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Metabolomics Study Of Oral Cancers

Xun Chen, Dongsheng Yu
Published 2019 · Medicine, Biology
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BackgroundOral cancer is one of the most frequently occurring cancers. Metabolic reprogramming is an important hallmark of cancer. Metabolomics characterizes all the small molecules in a biological sample, and a complete set of small molecules in such sample is referred as metabolome. Nuclear magnetic resonance spectroscopy and mass spectrometry are two widely used techniques in metabolomics studies. Increasing evidence demonstrates that metabolomics techniques can be used to explore the metabolic signatures in oral cancer. Elucidation of metabolic alterations in oral cancer is also important for the understanding of its pathological mechanisms.Aim of reviewIn this paper, we summarize the latest progress of metabolomics study in oral cancer and provide the suggestions for the future studies.Key scientific concepts of reviewThe metabolomics studies in saliva, serum, and tumor tissues revealed the existence of metabolic signatures in bio-fluids and tissues of oral cancer, and several tumor-specific metabolites identified in individual study could discriminate oral cancer from healthy controls or precancerous lesions, which are potential biomarkers for the screening or early diagnosis of oral cancer. Metabolomics study of oral cancers in the future should aim to establish a routine procedure with high sensitivity, profile intracellular metabolites to find out the metabolic characteristics of tumor cells, and investigate the mechanism behind metabolomic alterations and the metabolic response of cancer cells to chemotherapy.
This paper references
Metabolomic profiling of anionic metabolites in head and neck cancer cells by capillary ion chromatography with Orbitrap mass spectrometry.
Junhua Wang (2014)
Taurine, glutamic acid and ethylmalonic acid as important metabolites for detecting human breast cancer based on the targeted metabolomics.
Xinyang Wang (2018)
Choline metabolism in malignant transformation
Kristine Glunde (2011)
Analysis of salivary phenotypes of generalized aggressive and chronic periodontitis through nuclear magnetic resonance-based metabolomics.
Federica Romano (2018)
Analysis of urinary metabolic signatures of early hepatocellular carcinoma recurrence after surgical removal using gas chromatography-mass spectrometry.
G. Ye (2012)
Metabolic Profile of Oral Squamous Carcinoma Cell Lines Relies on a Higher Demand of Lipid Metabolism in Metastatic Cells
Ana Carolina B. Sant’Anna-Silva (2018)
NMR ((1)H and (13)C) based signatures of abnormal choline metabolism in oral squamous cell carcinoma with no prominent Warburg effect.
Swarnendu Bag (2015)
Search of new cytotoxic crude materials against human oral squamous cell carcinoma using 1H NMR-based metabolomics.
Ryuichiro Suzuki (2014)
Systems biology: Metabonomics
J. Nicholson (2008)
Role of Pancreatic Cancer-derived Exosomes in Salivary Biomarker Development*
Chang Shun Lau (2013)
Proton HR-MAS MR spectroscopy of oral squamous cell carcinoma tissues: an ex vivo study to identify malignancy induced metabolic fingerprints
Shatakshi Srivastava (2010)
Diagnostic approach to breast cancer patients based on target metabolomics in saliva by liquid chromatography with tandem mass spectrometry.
Takahiro Takayama (2016)
The future of NMR-based metabolomics.
John L. Markley (2017)
Distinct signatures of dental plaque metabolic byproducts dictated by periodontal inflammatory status
Akito Sakanaka (2017)
Impact of 2-deoxy-D-glucose on the target metabolome profile of a human endometrial cancer cell line.
Kenichi Urakami (2013)
Delineating metabolic signatures of head and neck squamous cell carcinoma: phospholipase A2, a potential therapeutic target.
P. Tripathi (2012)
Incorporation of salivary metabolomics in oral cancer diagnostics.
Akhil A. Shankar (2014)
Identification of Plasma Metabolomic Profiling for Diagnosis of Esophageal Squamous-Cell Carcinoma Using an UPLC/TOF/MS Platform
R. Liu (2013)
¹H NMR-derived serum metabolomics of leukoplakia and squamous cell carcinoma.
Ashish Kumar Gupta (2015)
Salivary metabolite signatures of oral cancer and leukoplakia.
Jie Wei (2011)
Magic angle spinning NMR-based metabolic profiling of head and neck squamous cell carcinoma tissues.
B. Somashekar (2011)
Lipid Metabolic Reprogramming in Hepatocellular Carcinoma
Hayato Nakagawa (2018)
Pharmacometabonomic Profiling as a Predictor of Toxicity in Patients with Inoperable Colorectal Cancer Treated with Capecitabine
Alexandra Backshall (2011)
Study of induction chemotherapy efficacy in oral squamous cell carcinoma using pseudotargeted metabolomics.
G. Ye (2014)
1H nuclear magnetic resonance-based extracellular metabolomic analysis of multidrug resistant Tca8113 oral squamous carcinoma cells.
Hui Wang (2015)
Induction of cell death by combination treatment with cisplatin and 5-fluorouracil in a human oral squamous cell carcinoma cell line.
Masahiko Okamura (2007)
Untargeted saliva metabonomics study of breast cancer based on ultra performance liquid chromatography coupled to mass spectrometry with HILIC and RPLC separations.
Liping Zhong (2016)
Changes in salivary amino acid composition during aging.
Shoji Tanaka (2010)
Metabolomic analysis of the saliva of Japanese patients with oral squamous cell carcinoma.
Mitsuyoshi Ohshima (2017)
Elevated Polyamines in Saliva of Pancreatic Cancer
Yasutsugu Asai (2018)
The early diagnosis and monitoring of squamous cell carcinoma via saliva metabolomics
Qihui Wang (2014)
Metabolomics Study of Stepwise Hepatocarcinogenesis From the Model Rats to Patients: Potential Biomarkers Effective for Small Hepatocellular Carcinoma Diagnosis*
Yexiong Tan (2011)
Early Stage Diagnosis of Oral Cancer Using 1 H NMR – Based Metabolomics 1 , 2
S. Tiziani (2009)
Bortezomib resistance in multiple myeloma is associated with increased serine synthesis
Esther A Zaal (2017)
Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids.
Jeanine M. L. Roodhart (2011)
1H NMR-based metabonomic and pattern recognition analysis for detection of oral squamous cell carcinoma.
Jinglin Zhou (2009)
Glucose and glutamine metabolism in oral squamous cell carcinoma: insight from a quantitative metabolomic approach.
Tamaki Ogawa (2014)
Proton MR spectroscopy of squamous cell carcinoma of the extracranial head and neck: in vitro and in vivo studies.
Suresh K. Mukherji (1997)
Salivary Biomarkers for Detection of Oral Squamous Cell Carcinoma: Current State and Recent Advances
Maha Yakob (2014)
Human papillomavirus infection in oral potentially malignant disorders and cancer.
Xun Chen (2017)
Identification of salivary metabolomic biomarkers for oral cancer screening
Shigeo Ishikawa (2016)
Urine metabolite profiling offers potential early diagnosis of oral cancer
Guo X. Xie (2011)
Fluorescence spectroscopic characterization of salivary metabolites of oral cancer patients.
Manoharan Yuvaraj (2014)
An ex vivo study exploring the diagnostic potential of 1H magnetic resonance spectroscopy in squamous cell carcinoma of the head and neck region.
S. El-Sayed (2002)
Metabolomic analysis identifies differentially produced oral metabolites, including the oncometabolite 2-hydroxyglutarate, in patients with head and neck squamous cell carcinoma
Pranab K Mukherjee (2017)
Analysis of plasma metabolic biomarkers in the development of 4-nitroquinoline-1-oxide-induced oral carcinogenesis in rats
Xiangli Kong (2015)
"Omics" in oral cancer: New approaches for biomarker discovery.
Vertika Rai (2018)
Temporal molecular and biological assessment of an erlotinib-resistant lung adenocarcinoma model reveals markers of tumor progression and treatment response.
Zoë Weaver (2012)
Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect.
Linchong Sun (2018)
Metabolomics of Head and Neck Cancer: A Mini-Review
J. M. Shin (2016)
Investigations on the cell metabolomics basis of multidrug resistance from tumor cells by ultra-performance liquid chromatography–mass spectrometry
Ruixing Zhang (2016)
Investigation and identification of potential biomarkers in human saliva for the early diagnosis of oral squamous cell carcinoma.
Qihui Wang (2014)
A Metabolomic Approach to Predict Breast Cancer Behavior and Chemotherapy Response
Marcella Regina Cardoso (2018)
Metabolomic analysis of human oral cancer cells with adenylate kinase 2 or phosphorylate glycerol kinase 1 inhibition
Eoon Hye Ji (2017)
Magic angle spinning NMR-based metabolic profiling of head and neck squamous cell carcinoma
Somashekar (2011)
In vivo 1H MR spectroscopy of human head and neck lymph node metastasis and comparison with oxygen tension measurements.
J. Star-lack (2000)
[Origin of cancer cells].
O. Warburg (1956)
A metabonomic approach to the diagnosis of oral squamous cell carcinoma, oral lichen planus and oral leukoplakia.
Shi-kai Yan (2008)
Understanding the human salivary metabolome.
Ienaka Takeda (2009)
Glutaminolysis: A Hallmark of Cancer Metabolism.
Lifeng Yang (2017)
Effects of inter-day and intra-day variation on salivary metabolomic profiles.
Norishige Kawanishi (2019)
Identification of plasma metabolomic profiling
R Liu (2013)
The Glycolytic Switch in Tumors: How Many Players Are Involved?
Li Yu (2017)
Analysis of metabolic profiles of generalized aggressive periodontitis
H W Chen (2018)
Prediction of treatment response in head and neck cancer by magnetic resonance spectroscopy.
Tedros Bezabeh (2005)
Effect of timing of collection of salivary metabolomic biomarkers on oral cancer detection
Shigeo Ishikawa (2017)
NanoLC MALDI MS/MS based quantitative metabolomics reveals the alteration of membrane biogenesis in oral cancer
Swarnendu Bag (2016)
Polyamines and cancer: old molecules, new understanding
E. Gerner (2004)
Metabolite Profiling of Preneoplastic and Neoplastic Lesions of Oral Cavity Tissue Samples Revealed a Biomarker Pattern
Syed Ghulam Musharraf (2016)
Prediction of Periodontal Inflammation via Metabolic Profiling of Saliva
Masae Kuboniwa (2016)
Serum and tissue metabolomics of head and neck cancer.
Koichiro Yonezawa (2013)
Salivary biomarkers in cancer detection
Xiaoqian Wang (2016)
Salivary metabolomics
S. maa (2016)
On the origin of cancer cells.
O. Warburg (1956)
Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles
Masahiro Sugimoto (2009)
Effects of processing and storage conditions on charged metabolomic profiles in blood.
Akiyoshi Hirayama (2015)
Effect of storage conditions on salivary polyamines quantified via liquid chromatography-mass spectrometry
Atsumi Tomita (2018)
Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific
M. Sugimoto (2010)
Salivary metabolomics in the diagnosis of oral cancer and periodontal diseases.
Jopi J W Mikkonen (2016)
Time profile of putrescine, cadaverine, indole and skatole in human saliva.
Matthew G. Cooke (2003)
Cadaverine as a Putative Component of Oral Malodor
Stefan Goldberg (1994)

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