Prognostic Value Of Metabolic Tumor Volume Measured By 18F-FDG PET/CT In Locally Advanced Head And Neck Squamous Cell Carcinomas Treated By Surgery
Kyu-Ho Choi, Ie Ryung Yoo, Eun Ji Han, Yeon Sil Kim, Gi Won Kim, Sae Jung Na, Dong-Il Sun, So Lyung Jung, Chan-Kwon Jung, M. Kim, So-Yeon Lee, Sung Hoon Kim
Published 2011 · Medicine
Download PDFAnalyze on Scholarcy
PurposeWe assessed the prognostic value of metabolic tumor volume (MTV) measured using18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) inpatients with locally advanced head and neck squamous cell carcinoma (HNSCC).MethodsWe retrospectively reviewed 56 patients (51 men, five women; mean age 56.0 ± 8.8years) who had locally advanced HNSCC and underwent FDG PET/CT for initial evaluation. All patients had surgical resection and radiotherapy with or without concurrent chemotherapy. The peak standardized uptake value (SUVpeak) and MTV of the target lesion, including primary HNSCC andmetastatic cervical lymph nodes, were measured from FDG PET/CT images. We compared SUVpeak, MTV, and clinicopathologic variables such as age, Eastern Cooperative Oncology Group (ECOG) performance status, pN stage, pT stage, TNM stage, histologic grade and treatment modality to disease-free survival (DFS) and overall survival (OS).ResultsOn the initial FDG PET/CT scans, the median SUVpeak was 7.8 (range, 1.8-19.0) and MTV was17.0 cm3 (range, 0.1-131.0 cm3). The estimated 2-year DFS and OS rates were 67.2% and 81.8%. The cutoff points of SUVpeak 6.2 and MTV 20.7 cm3 were the best discriminative values for predicting clinical outcome. MTV and ECOG performance status were significantly related to DFS and OS on univariate and multivariate analyses (p < 0.05).ConclusionThe MTV obtained from initial FDG PET/CT scan is a significant prognostic factor for disease recurrence and mortality in locally advanced HNSCC treated with surgery and radiotherapy with or without chemotherapy.
This paper references
[Fluorine-18]Fluorodeoxyglucose Positron Emission Tomography, DNA Ploidy and Growth Fraction in Squamous-Cell Carcinomas of the Head and Neck
Roland Jacob (2001)
Measurement of tumor volume by PET to evaluate prognosis in patients with head and neck cancer treated by chemo-radiation therapy
Young Mi Seol (2010)
Squamous cell carcinomas of the head and neck.
Richard J. Sanderson (2002)
Standardized uptake value of 2-[(18)F] fluoro-2-deoxy-D-glucose in predicting outcome in head and neck carcinomas treated by radiotherapy with or without chemotherapy.
Abdelkarim Said Allal (2002)
Maximally selected x2 statistics for small samples
J. Halpern (1982)
( NSCLC )
R Miller (2007)
Prognostic value of 18F-FDG PET in patients with head and neck squamous cell cancer.
Tatsuo Torizuka (2009)
Influence of the delay of adjuvant postoperative radiation therapy on relapse and survival in oropharyngeal and hypopharyngeal cancers.
Laurent Bastit (2001)
Prediction of outcome in head-and-neck cancer patients using the standardized uptake value of 2-[18F]fluoro-2-deoxy-D-glucose.
Abdelkarim Said Allal (2004)
Prognostic factors of survival in head and neck cancer patients treated with surgery and postoperative radiation therapy
>Christophe Le Tourneau (2008)
Maximally Selected Chi Square Statistics for Small Samples
Jerry Halpern (1982)
Fluorodeoxyglucose–Positron-Emission Tomography Imaging of Head and Neck Squamous Cell Cancer
Rathan Subramaniam (2010)
Maximally Selected Chi Square Statistics
Rupert G. Miller (1982)
Prognostic factors in head-and-neck cancer patients treated with surgery followed by intensity-modulated radiotherapy (IMRT), 3D-conformal radiotherapy, or conventional radiotherapy.
Dirk Rades (2007)
2-[18F]-Fluoro-2-deoxy-D-glucose positron emission tomography as guidance for primary treatment in patients with advanced-stage resectable squamous cell carcinoma of the larynx and hypopharynx.
Jong Lyel Roh (2007)
Cancer of the Lung
IanP. Todd (1953)
Comparison of different methods for delineation of 18F-FDG PET-positive tissue for target volume definition in radiotherapy of patients with non-Small cell lung cancer.
Ursula Nestle (2005)
Prognostic impact of tumor volumetry in patients with locally advanced head-and-neck carcinoma (non-nasopharyngeal) treated by radiotherapy alone or combined radiochemotherapy in a randomized trial.
Georgios Plataniotis (2004)
Clinical outcomes of patients receiving integrated PET/CT-guided radiotherapy for head and neck carcinoma.
Matthew R. Vernon (2008)
Serial positron emission tomography scans following radiation therapy of patients with head and neck cancer.
Kathryn McConnell Greven (2001)
Current status of PET/CT for tumour volume definition in radiotherapy treatment planning for non-small cell lung cancer (NSCLC).
Carlo Greco (2007)
Metabolic tumor volume predicts for recurrence and death in head-and-neck cancer.
Trang H. La (2009)
The effect of primary tumor volumes in advanced T-staged nasopharyngeal tumors.
Cheng-Chuan Chang (2002)
Intensity-modulated radiation therapy for oropharyngeal carcinoma: impact of tumor volume.
K S Clifford Chao (2004)
Maximally Selected x2 Statistics for k× 2 Tables
Rebecca A. Betensky (1999)
Clinical Applications of FDG PET and PET/CT in Head and Neck Cancer
Akram Al-Ibraheem (2009)
Prediction of survival with fluorine-18-fluoro-deoxyglucose and PET in head and neck cancer.
Heikki Minn (1997)
Florodeoxyglucose imaging: A method to assess the proliferative activity of human cancer in vivo. Comparison with DNA flow cytometry in head and neck tumors
Heikki Minn (1988)
Time factor in postoperative radiotherapy: a multivariate locoregional control analysis in 868 patients.
Rafal Suwinski (2003)
FDG-PET/CT imaging for preradiotherapy staging of head-and-neck squamous cell carcinoma.
David L. Schwartz (2005)
Fluorodeoxyglucose imaging: a method to assess the proliferative activity of human cancer in vivo. Comparison with DNA flow cytometry in head and neck tumors.
Heikki Minn (1988)
Postoperative radiotherapy in squamous cell carcinoma of the oral cavity: the importance of the overall treatment time.
Johannes A. Langendijk (2003)
Clinical applications of tumor volume measurements for predicting outcome in patients with squamous cell carcinoma of the upper aerodigestive tract.
Suresh K. Mukherji (2004)
Cancer : Principles and Practice of Oncology
Vincent T. Devita (1982)
Tumor volume in pharyngolaryngeal squamous cell carcinoma: comparison at CT, MR imaging, and FDG PET and validation with surgical specimen.
Jean-François Daisne (2004)
In vitro comparison of cell proliferation kinetics and uptake of tritiated fluorodeoxyglucose and L-methionine in squamous-cell carcinoma of the head and neck.
Heikki Minn (1995)
Preradiotherapy computed tomography as a predictor of local control in supraglottic carcinoma.
Anthony A. Mancuso (1999)
Metabolic Tumor Volume of [18F]-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Predicts Short-Term Outcome to Radiotherapy With or Without Chemotherapy in Pharyngeal Cancer
Man Ki Chung (2009)
Anemia is associated with decreased survival and increased locoregional failure in patients with locally advanced head and neck carcinoma: a secondary analysis of RTOG 85-27.
William Robert Lee (1998)
in vivo . Comparison with DNA flow cytometry in head and neck tumors
R Jacob (1988)
Primary Tumor Volume of Nasopharyngeal Carcinoma: Significance for Recurrence and Survival
Sau-Tung Chu (2008)
Comparison of fluorine-18-fluorodeoxyglucose PET, MRI and endoscopy for staging head and neck squamous-cell carcinomas.
Christian Laubenbacher (1995)
The integration of 18-fluoro-deoxy-glucose positron emission tomography and endoscopic ultrasound in the treatment-planning process for esophageal carcinoma.
Andre A. Konski (2005)
Tumor Volume as Outcome Predictor in Chemoradiation for Advanced Head and Neck Cancer
J. Knegjens (2007)
Correlation between MR imaging-derived nasopharyngeal carcinoma tumor volume and TNM system.
Vincent F.H. Chong (2006)
Tumor volume as prognostic factor in chemoradiation for advanced head and neck cancer.
Joost L Knegjens (2011)
This paper is referenced by
Prognostic Significance of Volume-based Metabolic Parameters by 18F-FDG PET/CT in Gallbladder Carcinoma
Jang Hak Yoo (2012)
Metabolic Tumor Volume Measured by F-18 FDG PET/CT can Further Stratify the Prognosis of Patients with Stage IV Non-Small Cell Lung Cancer
Su Woong Yoo (2012)
Correlation of Choline/Creatine and Apparent Diffusion Coefficient values with the prognostic parameters of Head and Neck Squamous Cell Carcinoma.
Ahmed Aka Razek (2016)
Metabolic response evaluated by 18F-FDG PET/CT as a potential screening tool in identifying a subgroup of patients with advanced non-small cell lung cancer for immediate maintenance therapy after first-line chemotherapy
Seung Hwan Moon (2013)
Volume-Based Parameters of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Improve Outcome Prediction in Early-Stage Non–Small Cell Lung Cancer After Surgical Resection
Seung Hyup Hyun (2013)
Prognostic Value of Volume-Based Metabolic Parameters Measured by 18F-FDG PET/CT of Pancreatic Neuroendocrine Tumors
Ho Seong Kim (2014)
Prognostic Significance of Volume-Based PET Parameters in Cancer Patients
Seung Hwan Moon (2013)
Prognostic value of 18F-FDG PET/CT functional parameters in patients with head and neck cancer: a meta-analysis
Lihong Wang (2019)
Prognostic Value of Volume-Based 18F-Fluorodeoxyglucose PET/CT Parameters in Patients with Clinically Node-Negative Oral Tongue Squamous Cell Carcinoma
Su Jin Lee (2012)
Prognostic evaluation of percentage variation of metabolic tumor burden calculated by dual-phase (18) FDG PET-CT imaging in patients with head and neck cancer.
Ronan Abgral (2016)
Prognostic Value of Metabolic Tumor Volume Measured by 18F-FDG PET/CT in Esophageal Cancer Patients
Çiğdem Soydal (2014)
Prognostic Significance of Volume-Based Metabolic Parameters in Uterine Cervical Cancer Determined Using 18F-Fluorodeoxyglucose Positron Emission Tomography
Jang Hak Yoo (2012)
Total lesion glycolysis: a possible new prognostic parameter in oral cavity squamous cell carcinoma.
Yasser G Abd El-Hafez (2013)
Prognostic value of volumetric metabolic parameters measured by [18F]Fluorodeoxyglucose-positron emission tomography/computed tomography in patients with small cell lung cancer
Soo Bin Park (2014)
Prognostic effects of the metabolic tumor volume and total lesion glycolysis in patients with advanced squamous cell carcinoma of head and neck
He-Yuan Hsieh (2018)
Management of the Neck in Oral Cavity Cancer
Robert A. Ord (2017)
Evaluation of the Prognostic Value of FDG PET/CT Parameters for Patients With Surgically Treated Head and Neck Cancer: A Systematic Review.
Gwenaelle Creff (2020)
Prognostic value of simultaneous 18F-FDG PET/MRI using a combination of metabolo-volumetric parameters and apparent diffusion coefficient in treated head and neck cancer
Yong-Il Kim (2018)
The role of PET/CT in the management of patients affected by head and neck tumors: a review of the literature
Giovanni Cammaroto (2015)
Prognostic Value of Volume-Based Positron Emission Tomography/Computed Tomography in Patients With Nasopharyngeal Carcinoma Treated With Concurrent Chemoradiotherapy
Seung Hwan Moon (2015)
18F-fludrodeoxyglucose maximal standardized uptake value and metabolic tumor burden are associated with major chemotherapy-related tumor markers in NSCLC patients
Lu Bai (2016)
A review of the predictive role of functional imaging in patients with mucosal primary head and neck cancer treated with radiation therapy
Myo Min (2017)
Role of Pre -Treatment FDG PET Quantitative Parameters in Prognostication of Head and Neck Squamous Cell Carcinoma-A Review
Narayana Subramaniam (2017)
Pretreatment F-18 FDG PET/CT Parameters to Evaluate Progression-Free Survival in Gastric Cancer
Jeonghun Kim (2013)
Organ Preservation Protocols in T4 Laryngeal Cancer: a Review of the Literature
Narayana Subramaniam (2018)
Prognostic value of volumetric parameters measured by 18F-FDG PET/CT in patients with head and neck squamous cell carcinoma
Ronan Abgral (2013)
Usefulness of Combined Metabolic–Volumetric Indices of 18F-FDG PET/CT for the Early Prediction of Neoadjuvant Chemotherapy Outcomes in Breast Cancer
Hyung-Jun Im (2012)
Pretreatment metabolic tumor volume as a prognostic factor in HPV‐associated oropharyngeal cancer in the context of AJCC 8th edition staging
John M Floberg (2018)
[The role of 18F-fluorodeoxyglucose positron emission tomography as a prognostic indicator for bile duct and gallbladder cancer: need for a prospective study using various quantitative parameters].
Jae Seon Eo (2013)
Hypoxic volume evaluated by 18F-fluoromisonidazole positron emission tomography (FMISO-PET) may be a prognostic factor in patients with oral squamous cell carcinoma: preliminary analyses.
Jun Sato (2018)
Role of pretreatment fluorodeoxyglucose positron emission tomography quantitative parameters in prognostication of head-and-neck squamous cell carcinoma
Narayana Subramaniam (2019)
Prognostic significance of the intratumoral heterogeneity of (18) F-FDG uptake in oral cavity cancer.
Soo Hyun Kwon (2014)See more