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Secondary Metabolites Of Ferula Foetida

E. K. Khalilova, Kh. M. Bobakulov, S. Aripova, N. Abdullaev
Published 2013 · Chemistry

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The plant Ferula foetida Regel (Apiaceae) is broadly distributed in the flora of Central Asia [1]. It is well known in Eastern folk medicine and is still used as an anticonvulsant, expectorant, and antiflatulent for tuberculosis and syphilis and to improve digestion for gastrointestinal diseases in non-traditional medicine to treat various diseases [2–5]. Several S-containing aliphatic compounds, derivatives of thiophene, coumarins, and their derivatives in addition to several terpenes, were isolated from resin obtained from roots of this plant [6–9]. Several S-containing compounds, derivatives of thiophene and disulfides, were isolated earlier from the plant growing in Uzbekistan [8]. We studied the aerial part of F. foetida collected in Bukhar Oblast in the vicinity of Gazli during the generative phase (third year of growth) at the start of growth and during rapid development of leaf clusters, March through May, 2009. Air-dried samples were extracted with EtOH (85%, 6 ) to afford sample 1 (collected in March), yield of total extracted substances 18% of the plant weight; sample 2 (April), 17%; and sample 3 (May), 10%. Components of the dried EtOH extracts from the three samples in addition to juice from the aerial part of F. foetida were studied by GC-MS. According to TLC (hydrocarbons:EtOAc, 2:1), the second and third samples contained coumarin-type compounds whereas the first sample did not. Juice of F. foetida contained according to GC-MS data the principal components 2,3,4,5-tetramethylthiophene and 2-ethylthiopyridine. The extracts also contained 1,3-dimethyltrisulfane, 1,8-cineol (eucalyptol), S-methylmethanethiosulfonate, 2,3,4,5-tetramethylthiophene, (+)-trans-chrysanthenylacetate, (+)-calarene, bulnesol, etc. (Table 1).
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