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The Efficacy Of Gamma Knife Radiosurgery For Advanced Gastric Cancer With Brain Metastases

Young Seok Park, Jong Hee Chang, Jin Woo Chang, Yong Gou Park
Published 2010 · Medicine
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The aim of this study was to retrospectively investigate the efficacy of gamma knife radiosurgery for brain metastases from advanced gastric cancer (AGC) comparing whole brain radiotherapy (WBRT). Between January 1991 and May 2008, 56 patients with brain metastases from AGC, treated with GKR or WBRT, were reviewed to assess prognostic factors affecting survival. Most brain metastases were diagnosed based on MRI, both metachronous and synchronous brain metastases, adenocarcinoma and signet ring carcinoma were included, but excluded cases of gastric lymphoma. Fifteen patients with a median age of 54.0 years (range, 42–67 years) were treated with GKR: 11 were treated with GKR only, 2 with surgery plus GKR, 1 with repeated GKR, 1 with GKR plus WBRT, and the other 1 with WBRT plus GKR. Forty-one were treated with WBRT only. The median number of metastatic brain lesions was 3 (range, 1–15), and treatment involved 17.0 Gy (range 14–23.6 Gy), or 30 Gy with fractionated radiotherapy. The median survival after brain metastases for GKR treatment was 40.0 weeks [95% confidence interval (CI) 44.9–132.1 weeks] and WBRT was 9.0 weeks 95% CI, 8.8–21.9 weeks). The progression free survival of 15 GKR treated patients was 56.5 weeks (95% CI 33.4–79.5 weeks). The recursive partitioning analysis (RPA) (class 2 vs. class 3) and use of GKR were correlated with prolonged survival in univariate and multivariate analyses. Age, sex, pathology, leptomeningeal seeding, tumor size (≥3 cm), extracranial metastases, single metastasis, chemotherapy, and synchronous metastases were not correlated with a good prognosis in both univariate and multivariate analysis. Based on our study, the use of GKR and RPA class 2 resulted in more favorable clinical outcomes in patients with brain metastases from AGC.
This paper references
J Neurooncol
[A case of brain metastasis from gastric cancer involving bilateral middle cerebellar peduncles].
Shinichiro Mizumatsu (2006)
10.1016/0360-3016(95)02156-6
Analysis of outcome in patients reirradiated for brain metastases.
William W. Wong (1995)
Ministry of Health and Welfare
(2002)
10.1002/1097-0142(197408)34:2<257::AID-CNCR2820340206>3.0.CO;2-6
Rapid fractionation technique and re-treatment of cerebral metastases by irradiation.
Wagih M. Shehata (1974)
10.1002/CNCR.23037
Whole-brain radiotherapy versus stereotactic radiosurgery for patients in recursive partitioning analysis classes 1 and 2 with 1 to 3 brain metastases.
Dirk Rades (2007)
COMPLICATIONS OF CANCERLeptomeningeal carcinomatosis
Stuart A. Grossman (1999)
10.3904/kjim.2007.22.4.304
A Case of Gastric Adenocarcinoma Presenting as Meningeal Carcinomatosis
Hong Gi Lee (2007)
Patients with brain metastases from gastrointestinal tract cancer treated with whole brain radiation therapy: Prognostic factors and survival
SusanneBartelt (2004)
10.1097/00000421-200304000-00013
Leptomeningeal Carcinomatosis Originating from Gastric Cancer: Report of Eight Cases and Review of the Literature
Yulia Lisenko (2003)
10.1007/s00432-002-0354-1
Long-term survival in patients with brain metastases
Johannes Lutterbach (2002)
10.1056/NEJM199002223220802
A randomized trial of surgery in the treatment of single metastases to the brain.
R. Patchell (1990)
10.1007/s00701-009-0554-4
Radiosurgery for brain metastasis from advanced gastric cancer
Jung Ho Han (2009)
10.1016/S0140-6736(04)16250-8
Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial
David W. Andrews (2004)
10.1016/S0360-3016(96)00619-0
Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials.
Laurie E. Gaspar (1997)
10.1002/cncr.22729
Stereotactic radiosurgery alone versus resection plus whole-brain radiotherapy for 1 or 2 brain metastases in recursive partitioning analysis class 1 and 2 patients.
Dirk Rades (2007)
10.1053/ctrv.1999.0119
Leptomeningeal carcinomatosis.
S. Grossman (1999)
10.1023/A:1006156204385
Intracranial Involvement by Metastatic Advanced Gastric Carcinoma
Manho Kim (1999)
10.1007/s005950070112
Clinicopathological study of brain metastasis in gastric cancer patients
Yuichi Kasakura (2010)
[A case of effective paclitaxel therapy for gastric cancer with brain metastasis].
Yoshihiro Kitayama (2006)
10.1007/s10434-999-0771-3
Gastric Cancer and Metastasis to the Brain
J. York (1999)
10.1016/S0360-3016(00)00527-7
Application of recursive partitioning analysis and evaluation of the use of whole brain radiation among patients treated with stereotactic radiosurgery for newly diagnosed brain metastases.
M. A. Chidel (2000)
10.1002/1097-0142(19801215)46:12<2587::AID-CNCR2820461209>3.0.CO;2-4
Results of re-irradiation for cerebral metastases.
P. Kurup (1980)
10.1023/B:NEON.0000013462.43156.f4
Leptomeningeal Carcinomatosis in Gastric Cancer
J. Lee (2004)
10.1002/cncr.20659
Carcinoid metastasis to the brain.
R. Hlatký (2004)
Leptomeningeal carcinomatosis originating from gastric cancer: report of J Neurooncol eight cases and review of the literature
Y Lisenko (2003)
10.1016/S0360-3016(98)90026-8
Brain metastases: results and effects of re-irradiation.
Mark B. Hazuka (1988)
10.1016/S0090-3019(03)00356-2
Stereotactic radiosurgery for brain metastases from gastrointestinal tract cancer.
T. Hasegawa (2003)
Mortality and prevalence worldwide
J. Ferlay (2000)
10.3171/2008.9.JNS08281
Gamma Knife surgery for brain metastases from gastrointestinal cancer.
Arnaldo Neves Da Silva (2009)
10.1016/S0360-3016(99)00549-0
Radiosurgery for brain metastases: a score index for predicting prognosis.
Eduardo Weltman (2000)
Leptomeningeal carcinomato
SA Grossman (1999)
10.1148/radiology.174.3.2305074
Cerebral metastases: value of reirradiation in selected patients.
J. Cooper (1990)
GLOBOCAN 2002 : cancer incidence
J Ferlay (2004)
10.1016/S0360-3016(99)00416-2
Prognostic factors in brain metastases: should patients be selected for aggressive treatment according to recursive partitioning analysis (RPA) classes?
Carsten Nieder (1999)
[Case of gastric cancer with isolated brain metastasis successfully managed by gamma knife radiotherapy and chemotherapy].
K. Hizawa (2008)
[Irinotecan+cisplatin and irradiation are effective for brain metastases of gastric cancer--two case reports].
Y. Rino (2007)



This paper is referenced by
10.1016/s0923-7534(20)33134-3
Brain Metastases in Gastrointestinal Cancers
Dilek Erdem (2012)
[Metastatic brain tumors from gastrointestinal cancer: an analysis of patient background and treatment results].
Yoshihito Mizokami (2013)
10.1111/jcpt.12708
Combination of apatinib and continuous nutritional support for a gastric cancer patient with brain metastasis prolongs survival
Yuyan Yang (2018)
10.1016/B978-0-12-801419-6.00015-X
Gastrointestinal Cancer and Brain Metastasis Outcomes and Management
Ronald S Chamberlain (2015)
10.1016/j.rpor.2014.08.003
Brain metastases from stomach cancer - The role of different treatment modalities and efficacy of palliative radiotherapy.
Malgorzata Kraszkiewicz (2015)
10.3892/ol.2013.1699
Advanced gastric cancer with brain metastasis effectively treated by arterial infusion chemotherapy: A case report
Zhaohong Peng (2014)
10.1007/s12032-017-0919-0
Clinical outcome and molecular characterization of brain metastases from esophageal and gastric cancer: a systematic review
Michele Ghidini (2017)
10.2217/cns-2016-0026
Gamma Knife treatment of recurrent CNS metastases of pancreatic origin: a case report and review of the literature.
Subha Perni (2017)
10.2176/nmccrj.cr.2018-0175
Exclusive Cerebellar and Leptomeningeal Metastases from Early Gastric Cancer 14 Months after Proximal Gastrectomy: An Autopsy Case Report
Yuta Murakami (2019)
10.1007/s12094-015-1341-8
Patients with brain metastases derived from gastrointestinal cancer: clinical characteristics and prognostic factors
Lin Lin (2015)
10.3390/ijms150916816
Brain Metastases in Gastrointestinal Cancers: Is there a Role for Surgery?
J. Lemke (2014)
10.1155/2019/8075421
A Rare Occurrence of Isolated Brain Metastases from Gastric Cancer
Manish M Karamchandani (2019)
10.1111/ijcp.12395
Brain metastasis from gastrointestinal cancers: a systematic review.
Maryam Esmaeilzadeh (2014)
Brain metastases of gastro-oesophageal cancer: evaluation of molecules with relevance for targeted therapies.
M. Preusser (2013)
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