Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Development Of Surface-attached Thin Film Of Non-fouling Hydrogel From Poly(2-oxazoline)

B. Pidhatika, N. Zhao, J. Rühe
Published 2019 · Materials Science

Save to my Library
Download PDF
Analyze on Scholarcy
Share
In this study poly(2-ethyl-2-oxazoline) (PEOXA) chains that contains 11 mol% of benzophenone molecules was synthesized and coated on either 3-ethoxybenzophenonesilane-modified inorganic or bare organic substrates. Upon irradiation under UV light, the photo-active benzophenone molecules enabled the formation of polymer network as well as attachment of the polymer network onto the substrates. Important variables for the generation of hydrogel film with high gel content and stability, such as the heat treatment for solvent removal, the UV wavelength (that determines the irradiation energy), and the input of energy dose were varied and their influence to the gel content and stability of the hydrogel film was studied. The thickness, lifetime of benzophenone, and chemical composition of the film were determined using ellipsometry, UV/Vis spectroscopy, and XPS methods, respectively. On a film that has been exposed to physiological buffer for 14 days, XPS results indicated that chemical degradation of the copolymer did not take place. Ellipsometry results, however, indicated that some portion of the film detached and the remaining thickness was dependent on the input of energy dose during the hydrogel preparation. It was shown that when suitable conditions are applied during preparation, a stable surface-attached PEOXA-based hydrogel, i.e. approximately 78% gel content and 75–90% stability after 30 days of incubation in physiological buffer, could be generated on the surface. Dry and swollen thicknesses of the stable surface-attached film measured from AFM experiments revealed a swelling factor of 1.7. Furthermore, the AFM morphology image showed a homogenous polymer film with an average roughness of 30 nm. Protein adsorption test revealed that the resulting surface-attached PEOXA-based hydrogel film on PMMA substrate hinders BSA adsorption to the same extent as the reference system generated from benzophenone-bearing poly(dimethylacrylamide) (PDMAA).
This paper references
10.1002/mabi.201200445
Influence of the molecular structure of surface-attached poly(N-alkyl acrylamide) coatings on the interaction of surfaces with proteins, cells and blood platelets.
C. K. Pandiyarajan (2013)
10.2533/CHIMIA.2008.264
Nonfouling Surface Coatings Based on Poly(2-methyl-2-oxazoline)
B. Pidhatika (2008)
10.1021/LA0483414
Characterization of aldehyde-PEG tethered surfaces: influence of PEG chain length on the specific biorecognition.
H. Otsuka (2004)
10.3390/polym9120686
On the Limits of Benzophenone as Cross-Linker for Surface-Attached Polymer Hydrogels
Esther K. Riga (2017)
10.1016/J.EURPOLYMJ.2016.11.003
Polyoxazoline biointerfaces by surface grafting
Giulia Morgese (2017)
10.1016/S0142-9612(02)00206-5
Evaluation of a poly(vinyl pyrollidone)-coated biomaterial for urological use.
M. Tunney (2002)
10.1021/ACS.MACROMOL.5B02734
Kinetics of the Generation of Surface-Attached Polymer Networks through C, H-Insertion Reactions
Martin Koerner (2016)
10.1021/am200324f
One-step photochemical synthesis of permanent, nonleaching, ultrathin antimicrobial coatings for textiles and plastics.
Vikram Dhende (2011)
10.1002/ADFM.201404560
Colorimetric Logic Gates Based on Poly(2-alkyl-2-oxazoline)-Coated Gold Nanoparticles
V. Rosa (2015)
10.1021/LA001222D
Polymeric Thin Films That Resist the Adsorption of Proteins and the Adhesion of Bacteria
R. Chapman (2001)
10.1007/s10965-018-1625-0
Effect of bis[2-(methacryloyloxy)ethyl] phosphate as a crosslinker on poly(AAm-co-AMPS)/Na-MMT hydrogel nanocomposite as potential adsorbent for dyes: kinetic, isotherm and thermodynamic study
Mahdi Taghvay Nakhjiri (2018)
Biointeractive hydrogels. Materials Today (Oxford United Kingdom
P Krsko (2005)
10.1007/s10965-018-1610-7
Preparation and characterization of modified ultrafiltration nylon 6 membrane modified by poly (acrylamide-co-maleic anhydride)
H. Mahdavi (2018)
10.1039/C5TB00681C
Mechanically strong hybrid double network hydrogels with antifouling properties.
H. Chen (2015)
10.4028/www.scientific.net/KEM.288-289.343
Glucosamine Coating for Inhibiting Bacterial Adhesion to Titanium Surfaces
Y. An (2005)
brushes in aqueous environments : a Tiramis √ π for cell - culture applications
B Pidhatika (2008)
10.1007/s13758-011-0001-y
Comparative Stability Studies of Poly(2-methyl-2-oxazoline) and Poly(ethylene glycol) Brush Coatings
B. Pidhatika (2012)
10.1007/978-3-319-57494-3_8
Anti-fouling Medical Coatings
J. Li (2017)
10.1016/S0927-7757(01)00952-9
Surface-attached polymer monolayers for the control of endothelial cell adhesion
Bong-Jun Chang (2002)
Evaluation of a poly(vinyl pyrrolidone)-coated biomaterial for urological use. Biomaterials
MM Tunney (2002)
10.1016/S0927-7765(99)00152-6
Phosphorylcholine-based polymers and their use in the prevention of biofouling.
Lewis (2000)
10.1002/MACP.200600558
Poly(2‐oxazoline)s: Alive and Kicking
R. Hoogenboom (2007)
10.1002/MACP.201500243
On the Lubrication Mechanism of Surfaces Covered with Surface-Attached Hydrogels
Ke Li (2016)
10.1016/J.POLYMER.2016.04.042
Understanding the effect of hydrophobic protecting blocks on the stability and biopassivity of polymer brushes in aqueous environments: A Tiramisù for cell-culture applications
Mohammad Divandari (2016)
Liefeith K, Schubert US (2014) Amine end-functionalized poly(2-ethyl-2oxazoline) as promising coating material for antifouling applications
L Tauhardt (2014)
10.1021/acs.langmuir.6b00386
Molecular Understanding and Structural-Based Design of Polyacrylamides and Polyacrylates as Antifouling Materials.
Hong Chen (2016)
10.1163/156856299X00711
Non-fouling properties of polysaccharide-coated surfaces.
M. Morra (1999)
10.1021/acs.langmuir.5b00537
Temperature-Triggered Protein Adsorption on Polymer-Coated Nanoparticles in Serum.
Olga Koshkina (2015)
10.1163/156856206778366059
Blood cell and plasma protein repellent properties of Star-PEG-modified surfaces
J. Hoffmann (2006)
10.1021/am200690s
Evaluation of photochemically immobilized poly(2-ethyl-2-oxazoline) thin films as protein-resistant surfaces.
H. Wang (2011)
10.1116/1.4878461
Comparative assessment of the stability of nonfouling poly(2-methyl-2-oxazoline) and poly(ethylene glycol) surface films: an in vitro cell culture study.
Y. Chen (2014)
Khutoryanskiy VV (2016) Side chain variations radically alter the diffusion of poly(2-alkyl-2-oxazoline) functionalised nanoparticles through amucosal barrier
EDH Mansfield (2016)
10.1021/ACS.CHEMMATER.5B00252
Ultrastable Suspensions of Polyoxazoline-Functionalized ZnO Single Nanocrystals
Giulia Morgese (2015)
10.1021/la402287a
Enhanced stability of low fouling zwitterionic polymer brushes in seawater with diblock architecture.
R. Quintana (2013)
10.1039/C4TB01766H
Antifouling property of monothiol-terminated bottle-brush poly(methylacrylic acid)-graft-poly(2-methyl-2-oxazoline) copolymer on gold surfaces.
Xiajun Zheng (2015)
10.1016/J.BIOMATERIALS.2003.08.010
The biocompatibility of crosslinkable copolymer coatings containing sulfobetaines and phosphobetaines.
S. L. West (2004)
10.4028/www.scientific.net/KEM.288-289.331
Surface Characterization and Antibacterial Evaluation of Poly(Ethylene Terephthalate) Modified by Chitosan-Immobilization
P. Li (2005)
10.1002/APP.12217
Hydrogels based on poly(ethylene oxide) and poly(tetramethylene oxide) or poly(dimethyl siloxane). II. Physical properties and bacterial adhesion
J. Park (2003)
10.1002/anie.200901607
Poly(2-oxazoline)s: a polymer class with numerous potential applications.
R. Hoogenboom (2009)
10.1039/c6bm00375c
Side chain variations radically alter the diffusion of poly(2-alkyl-2-oxazoline) functionalised nanoparticles through a mucosal barrier.
Edward D. H. Mansfield (2016)
10.1016/J.EURPOLYMJ.2017.01.014
50 years of poly(2-oxazoline)s
R. Hoogenboom (2017)
10.1023/A:1024455114745
Control of Mammalian Cell and Bacteria Adhesion on Substrates Micropatterned with Poly(ethylene glycol) Hydrogels
Won-Gun Koh (2003)
10.1021/BI00185A001
Benzophenone photophores in biochemistry.
G. Dorman (1994)
10.1016/j.biomaterials.2011.03.080
Formation and characterization of DNA-polymer-condensates based on poly(2-methyl-2-oxazoline) grafted poly(L-lysine) for non-viral delivery of therapeutic DNA.
Thomas von Erlach (2011)
10.1016/J.POLYMDEGRADSTAB.2013.08.003
Degradation of ROMP-based bio-renewable polymers by UV radiation
H. Cui (2013)
10.1021/la300503p
Micropatterning of functional conductive polymers with multiple surface chemistries in register.
Johan U. Lind (2012)
10.1007/s10965-017-1237-0
Poly(2-oxazoline) hydrogels by photoinduced thiol-ene “click” reaction using different dithiol crosslinkers
Petra Šrámková (2017)
10.1023/A:1008904326950
Stabilization of polyvinyl alcohol coating of polyester cloth for reduction of bacterial adhesion
J. Koziarz (1999)
10.1016/j.biomaterials.2010.08.033
The role of the interplay between polymer architecture and bacterial surface properties on the microbial adhesion to polyoxazoline-based ultrathin films.
B. Pidhatika (2010)
10.1039/C4TB00193A
Amine end-functionalized poly(2-ethyl-2-oxazoline) as promising coating material for antifouling applications.
L. Tauhardt (2014)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar