Please confirm you are human (Sign Up for free to never see this)
← Back to Search
Microarchitectural Changes In The Aging Skeleton
Y. Gabet, I. Bab
Published 2011 · Materials Science, Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
The age-related reduction in bone mass is disproportionally related to skeletal weakening, suggesting that microarchitectural changes are also important determinants of bone quality. The study of cortical and trabecular microstructure, which for many years was mainly based on two-dimensional histologic and scanning electron microscopy imaging, gained a tremendous momentum in the last decade and a half, due to the introduction of microcomputed tomography (μCT). This technology provides highly accurate qualitative and quantitative analyses based on three-dimensional images at micrometer resolution, which combined with finite elemental analysis predicts the biomechanical implications of microstructural changes. Global μCT analyses of trabecular bone have repeatedly suggested that the main age-related change in this compartment is a decrease in trabecular number with unaltered, or even increased, trabecular thickness. However, we show here that this may result from a bias whereby thick trabeculae near the cortex and the early clearance of thin struts mask authentic trabecular thinning. The main cortical age-related change is increased porosity due to negatively balanced osteonal remodeling and expansion of Haversian canals, which occasionally merge with endosteal and periosteal resorption bays, thus leading to rapid cortical thinning and cortical weakening. The recent emergence of CT systems with submicrometer resolution provides novel information on the age-related decrease in osteocyte lacunar density and related micropetrosis, the result of lacunar hypermineralization. Last but not least, the use of the submicrometer CT systems confirmed the occurrence of microcracks in the skeletal mineralized matrix and vastly advanced their morphologic characterization and mode of initiation and propagation.
This paper references
Structure and remodelling of the human parietal bone: an age and gender histomorphometric study.
D. Torres-Lagares (2010)
Quantitative analysis of trabecular microstructure by 400 MHz nuclear magnetic resonance imaging
H. Chung (1995)
Osteocytes as Dynamic Multifunctional Cells
L. Bonewald (2007)
In vivo micro-computed tomography allows direct three-dimensional quantification of both bone formation and bone resorption parameters using time-lapsed imaging.
F. A. Schulte (2011)
Determination of cortical bone porosity and pore size distribution using a low field pulsed NMR approach
X. Wang (2003)
Design of intramedullary prostheses to prevent bone loss: predictions based on damage-stimulated remodelling.
P. Prendergast (1992)
Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures
D. Marshall (1996)
Age-related changes in vertebral trabecular bone architecture--assessed by a new method.
L. Mosekilde (1988)
The role of three-dimensional trabecular microstructure in the pathogenesis of vertebral compression fractures
M. Kleerekoper (2007)
Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: comparison with transiliac bone biopsy
A. Cohen (2009)
Age-related changes in porosity and mineralization and in-service damage accumulation.
T. L. Norman (2008)
Detecting microdamage in bone
T. C. Lee (2003)
Time-lapsed assessment of microcrack initiation and propagation in murine cortical bone at submicrometer resolution.
R. Voide (2009)
Age- and gender-dependent changes in three-dimensional microstructure of cortical and trabecular bone at the human femoral neck
H. Chen (2009)
Age-related changes in human trabecular bone: Relationship between microstructural stress and strain and damage morphology.
J. O. Green (2011)
The role of cortical bone and its microstructure in bone strength.
P. Augat (2006)
Osteocyte lacuna size and shape in women with and without osteoporotic fracture.
B. Mccreadie (2004)
The osteoporotic vertebral structure is well adapted to the loads of daily life, but not to infrequent "error" loads.
J. Homminga (2004)
Bone age, mineral density, and fatigue damage
A. Parfitt (2005)
Bone, exercise, and stress fractures.
D. Burr (1997)
Decrease in the osteocyte lacunar density accompanied by hypermineralized lacunar occlusion reveals failure and delay of remodeling in aged human bone
B. Busse (2010)
The Growth and Age-Related Origins of Bone Fragility in Men
E. Seeman (2004)
Bone Structure in Patients with Low Bone Mineral Density With or Without Vertebral Fractures
A. Oleksik (2000)
Trabecular architecture in women and men of similar bone mass with and without vertebral fracture: II. Three-dimensional histology.
J. Aaron (2000)
Do osteocytes contribute to bone mineral homeostasis? Osteocytic osteolysis revisited.
A. Teti (2009)
Mechanical Contributions of the Cortical and Trabecular Compartments Contribute to Differences in Age-Related Changes in Vertebral Body Strength in Men and Women Assessed by QCT-Based Finite Element Analysis
B. Christiansen (2011)
Intracapsular Hip Fracture and the Region‐Specific Loss of Cortical Bone: Analysis by Peripheral Quantitative Computed Tomography
N. Crabtree (2001)
Alterations of Cortical and Trabecular Architecture Are Associated With Fractures in Postmenopausal Women, Partially Independent of Decreased BMD Measured by DXA: The OFELY Study
E. Sornay-Rendu (2007)
Sexual Dimorphism in Vertebral Fragility Is More the Result of Gender Differences in Age‐Related Bone Gain Than Bone Loss
Y. Duan (2001)
Ultrastructure of the osteocyte process and its pericellular matrix.
L. You (2004)
Mice lacking bone sialoprotein (BSP) lose bone after ovariectomy and display skeletal site-specific response to intermittent PTH treatment.
Ndéyé Marième Wade-Guéye (2010)
BMD at Multiple Sites and Risk of Fracture of Multiple Types: Long‐Term Results From the Study of Osteoporotic Fractures
K. Stone (2003)
Comparison Insight Bone Measurements by Histomorphometry and μCT
D. Chappard (2005)
Age‐Related Changes in Trabecular Architecture Differ in Female and Male C57BL/6J Mice
V. Glatt (2007)
Three-dimensional osseous micro-architecture of the distal humerus: implications for internal fixation of osteoporotic fracture.
S. Park (2010)
Age-related bone loss in the LOU/c rat model of healthy ageing
G. Duque (2009)
Tibial Stress Injuries
B. Beck (1998)
Histological assessment of osteoporosis by iliac crest biopsy.
J. Beck (1960)
A generalized procedure for predicting bone mass regulation by mechanical strain
M. Viceconti (2007)
Effects of chronic estrogen treatment on modulating age‐related bone loss in female mice
F. Syed (2010)
Age‐related variations in the microstructure of human tibial cancellous bone
M. Ding (2002)
Reduced Iliac Cancellous Osteocyte Density in Patients With Osteoporotic Vertebral Fracture
S. Qiu (2003)
Histomorphometric analysis of bone biopsies from the iliac crest of normal British subjects.
S. Vedi (1982)
Decline in osteocyte lacunar density in human cortical bone is associated with accumulation of microcracks with age.
D. Vashishth (2000)
Variations in strength of vertebrae with age and their relation to osteoporosis
G. H. Bell (2005)
Fluorescence‐aided detection of microdamage in compact bone
T. C. Lee (1998)
Age-related changes in trabecular bone microstructures: global and local morphometry
M. Stauber (2005)
An Aetiological Review for the Purposes of Guiding Management
B. Beck (1998)
Regional, age and gender differences in architectural measures of bone quality and their correlation to bone mechanical competence in the human radius of an elderly population.
Thomas L. Mueller (2009)
Region-Specific Sex-Dependent Pattern of Age-Related Changes of Proximal Femoral Cancellous Bone and Its Implications on Differential Bone Fragility
M. Djurić (2009)
Influence of age and sex steroids on bone density and geometry in middle-aged and elderly European men
K. A. Ward (2010)
Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study.
S. C. Schuit (2004)
The Biomechanical Basis of Vertebral Body Fragility in Men and Women
Y. Duan (2001)
Bone adaptation to load: microdamage as a stimulus for bone remodelling
T. C. Lee (2002)
Stereological measures of trabecular bone structure: comparison of 3D micro computed tomography with 2D histological sections in human proximal tibial bone biopsies
J. Thomsen (2005)
Toward a unifying theory of bone remodeling.
R. B. Martin (2000)
BoneJ: Free and extensible bone image analysis in ImageJ.
M. Doube (2010)
Sexual dimorphism and age dependence of osteocyte lacunar density for human vertebral cancellous bone.
D. Vashishth (2005)
The canalicular structure of compact bone in the rat at different ages.
Shigenori Okada (2002)
Age-Related Changes in Bone Structure and Strength in Female and Male BALB/c Mice
Mark D. Willinghamm (2010)
Spatial clustering of remodeling osteons in the femoral neck cortex: a cause of weakness in hip fracture?
G. R. Jordan (2000)
Micromechanical analyses of vertebral trabecular bone based on individual trabeculae segmentation of plates and rods.
X. Liu (2009)
Micro-Tomographic Atlas of the Mouse Skeleton
I. Bab (2007)
Estimation of bone permeability using accurate microstructural measurements.
T. Beno (2006)
Relationship Between Computed Tomographic Image Analysis and Histomorphometry for Microarchitectural Characterization of Human Calcaneus
B. Cortet (2004)
Pathologie tibiale et effort physique
J. Leonard (1999)
Trabecular bone structure and strength - remodelling and repair.
L. Mosekilde (2000)
Quantification of connectivity in cancellous bone, with special emphasis on 3-D reconstructions.
A. Odgaard (1993)
Age-dependent change in the 3D structure of cortical porosity at the human femoral midshaft.
D. M. Cooper (2007)
In vivo reproducibility of three‐dimensional structural properties of noninvasive bone biopsies using 3D‐pQCT
R. Mueller (1996)
Visualisation of three‐dimensional microcracks in compact bone
F. Obrien (2000)
Calibration of trabecular bone structure measurements of in vivo three-dimensional peripheral quantitative computed tomography with 28-microm-resolution microcomputed tomography.
A. Laib (1999)
New imaging technologies in the diagnosis of osteoporosis
G. Kazakia (2006)
Trabecular Bone Microarchitecture, Bone Mineral Density, and Vertebral Fractures in Male Osteoporosis
E. Legrand (2000)
This paper is referenced by
Association of volumetric bone mineral density with abdominal aortic calcification in African ancestry men
A. Kuipers (2013)
ff ects , outcome variables and methods of measurement for health claims proposed under Regulation ( EC ) 1924 / 2006 in the framework of bone health
D. Martinia (2017)
Transmission and scanning electron microscopy confirm that bone microstructure is similar in osteopenic and osteoporotic patients.
Orkun Gül (2013)
Optimizing Human Health Span and Life Span
D. Willcox (2013)
Modifiable risk factors in periodontitis: at the intersection of aging and disease.
M. Reynolds (2014)
An anatomical study of the entry point in the greater trochanter for intramedullary nailing.
K. Farhang (2014)
Age-related changes of sulcal imprints on the endocranium in the Japanese macaque (Macaca fuscata).
Nguyen Van Minh (2017)
Age-related changes in bone architecture.
V. Giordano (2016)
Twelve months of voluntary heavy alcohol consumption in male rhesus macaques suppresses intracortical bone remodeling.
Gino W. Gaddini (2015)
Efeitos do ácido zoledrônico na rede de canais, no sistema lacunocanalicular e nas propriedades biomecânicas do osso cortical
G. D. Rabelo (2012)
Claimed effects, outcome variables and methods of measurement for health claims proposed under Regulation (EC) 1924/2006 in the framework of bone health
D. Martini (2018)
Bone three-dimensional microstructural features of the common osteoporotic fracture sites.
H. Chen (2014)
The role of sclerostin and dickkopf-1 in oral tissues – A review from the perspective of the dental disciplines
M. Samiei (2019)
Zur Geschlechts- und Altersabhängigkeit der Ossifikation der Cartilago thyroidea
Luisa Clara Marie Hartrampf (2019)
Biological and cultural drivers of oral microbiota in Medieval and Post-Medieval London, UK
Andrew G. Farrer (2018)
Association of bone mineral density and trabecular bone score with cardiovascular disease
Tzyy-Ling Chuang (2020)
Erythropoietin directly stimulates osteoclast precursors and induces bone loss
Sahar Hiram-Bab (2015)
Age-Related Changes in Trabecular and Cortical Bone Microstructure
H. Chen (2013)
Wnt signaling regulates homeostasis of the periodontal ligament.
W. Lim (2014)
Bone status of adult female butyrylcholinesterase gene-deficient mice.
M. Haupt (2015)
Degeneration of the osteocyte network in the C 57 BL / 6 mouse model of
LeAnn M. Tiede-Lewis (2017)
High-impact exercise stimulated localised adaptation of microarchitecture across distal tibia in postmenopausal women
J. Du (2020)
Body mass prediction from femoral volume and sixteen other femoral variables in the elderly: BMI and adipose tissue effects.
T. Chevalier (2018)
Skeletal dynamics of down syndrome: A developing perspective.
Jonathan M. LaCombe (2019)
Intrinsic Sex‐Linked Variations in Osteogenic and Adipogenic Differentiation Potential of Bone Marrow Multipotent Stromal Cells
Beth Bragdon (2015)
The Methodological and Diagnostic Applications of Micro-CT to Palaeopathology: A Quantitative Study of Porotic Hyperostosis
J. A. Morgan (2014)
TBS Predict Coronary Artery Calcification in Adults
Tzyy-Ling Chuang (2016)
Wnt Signaling Regulates Pulp Volume and Dentin Thickness
W. H. Lim (2014)
Osteoporosis and Mechanisms of Skeletal Aging
J. Glowacki (2016)
Micro-CT analyses of historical bone samples presenting with osteomyelitis
C. Lamm (2015)
Age-related changes in bone architecture Alterações na estrutura óssea relacionadas à idade
V. Giordano (2016)
Osteocyte mechanotransduction: changes with age - a parametric finite element study
Teri L. Cline (2013)See more