chip
S. Stott (2010)
Enzyme‐Linked Immunosorbent Assays
P. Hornbeck (2001)
Control of Pore Sizes in Mesoporous Silica Templated by Liquid Crystals in Block Copolymer−Cosurfactant−Water Systems
P. Feng (2000)
Multicolor microcontact printing of proteins on nanoporous surface for patterned immunoassay
Elaine Ng (2011)
Hierarchical Mesoporous Films: From Self-Assembly to Porosity with Different Length Scales
P. Innocenzi (2011)
Versatile immunomagnetic nanocarrier platform for capturing cancer cells.
Chun-hsien Wu (2013)
On-chip separation and analysis of RNA and DNA from single cells.
H. Shintaku (2014)
Hybrid capillary/microfluidic system for comprehensive online liquid chromatography-capillary electrophoresis-electrospray ionization-mass spectrometry.
J. S. Mellors (2013)
Microfluidics: Fluid physics at the nanoliter scale
T. Squires (2005)
Microfluidic devices for size-dependent separation of liver cells
M. Yamada (2007)
An integrated PCR microfluidic chip incorporating aseptic electrochemical cell lysis and capillary electrophoresis amperometric DNA detection for rapid and quantitative genetic analysis.
S. Jha (2012)
Isolation and retrieval of circulating tumor cells using centrifugal forces
H. Hou (2013)
Tailoring of the nanotexture of mesoporous silica films and their functionalized derivatives for selectively harvesting low molecular weight protein.
Ye Hu (2010)
Molecular Biomarker Analyses Using Circulating Tumor Cells
Elizabeth A. Punnoose (2010)
Semiconductor Clusters, Nanocrystals, and Quantum Dots
A. P. Alivisatos (1996)
Antibody-conjugated gold-gold sulfide nanoparticles as multifunctional agents for imaging and therapy of breast cancer
E. Day (2010)
The origins and the future of microfluidics
G. Whitesides (2006)
Highly parallel mix-and-match fabrication of nanopillar arrays integrated in microfluidic channels for long DNA molecule separation
J. Shi (2007)
Immunomagnetic nanoscreening of circulating tumor cells with a motion controlled microfluidic system
Y. Huang (2013)
Microfluidic electrochemical immunoarray for ultrasensitive detection of two cancer biomarker proteins in serum.
Bhaskara V. Chikkaveeraiah (2011)
Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications.
S. Laurent (2008)
Dual magnetic-/temperature-responsive nanoparticles for microfluidic separations and assays.
J. Lai (2007)
Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles.
Zongxing Wang (2013)
Two‐dimensional gel electrophoresis in proteomics: Old, old fashioned, but it still climbs up the mountains
T. Rabilloud (2002)
Patterned nanomagnets on-chip for screening circulating tumor cells in blood
Yu-Yen Huang (2012)
Antibody conjugated magnetic iron oxide nanoparticles for cancer cell separation in fresh whole blood.
Hengyi Xu (2011)
Microfluidics for Processing Surfaces and Miniaturizing Biological Assays
E. Delamarche (2005)
Biosensors: the new wave in cancer diagnosis.
Brian Bohunicky (2010)
An integrated microfluidic platform for in situ cellular cytokine secretion immunophenotyping.
N. Huang (2012)
PDMS microfludic device for optical detection of protein immunoassay using gold nanoparticles.
Chunxiong Luo (2005)
PEGylated gold nanoparticles conjugated to monoclonal F19 antibodies as targeted labeling agents for human pancreatic carcinoma tissue.
W. Eck (2008)
High-Performance Size-Based Microdevice for the Detection Of Circulating Tumor Cells from Peripheral Blood in Rectal Cancer Patients
W. Sun (2013)
Electroosmotic flow in microchannels with nanostructures.
T. Yasui (2011)
Dried blood spot analysis by digital microfluidics coupled to nanoelectrospray ionization mass spectrometry.
S. C. Shih (2012)
Preconcentration and separation of double‐stranded DNA fragments by electrophoresis in plastic microfluidic devices
A. Wainright (2003)
Mesoporous silica as a membrane for ultra-thin implantable direct glucose fuel cells.
T. Sharma (2011)
Array-based capture, distribution, counting and multiplexed assaying of beads on a centrifugal microfluidic platform.
R. Burger (2012)
Why the move to microfluidics for protein analysis?
N. Lion (2004)
Centrifugal gas-phase transition magnetophoresis (GTM)--a generic method for automation of magnetic bead based assays on the centrifugal microfluidic platform and application to DNA purification.
O. Strohmeier (2013)
Magnetic nanoparticles: synthesis, protection, functionalization, and application.
A. Lu (2007)
Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection.
Y. Cao (2002)
Passively driven integrated microfluidic system for separation of motile sperm.
B. Cho (2003)
Concentration and purification of human immunodeficiency virus type 1 virions by microfluidic separation of superparamagnetic nanoparticles.
Grace D Chen (2010)
Circulating tumor cells (CTCs): detection methods and their clinical relevance in breast cancer.
B. Mostert (2009)
Integration of nanoporous membranes into microfluidic devices: electrokinetic bio-sample pre-concentration.
M. Kim (2013)
Combined microfluidic-micromagnetic separation of living cells in continuous flow
N. Xia (2006)
Quantitative analysis of molecular interaction in a microfluidic channel: the T-sensor.
A. Kamholz (1999)
Sol-Gel Methods for Materials Processing
P. Innocenzi (2008)
Encyclopedia of Surface And Colloid Science
P. Somasundaran (2006)
Zero-dimensional, one-dimensional, two-dimensional and three-dimensional nanostructured materials for advanced electrochemical energy devices
J. N. Tiwari (2012)
Nanoroughened surfaces for efficient capture of circulating tumor cells without using capture antibodies.
Weiqiang Chen (2013)
Separation of sperm and epithelial cells in a microfabricated device: potential application to forensic analysis of sexual assault evidence.
Katie M. Horsman (2005)
Density-gradient-free microfluidic centrifugation for analytical and preparative separation of nanoparticles.
P. Arosio (2014)
Exosomes: composition, biogenesis and function
C. Théry (2002)
The present and future role of microfluidics in biomedical research
E. Sackmann (2014)
Microscale Magnetic Field Modulation for Enhanced Capture and Distribution of Rare Circulating Tumor Cells
Peng Chen (2015)
Springer Handbook of Nanotechnology
B. Bhushan (2017)
Multifunctionalized gold nanoparticles with peptides targeted to gastrin-releasing peptide receptor of a tumor cell line.
Leticia Hosta-Rigau (2010)
Monoclonal antibody-functionalized mesoporous silica nanoparticles (MSN) for selective targeting breast cancer cells
Chih-Pin Tsai (2009)
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.
A. Gupta (2005)
On-chip magnetic field modulation for distributed immunomagnetic detection of circulating tumor cells
Peng Chen (2013)
Scanometric DNA array detection with nanoparticle probes.
T. Taton (2000)
Ultrasensitive detection of cancer biomarkers in the clinic by use of a nanostructured microfluidic array.
R. Malhotra (2012)
Microcontact printing of self-assembled monolayers: applications in microfabrication
J. Wilbur (1996)
A patterned anisotropic nanofluidic sieving structure for continuous-flow separation of DNA and proteins.
J. Fu (2007)
in plastic microfluidic devices
Z. Wang (2003)
Continuous Particle Separation Through Deterministic Lateral Displacement
M. Laub (2004)
Single-molecule DNA amplification and analysis in an integrated microfluidic device.
E. Lagally (2001)
Isolation of rare circulating tumour cells in cancer patients by microchip technology
S. Nagrath (2007)
Streptavidin‐Functionalized Silver‐Nanoparticle‐Enriched Carbon Nanotube Tag for Ultrasensitive Multiplexed Detection of Tumor Markers
G. Lai (2011)
D. Di Carlo (2009)
Exosome isolation for proteomic analyses and RNA profiling.
D. Taylor (2011)
Microfluidic immunodetection of cancer cells via site-specific microcontact printing of antibodies on nanoporous surface.
Elaine Ng (2013)
This paper is referenced by
Electroosmotic Flow in Microchannel with Black Silicon Nanostructures
An Eng Lim (2018)
Microfluidic Technology for Clinical Applications of Exosomes
F. S. Iliescu (2019)
Chemically controlled micro-pores and nano-filters for separation tasks in 2D and 3D microfluidic systems
S. Haefner (2017)
Effect of nanostructures orientation on electroosmotic flow in a microfluidic channel.
An Eng Lim (2017)
Nanocapillary and nanopore array integrated through low-resolution patterning techniques for biomolecular analysis
Lian Duan (2018)
Electrokinetically Operated Integrated Microfluidic Devices for Preterm Birth Biomarker Analysis
Mukul Sonker (2017)
Standing Air Bubble-Based Micro-Hydraulic Capacitors for Flow Stabilization in Syringe Pump-Driven Systems
Yidi Zhou (2020)
Recent advances in microfluidic methods in cancer liquid biopsy.
F. S. Iliescu (2019)
Microfluidic Mimic for Colloid Membrane Filtration: A Review
N. Debnath (2018)
Recent advances in microfluidic sample preparation and separation techniques for molecular biomarker analysis: A critical review.
M. Sonker (2017)
Continuous-Flow Electrophoresis of DNA and Proteins in a Two-Dimensional Capillary-Well Sieve.
Lian Duan (2017)
Progress in Microfluidics-Based Exosome Separation and Detection Technologies for Diagnostic Applications.
Shujing Lin (2019)