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Compatibility Study Between Diazepam And Tablet Excipients

Ana Paola dos Santos Matos, J. S. Costa, J. Boniatti, R. Seiceira, A. Pitaluga, D. L. Oliveira, A. Viçosa, C. Holandino
Published 2016 · Chemistry

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Compatibility between diazepam (DZP), a benzodiazepine drug used for the treatment of anxiety, and tablet excipients has been investigated by thermal analysis (differential scanning calorimetry—DSC and thermogravimetry—TG) and infrared (IR) spectroscopy. In order to investigate possible interactions, the components were prepared in 1:1 (w/w) mixtures. Moreover, individual samples as well as physical mixtures were stored in accelerated conditions at 40 °C/75 % RH for 3 months. Mixtures, which showed possible interactions, were also investigated in other ratios based on typical pharmaceutical solid formulation. DSC curves of DZP have shown an endothermic peak at 132 °C, which corresponds to the melting process in agreement with the literature. DSC curves of the mixtures containing DZP and colloidal silicon dioxide (CSD) indicated a possible interaction due to enthalpy values lower than expected. However, as this interaction was not confirmed by IR and TG, this suggests that these techniques are not sensitive enough to identify such interaction. These results suggest that there is a possible interaction, but not an incompatibility between DZP and CSD. For all other mixtures, it was not possible to identify significant interactions, suggesting that there are no compatibility issues.
This paper references
Vibrational spectra and normal coordinate analysis of diazepam, phenytoin and phenobarbitone.
S. Gunasekaran (2006)
Quality control Fourier transform infrared determination of diazepam in pharmaceuticals.
J. Moros (2007)
Compatibility study between sitagliptin and pharmaceutical excipients used in solid dosage forms
S. Shantikumar (2013)
Drug-excipient compatibility testing-Identification and characterization of degradation products of phenylephrine in several pharmaceutical formulations against the common cold.
M. Douša (2011)
Compatibility studies of acyclovir and lactose in physical mixtures and commercial tablets.
F. Monajjemzadeh (2009)
Compatibility of the antitumoral beta-lapachone with different solid dosage forms excipients.
M. S. S. Cunha-Filho (2007)
Incompatibility study of ibuprofen in ternary interactive mixture by using differential scanning calorimetry
H. Maswadeh (2015)
Compatibility study between ketoprofen and pharmaceutical excipients used in solid dosage forms.
B. Tiťa (2011)
Diazepam-Loaded Solid Lipid Nanoparticles: Design and Characterization
G. Abdelbary (2009)
Compatibility study between ibuproxam and pharmaceutical excipients using differential scanning calorimetry, hot-stage microscopy and scanning electron microscopy.
P. Mura (1998)
Drug-excipient compatibility screening--role of thermoanalytical and spectroscopic techniques.
R. Chadha (2014)
Compatibility studies between isosorbide mononitrate and selected excipients used in the development of extended release formulations.
R. Verma (2004)
Comparison of Generic Hydrochlorothiazide Formulations by Means of TG and DSC Coupled to a Photovisual System
R. Macêdo (2001)
Fourier transform Raman and infrared vibrational study of diazepam and four closely related 1,4‐benzodiazepines
G. Neville (1990)
Preformulation compatibility studies of etamsylate and fluconazole drugs with lactose by DSC
S. R. Desai (2003)
Selection of solid-state excipients for simvastatin dosage forms through thermal and nonthermal techniques
Ionuț Ledeți (2015)
A hybrid method for estimation of molecular dynamics of diazepam-density functional theory combined with NMR and FT-IR spectroscopy.
J. Mielcarek (2011)
Solid state compatibility studies with tablet excipients using non thermal methods.
K. Liltorp (2011)
Compatiblity Study Between Oxprenolol Hydrochloride, Temazepam and Tablet Excipients using Differential Scanning Calorimetry
S. Botha (1990)
Evaluation of carvedilol compatibility with lipid excipients for the development of lipid-based drug delivery systems
L. A. Silva (2015)
Diazepam receptor characterization: Specific binding of a benzodiazepine to macromolecules in various areas of rat brain
H. Bosmann (1977)
Rapid, practical and predictive excipient compatibility screening using isothermal microcalorimetry
E. Schmitt (2001)
Dissolution behaviour and characterization of diazepam-Pullulan coground mixtures
K. B. Choudhari (1993)
Investigation of diazepam drug using thermal analyses, mass spectrometry and semi-empirical MO calculation.
M. Zayed (2005)
Differential scanning calorimetry: applications in drug development.
Clas (1999)
Design and utilization of the drug-excipient chemical compatibility automated system.
V. H. Thomas (2008)

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