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Midlife Muscle Strength And Human Longevity Up To Age 100 Years: A 44-year Prospective Study Among A Decedent Cohort

T. Rantanen, K. Masaki, Q. He, G. W. Ross, B. Willcox, L. White
Published 2011 · Psychology, Medicine

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We studied prospectively the midlife handgrip strength, living habits, and parents’ longevity as predictors of length of life up to becoming a centenarian. The participants were 2,239 men from the Honolulu Heart Program/Honolulu–Asia Aging Study who were born before the end of June 1909 and who took part in baseline physical assessment in 1965–1968, when they were 56–68 years old. Deaths were followed until the end of June 2009 for 44 years with complete ascertainment. Longevity was categorized as centenarian (≥100 years, n = 47), nonagenarian (90–99 years, n = 545), octogenarian (80–89 years, n = 847), and ≤79 years (n = 801, reference). The average survival after baseline was 20.8 years (SD = 9.62). Compared with people who died at the age of ≤79 years, centenarians belonged 2.5 times (odds ratio (OR) = 2.52, 95% confidence interval (CI) = 1.23–5.10) more often to the highest third of grip strength in midlife, were never smokers (OR = 5.75 95% CI = 3.06–10.80), had participated in physical activity outside work (OR = 1.13 per daily hour, 95% CI = 1.02–1.25), and had a long-lived mother (≥80 vs. ≤60 years, OR = 2.3, 95% CI = 1.06–5.01). Associations for nonagenarians and octogenarians were parallel, but weaker. Multivariate modeling showed that mother’s longevity and offspring’s grip strength operated through the same or overlapping pathway to longevity. High midlife grip strength and long-lived mother may indicate resilience to aging, which, combined with healthy lifestyle, increases the probability of extreme longevity.
This paper references
Do children of long-lived parents agemore successfully? Epidemiology
H Frederiksen (2002)
Heritability of maximal isometric muscle strength in older female twins.
K. Tiainen (2004)
Parental effects on offspring longevity—evidence from 17th to 19th century reproductive histories
A. Kemkes-Grottenthaler (2004)
Ageing populations: the challenges ahead
K. Christensen (2009)
The genetics of ageing
C. Kenyon (2010)
Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans
G. de Benedictis (1999)
Immunological outcomes of exercise in older adults
D. Senchina (2007)
C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
S. Kaptoge (2010)
Association between different domains of physical activity and markers of inflammation.
Christine S. Autenrieth (2009)
Handgrip Strength and Cause‐Specific and Total Mortality in Older Disabled Women: Exploring the Mechanism
T. Rantanen (2003)
Physical activity and mortality: is the association explained by genetic selection?
S. Carlsson (2007)
Midlife hand grip strength as a predictor of old age disability.
T. Rantanen (1999)
Prevalence and trends in obesity among US adults, 1999-2008.
K. Flegal (2010)
Survival after 100 years of age: a multivariate model of exceptional survival in Swedish centenarians.
B. Hagberg (2008)
Centenarians – a useful model for healthy aging? A 29‐year follow‐up of hospitalizations among 40 000 Danes born in 1905
H. Engberg (2009)
Exercise Training and Plasma C‐Reactive Protein and Interleukin‐6 in Elderly People
B. Nicklas (2008)
Aging gracefully: a retrospective analysis of functional status in Okinawan centenarians.
D. Willcox (2007)
Heritability of body size and muscle strength in young adulthood: a study of one million Swedish men
K. Silventoinen (2008)
Genes and longevity: lessons from studies of centenarians.
A. Yashin (2000)
Grip strength changes over 27 yr in Japanese-American men.
T. Rantanen (1998)
Midlife risk factors and healthy survival in men.
B. Willcox (2006)
The genetics of aging.
G. M. Martin (1998)
Effects of walking on mortality among nonsmoking retired men.
A. Hakim (1998)
FALCon and HALCyon Study Teams Objectively measured physical capability AGE (2012) 34:563–570 levels and mortality: systematic review and meta-analysis Smoking, pulmonary function, and mortality
R Cooper (1990)
Do Children of Long-Lived Parents Age More Successfully?
H. Frederiksen (2002)
Relation of social integration to inflammatory marker concentrations in men and women 70 to 79 years.
E. Loucks (2006)
Genetics of aging.
C. Finch (1997)
United States Life Tables, 2001.
E. Arias (2004)
Interleukin-1 receptor antagonist, interleukin-6, and C-reactive protein as predictors of mortality in nonagenarians: the vitality 90+ study.
M. Jylhä (2007)
How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging
D. Karasik (2010)
Genetic influences and grip strength norms in the NHLBI twin study males aged 59-69.
T. Reed (1991)
The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870–1900
A. Herskind (2005)
Social integration and concentrations of C-reactive protein among US adults.
E. Ford (2006)
Prevalence and trends in obesity among US adults
K M Flegal (1999)
Muscle strength and body mass index as long-term predictors of mortality in initially healthy men.
T. Rantanen (2000)
C-reactive protein concentrations and risk of coronary heart disease, stroke, and mortality: an individual participants metaanalysis
S Kaptoge (2010)
FALCon and HALCyon Study Teams (2010) Objectively measured physical capability levels and mortality: systematic review and meta-analysis
R Cooper
United States Life Tables
J. W. Glover (2013)
Aging in America in the twenty-first century: demographic forecasts from the MacArthur Foundation Research Network on an Aging Society.
S. J. Olshansky (2009)
Smoking, physical activity, and active life expectancy.
L. Ferrucci (1999)
Muscle strength and body-mass index as long-term predictors of mortality in Japanese-American men
T Rantanen (2000)
Objectively measured physical capability levels and mortality: systematic review and meta-analysis
R. Cooper (2010)
Smoking, pulmonary function, and mortality.
J. Curb (1990)
Impact of socioeconomic, behavioral and clinical risk factors on mortality.
K. Rask (2009)
Aging and age-related diseases : the basics
M. Karásek (2006)
Heritability of life span in the Old Order Amish.
B. Mitchell (2001)
Imunological outcomes of exercise in older adults
DS Senchina (2007)

This paper is referenced by
Avaliação da força muscular manual em indivíduos frequentadores de um grupo de convivência Muscle strength asseessment manual on individuals goers coexistence of a group
M. Castro (2015)
Muscular strength as a strong predictor of mortality: A narrative review.
K. Volaklis (2015)
Biological Parameters Explain Why Shorter or Smaller People have Lower Cardiovascular Disease and Greater Longevity
T. Samaras (2017)
Readiness for health behavior changes among low fitness men in a Finnish health promotion campaign.
Karoliina Kaasalainen (2016)
Functional capacity and level of physical activity in centenarians of Florianópolis, Brazil
Inês Amanda Streit (2017)
Can human biology allow most of us to become centenarians?
B. Carnes (2013)
The association between retirement and age on physical activity in older adults
B. V. Bonsdorff (2014)
Upper Extremity Muscular Strength in Push–Pull Tasks: Model Approach Towards Task Design
J. Majumder (2018)
The association between retirement and age on physical activity in older adults.
A. Godfrey (2014)
Evidence from Eight Different Types of Studies Showing that Smaller Body Size is Related to Greater Longevity
T. Samaras (2014)
Clinical assessment tools identify functional deficits in fragility fracture patients
T. D. Ames (2016)
Strong or Weak Handgrip? Normative Reference Values for the German Population across the Life Course Stratified by Sex, Age, and Body Height
Nadia Steiber (2016)
Psychometric Properties of a Short Measure for Psychosocial Factors and Associations With Phase of Physical Activity Change Among Finnish Working-Aged Men
Karoliina Kaasalainen (2017)
Developmental Programming and Life Course Regulation of Skeletal Muscle Inflammation and Oxidative Function
C. Pileggi (2016)
ePubWU Institutional Repository
D. Philipov (2017)
Physical fitness, activity and hand-grip strength are not associated with arterial stiffness in older individuals
S. C. Dijk (2015)
Role of Dietary Protein and Muscular Fitness on Longevity and Aging
B. Strasser (2018)
Midlife predictors of active and healthy aging (AHA) among older businessmen
A. Urtamo (2018)
Chronic Microglial Activation in the GFAP-IL6 Mouse Contributes to Age-Dependent Cerebellar Volume Loss and Impairment in Motor Function
Erika Gyengesi (2019)
Physical Functioning among Community-Dwelling Older People
Päivi Tikkanen (2015)
Neurobiological Mechanisms of Stress Resilience and Implications for the Aged Population
C. Faye (2018)
Phase Angle as a Marker of Muscular Strength in Breast Cancer Survivors
C. Matias (2020)
Body size, non-occupational physical activity and the chance of reaching longevity in men and women: findings from the Netherlands Cohort Study
L. Brandts (2019)
Centenarians’ offspring as a model of healthy aging: a reappraisal of the data on Italian subjects and a comprehensive overview
L. Bucci (2016)
Handgrip strength, functionality and plasma levels of IL-6 in elderly women
D. Pereira (2015)
circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan
Shahnaz Haque (2019)
Self-reported fatigue and physical function in late mid-life.
H. Boter (2014)
Predictingfat-freemassindexandsarcopeniain assisted-living older adults
Taylor M. Campbell (2014)
Koettu terveys jäljellä olevan elinajan ennustajana
Helena Tietäväinen (2015)
Midlife and late-life handgrip strength and risk of cause-specific death in a general Japanese population: the Hisayama Study
H. Kishimoto (2014)
Prognostic value of physical function tests: hand grip strength and six-minute walking test in elderly hospitalized patients
E. Martín-Ponce (2014)
Upper extremity muscular strength in wrist‐twisting tasks: Model approach towards task design
J. Majumder (2020)
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