Association Of Proton Pump Inhibitor Use With Recurrent Falls And Risk Of Fractures In Older Women: A Study Of Medication Use In Older Fallers.
Heinrich Wolfgang Thaler, Carolyn Shanty Sterke, Tischa J. M. van der Cammen
Published 2016 · Medicine
Download PDFAnalyze on Scholarcy
OBJECTIVES To examine the association between Proton pump inhibitors (PPIs) use and falls and fractures. DESIGN A cross-sectional study. SETTING AND PARTICIPANTS 400 female patients aged 70 years or older who were consecutively admitted to the Trauma Center Meidling, Vienna, after a fall and who required hospital admission. METHODS We quantified the strength of the associations between PPI use and falls, and between PPI use and fractures, using a logistic regression. RESULTS use of PPIs was significantly associated with risk of recurrent falls (OR 1.92, 95% CI = 1.05 - 3.50, p = 0.04) as well as with risk of a fracture (OR 2.15, 95% CI 1.10 - 4.21, p = 0.03). CONCLUSIONS In conclusion, our results provide further evidence that PPI use may increase risk of falls and fractures in older women and highlight the need for clinicians to reassess the original indication and the need for continuation of PPIs on a regular basis.
This paper references
The prevention of falls in later life. A report of the Kellogg International Work Group on the Prevention of Falls by the Elderly.
Drugs and falls in older people: a systematic review and meta-analysis: II. Cardiac and analgesic drugs.
Rosanne M. Leipzig (1999)
Rapid increase in hospitalizations resulting from fall-related traumatic head injury in older adults in The Netherlands 1986-2008.
K. Hartholt (2011)
Proton-pump inhibitor use is not associated with osteoporosis or accelerated bone mineral density loss.
L. Targownik (2010)
Meta-analysis: risk of fractures with acid-suppressing medication.
Chun Shing Kwok (2011)
Trends in fall-related hospital admissions in older persons in the Netherlands.
K. Hartholt (2010)
Severe hypomagnesaemia in long-term users of proton-pump inhibitors.
T. F. Cundy (2008)
Antihypertensive medications and serious fall injuries in a nationally representative sample of older adults.
Mary Tinetti (2014)
Long-term proton pump inhibitor therapy and risk of hip fracture.
Yu-Xiao Yang (2006)
Interventions for preventing falls in older people living in the community.
Lesley Diane Gillespie (2012)
Proton pump inhibitors and risk of fractures: a meta-analysis of 11 international studies.
Elaine W. Yu (2011)
Proton pump inhibitor use, hip fracture, and change in bone mineral density in postmenopausal women: results from the Women's Health Initiative.
S. Gray (2010)
Guideline for the Prevention of Falls in Older Persons
Orthopaedic Surgeons Panel On Falls Prevention (2001)
Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs.
Rosanne M. Leipzig (1999)
Severe hypomagnesemia during long-term treatment with a proton pump inhibitor.
Giuseppe Regolisti (2010)
What Works Better for Community-Dwelling Older People at Risk to Fall?
Eleni Th Petridou (2009)
Association between use of benzodiazepines and risk of fractures: a meta-analysis
Dan Xing (2013)
Different Risk-Increasing Drugs in Recurrent versus Single Fallers: Are Recurrent Fallers a Distinct Population?
Marjan Askari (2013)
Impact near the hip dominates fracture risk in elderly nursing home residents who fall
W. Hayes (2004)
Hypomagnesaemia due to use of proton pump inhibitors--a review.
Kuipers Mt (2009)
Majority of Hip Fractures Occur as a Result of a Fall and Impact on the Greater Trochanter of the Femur: A Prospective Controlled Hip Fracture Study with 206 Consecutive Patients
J. Parkkari (1999)
Fall-risk screening test: a prospective study on predictors for falls in community-dwelling elderly.
A. M. Tromp (2001)
Selective Serotonin Reuptake Inhibiting Antidepressants Are Associated With an Increased Risk of Nonvertebral Fractures
G. Ziere (2008)
Meta-analysis of the impact of 9 medication classes on falls in elderly persons.
John C. Woolcott (2009)
Proton pump inhibitors and functional decline in older adults discharged from acute care hospitals.
Andrea Corsonello (2014)
Long-term proton pump inhibitor therapy and falls and fractures in elderly women: a prospective cohort study.
Joshua R. Lewis (2014)
Recent safety concerns with proton pump inhibitors.
Joan Chen (2012)
Fracture risk in nursing home residents initiating antipsychotic medications.
Sally K. Rigler (2013)
This paper is referenced by
Adverse bone effects of medications used to treat non-skeletal disorders
Nelson B. Watts (2017)
A Closer Look at the 2015 Beers Criteria
Rebecca L. Salbu (2017)
Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger–Ellison Syndrome
Lingaku Lee (2019)
Adverse Effects of Proton Pump Inhibitors—Evidence and Plausibility
R. Fossmark (2019)
Fractures in postmenopausal women. Background factors and fracture risk assessment.
L Moberg (2016)
Proton pump inhibitors and fracture: they impair bone quality and increase fall risk?
Toshihiro Sugiyama (2016)
Proton Pump Inhibitors and the Risk for Fracture at Specific Sites: Data Mining of the FDA Adverse Event Reporting System
Liwei Wang (2017)
Injuries Sustained by Falls - A Review
Hans Granhed (2017)
The impact of proton pump inhibitors on bone regeneration and implant osseointegration
Alexandru Mester (2019)
Potentially inappropriate medications in hospitalized older patients: a cross-sectional study using the Beers 2015 criteria versus the 2012 criteria
Xiaolin Zhang (2017)
Risk of fall in patients taking proton pump inhibitors: a meta-analysis
K. Lapumnuaypol (2019)
Prevalence of potentially inappropriate medications in older adults in Argentina using Beers criteria and the IFAsPIAM List
Luciana C Chiapella (2019)
Psychotropic Medications and Proton Pump Inhibitors and the Risk of Fractures in the Teriparatide versus Risedronate VERO Clinical Trial.
D. Kendler (2019)
Proton pump inhibitors therapy and risk of bone diseases: An update meta‐analysis
J. Liu (2019)
Proton pump inhibitors and osteoporosis
Bjarne Nesgaard Andersen (2016)
Medications as a Risk Factor for Fragility Hip Fractures: A Systematic Review and Meta-analysis
Sharri Junadi Mortensen (2020)