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Association Of CYP1A1, GSTM1, And GSTT1 Gene Polymorphism With Risk Of Oral Submucous Fibrosis In A Section Of North Indian Population

Tanima Ghosh, Shalini Gupta, P. Bajpai, Deepti Agarwal, M. Agarwal, O. Gupta, D. Agrawal
Published 2012 · Biology, Medicine

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Genetic alterations in the genes expressing drug metabolizing enzymes can make an individual susceptible to various cancers. This study detects the polymorphisms at CYP1A1, GSTM1, and GSTT1 genes in a section of North Indian population and determines the susceptibility to oral submucous fibrosis (OSF). In this case–control study one hundred and two OSF patients were genotyped to detect the GSTM1, GSTT1, CYP1A1 polymorphism. Two hundred healthy controls were also included. Genotypes were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) approach. The frequency of GSTM1 and GSTT1 genotype was higher in OSF patients, as compared to controls. A trend risk analysis showed 7.6 fold increase in risk, when both the genes were absent. The frequency of CYP1A1 (m1) and CYP1A1 (m2) genotypes was higher in controls. No polymorphic alleles were detected in the m4 site. CYP1A1 (m1) wild genotype in the absence of GSTM1 null genotype, falls under the highest risk group (OR 3.74). Our findings suggest that CYP1A1 (m1) genotype and (m2) genotype singly acts as a protective factor but in the absence of GSTM1 and/or GSTT1 gene significantly alters risk towards OSF.
This paper references
Submucous fibrosis of the oral cavity. 1. Clinical features.
P. N. Wahi (1966)
Submucous fibrosis of the oral cavity. 2. Studies on epidemiology.
P. N. Wahi (1966)
10.3109/10409239009090605
The role of glutathione and glutathione transferases in chemical carcinogenesis.
B. Coles (1990)
Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP.
D. D. Petersen (1991)
10.1042/BJ2740409
Theta, a new class of glutathione transferases purified from rat and man.
D. J. Meyer (1991)
Polymorphic enzymes and cancer risk: concepts, methodology and datareview Pharmacogenetics of drug metabolism
I Roots (1992)
Polymorphic enzymes and cancer risk: concepts, methodology and datareview. In: Kalow W (ed) Pharmacogenetics of drug metabolism
I Roots (1992)
Polymorphic enzymes and cancer risk : concepts , methodology and datareview
I Roots (1992)
Racial differences in restriction fragment length polymorphisms and messenger RNA inducibility of the human CYP1A1 gene.
G. Cosma (1993)
Racial differences in restriction fragment length polymorphism and mRNA inducibility in human CYP1A1 gene
GN Cosma (1993)
A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility.
I. Cascorbi (1996)
CYP1A1 and GSTM1 polymorphisms and oral cancer risk.
J. Park (1997)
10.1097/00008571-199802000-00001
The glutathione S-transferase GSTP1 polymorphism: effects on susceptibility to oral/pharyngeal and laryngeal carcinomas.
C. Matthias (1998)
10.1093/CARCIN/20.5.743
Glutathione S-transferase M1 and T1 null genotypes as risk factors for oral leukoplakia in ethnic Indian betel quid/tobacco chewers.
U. Nair (1999)
10.1002/(SICI)1097-0215(19991126)83:5<606::AID-IJC6>3.0.CO;2-P
Genetic polymorphisms of tobacco‐ and alcohol‐related metabolizing enzymes and oral cavity cancer
T. Katoh (1999)
10.1042/0264-6021:3370141
Gene structure, expression and chromosomal localization of murine theta class glutathione transferase mGSTT1-1.
A. Whittington (1999)
10.1289/EHP.99107S137
Polymorphisms of xenobiotic-metabolizing enzymes and susceptibility to cancer.
A. Hirvonen (1999)
Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers.
H. Bartsch (2000)
10.1093/CARCIN/22.1.11
CYP 1A1 polymorphism and risk of lung cancer in relation to tobacco smoking: a case-control study in China.
N. Song (2001)
10.1016/S1368-8375(01)00028-8
Genetic polymorphism of CYP1A1, GSTM1 and GSTT1 genes in Indian oral cancer.
T. Sreelekha (2001)
"Frequency of Glutathione S-transferase M1 (GSTM1) and GSTT1 Null Genotypes in Fars Population (South of Iran)"
M. Saadat (2001)
10.1093/CARCIN/23.5.803
Polymorphism at GSTM1, GSTM3 and GSTT1 gene loci and susceptibility to oral cancer in an Indian population.
S. Buch (2002)
10.1016/S0194-5998(03)00176-1
Gene polymorphisms in detoxification enzymes as susceptibility factor for head and neck cancer?
S. Gronau (2003)
10.1007/s10038-005-0303-3
Possible risk modification by CYP1A1, GSTM1 and GSTT1 gene polymorphisms in lung cancer susceptibility in a South Indian population
L. Sreeja (2005)
10.1016/J.ORALONCOLOGY.2005.08.005
Oral submucous fibrosis: review on aetiology and pathogenesis.
W. Tilakaratne (2006)
10.1093/AJE/KWJ321
Meta- and pooled analysis of GSTT1 and lung cancer: a HuGE-GSEC review.
S. Raimondi (2006)
10.1093/CARCIN/BGM038
Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator.
D. Anantharaman (2007)
10.1002/cncr.23392
CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility
H. Hirata (2008)
10.1155/2008/741310
CYP1A1, mEH, and GSTM1 Polymophisms and Risk of Oral and Pharyngeal Cancer: A Spanish Case-Control Study
L. Varela-Lema (2008)
GSTM1, GSTT1 and CYP1A1 polymorphism and risk of oral cancer: a case-control study in Jakarta population, Indonesia
Rahmi (2008)
10.1186/1756-9966-28-46
GSTM1 and GSTT1 polymorphisms and nasopharyngeal cancer risk: an evidence-based meta-analysis
Xianlu Zhuo (2009)
10.1016/j.etap.2009.12.001
CYP1A1 and CYP3A4 polymorphic variations in Delhi population of Northern India.
V. Kumar (2010)
10.1159/000318533
Role of GSTM1 and GSTT1 Polymorphism: Susceptibility to Oral Submucous Fibrosis in the North Indian Population
D. Agrawal (2010)
10.1016/j.canep.2010.05.002
Smoking related risk involved in individuals carrying genetic variants of CYP1A1 gene in head and neck cancer.
K. Sabitha (2010)
10.3923/RJI.2010.12.21
CYP1A1, GSTM1 and GSTT1 genetic polymorphism in Egyptian chronic myeloid leukemia patients.
Shereen Mahmoud (2010)
Association of GSTM1 and GSTT1 gene deletions with risk of head and neck cancer in Pakistan: a case control study.
M. Nosheen (2010)
10.3892/OL_00000097
Oral cancer susceptibility associated with the CYP1A1 and GSTM1 genotypes in Chilean individuals.
K. Cordero (2010)
Mol Biol Rep
(2012)



This paper is referenced by
10.3390/ijms22052252
New Insights Into Oral Squamous Cell Carcinoma: From Clinical Aspects to Molecular Tumorigenesis
Shang-Hung Chen (2021)
10.1007/978-3-319-14911-0_8
Oral Submucous Fibrosis
S. Warnakulasuriya (2017)
10.1016/J.AJOMS.2017.11.008
GSTM1 and GSTT1 null polymorphism and antioxidant levels in oral submucous fibrosis, leukoplakia and oral cancer patients among a South Indian Population ☆
G. Madhulatha (2017)
10.1016/j.oraloncology.2016.08.005
Single nucleotide polymorphisms as markers of genetic susceptibility for oral potentially malignant disorders risk: Review of evidence to date
K. Shridhar (2016)
10.1016/j.oooo.2016.04.003
Oral submucous fibrosis: a historical perspective and a review on etiology and pathogenesis.
W. Tilakaratne (2016)
Roles of CYP1A1 and CYP2E1 Gene Polymorphisms in Oral Submucous Fibrosis.
Punyo Yaming (2016)
ORAL SUBMUCOUS FIBROSIS : AN UPDATE ON ETIOLOGY AND PATHOGENESIS-A REVIEW
Srivastava (2015)
10.1371/journal.pone.0118660
GST M1-T1 null Allele Frequency Patterns in Geographically Assorted Human Populations: A Phylogenetic Approach
Senthilkumar Pitchalu Kasthurinaidu (2015)
A Short Review on Human Leukocyte Antigens and Oral Submucous Fibrosis
V. Biradar (2014)
DEVELOPMENT OF AN ORAL SUBMUCOUS FIBROSIS-SPECIFIC HAPLOTYPIC SIGNATURE – HOW FAR ARE WE?
K. SureshP. (2014)
10.1007/s11033-014-3433-x
Risk modulation of GSTM1–GSTT1 interactions to head and neck cancer in tobacco users
K. Senthilkumar (2014)
10.4172/2157-2518.S5-002
Oral Submucous Fibrosis: Review on Mechanisms of Pathogenesis and Malignant Transformation
R. Ekanayaka (2013)
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