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Biosynthesis, Characterization, And Evaluation Of The Cytotoxic Effects Of Biologically Synthesized Silver Nanoparticles From Cyperus Conglomeratus Root Extracts On Breast Cancer Cell Line MCF-7

Amani Ghassan Al-Nuairi, Kareem A. Mosa, M. G. Mohammad, A. El-Keblawy, S. Soliman, H. Alawadhi
Published 2019 · Medicine, Chemistry

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Over recent years, metal nanoparticles have largely been investigated due to their potential activities. This study focused on synthesizing silver nanoparticles (AgNPs) using the desert plant Cyperus conglomeratus, which is the most abundant species on the sand dunes in the UAE, and their anticancer activity. The synthesized AgNPs were characterized using UV-visible spectra, X-ray diffraction, energy dispersive X-ray spectroscopy, fourier transform infrared spectroscopy, dynamic light scattering, and scanning electron microscope. The results showed that the AgNPs are monodispersed and mostly spherical in shape. The cytotoxicity effects were investigated against breast cancer cells MCF-7 and normal fibroblast using MTT assay which showed selective cytotoxicity against MCF-7 with an IC50 at 5 μg/mL but not fibroblast. Moreover, the apoptotic effects were confirmed using annexin V-FITC-PI double staining kit and real-time PCR for apoptotic genes. Therefore, our results revealed potential anticancer applications of the C. conglomeratus biosynthesized silver nanoparticles.
This paper references
10.1016/j.msec.2015.04.038
Bio-synthesis of silver nanoparticles using Potentilla fulgens Wall. ex Hook. and its therapeutic evaluation as anticancer and antimicrobial agent.
A. Mittal (2015)
10.1039/C1GC15386B
Green synthesis of metal nanoparticles using plants
S. Iravani (2011)
10.7598/cst2014.815
Efficacy of Green Synthesis of Silver Nanoparticles using Flowers of Calendula Officinalis
J. Chidambaram (2014)
Dendrophthoe falcata (Lf) Ettingsh (Neem mistletoe): a potent bioresource to fabricate silver nanoparticles for anticancer effect against human breast cancer cells (MCF-7)
G Sathishkumar (2014)
Subapriya MS (2012) Green synthesis of silver nanoparticles
M Ramya (2012)
10.1016/j.jsps.2018.03.007
Anticandidal activity of the extract and compounds isolated from Cyperus conglomertus Rottb
Ghaferah H Al-Hazmi (2018)
10.1007/s12011-016-0666-7
In Vitro Anticancer Activity of Au, Ag Nanoparticles Synthesized Using Commelina nudiflora L. Aqueous Extract Against HCT-116 Colon Cancer Cells
P. Kuppusamy (2016)
10.3390/ijms17091534
Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches
Xi-Feng Zhang (2016)
10.1016/J.JPHOTOCHEM.2013.02.015
Green synthesis of silver nanoparticles using sunlight
G. A. Bhaduri (2013)
10.1016/j.saa.2012.09.042
Green synthesis of gold nanoparticles using Citrus fruits (Citrus limon, Citrus reticulata and Citrus sinensis) aqueous extract and its characterization.
M. V. Sujitha (2013)
10.1016/j.susmat.2017.08.001
Synthesis paradigm and applications of silver nanoparticles (AgNPs), a review
Hayelom Dargo Beyene (2017)
Qualitative phytochemical analysis of some selected medicinal plants occurring in local area of Faisalabad, Pakistan
F. Mumtaz (2014)
10.3892/mmr.2011.640
Differences in Yes-associated protein and mRNA levels in regenerating liver and hepatocellular carcinoma.
C. Wang (2012)
10.1155/2016/9204573
Green Synthesis of Silver Nanoparticles and Their Bactericidal and Antimycotic Activities against Oral Microbes
O. Rodríguez-Luis (2016)
Green synthesis of silver nanoparticles from seed extracts of Cyperus esculentus and Butyrospermum paradoxum
I. Ajayi (2015)
10.1007/s11356-017-9581-5
Bio-fabrication of silver nanoparticles using the leaf extract of an ancient herbal medicine, dandelion (Taraxacum officinale), evaluation of their antioxidant, anticancer potential, and antimicrobial activity against phytopathogens
R. Saratale (2017)
10.1016/j.saa.2009.02.037
Biosynthesis of Au, Ag and Au-Ag nanoparticles using edible mushroom extract.
D. Philip (2009)
Anticancer activity of the roots of Ichnocarpus frutescens R. Br. and isolated triterpenes.
N. Singh (2014)
10.1155/2013/535796
Cytotoxicity of Biologically Synthesized Silver Nanoparticles in MDA-MB-231 Human Breast Cancer Cells
S. Gurunathan (2013)
10.1016/j.ijbiomac.2016.08.086
Pectin mediated gold nanoparticles induces apoptosis in mammary adenocarcinoma cell lines.
K. Suganya (2016)
Green Synthesis of Silver Nanoparticles via Various Plant Extracts for Anti-Cancer Applications
J. Singh (2017)
10.1016/j.ejmech.2014.08.024
Biological activities of green silver nanoparticles synthesized with Acorous calamus rhizome extract.
Jayachandra Reddy Nakkala (2014)
10.1002/9780470661345.SMC195
Nanotechnology: The “Top‐Down” and “Bottom‐Up” Approaches
Parvez Iqbal (2012)
10.3844/AJBBSP.2017.1.6
Green Synthesis of Silver Nanoparticles using Mediterranean Cypress (Cupressus sempervirens) Leaf Extract
A. Ebrahiminezhad (2017)
10.1007/s13204-012-0121-9
Coleus aromaticus leaf extract mediated synthesis of silver nanoparticles and its bactericidal activity
M. Vanaja (2012)
10.1016/j.jsps.2018.05.015
Anticancer activity and concurrent analysis of ursolic acid, β-sitosterol and lupeol in three different Hibiscus species (aerial parts) by validated HPTLC method
P. Alam (2018)
10.1016/J.ARABJC.2017.05.011
Nanoparticles: Properties, applications and toxicities
I. Khan (2017)
10.15258/SST.2011.39.2.09
Interactive effects of salinity, light and temperature on seed germination of sand dunes glycophyte Cyprus conglomeratus growing in the United Arab Emirates deserts
A. E. Keblawy (2011)
10.1016/j.biortech.2010.05.051
Immobilization of silver nanoparticles synthesized using Curcuma longa tuber powder and extract on cotton cloth for bactericidal activity.
M. Sathishkumar (2010)
Antibacterial and Anticancer Activity of Silver Nanoparticles Synthesized from Cynodon dactylon Leaf Extract
S. Supraja (2015)
10.7324/japs.2018.8111
A Simple Biosynthesis of Silver Nanoparticles from Syzygium cumini Stem Bark Aqueous Extract and their Spectrochemical and Antimicrobial Studies
E. C. Sekhar (2018)
10.5897/AJB2005.000-3127
Phytochemical constituents of some Nigerian medicinal plants
H. O. Edeoga (2005)
10.1267/ahc.06005
Survivin as a Prognostic Factor for Osteosarcoma Patients
E. Osaka (2006)
10.1016/j.msec.2016.03.101
In-vitro anticancer activity of green synthesized silver nanoparticles on MCF-7 human breast cancer cells.
Suk Ju Jang (2016)
10.1161/JAHA.112.003855
Defects of mtDNA Replication Impaired Mitochondrial Biogenesis During Trypanosoma cruzi Infection in Human Cardiomyocytes and Chagasic Patients: The Role of Nrf1/2 and Antioxidant Response
Xianxiu Wan (2012)
10.5958/2322-0996.2017.00001.1
Green Synthesis of Silver Nanoparticles
Preeti Rajoriya (2017)
A (2012) Gold nanoparticles induce apoptosis in MCF-7 human breast cancer cells
M Selim (2012)
10.1038/nnano.2009.242
Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective.
M. Auffan (2009)
10.1088/2043-6254/AA690B
Synthesis and characterization of novel silver nanoparticles using Chamaemelum nobile extract for antibacterial application
H. Erjaee (2017)
10.1088/2043-6262/7/4/045009
Antibacterial and photocatalytic degradation efficacy of silver nanoparticles biosynthesized using Cordia dichotoma leaf extract
R. Kumari (2016)
2016) In vitro anticancer activity of Au, Ag nanoparticles synthesized using Commelina nudiflora L. aqueous extract against HCT-116 colon cancer cells
P Kuppusamy
10.1016/j.sjbs.2015.09.006
Green synthesis of silver nanoparticles using Andean blackberry fruit extract
B. Kumar (2017)
10.1016/j.msec.2015.08.022
Bark extract mediated green synthesis of silver nanoparticles: Evaluation of antimicrobial activity and antiproliferative response against osteosarcoma.
D. Nayak (2016)
10.1186/s11671-016-1511-9
Biosynthesis, Antibacterial Activity and Anticancer Effects Against Prostate Cancer (PC-3) Cells of Silver Nanoparticles Using Dimocarpus Longan Lour. Peel Extract
Y. He (2016)
10.1371/journal.pone.0116049
Evaluation of In Vitro Anticancer Activity of Ocimum Basilicum, Alhagi Maurorum, Calendula Officinalis and Their Parasite Cuscuta Campestris
M. Behbahani (2014)
10.5923/J.NN.20120204.06
Green Synthesis of Silver Nanoparticles byMulberry LeavesExtract
Akl M. Awwad (2012)
10.1155/2016/7274949
High Surface Area Ceria Nanoparticles via Hydrothermal Synthesis Experiment Design
S. Kurajica (2016)
Green , effective biological route for the synthesis of silver nanoparticles using Cyperus rotundus grass extracts
S Siva (2014)
10.18638/SCIECONF.2016.4.1.386
Green synthesis of silver nanoparticles using plant extracts
Ana-Alexandra Sorescu (2016)
10.1016/J.KIJOMS.2017.10.007
Plant-mediated synthesis of silver nanoparticles using fruit extract of Cleome viscosa L.: Assessment of their antibacterial and anticancer activity
G. Lakshmanan (2018)
10.3390/nano6090160
Biosynthesis of Silver Nanoparticles Using Taxus yunnanensis Callus and Their Antibacterial Activity and Cytotoxicity in Human Cancer Cells
Q. Xia (2016)
10.1038/s41598-018-32480-5
Apoptotic efficacy of multifaceted biosynthesized silver nanoparticles on human adenocarcinoma cells
Blassan Plackal Adimuriyil George (2018)
2016) Silver nanoparticles: synthesis, characterization, properties, applications, and therapeutic approaches
Zhang X-F (2016)
10.1557/JMR.2007.0308
A simple route for manufacturing highly dispersed silver nanoparticles
D. Andreescu (2007)
10.1080/21691401.2018.1430697
Green synthesis of silver nanoparticles using Artemisia turcomanica leaf extract and the study of anti-cancer effect and apoptosis induction on gastric cancer cell line (AGS)
B. Mousavi (2018)
10.1039/C4RA10626A
β-Sitosterol-D-glucopyranoside isolated from Desmostachya bipinnata mediates photoinduced rapid green synthesis of silver nanoparticles
Khan Behlol Ayaz Ahmed (2014)
10.7314/APJCP.2012.13.4.1617
Gold nanoparticles induce apoptosis in MCF-7 human breast cancer cells.
Manar E. Selim (2012)
10.2217/nnm.11.171
Nanoimmunotherapy: application of nanotechnology for sustained and targeted delivery of antigens to dendritic cells.
Z. Zhang (2012)
10.1016/j.saa.2014.02.096
Dendrophthoe falcata (L.f) Ettingsh (Neem mistletoe): a potent bioresource to fabricate silver nanoparticles for anticancer effect against human breast cancer cells (MCF-7).
Gnanasekar Sathishkumar (2014)
Nanotechnology: the “topdown” and “bottom-up” approaches. In: Supramolecular chemistry
P Iqbal (2012)
RS (2014) Green, effective biological route for the synthesis of silver nanoparticles using Cyperus rotundus grass extracts
S Siva (2014)
10.2147/IJN.S189295
Selective cytotoxicity of green synthesized silver nanoparticles against the MCF-7 tumor cell line and their enhanced antioxidant and antimicrobial properties
S. Khorrami (2018)
10.1016/j.jphotobiol.2017.07.003
Photo-catalytic, anti-bacterial, and anti-cancer properties of phyto-mediated synthesis of silver nanoparticles from Artemisia tournefortiana Rchb extract.
F. Baghbani-Arani (2017)
10.1111/J.1365-2125.2006.02720.X
New targets and challenges in the molecular therapeutics of cancer.
A. Eastman (2006)
Phytochemical analysis of selected medicinal plants of Margalla Hills and surroundings
A. M. Khan (2011)
10.1016/j.jdent.2014.07.007
The effects of LPS on adhesion and migration of human dental pulp stem cells in vitro.
Dongmei Li (2014)



This paper is referenced by
10.1007/s10876-020-01903-7
Biosynthesis and Chemical Characterization of Silver Nanoparticles Using Satureja Rechingeri Jamzad and Their Apoptotic Effects on AGS Gastric Cancer Cells
Roghayeh Shiripoure Ganjineh Ketab (2020)
10.1007/s12011-020-02394-3
Nanoparticles as Novel Emerging Therapeutic Antibacterial Agents in the Antibiotics Resistant Era.
F. Fatima (2020)
10.1007/s12011-019-01984-0
Rapid and Facile Microwave-Assisted Synthesis of Palladium Nanoparticles and Evaluation of Their Antioxidant Properties and Cytotoxic Effects Against Fibroblast-Like (HSkMC) and Human Lung Carcinoma (A549) Cell Lines
Atefeh Ameri (2019)
10.1371/journal.pone.0240156
Effective targeting of breast cancer cells (MCF7) via novel biogenic synthesis of gold nanoparticles using cancer-derived metabolites
S. Soliman (2020)
10.3390/nano9121716
Exogenous Production of Silver Nanoparticles by Tephrosia apollinea Living Plants under Drought Stress and Their Antimicrobial Activities
M. A. Ali (2019)
10.1007/s12649-020-01175-2
Effect of Probe Ultrasonication, Microwave and Sunlight on Biosynthesis, Bioactivity and Structural Morphology of Punica granatum Peel’s Polyphenols-Based Silver Nanoconjugates
Rimpi Foujdar (2020)
10.2147/IJN.S221021
Chitosan gold nanoparticles induce different ROS-dependent cell death modalities in leukemic cells
A. C. Martínez-Torres (2019)
10.1007/s12011-020-02188-7
Green Approach to Overcome the Resistance Pattern of Candida spp. Using Biosynthesized Silver Nanoparticles Fabricated by Penicillium chrysogenum F9
A. Z. Soliman (2020)
10.1016/j.jtemb.2020.126630
Anticancer potential of AgNPs synthesized using Acinetobacter sp. and Curcuma aromatica against HeLa cell lines: A comparative study.
S. Nadhe (2020)
10.1016/j.semcancer.2019.08.013
Nanomaterials multifunctional behavior for enlighten cancer therapeutics.
Seeta Rama Raju Ganji (2019)
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