PH Sensitive Nanocomposite Hydrogel Beads Based On Carboxymethyl Cellulose/layered Double Hydroxide As Drug Delivery Systems
Soroush Barkhordari, Mehdi Yadollahi, Hassan Namazi
Published 2014 · Materials Science
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In this paper new pH sensitive nanocomposite beads were prepared by the combination of layered double hydroxides (LDH) and carboxymethyl cellulose (CMC). Ibuprofen (IBU), as a model drug, was intercalated between LDH layers through the co-precipitation method. The synthesized LDH-IBU nanohybrids and nanocomposites beads were characterized using FTIR, XRD, and SEM. In vitro tests of drug delivery in conditions simulating the gastrointestinal tract were carried out to prove the effectiveness of this novel type of nanocomposite beads as a controlled drug delivery system (DDS). The drug release tests revealed a better protection against stomach pH and a controlled liberation in the intestinal tract conditions for new nanocomposite beads.
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