Online citations, reference lists, and bibliographies.

Colorectal Cancer Outcomes, Recurrence, And Complications In Persons With And Without Diabetes Mellitus: A Systematic Review And Meta-Analysis

Kelly B. Stein, Claire F Snyder, Bethany B. Barone, Hsin-Chieh Yeh, Kimberly S. Peairs, Rachel L. Derr, Antonio C. Wolff, Frederick L. Brancati
Published 2009 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
BackgroundDiabetes mellitus increases the risk of incident colorectal cancer, but it is less clear if pre-existing diabetes mellitus influences mortality outcomes, recurrence risk, and/or treatment-related complications in persons with colorectal cancer.MethodsWe performed a systematic review and meta-analysis comparing colorectal cancer mortality outcomes, cancer recurrence, and treatment-related complications in persons with and without diabetes mellitus. We searched MEDLINE and EMBASE through October 1, 2008, including hand-searching references of qualifying articles. We included studies in English that evaluated diabetes mellitus and cancer treatment outcomes, prognosis, and/or mortality. The initial search identified 8,208 titles, of which 15 articles met inclusion criteria. Each article was abstracted by one author using a standardized form and re-reviewed by another author for accuracy. Authors graded quality based on pre-determined criteria.ResultsWe found significantly increased short-term perioperative mortality in persons with diabetes mellitus. In the meta-analysis of long-term mortality, persons with diabetes mellitus had a 32% increase in all-cause mortality compared to those without diabetes mellitus (95% CI: 1.24, 1.41). Although data on other outcomes are limited, available studies suggest that pre-existing diabetes mellitus predicts increased risk of some post-operative complications as well as 5-year cancer recurrence. In contrast, there is little evidence that diabetes confers increased risk for long-term cancer-specific mortality.ConclusionsPatients with colorectal cancer and pre-existing diabetes mellitus have an increased risk of short- and long-term mortality. Future research should determine whether improvements in prevention and treatment of diabetes mellitus will improve outcomes for colorectal cancer patients.
This paper references
The influence of other diseases upon the outcome of colorectal cancer patients.
John E. Payne (1995)
The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.
Erik von Elm (2007)
Comorbid diabetes mellitus and risk of death after diagnosis of colorectal cancer: a population-based study.
Anthony P Polednak (2006)
Comorbidity in older surgical cancer patients: influence on patient care and outcome.
M. L. G. Janssen-Heijnen (2007)
Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults.
Steven Scott Coughlin (2004)
Diabetes mellitus and risk of colorectal cancer: a meta-analysis.
Susanna C. Larsson (2005)
Impact of diabetes mellitus on outcomes in patients with colon cancer.
Jeffrey A. Meyerhardt (2003)
The impact of chronic illnesses on the use and effectiveness of adjuvant chemotherapy for colon cancer.
Cary P Gross (2007)
Therapeutic strategy of emergency surgery for colon cancer in 71 patients over 70 years of age in Japan.
Kouji Tsugawa (2002)
Effect of diabetes mellitus on the epidemiology and outcomes of colon cancer
Nicole A Shonka (2006)
Attribution of deaths following cancer treatment.
Colin B. Begg (2002)
Prospective study of adult onset diabetes mellitus (type 2) and risk of colorectal cancer in women.
Frank B Hu (1999)
Elevated HbA1c Is an Independent Predictor of Aggressive Clinical Behavior in Patients with Colorectal Cancer: A Case-Control Study
Ali A Siddiqui (2008)
Multimorbidity and survival in older persons with colorectal cancer.
Cary P Gross (2006)
The Association of Elevated HbA1c on the Behavior of Adenomatous Polyps in Patients with Type-II Diabetes Mellitus
Ali A Siddiqui (2007)
Serum insulin levels and the prevalence of adenomatous and hyperplastic polyps in the proximal colon
吉田 功 (2007)
Colorectal cancer in patients over 80 years of age.
Yehuda G. Adam (1972)
Less aggressive treatment and worse overall survival in cancer patients with diabetes: a large population based analysis.
Lonneke V van de Poll-Franse (2007)
Survival of 727 patients with single carcinomas of the large bowel
H. C. Umpleby (1984)
Emergency surgery for colon cancer in the aged.
Thomas Koperna (1997)
Working group on
Gerhard Jentzsch (1991)
Colorectal cancer: another complication of diabetes mellitus?
J. C. Ogilvie Will (1998)
Colorectal cancer deaths as determined by expert committee and from death certificate: a comparison. The Minnesota Study.
Fred Ederer (1999)
Comorbidity and colorectal cancer according to subsite and stage: a population-based study.
Matteo De Marco (2000)
Diabetes Mellitus Affects Response to Neoadjuvant Chemoradiotherapy in the Management of Rectal Cancer
Abigail S Caudle (2008)
Co-morbidity leads to altered treatment and worse survival of elderly patients with colorectal cancer.
Valery E P P Lemmens (2005)
Postoperative 30-day Mortality Following Surgical Resection for Colorectal Cancer in Veterans: Changes in the Right Direction
Jessica A. Davila (2005)
Diabetes is associated with increased perioperative mortality but equivalent long-term outcome after hepatic resection for colorectal cancer
Sarah A. Little (2002)
Impact of prediagnosis smoking, alcohol, obesity, and insulin resistance on survival in male cancer patients: National Health Insurance Corporation Study.
Sang Min Park (2006)

This paper is referenced by
Colorectal cancer, diabetes and survival: epidemiological insights.
M.M.J. Zanders (2014)
Risk of Colorectal Cancer in Type2 Diabetic Patients
Hosein Azizi (2016)
Does glucose control matter in people with diabetes and cancer ?
Peter Jacob (2015)
Postoperative hyperglycemia in patients undergoing cytoreductive surgery and HIPEC: A cohort study.
Julie A Disano (2019)
Long Term Survival in 200 Patients with Advanced Stage of Colorectal Carcinoma and Diabetes Mellitus – A Single Institution Experience
Nikola Besic (2019)
Metformin Increases Overall Survival in Patients with Diabetes Undergoing Surgery for Colorectal Cancer
Tina Fransgaard (2015)
Diabetes and cancer: A critical appraisal of the pathogenetic and therapeutic links.
Valerio Gristina (2015)
Outcomes of preexisting diabetes mellitus in breast, colorectal, and prostate cancer
Robert I Griffiths (2017)
The role of physical activity in the molecular regulation of colon cancer risk
Barnabas Shaw (2015)
Inhibitory effect of metformin on bone metastasis of cancer via OPG/RANKL/RANK system.
Jian You Wang (2013)
Type 2 diabetes and cancer: umbrella review of meta-analyses of observational studies
Konstantinos K Tsilidis (2015)
The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus.
Jin Ha Lee (2012)
Does the hospitalization after a cancer diagnosis modify adherence to process indicators of diabetes care quality?
Laura Policardo (2016)
Is obesity an advantage in patients with colorectal cancer?
Pashtoon Murtaza Kasi (2015)
Quality of care for comorbid conditions during the transition to survivorship: differences between cancer survivors and noncancer controls.
Claire F Snyder (2013)
Diabetes mellitus is a predictive factor for radiation pneumonitis after thoracic radiotherapy in patients with lung cancer
Moonkyoo Kong (2019)
Management of colorectal cancer and diabetes
Caroline Yao (2014)
Diabetes and pancreatic cancer.
Donghui Li (2012)
Diabetes Mellitus and the Colon
Marc S Piper (2017)
The Role of Pre-Existing Type 2 Diabetes Mellitus in Colorectal Cancer Stage and Survival in Elderly Americans: A Seer-Medicare Population-Based Study 2002-~2011
Sanae El Ibrahimi (2017)
Insulin, Insulin Resistance, Obesity, and Cancer
E. Gallagher (2010)
Review: Diabetes, Obesity and Cancer - Pathophysiology and Clinical Implications.
Iliana C Lega (2019)
Effect of Diabetes Mellitus on Outcomes of Colorectal Cancer
Geum Youb Noh (2010)
Drug resistance related to aberrant glycosylation in colorectal cancer
Ninon Very (2018)
Role of pre-existing type 2 diabetes in colorectal cancer survival among older Americans: a SEER-Medicare population-based study 2002–2011
Sanae El brahimi (2019)
Epithelial cancers in the post-genomic era: should we reconsider our lifestyle?
Jeff M. P. Holly (2013)
Endocrine and Metabolic Diseases among Colorectal Cancer Survivors in a Population-Based Cohort.
Makenzie L. Hawkins (2019)
Colorectal cancer survival in Jordan 2003-2007
Mohannad Al Nsour (2014)
Determining the Impact of a Cancer Diagnosis on Diabetes Management
Laura C Pinheiro (2019)
Epidemiology and Molecular Mechanisms Tying Obesity, Diabetes, and the Metabolic Syndrome With Cancer
Emily J Gallagher (2013)
Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN
Hui Ran (2018)
Fasting Blood Glucose Level in Locally Advanced Non-Small Cell Lung Cancer: a New Prognostic Factor?
Esra Korkmaz Kıraklı (2018)
See more
Semantic Scholar Logo Some data provided by SemanticScholar