Online citations, reference lists, and bibliographies.

Prognostic Value Of 18F-FDG PET Metabolic Parameters In Oropharyngeal Squamous Cell Carcinoma

Adam A. Garsa, Albert J. Chang, Todd A DeWees, Christopher R. Spencer, Douglas R. Adkins, Farrokh Dehdashti, Hiram A. Gay, Wade L. Thorstad
Published 2012 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
ObjectiveTo evaluate whether pretreatment metabolic parameters obtained from positron emission tomography (PET) with [18F]fluorodeoxyglucose (FDG) can improve risk prediction for patients with oropharyngeal squamous cell carcinoma (OPSCC) treated with definitive intensity-modulated radiation therapy (IMRT).MethodsBetween 2003 and 2009, 86 patients with OPSCC had FDG-PET/CT prior to treatment with definitive IMRT. Chemotherapy was administered to 90 % of the patients. Metabolic tumor volume (MTV), total lesion glycolysis (TLG), maximum standardized uptake value (SUVmax), mean SUV (SUVmean), and inverse coefficient of variation (1/CoV) were analyzed for the primary tumor alone and the total of the primary tumor and involved lymph nodes.ResultsMedian follow-up time for surviving patients was 41 months. On univariate analysis, total MTV and total TLG were significant predictors of disease-free survival (DFS) and overall survival (OS). SUVmax, SUVmean, and 1/CoV failed to predict DFS or OS. On multivariate analysis controlling for T- and N-classification, total MTV remained a significant predictor of DFS and OS. The optimal cutpoint for total MTV was 20.5 ml. A total MTV >20.5 ml was associated with a 4.13-fold increased risk of death (95 % confidence interval [CI], 2.12–8.05; p < 0.0001). Total MTV remained a significant predictor of DFS and OS for the subgroups with p16-positive (n = 25) and p16-negative (n =18) cancer.ConclusionTotal MTV is an independent predictor of DFS and OS for patients with OPSCC treated with definitive radiotherapy. Total MTV remained predictive of DFS and OS for both p16-positive and p16-negative cancer.
This paper references
Analysis of pretreatment FDG-PET SUV parameters in head-and-neck cancer: tumor SUVmean has superior prognostic value.
Kristin Higgins (2012)
Finding Optimal Cutpoints for Continuous Covariates with Binary and Time-to-Event Outcomes
Brent A. Williams (2006)
Variability of gross tumor volume delineation in head-and-neck cancer using CT and PET/CT fusion.
Adam C. Riegel (2005)
The influence of HPV-associated p16-expression on accelerated fractionated radiotherapy in head and neck cancer: evaluation of the randomised DAHANCA 6&7 trial.
Pernille Lassen (2011)
Prognostic value of 18F-FDG PET/CT in patients with squamous cell carcinoma of the tonsil: comparisons of volume-based metabolic parameters.
Seung Hwan Moon (2013)
Is PET-based treatment planning the new standard in modern radiotherapy? The head and neck paradigm.
Vincent Grégoire (2006)
Tumor Treatment Response Based on Visual and Quantitative Changes in Global Tumor Glycolysis Using PET-FDG Imaging. The Visual Response Score and the Change in Total Lesion Glycolysis.
Steven M. Larson (1999)
Measurement of tumor volume by PET to evaluate prognosis in patients with head and neck cancer treated by chemo-radiation therapy
Young Mi Seol (2010)
Spatial Heterogeneity in Sarcoma 18F-FDG Uptake as a Predictor of Patient Outcome
Betty Jean Manaster (2010)
Comparison of five segmentation tools for 18F-fluoro-deoxy-glucose-positron emission tomography-based target volume definition in head and neck cancer.
Dominic A. X. Schinagl (2007)
Evaluation of a cumulative SUV-volume histogram method for parameterizing heterogeneous intratumoural FDG uptake in non-small cell lung cancer PET studies
Floris H P van Velden (2011)
Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial.
Marshall R. Posner (2011)
Validation that metabolic tumor volume predicts outcome in head-and-neck cancer.
Chad Tang (2012)
Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer
James A. Stockman (2012)
Metabolic Tumor Volume of [18F]-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Predicts Short-Term Outcome to Radiotherapy With or Without Chemotherapy in Pharyngeal Cancer
Man Ki Chung (2009)
FDG-PET prediction of head and neck squamous cell cancer outcomes.
David L. Schwartz (2004)
FDG-PET staging and importance of lymph node SUV in head and neck cancer
Gregory J Kubicek (2010)
Intratumoral Metabolic Heterogeneity of Cervical Cancer
Elizabeth A Kidd (2008)
Radiation treatment planning with an integrated positron emission and computer tomography (PET/CT): a feasibility study.
I. Frank Ciernik (2003)
Metabolic tumor volume predicts for recurrence and death in head-and-neck cancer.
Trang H. La (2008)
Spatial Heterogeneity in Sarcoma 18F-FDG Uptake as a Predictor of Patient Outcome
Janet F Eary (2008)

This paper is referenced by
Multimodal imaging analysis of an orthotopic head and neck cancer mouse model and application of anti-CD137 tumor immune therapy.
Anne-Kristin Vahle (2016)
Predictive modeling of outcomes following definitive chemoradiotherapy for oropharyngeal cancer based on FDG-PET image characteristics.
Michael R. Folkert (2017)
nab-Paclitaxel-based induction chemotherapy followed by cisplatin and radiation therapy for human papillomavirus-unrelated head and neck squamous-cell carcinoma
Kai C. C. Johnson (2019)
Prognostic Value of 18F-FDG PET/CT Metabolic Parameters in Metastatic Differentiated Thyroid Cancers
Soizic Masson-Deshayes (2015)
The prognostic role of 18F-fluorodeoxyglucose PET in head and neck cancer depends on HPV status.
Jon M Moan (2019)
18F-FDG PET-CT performed before and during radiation therapy of head and neck squamous cell carcinoma: Are they independent or complementary to each other?
Myo Min (2016)
Interaction of quantitative (18)F-FDG-PET-CT imaging parameters and human papillomavirus status in oropharyngeal squamous cell carcinoma.
Charlotte S. Schouten (2016)
18F-FDG PET/CT as a semiquantitative imaging marker in HPV-p16-positive oropharyngeal squamous cell cancers
Yu-Ting Huang (2015)
Outcomes and Predictive Value of Post-adjuvant Therapy PET/CT for Locally Advanced Oral Squamous Cell Carcinoma.
David C. Qian (2020)
Prognostic value of maximum standardized uptake value measured by pretreatment 18F-FDG PET/CT in locally advanced head and neck squamous cell carcinoma
Jon Cacicedo (2017)
18-F-FDG as a Semi-quantitative Imaging Marker in HPV-p 16 positive Oral Cavity and Oropharyngeal Squamous Cell Cancer
Y.-T. Huang (2013)
PET-based radiation therapy planning.
Christina K. Speirs (2015)
The Prognostic Value of Baseline 18F-FDG PET/CT in Human Papillomavirus–Positive Versus Human Papillomavirus–Negative Patients With Oropharyngeal Cancer
Zeno A. R. Gouw (2019)
Pretreatment metabolic tumor volume as a prognostic factor in HPV‐associated oropharyngeal cancer in the context of AJCC 8th edition staging
John M Floberg (2018)
Prognostic value of volumetric FDG PET/CT parameters in patients with oral tongue squamous cell carcinoma who were treated by superselective intra-arterial chemoradiotherapy
Satoko Suzuki-Shibata (2017)
Use of 18F-Fludeoxyglucose-Positron Emission Tomography/Computed Tomography for Patient Management and Outcome in Oropharyngeal Squamous Cell Carcinoma: A Review.
Mehdi Taghipour (2016)
How Effective Are Noninvasive Tests for Diagnosing Malignant Peripheral Nerve Sheath Tumors in Patients with Neurofibromatosis Type 1? Diagnosing MPNST in NF1 Patients
Maria T Schwabe (2019)
Prognostic Value of Metabolic Tumor Volume and Total Lesion Glycolysis in Head and Neck Cancer: A Systematic Review and Meta-Analysis
Kyoungjune Pak (2014)
[18F]Fluorodeoxyglucose uptake by positron emission tomography predicts outcomes for oropharyngeal and hypopharyngeal cancer treated with definitive radiotherapy
Takeaki Ishihara (2017)
A review of the predictive role of functional imaging in patients with mucosal primary head and neck cancer treated with radiation therapy
Myo Min (2017)
Prognostic significance of metabolic tumor volume in patients with piriform sinus carcinoma treated by radiotherapy with or without concurrent chemotherapy.
Kenichiro Yabuki (2016)
Survival for HPV-positive oropharyngeal squamous cell carcinoma with surgical versus non-surgical treatment approach: A systematic review and meta-analysis.
Parul Khare Sinha (2018)
Predictive and Prognostic Value of Metabolic Tumor Volume (MTV) in Patients with Laryngeal Carcinoma Treated by Radiotherapy (RT) / Concurrent Chemoradiotherapy (CCRT)
Kenichiro Yabuki (2015)
Role of fluorine-18 fluorodeoxyglucose PET/CT in head and neck oncology: the point of view of the radiation oncologist.
Jon Cacicedo (2016)
Semantic Scholar Logo Some data provided by SemanticScholar