← Back to Search
Selected Topics In The Pathology Of The Thyroid And Parathyroid Glands In Children And Adolescents
Published 2021 · Medicine
Save to my Library
Download via 🐼 PaperPanda Download via oaDOI Download via OAB Download via LibKey Download via Google Google ScholarAnalyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
The goals of this chapter in keeping with the overall general themes of this special edition will be (1) to highlight aspects of development of the thyroid and parathyroid glands with particular focus on the role and contribution of the neural crest (or not) and how this may impact on the pathology that is seen, (2) to emphasize those lesions particularly more commonly arising in the pediatric population that actually generate specimens that the surgical pathologist would encounter, and (3) highlight more in depth specific lesions associated with heritable syndromes or specific gene mutations since the heritable syndromes tends to manifest in the pediatric age group. In this light, the other interesting areas of pediatric thyroid disease including medical thyroid diseases, congenital hypothyroidism, anatomic variants and aberrations of development that lead to structural anomalies will not be emphasized here.
This paper references
Tumors of the parathyroid; a review of twenty-three cases.
B. K. Black (1950)
Tumors of the parathyroid. A review of twenty‐three cases
B. K. Black (1950)
Parathyroid carcinoma. A study of 70 cases
A. Schantz (1973)
The C cells (parafollicular cells) of the thyroid gland and medullary thyroid carcinoma. A review.
J. Hazard (1977)
JB Hazard (1977)
Parathyroid carcinoma in a child: unusual presentation with seizures.
T. O. Young (1984)
Cowden disease (multiple hamartoma syndrome).
D. Gardner (1990)
Parathyroid crisis of unusual features in a child
C. McHenry (1993)
Expression of the c-ret proto-oncogene during mouse embryogenesis.
V. Pachnis (1993)
V Pachnis (1993)
Atlas of the head and neck pathology
L. Lowry (1994)
Cx43 gap junction gene expression and gap junctional communication in mouse neural crest cells.
C. Lo (1997)
Thyroid Cancer in Patients with Familial Adenomatous Polyposis
N. Perrier (1998)
PTEN and inherited hamartoma-cancer syndromes
C. Eng (1998)
Parathyroid carcinoma in a child.
D. Meier (1999)
The spectrum of thyroid diseases in childhood and its evolution during transition to adulthood: Natural history, diagnosis, differential diagnosis and management
C. A. Koch (2001)
Public Use Database Data Standards and Data Dictionary
V Benard (2001)
Familial parathyroid carcinoma in a child
J. Hamill (2002)
Parathyroid carcinoma: A 22‐year experience
N. Busaidy (2004)
Telomerase expression and proliferative activity suggest a stem cell role for thyroid solid cell nests
A. Preto (2004)
Hoxa3 regulates the proliferation and differentiation of the third pharyngeal arch mesenchyme in mice
O. Chisaka (2004)
The Role of Hoxa3 Gene in Parathyroid Gland Organogenesis of the Mouse
Y. Kameda (2004)
Surgical treatment of ten cases of parathyroid carcinoma: Importance of an initial en bloc tumor resection
Y. Fujimoto (2005)
Follicular Cell-Derived Thyroid Cancer in Children
S. Leboulleux (2005)
Carney complex (CNC)
J. Bertherat (2006)
Surveillance for Early Detection of Aggressive Parathyroid Disease: Carcinoma and Atypical Adenoma in Familial Isolated Hyperparathyroidism Associated With a Germline HRPT2 Mutation
Thomas G Kelly (2006)
Multiple endocrine neoplasia type 1
F. Marini (2006)
Neural crest progenitors and stem cells.
E. Dupin (2007)
Expression of the Epithelial Marker E-Cadherin by Thyroid C Cells and Their Precursors During Murine Development
Y. Kameda (2007)
Mash1 regulates the development of C cells in mouse thyroid glands
Y. Kameda (2007)
Differentiated thyroid cancer in children and adults: same or distinct disease?
B. Jarzab (2007)
Differentiated thyroid cancer in children and adults: same or distinct disease? Hormones (Athens)
B Jarzab (2007)
B Jarzab (2007)
Mediastinal Parathyroid Carcinoma With Tumor Implants in a Child: A Unique Occurrence
A. Righi (2008)
Parathyroid carcinoma in a child: an unusual case of an ectopically located malignant parathyroid gland with tumor invading the thymus.
A. Fiedler (2009)
Selective Pathologies of the Head and Neck in Children: A Developmental Perspective
J. Ozolek (2009)
Diagnostic pathology and molecular genetics of the thyroid
Y. Nikiforov (2009)
Familial pediatric endocrine tumors.
Sarinda Millar (2011)
Inmunohistochemical Profile of Solid Cell Nest of Thyroid Gland
María José Ríos Moreno (2011)
The epidemiology of thyroid disease.
M. Vanderpump (2011)
Intrathyroidal parathyroid carcinoma in a pediatric patient
Alvaro A. Herrera-Hernandez (2011)
Development of thyroid gland and ultimobranchial body cyst is independent of p63
T. Ozaki (2011)
Familial pediatric endocrine tumors. Oncologist
S Millar (2011)
Multiple endocrine neoplasias type 2B and RET proto-oncogene
G. Martucciello (2012)
Multiple endocrine neoplasia type 1
R. Thakker (2012)
[Epidemiology of thyroid disease].
H. Shimura (2012)
Parafibromin immunohistochemical staining to differentiate parathyroid carcinoma from parathyroid adenoma
H. Kim (2012)
Thyroid Cancer in the Pediatric Population
Silva Frieda (2012)
Parathyroid carcinoma presenting as genu valgum.
M. Vinodh (2012)
Y Nikiforov (2012)
Central role of RET in thyroid cancer.
M. Santoro (2013)
Thyroid hormone and retinoic acid interact to regulate zebrafish craniofacial neural crest development.
Brenda L. Bohnsack (2013)
RE: Cowden syndrome and PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
M. Tan (2014)
CDC73 Intragenic Deletion in Familial Primary Hyperparathyroidism Associated With Parathyroid Carcinoma
E. Korpi-hyövälti (2014)
Tumors of the thyroid and parathyroid glands
J. Rosai (2014)
Parathyroid conditions in childhood.
J. Burke (2014)
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer
L. FrancisGary (2015)
Pictorial essay of developmental thyroid anomalies identified by Technetium thyroid scintigraphy
P. Subramanyam (2015)
Revising the embryonic origin of thyroid C cells in mice and humans
Ellen Johansson (2015)
Evaluation and management of the pediatric thyroid nodule.
J. Guille (2015)
Predictors of Malignancy in Children with Thyroid Nodules.
A. Mussa (2015)
Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma.
S. Wells (2015)
Ultrasonography of Various Thyroid Diseases in Children and Adolescents: A Pictorial Essay
H. Hong (2015)
Parathyroid Carcinoma in a 10 Years Old Female Child.
M. Rahman (2015)
PTEN hamartoma tumor syndrome.
J. Mester (2015)
nodules and differentiated thyroid cancer
M Santoro (2015)
MM Rahman (2015)
Somatic HRPT2 Mutation (Arg234X) of Parathyroid Carcinoma Associated with Slipped Capital Femoral Epiphysis: A First Case Report.
Sathit Niramitmahapanya (2016)
Cancer Stem Cells in the Thyroid
Y. Nagayama (2016)
Cellular and molecular events on the development of mammalian thyroid C cells
Y. Kameda (2016)
Shear wave elastography diagnosis of the diffuse sclerosing variant of papillary thyroid carcinoma: A case report.
Nianyu Xue (2016)
High endothelial venule-like vessels and lymphocyte recruitment in diffuse sclerosing variant of papillary thyroid carcinoma.
Shulin Low (2016)
Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors.
Y. Nikiforov (2016)
A germline mutation of HRPT2/CDC73 (70 G>T) in an adolescent female with parathyroid carcinoma: first case report and a review of the literature
Mónica Serrano-González (2016)
Cribriform-morular variant of papillary thyroid carcinoma at pediatric age - case report and review of the literature.
A. Brehar (2016)
On the Origin of Cells and Derivation of Thyroid Cancer: C Cell Story Revisited
M. Nilsson (2016)
Molecular Characterization of Sporadic Pediatric Thyroid Carcinoma with the DNA/RNA ThyroSeq v2 Next-Generation Sequencing Assay
J. Picarsic (2016)
Outcome of the Diffuse Sclerosing Variant of Papillary Thyroid Cancer: A Meta-Analysis.
P. Malandrino (2016)
Diffuse sclerosing variant of papillary thyroid carcinoma: major genetic alterations and prognostic implications
J. Joung (2016)
Ninety-four cases of encapsulated follicular variant of papillary thyroid carcinoma: A name change to Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features would help prevent overtreatment
L. Thompson (2016)
Pitukcheewanont P. A germline mutation of HRPT2/CDC73 (70 G>T) in an adolescent female with parathyroid carcinoma: first case report and a review of the literature
M Serrano-Gonzalez (2016)
AC Brehar (2016)
S Niramitmahapanya (2016)
Development of the thyroid gland
M. Nilsson (2017)
PTEN, DICER1, FH, and Their Associated Tumor Susceptibility Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood
K. Schultz (2017)
Correlation between BRAFV600E mutation and clinicopathological features in pediatric papillary thyroid carcinoma
J. Geng (2017)
LEF-1 is a Sensitive Marker of Cribriform Morular Variant of Papillary Thyroid Carcinoma
S. Mohindra (2017)
Cowden syndrome-associated germline succinate dehydrogenase complex subunit D (SDHD) variants cause PTEN-mediated down-regulation of autophagy in thyroid cancer cells
Wanfeng Yu (2017)
Tall cell and diffuse sclerosing variants of papillary thyroid cancer: outcome and predicting value of risk stratification methods
M. Russo (2017)
Hypercalcemic Disorders in Children
V. Stokes (2017)
C Cell and Follicular Epithelial Cell Precursor Lesions of the Thyroid.
T. Scognamiglio (2017)
Differentiated thyroid cancer in childhood: a literature update
O. Karapanou (2017)
Treatment of medullary thyroid carcinoma with apatinib
S. Cai (2017)
Recent advances in the biology and therapy of medullary thyroid carcinoma
B. Nelkin (2017)
Molecular correlates and rate of lymph node metastasis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features and invasive follicular variant papillary thyroid carcinoma: the impact of rigid criteria to distinguish non-invasive follicular thyroid neoplasm with papillary-lik
Uiju Cho (2017)
Systematic Review to Compare Urothelium Differentiation with Urethral Epithelium Differentiation in Fetal Development, as a Basis for Tissue Engineering of the Male Urethra.
P. de Graaf (2017)
WHO classification of tumours of endocrine organs
R. Lloyd (2017)
Correlation between BRAF (V600E) mutation and clinicopathological features in pediatric papillary thyroid carcinoma
J Geng (2017)
Correlation between BRAF (V600E) mutation and clinicopathological features in pediatric papillary thyroid carcinoma. Sci China Life Sci
J Geng (2017)
Cribriform-Morular Variant of Papillary Thyroid Carcinoma: Clinical and Pathological Features of 30 Cases
J. Akaishi (2018)
Aggressive cribriform‐morular variant of papillary thyroid carcinoma: Report of an unusual case with pulmonary metastasis displaying poorly differentiated features
Hiromi Tsuji (2018)
Hox genes in the pharyngeal region: how Hoxa3 controls early embryonic development of the pharyngeal organs.
J. Gordon (2018)
Genetic Disorders of Parathyroid Development and Function.
Rebecca J. Gordon (2018)
Considerations for total thyroidectomy in an adolescent with PTEN mutation
M. Tosur (2018)
Noninvasive follicular thyroid neoplasm with papillary‐like nuclear features in the pediatric age group
E. Rossi (2018)
Management Guidelines for Children With Thyroid Nodules and Differentiated Thyroid Cancer
G. Francis (2018)
Calcifications in Thyroid Tumors on Ultrasonography: Calcification Types and Relationship with Histopathological Type
Kaoru Kobayashi (2018)
Prognostic significance of cell-adhesion molecules in histological variants of papillary thyroid carcinoma.
E. Andriescu (2018)
Embryology of the Parathyroid Glands.
Kristen B Peissig (2018)
Multiple Endocrine Neoplasia Syndromes from Genetic and Epigenetic Perspectives
F. Khatami (2018)
PTEN Hamartoma Tumor Syndrome and Immune Dysregulation
Marc Eissing (2018)
Noninvasive encapsulated follicular variant of papillary thyroid carcinoma: Should it also be reclassified in children?
R. Mariani (2018)
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: a review for pathologists
R. Seethala (2018)
Survival of aggressive variants of papillary thyroid carcinoma in patients under 55 years old: a SEER population-based retrospective analysis
Jian-hua Feng (2018)
Maternal smoking and high BMI disrupt thyroid gland development
P. Filis (2018)
NPCR and SEER Incidence — U . S . Cancer Statistics 2001 – 2016 Public Use Database Data Standards and Data Dictionary
V Benard (2018)
EC Andriescu (2018)
Surgical Management of Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma. Experience in 25 Patients
C. Spinelli (2019)
Control of lung metastases and colon polyposis with lenvatinib therapy in a patient with cribriform-morular variant of papillary thyroid carcinoma and an APC gene mutation: a case study.
Yasuhiro Ito (2019)
Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features in Children: An Institutional Experience and Literature Review
Huiying Wang (2019)
Diagnosis and pathologic characteristics of medullary thyroid carcinoma-review of current guidelines.
C. M. Thomas (2019)
Aggressive variants of papillary thyroid microcarcinoma are associated with high-risk features, but not decreased survival.
Simon A Holoubek (2019)
Multifocality in a Patient with Cribriform-Morular Variant of Papillary Thyroid Carcinoma is an Important Clue for the Diagnosis of Familial Adenomatous Polyposis.
J. Chung (2019)
Trends in pediatric thyroid cancer incidence in the United States, 1998‐2013
M. Bernier (2019)
Pulmonary metastasis of cribriform‐morular variant of thyroid carcinoma mimicking primary adenocarcinoma of the lung: A potential pitfall
J. Laforga (2019)
Pediatric Thyroid Cancer Incidence and Mortality Trends in the United States, 1973-2013.
Z. J. Qian (2019)
PTEN Hamartoma Tumor Syndrome: A Clinical Overview
R. Pilarski (2019)
Case report of parathyroid carcinoma in a pediatric patient.
V. Zivaljevic (2019)
Cribriform-Morular Variant of Papillary Thyroid Carcinoma Shows High Ki-67 Labeling Indices, despite Its Excellent Prognosis
M. Hirokawa (2019)
A unique case of two somatic APC mutations in an early onset cribriform-morular variant of papillary thyroid carcinoma and overview of the literature
M. D. Aydemirli (2019)
Thyrotropin serum levels and coexistence with Hashimoto’s thyroiditis as predictors of malignancy in children with thyroid nodules
G. Zirilli (2019)
Incidence and malignancy rates of indeterminate pediatric thyroid nodules
Huiying Wang (2019)
Familial Adenomatous Polyposis Syndrome: An Update and Review of Extraintestinal Manifestations.
P. Dinarvand (2019)
PTEN Hamartoma Tumor Syndrome and Immune Dysregulation123
Marc Eissing (2019)
Thyroid Cancer in the Pediatric Population
Vera A Paulson (2019)
Does Aggressive Variant Histology Without Invasive Features Predict Overall Survival in Papillary Thyroid Cancer?
J. Limberg (2019)
Current Knowledge of Germline Genetic Risk Factors for the Development of Non-Medullary Thyroid Cancer
Kinga Hińcza (2019)
Comparison of pediatric and adult medullary thyroid carcinoma based on SEER program
Zhuang Zhao (2020)
Thyroid carcinomas that occur in familial adenomatous polyposis patients recurrently harbor somatic variants in APC, BRAF, and KTM2D.
T. Nieminen (2020)
carcinomas that occur in familial adenomatous polyposis patients recurrently harbor somatic variants in APC , BRAF , and KTM 2 D
TT Nieminen (2020)
Management guidelines for children with
Cowden Disease (Multiple Hamartoma Syndrome). StatPearls. Treasure Island (FL)
Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations