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Antihypertensive Treatment And Sexual Dysfunction

Athanasios Manolis, Michael Doumas
Published 2012 · Medicine
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Sexual dysfunction is frequently encountered in hypertensive patients. Available data indicates that sexual dysfunction is more frequent in treated than in untreated patients, generating the hypothesis that antihypertensive therapy might be associated with sexual dysfunction. Several lines of evidence suggest that differences between antihypertensive drugs exist regarding their effects on sexual function. Older antihypertensive drugs (diuretics, beta blockers) exert detrimental effects on erectile function whereas newer drugs (nebivolol, angiotensin receptor blockers) have neutral or even beneficial effects. Phosphodiesterase (PDE)-5 inhibitors are effective in hypertensive patients and can be safely administered even when multidrug regimes are used. Precautions need to be taken with alpha blockers or patients with uncontrolled high-risk hypertension, while co-administration with nitrates is contraindicated.
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Abbreviations Ace Angiotensin Converting Enzyme Adr Adverse Drug Reaction Arb Angiotensin Ii Type I Blockers Atc Anatomical Therapeutic Chemical Classification Bcpnn Bayesian Confidence Propagation Neural Network Ccb Calcium Channel Blockers Ddd Defined Daily Doses Ed Erectile Dysfunction Eea Europe
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