Epithelial Cancers In The Post-genomic Era: Should We Reconsider Our Lifestyle?
Jeff M. P. Holly, Li Yan Zeng, Claire M. Perks
Published 2013 · Biology, Medicine
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The age-related epithelial cancers of the breast, colorectum and prostate are the most prevalent and are increasing in our aging populations. Epithelial cells turnover rapidly and mutations naturally accumulate throughout life. Most epithelial cancers arise from this normal mutation rate. All elderly individuals will harbour many cells with the requisite mutations and most will develop occult neoplastic lesions. Although essential for initiation, these mutations are not sufficient for the progression of cancer to a life-threatening disease. This progression appears to be dependent on context: the tissue ecosystem within individuals and lifestyle exposures across populations of individuals. Together, this implies that the seeds may be plentiful but they only germinate in the right soil. The incidence of these cancers is much lower in Eastern countries but is increasing with Westernisation and increases more acutely in migrants to the West. A Western lifestyle is strongly associated with perturbed metabolism, as evidenced by the epidemics of obesity and diabetes: this may also provide the setting enabling the progression of epithelial cancers. Epidemiology has indicated that metabolic biomarkers are prospectively associated with cancer incidence and prognosis. Furthermore, within cancer research, there has been a rediscovery that a switch in cell metabolism is critical for cancer progression but this is set within the metabolic status of the host. The seed may only germinate if the soil is fertile. This perspective brings together the different avenues of investigation implicating the role that metabolism may play within the context of post-genomic concepts of cancer.
This paper references
High birthweight as a predictor of prostate cancer risk.
Gösta Tibblin (1995)
Colorectal Cancer Outcomes, Recurrence, and Complications in Persons With and Without Diabetes Mellitus: A Systematic Review and Meta-Analysis
Kelly B. Stein (2009)
Hyperglycemia and prostate cancer recurrence in men treated for localized prostate cancer
Jonathan Wright (2013)
Metastasis: from dissemination to organ-specific colonization
Don Nguyen (2009)
Serum insulin-like growth factors and mortality in localised and advanced clinically detected prostate cancer
Mari-Anne Rowlands (2011)
Potential biomarker for aspirin use in colorectal cancer therapy: Biological markers
Ruth Langley (2013)
The embryonic environment strongly attenuates v-src oncogenesis in mesenchymal and epithelial tissues, but not in endothelia
Andrew W Stoker (1990)
Epigenetic differences arise during the lifetime of monozygotic twins.
Mario F. Fraga (2005)
Glycemic control and prostate cancer
H. S. Kim (2010)
Cancer without disease
Judah Folkman (2004)
The developmental origins of adult disease
Lisa Joss-Moore (2009)
Are Flågan (2002)
Diet, lifestyle and BRCA-related breast cancer risk among French-Canadians
André Nkondjock (2006)
Context is everything: Mining the normal and preneoplastic microenvironment for insights into the diet and cancer risk conundrum.
Norman G. Hord (2007)
Estimation of mutation frequencies in normal mammalian cells and the development of cancer.
Mitchell S Turker (1998)
Trends in the risks and benefits to patients with cancer participating in phase 1 clinical trials.
Thomas Grady Roberts (2004)
The role of genetic breast cancer susceptibility variants as prognostic factors.
Peter A. Fasching (2012)
The Forkhead Box Transcription Factor FOXC1 Promotes Breast Cancer Invasion by Inducing Matrix Metalloprotease 7 (MMP7) Expression*
Steven T Sizemore (2012)
Finding the tumor copycat: Therapy fails, patients don't
Lee M. Ellis (2010)
Akt Stimulates Aerobic Glycolysis in Cancer Cells
Rebecca L. Elstrom (2004)
Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium.
Annegien Broeks (2011)
Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. 3. Stimulation by tuberculin and allogeneic cells.
Johannes Antonius Loos (1973)
Tumours with PI3K activation are resistant to dietary restriction
Nada Y Kalaany (2009)
Dynamic Proteomics of Individual Cancer Cells in Response to a Drug
Ariel A. Cohen (2008)
Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model
Nyosha Alikhani (2013)
Regulation of a transcription factor network required for differentiation and metabolism.
Stephen A Duncan (1998)
Microbial deprivation, inflammation and cancer. Cancer Metastasis Reviews
L C Von Hertzen (2011)
Prenatal and Postnatal Milk Supplementation and Adult Insulin-like Growth Factor I: Long-term Follow-up of a Randomized Controlled Trial
Yoav Ben-Shlomo (2005)
Comparative lesion sequencing provides insights into tumor evolution
Siân Jones (2008)
Insulin-like growth factor-2 (IGF2) loss of imprinting marks a field defect within human prostates containing cancer.
Sachin S. Bhusari (2011)
Cancer as an overhealing wound: an old hypothesis revisited
Matthias R Schaefer (2008)
Incidental carcinoma of the prostate: a review of the literature and critical reappraisal of classification.
Curtis A. Sheldon (1980)
Twins and the mystery of missing heritability: the contribution of gene-environment interactions.
Jaakko Kaprio (2012)
KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells Published, JLR Papers in Press, September 14, 2005. DOI 10.1194/jlr.M500154-JLR200
Yongsheng Chang (2005)
Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk
Atsushi Kaneda (2007)
The genetics of ageing
Cynthia J. Kenyon (2010)
Peto's Paradox: evolution's prescription for cancer prevention.
Aleah F. Caulin (2011)
The hepatocyte nuclear factor 6 (HNF6) and FOXA2 are key regulators in colorectal liver metastases.
Frank Lehner (2007)
Population-based study of changing breast cancer risk in Icelandic BRCA2 mutation carriers, 1920-2000.
Laufey Tryggvadottir (2006)
Changes in serum IGF-1 level and tumor VEGF expression in mice with colorectal cancer under hyperglycemic conditions.
Hong Cao (2013)
Non-genetic heterogeneity — a mutation-independent driving force for the somatic evolution of tumours
Amy L. Brock (2009)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan (2011)
Eating patterns and risk of colon cancer.
Martha L. Slattery (1998)
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.
Eugenia E. Calle (2003)
hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase*
Maya P Byfield (2005)
A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates
Peter P. Calabrese (2009)
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN.
Min Zhao (2006)
Comparative epidemiology of cancer between the United States and Japan. A second look.
Ernst L. Wynder (1991)
“Control” laboratory rodents are metabolically morbid: Why it matters
Bronwen Martin (2010)
Influence of host age on lung colony forming capacity of injected rat rhabdomyosarcoma cells.
Vladimir Anisimov (1988)
Detectable clonal mosaicism and its relationship to aging and cancer
Kevin B. Jacobs (2012)
Large-scale exploration of gene-gene interactions in prostate cancer using a multistage genome-wide association study.
Julia Ciampa (2011)
Birthweight, childhood growth and risk of breast cancer in a British cohort
B L De Stavola (2000)
Transgenerational epigenetic inheritance in health and disease.
Nadia C. Whitelaw (2008)
The stroma as a crucial target in rat mammary gland carcinogenesis
Maricel V Maffini (2004)
Diet and breast cancer: A review of the prospective observational studies
Karin B. Michels (2007)
Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT).
Scott Michael Lippman (2009)
Ian Forgacs (1988)
Measurement of single-cell dynamics
David G. Spiller (2010)
Marine Mammal Neoplasia: A Review
Shelley J Newman (2006)
Quantitation of cell shedding into efferent blood of mammary adenocarcinoma.
Thomas P. Butler (1975)
Genetic Progression and the Waiting Time to Cancer
Niko Beerenwinkel (2007)
Defining the blueprint of the cancer genome.
Victor E. Velculescu (2008)
Methyl donor supplementation prevents transgenerational amplification of obesity
Robert A. Waterland (2008)
Breast cancer--early life matters.
Karin B. Michels (2004)
Armand M. Leroi (2003)
Insulin-like growth factor physiology: what we have learned from human studies.
Jeff M. P. Holly (2012)
Maternal high-fat diet effects on third-generation female body size via the paternal
G. A. Dunn (2011)
Prenatal and postnatal milk supplementation and adult insulin-like growth factor I: long-term followup of a randomized controlled trial
Y. Ben-Shlomo (2005)
The rejuvenated scenario of epithelial–mesenchymal transition (EMT) and cancer metastasis
Fanyan Meng (2012)
Impact of Diabetes and Hyperglycemia on Survival in Advanced Breast Cancer Patients
Cynthia Villarreal-Garza (2012)
Fasting C-peptide levels and death resulting from all causes and breast cancer: the health, eating, activity, and lifestyle study.
Melinda L. Irwin (2011)
Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis.
Yingjie Wu (2010)
Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms.
Thomas K. Hunt (2007)
The frequency of latent prostatic carcinoma in young males: the Japanese experience.
Toshio Shiraishi (1994)
An ecological study on diet/nutrition and cancer in Japan.
Suketami Tominaga (1997)
FOXOs: signalling integrators for homeostasis maintenance
Astrid Eijkelenboom (2013)
Diabetes mellitus and risk of prostate cancer: an updated meta-analysis based on 12 case–control and 25 cohort studies
Fan Zhang (2012)
Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy
Kathryn N. Phoenix (2009)
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
Marco Gerlinger (2012)
Regulation of translation initiation by FRAP/mTOR.
Alexandre Gingras (2001)
Experimental evidence of dietary factors and hormone-dependent cancers.
Kenneth K. Carroll (1975)
Metformin in cancer: translational challenges.
Ryan J. O. Dowling (2012)
Dose-dependent effects of calorie restriction on gene expression, metabolism, and tumor progression are partially mediated by insulin-like growth factor
L M Nogueira (2012)
Breast cancer risk in relation to the joint effect of BRCA mutations and diet diversity. Breast Cancer Research and Treatment
P Ghadirian (2009)
Insulin-like Growth Factors, Their Binding Proteins, and Prostate Cancer Risk: Analysis of Individual Patient Data from 12 Prospective Studies
Andrew Wilfred Roddam (2008)
Morphogens, morphostats, microarchitecture and malignancy
John D. Potter (2007)
Epistasis and its implications for personal genetics.
Jason H. Moore (2009)
Glycemic control and prostate cancer progression: results from the SEARCH database.
Howard S Kim (2010)
Genetic susceptibility to prostate, breast, and colorectal cancer among Nordic twins.
Stuart G. Baker (2005)
Cancer Epigenetics: From Mechanism to Therapy
Mark A. Dawson (2012)
Environment-Sensitive Epigenetics and the Heritability of Complex Diseases
Robert E. Furrow (2011)
Cancer genetics and epigenetics: two sides of the same coin?
Jueng Soo You (2012)
Somatic mutations are frequent and increase with age in human kidney epithelial cells.
George M. Martin (1996)
Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice.
Sandra E. Dunn (1997)
Fetal nutrition and cardiovascular disease in adult life
Alexander R. P. Walker (1993)
Hyperinsulinemia promotes metastasis to the lung in a mouse model of Her2-mediated breast cancer.
Rosalyn D. Ferguson (2013)
Long term consequences of the 1944-1945 Dutch famine on the insulin-like growth factor axis.
S G Elias (2004)
Rethinking the Warburg effect with Myc micromanaging glutamine metabolism.
Chi V. Dang (2010)
High-fat or ethinyl-oestradiol intake during pregnancy increases mammary cancer risk in several generations of offspring
Sonia de Assis (2012)
High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20-69: an autopsy study of 249 cases.
Wael Ali Sakr (1994)
Cancer genes and the pathways they control
Bert Vogelstein (2004)
The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes
Arnold J. Levine (2010)
The distribution of secondary growths in cancer of the breast. The Lancet, I
Endocrinology and Metabolism Clinics of North America
Greet van den Berghe Md (2007)
Using autopsy series to estimate the disease "reservoir" for ductal carcinoma in situ of the breast: how much more breast cancer can we find?
Welch Hg (1997)
Finding the missing heritability of complex diseases
Teri A Manolio (2009)
The role of the insulin-like growth factor-I receptor in malignancy: an update.
Erica Seccareccia (2012)
Glucose Oxidation Modulates Anoikis and Tumor Metastasis
Sushama Kamarajugadda (2012)
Genome-wide association studies for complex traits: consensus, uncertainty and challenges
Mark I. McCarthy (2008)
Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy
Joseph C Anderson (2011)
Forkhead box A1 (FOXA1) is a key mediator of insulin-like growth factor I (IGF-I) activity.
Adam S. Potter (2012)
The role of prevalence in the diagnosis of prostate cancer.
Nicolas Barry Delongchamps (2006)
Obesity provides a permissive milieu in inflammation-associated carcinogenesis: analysis of insulin and IGF pathways.
Nomelí P. Núñez (2009)
Prevalence and characteristics of screen-detected prostate carcinomas at low prostate-specific antigen levels: aggressive or insignificant?
Claartje Gosselaar (2005)
Nesso fisio-pathologico tra la struttura dei nei materni e la genesi di alcuni tumori
Increase of O-Glycosylated Oncofetal Fibronectin in High Glucose-Induced Epithelial-Mesenchymal Transition of Cultured Human Epithelial Cells
Frederico Alisson-Silva (2013)
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN
Min Zhao (2006)
Epigenetic Memory in Mammals
Zoë Migicovsky (2011)
IGFBP7 Binds to the IGF-1 Receptor and Blocks Its Activation by Insulin-Like Growth Factors
Valentina Evdokimova (2012)
The genetic/metabolic transformation concept of carcinogenesis
Leslie C. Costello (2011)
Folic acid for the prevention of colorectal adenomas: a randomized clinical trial.
Bernard F. Cole (2007)
The multiethnic cohort study: exploring genes, lifestyle and cancer risk
Laurence N. Kolonel (2004)
Comparative epidemiology of cancers of the colon, rectum, prostate and breast in Shanghai, China versus the United States.
H Yu (1991)
Trends in frequency of latent prostate carcinoma in Japan from 1965-1979 to 1982-1986.
Ryuichi Yatani (1988)
Cell type-specific DNA methylation patterns in the human breast
Noga Bloushtain-Qimron (2008)
Associations of Plasma C-Peptide and IGFBP-1 Levels with Risk of Colorectal Adenoma in a Multiethnic Population
Loïc Le Marchand (2010)
Maternal high-fat diet effects on third-generation female body size via the paternal lineage.
Gregory A Dunn (2011)
Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2
Mary-Claire King (2003)
Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits
W G Hill (2008)
Using autopsy series to estimate the disease "reservoir" for ductal carcinoma in situ of the breast: how much more breast cancer can we find?
H Gilbert Welch (1997)
Genomic instability in neoplasia.
R Honchel (1995)
Does pre-existing diabetes affect prostate cancer prognosis? A systematic review
Claire F Snyder (2010)
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
Harold F. Dvorak (1986)
Missing heritability and strategies for finding the underlying causes of complex disease
Evan E. Eichler (2010)
Reprogramming metastatic tumour cells with embryonic microenvironments
Mary J. C. Hendrix (2007)
Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects.
Michael Rutledge DeBaun (2002)
Dose-dependent effects of calorie restriction on gene expression, metabolism, and tumor progression are partially mediated by insulin-like growth factor-1
Leticia M Nogueira (2012)
Unraveling Genes and Pathways Influenced by H-Prune PDE Overexpression: A Model to Study Cellular Motility
Anna D'Angelo (2004)
High-Fat, High-Sucrose, and High-Cholesterol Diets Accelerate Tumor Growth and Metastasis in Tumor-Bearing Mice
Yoshiyuki Kimura (2007)
Peter W. Laird (2005)
The Hallmarks of Cancer
Douglas Hanahan (2000)
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma.
Andrew J. Aguirre (2003)
The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells
Eric A. Newsholme (1985)
Migration patterns and breast cancer risk in Asian-American women.
Regina G. Ziegler (1993)
Endocrine and nutritional regulation of prenatal growth.
Peter Gluckman (1997)
Insulin, insulin-like growth factors and colon cancer: a review of the evidence.
Edward L. Giovannucci (2001)
Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy
Chin-Chih Lin (2012)
Height, leg length, and cancer risk: a systematic review.
D Gunnell (2001)
Population-based study of changing breast cancer risk in Icelandic BRCA2 mutation carriers
L Tryggvadottir (1920)
Selfreported birth weight and subsequent risk of colorectal cancer
M. S. Sandhu (2002)
Wendell W. Weber (2010)
Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies
Timothy J Key (2010)
Breast cancer risk in relation to the joint effect of BRCA mutations and diet diversity
Parviz Ghadirian (2008)
Cancer as an evolutionary process at the cell level: an epidemiological perspective.
Paolo Vineis (2003)
Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells.
M. H. Barcellos-Hoff (2000)
Breast cancer risk after caloric restriction during the 1944-1945 Dutch famine.
S G Elias (2004)
Changing demography of prostate cancer in Asia.
Hong Gee Sim (2005)
Tumour evolution inferred by single-cell sequencing
Nicholas Navin (2011)
Comparative studies of prostate cancer in Japan versus the United States. A review.
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
Kui Lin (2001)
Fetal nutrition and cardiovascular disease
D. J. Barker (1993)
Similarities between tumor stroma generation and wound healing
H F Dvorak (1986)
Peter R. Malone (1995)
Biological markers: Potential biomarker for aspirin use in colorectal cancer therapy
Ruth E. Langley (2013)
Differential Oestrogen Receptor Binding is Associated with Clinical Outcome in Breast Cancer
Rory Stark (2012)
c-Myc transactivation of LDH-A: implications for tumor metabolism and growth.
Hoon Seob Shim (1997)
The Consensus Coding Sequences of Human Breast and Colorectal Cancers
Tobias Sjöblom (2006)
Genetic and environmental influences on premature death in adult adoptees.
Tina Lindvig Sørensen (1988)
Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
Caryn S. Ross-Innes (2012)
What are we learning from the cancer genome?
Eric A. Collisson (2012)
Associations of adult measures of childhood growth with breast cancer: findings from the British Women's Heart and Health Study
D. A. Lawlor (2003)
Mortality and cancer incidence in acromegaly: a retrospective cohort study. United Kingdom Acromegaly Study Group.
Steve M Orme (1998)
Time distribution of the recurrence risk for breast cancer patients undergoing mastectomy: Further support about the concept of tumor dormancy
Romano Demicheli (2005)
E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer
Otto Schmalhofer (2008)
Obesity-related systemic factors promote an invasive phenotype in prostate cancer cells
R S Price (2012)
Circulating insulin-like growth factor peptides and prostate cancer risk: a systematic review and meta-analysis.
Mari-Anne Rowlands (2009)
Population-based, case-control study of blood C-peptide level and breast cancer risk.
Gong Yang (2001)
A Western-type diet accelerates tumor progression in an autochthonous mouse model of prostate cancer.
Gemma Llaverias (2010)
Cancer in migrants to Australia: extending the descriptive epidemiological data.
A. J. Mcmichael (1988)
Evidence supports a faster growth rate and/or earlier transformation to clinically significant prostate cancer in black than in white American men, and influences racial progression and mortality disparity.
Isaac J. Powell (2010)
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
Min Yu (2013)
Deaths: final data for 2001.
Elizabeth D. Arias (2003)
Mortality and Cancer Incidence in Acromegaly: A Retrospective Cohort Study
Stephen M. Orme (1998)
Why are diabetics at reduced risk for prostate cancer? A review of the epidemiologic evidence.
Brandon L. Pierce (2012)
Geographic pathology of latent prostatic carcinoma.
Ryuichi Yatani (1982)
Drug development: Raise standards for preclinical cancer research
Colin Glenn Begley (2012)
TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis
Karim Bensaad (2006)
Transcriptome-wide noise controls lineage choice in mammalian progenitor cells
Hannah H. Chang (2008)
Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps.
Robert E. Schoen (2005)
In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours.
Nathalie L G Sieben (2004)
The prevalence and characteristics of colorectal neoplasia in acromegaly.
Andrew G. Renehan (2000)
Copy Number Analysis Indicates Monoclonal Origin of Lethal Metastatic Prostate Cancer
Wennuan Liu (2009)
BRCA1 and BRCA2 gene mutations: decision-making dilemmas concerning testing and management.
Sozos J. Fasouliotis (2000)
Diet and breast
K. B. Michels (2007)
The c-Myc target gene network.
Chi V. Dang (2006)
Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland.
Paul Lichtenstein (2000)
Epithelial–mesenchymal transitions in tumour progression
Jean Paul Thiery (2002)
Seeing the Warburg effect in the developing retina
Brian P. Fiske (2012)
Stromal regulation of neoplastic development: age-dependent normalization of neoplastic mammary cells by mammary stroma.
Maricel V Maffini (2005)
Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer
Antonija Krešo (2013)
Growth patterns and the risk of breast cancer in women.
Martin Ahlgren (2006)
PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
Jianfeng Li (1997)
Cross-sectional associations of diet and insulin-like growth factor levels in 7- to 8-year-old children.
Imogen S Rogers (2005)
Diabetes mellitus and breast cancer outcomes: a systematic review and meta-analysis.
Kimberly S. Peairs (2011)
PTEN and the PI3-kinase pathway in cancer.
Nader Chalhoub (2009)
Aerobic glycolysis during lymphocyte proliferation
Tingchung Wang (1976)
Identification of stem cells in small intestine and colon by marker gene Lgr5
Nick Barker (2007)
Genomic responses in mouse models poorly mimic human inflammatory diseases
Junhee Seok (2013)
Hard Wired Genotype in Metastatic Breast Cancer
Britta Weigelt (2004)
Cancer Cell Phenotypes, in Fifty Shades of Grey
Andriy Marusyk (2013)
Investigating metformin for cancer prevention and treatment: the end of the beginning.
Michael N. Pollak (2012)
Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis.
Jing Ma (2008)
The changing global patterns of female breast cancer incidence and mortality
Freddie Bray (2004)
Finasteride Modifies the Relation between Serum C-Peptide and Prostate Cancer Risk: Results from the Prostate Cancer Prevention Trial
Marian L Neuhouser (2010)
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
R Kaplan (2005)
N Dubrawsky (1989)
Dose-dependent effects of 704 calorie restriction on gene expression, metabolism, and tumor progression are partially mediated by insulin-like growth
L M Nogueira (2012)
Cancer Metastasis Rev
Shadows of complexity: what biological networks reveal about epistasis and pleiotropy.
Anna L Tyler (2009)
Occurrence of tumors in wild house mice.
Howard B. Andervont (1962)
Familial aggregation of abnormal methylation of parental alleles at the IGF2/H19 and IGF2R differentially methylated regions.
Ionel Sandovici (2003)
Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. II. Relative importance of glycolysis and oxidative phosphorylation on phytohaemagglutinin stimulation.
David Roos (1973)
partly independent events
U. Veronesi (2013)
Finasteride modifies the relation 702 Cancer Metastasis Rev (2013) 32:673–705 between serum C-peptide and prostate cancer risk: results from the Prostate Cancer Prevention Trial
M. L. Neuhouser (2010)
Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery (2009)
AACR centennial series: the biology of cancer metastasis: historical perspective.
James E Talmadge (2010)
Circulation insulin-like growth factor peptides and colorectal cancer risk: an updated systematic review and meta-analysis
Feng Chi (2012)
Cellular heterogeneity and molecular evolution in cancer.
Vanessa Almendro (2013)
Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosa
Adriana C Vidal (2012)
Environmental and heritable causes of cancer among 9.6 million individuals in the Swedish Family-Cancer Database.
Kamila Czene (2002)
Controversies in clinical cancer dormancy
Jonathan W. Uhr (2011)
Polymorphisms and circulating levels in the insulin-like growth factor system and risk of breast cancer: a systematic review.
Olivia Fletcher (2005)
Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis.
Yiping Wu (2002)
Intra-individual change over time in DNA methylation with familial clustering.
Hans Tomas Bjornsson (2008)
Prevalence of prostate cancer among men with a prostate-specific antigen level < or =4.0 ng per milliliter.
Ian M Thompson (2004)
Deaths: Final Data for 2001. Mortality Data, NVSR
E Arias (2001)
DHS Publication no (NIH)
L A Ries
Nesso fisio-pathologico tra la struttura dei nei materni e la genesi di alcuni tumori maligni
F Durante (1874)
Genome Remodeling in a Basal-like Breast Cancer Metastasis and Xenograft
Li Ding (2010)
Links between metabolism and cancer.
Chi V. Dang (2012)
Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis
Feng Li (2005)
Gender difference in the association of insulin and the insulin-like growth factor axis with colorectal neoplasia
Taiki Yamaji (2012)
DNA Replication Fidelity*
T. A. Kunkel (2004)
Breast cancer and atypia among young and middle-aged women: a study of 110 medicolegal autopsies.
M. Nielsen (1987)
Physical activity for cancer survivors: meta-analysis of randomised controlled trials
Daniel Y. T. Fong (2012)
Energy balance: interpretation of data from rural China.
T. Colin Campbell (1999)
Regeneration: The origin of cancer or a possible cure?
Néstor J Oviedo (2009)
The decline and fall of the IGF-I receptor.
Renato Baserga (2013)
Scaling of number, size, and metabolic rate of cells with body size in mammals
Van M. Savage (2007)
The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today.
Richard Doll (1981)
Regulation of cancer cell metabolism
Rob A Cairns (2011)
Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. Phoenix Colon Cancer Prevention Physicians' Network.
David S. Alberts (2000)
Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility.
Milena Sabrina Nicoloso (2010)
Loss of IGF 2 imprinting : a potential marker of colorectal cancer risk
H. Cui (2003)
Regeneration versus neoplastic growth.
Richmond T. Prehn (1997)
Self-reported birth weight and subsequent risk of colorectal cancer.
Manjinder S. Sandhu (2002)
Hyperglycaemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase.
L Zeng (2010)
Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials
Peter M. Rothwell (2011)
Multimolecular forms of pyruvate kinase from rat and other mammalian tissues. I. Electrophoretic studies.
Kiichi Imamura (1972)
Cancer and ageing in mice and men.
Richard Peto (1975)
No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis
Katharina Bluemlein (2011)
p53 Regulates Mitochondrial Respiration
Satoaki Matoba (2006)
Environmentally induced epigenetic transgenerational inheritance of phenotype and disease
Carlos M Guerrero-Bosagna (2012)
The Polyp Prevention Trial–Continued Follow-up Study: No Effect of a Low-Fat, High-Fiber, High-Fruit, and -Vegetable Diet on Adenoma Recurrence Eight Years after Randomization
Elaine Lanza (2007)
Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival.
Xiaoyun Liao (2012)
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.
Ralph J. DeBerardinis (2008)
Hyperinsulinemia enhances c-Mycmediated mammary tumor development and advances metastatic Cancer Metastasis Rev (2013) 32:673–705 703 progression to the lung in a mouse model of type 2 diabetes
R. D. Ferguson (2012)
Increase of oglycosylated oncofetal fibronectin in high glucose-induced epithelial-mesenchymal transition of cultured human epithelial cells
F. Alisson-Silva (2013)
Prevalence and characteristics of screen-detected prostate carcinomas at low prostate-specific antigen levels: aggressive or insignificant? BJU International
C Gosselaar (2005)
Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span.
Bradley John Willcox (2007)
Microbial deprivation, inflammation and cancer
Leena von Hertzen (2011)
Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour
Osamu Ogawa (1993)
Alpha-Tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance.
Demetrius Albanes (1996)
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Heather R Christofk (2008)
Frequent clones of p53-mutated keratinocytes in normal human skin.
Alan S. Jonason (1996)
Prevalence of somatic alterations in the colorectal cancer cell genome
Tian-Li Wang (2002)
Molecular networks that regulate cancer metastasis.
Daniela Spano (2012)
Childhood diet and insulin-like growth factors in adulthood: 65-year follow-up of the Boyd Orr Cohort
Richard M. Martin (2007)
Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
Mina J. Bissell (2011)
Epidemiological evidence of the effects of behaviour and the environment on the risk of human cancer.
Richard Doll (1998)
Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes
Rosalyn D. Ferguson (2011)
The metastatic niche and stromal progression
Jonathan P. Sleeman (2012)
Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis
Andrea Decensi (2010)
FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers
Yunneng Tang (2011)
Circulating insulin-like growth factors and IGF-binding proteins in PSA-detected prostate cancer: the large case-control study ProtecT.
Mari-Anne Rowlands (2012)
Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
Roger L. Milne (2010)
Local recurrences and distant metastases after conservative breast cancer treatments: partly independent events.
Umberto Veronesi (1995)
Concepts of metastasis in flux: the stromal progression model.
Jonathan P. Sleeman (2012)
Fetal growth and subsequent risk of breast cancer: results from long term follow up of Swedish cohort
Valerie A. McCormack (2003)
Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells.
Sybille Mazurek (2011)
The Genomic Landscapes of Human Breast and Colorectal Cancers
Laura D. Wood (2007)
Hyper-insulinaemia and cancer, meta-analyses of epidemiological studies.
Paola Pisani (2008)
Deaths: Final Data
E. Arias (2001)
A metabolic phenotyping approach to understanding relationships between metabolic syndrome and breast tumour responses to chemotherapy.
Justin Stebbing (2012)
Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis
Sachie Hiratsuka (2006)
Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs
Rudolf P Talens (2012)
Cancer epidemiology in the last century and the next decade
Julian Peto (2001)
Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon.
Norifumi Yamashita (1995)
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
Kornelia Polyak (2009)
Increase in circulating levels of IGF-1 and IGF-1/IGFBP-3 molar ratio over a decade is associated with colorectal adenomatous polyps.
Adelheid Soubry (2012)
Insulin-like growth factors (IGFs) and IGF-binding proteins in active monitoring of localized prostate cancer: a population-based observational study
Mari-Anne Rowlands (2012)
Loss of IGF2 Imprinting: A Potential Marker of Colorectal Cancer Risk
Heng-mi Cui (2003)
Annual Report to the Nation on the status of cancer, 1975-2008, featuring cancers associated with excess weight and lack of sufficient physical activity.
Christie R. Eheman (2012)
Age-Related DNA Methylation Changes in Normal Human Prostate Tissues
Bernard Kwabi-Addo (2007)
Regeneration versus neoplastic growth. Carcinogenesis
R T Prehn (1997)
Dose-dependent effects of 704 Cancer Metastasis Rev (2013) 32:673–705 calorie restriction on gene expression, metabolism, and tumor progression are partially mediated by insulin-like growth factor1
L. M. Nogueira (2012)
Regeneration versus neoplastic
R. T. Prehn (1997)
The distribution of secondary growths in cancer of the breast. 1889.
Stephen Paget (1989)
Cancer statistics, 2008.
Ahmedin Jemal (2008)
Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts
Chiaho Shih (1981)
Global estimates of cancer prevalence for 27 sites in the adult population in 2008.
Freddie Bray (2013)
Incidence and mortality of testicular and prostatic cancers in relation to world dietary practices.
Patrick C. Walsh (2002)
Pyruvate kinase M2 is a phosphotyrosine-binding protein
Heather R Christofk (2008)
This paper is referenced by
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Jeffrey M P Holly (2019)
Proposal for Preventing the Children of the World from Being Burdened , Like Their Parents , by Disease and Making Beneficial Therapies ( shamelessly co ‐ opted from
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Nazanin S. Ruppender (2015)
Host manipulation by cancer cells: Expectations, facts, and therapeutic implications.
Tazzio Tissot (2016)
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Rainer Johannes Klement (2017)
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Hugo Ducasse (2015)
Prospects & Overviews Host manipulation by cancer cells : Expectations , facts , and therapeutic implications
Tazzio Tissot (2016)
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Rochelle Buffenstein (2014)
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Katarzyna Anna Makowska (2015)
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Rehanna Mansor (2015)
Dietary and pharmacological modification of the insulin/IGF-1 system: exploiting the full repertoire against cancer
Rainer J. Klement (2016)
Epigenetic regulation of insulin-like growth factor binding protein-3 (IGFBP-3) in cancer
Claire M Perks (2015)
Systemic Metabolism, Its Regulators, and Cancer: Past Mistakes and Future Potential
Jeffrey M P Holly (2019)
The role of insulin-like growth factors in the development of prostate cancer.
Jeffrey M P Holly (2020)
Proteins Involved in DNA Double-Strand Breaks Repair Pathways Are Essential to Prevent the Development of Cancer
Thais Sobanski (2015)
Une approche multi-échelle des processus écologiques et évolutifs impliqués dans le cancer
Tazzio Tissot (2017)
Mitochondrial and metabolic alterations are an early adaptation for pre-neoplastic cells during tumour initiation in a zebrafish model
Lisa Kelly (2019)