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Association Of Proton Pump Inhibitor Use With Recurrent Falls And Risk Of Fractures In Older Women: A Study Of Medication Use In Older Fallers.

Heinrich Wolfgang Thaler, Carolyn Shanty Sterke, Tischa J. M. van der Cammen
Published 2016 · Medicine
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OBJECTIVES To examine the association between Proton pump inhibitors (PPIs) use and falls and fractures. DESIGN A cross-sectional study. SETTING AND PARTICIPANTS 400 female patients aged 70 years or older who were consecutively admitted to the Trauma Center Meidling, Vienna, after a fall and who required hospital admission. METHODS We quantified the strength of the associations between PPI use and falls, and between PPI use and fractures, using a logistic regression. RESULTS use of PPIs was significantly associated with risk of recurrent falls (OR 1.92, 95% CI = 1.05 - 3.50, p = 0.04) as well as with risk of a fracture (OR 2.15, 95% CI 1.10 - 4.21, p = 0.03). CONCLUSIONS In conclusion, our results provide further evidence that PPI use may increase risk of falls and fractures in older women and highlight the need for clinicians to reassess the original indication and the need for continuation of PPIs on a regular basis.
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