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Depression Of Intramyocardial Oxyhemoglobin Dissociation By Angiographic Contrast Media.

D. Sheps, B. Cameron, S. Mallon, L. Sommer, W. Lo, D. Harkness, R. Myerburg
Published 1980 · Medicine

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The effect of the addition of radiographic contrast material (Renografin) to blood on the oxyhemoglobin dissociation curve and P50 was measured by a metabolic deoxygenation technique in a strongly buffered red cell suspension. With incubation time constant, increasing doses produced progressive decreases in P50. With incubation time varied at a constant dose, a decrease in P50 was seen after only one minute. In addition, in vivo studies were performed on 11 patients undergoing cardiac catheterization. Simultaneous proximal coronary sinus and aortic samples were drawn as controls, and then at one minute and five minutes after injection of the left coronary artery. In eight patients studies were performed after, and in three prior to left ventriculography. At one minute after left coronary injection there was a significant decrease of coronary sinus as compared to aortic P50 (p less than .10) (only when left ventriculography was performed prior to coronary arteriography). The magnitude of these effects in vivo is unknown, but they would be expected to be more severe in areas distal to a critical coronary lesion due to stasis of blood flow and ischemic metabolic changes.
This paper references
10.1097/00004424-197503000-00007
The relationship between angiography, intraerythrocytic pH and hemoglobin oxygen equilibrium.
A. Rosenthal (1975)
10.1016/S0033-0620(68)80003-9
Effects of Interrupted Coronary Flow Upon Myocardial Metabolism and Contractility
A. Katz (1968)
10.1152/JAPPL.1970.28.3.343
Rapid method for determining effect of agents on oxyhemoglobin dissociation curves.
I. Longmuir (1970)
10.1152/AJPLEGACY.1963.205.2.337
THE BOHR EFFECT RELATED TO BLOOD AND ERYTHROCYTE PH.
P. Hilpert (1963)
10.3109/00365516609065612
pH and molecular CO2 components of the Bohr effect in human blood.
N. Naeraa (1966)
10.1016/0002-9149(67)90452-3
Myocardial metabolism in cardiac hypoxia.
J. Scheuer (1967)
10.1161/01.CIR.52.1.119
Blood Calcium Levels in the Presence of Arteriographic Contrast Material
J. Caulfield (1975)
10.1161/01.CIR.53.1.3
Histopathology of the Conduction System in the Sudden Infant Death Syndrome
J. Lie (1976)
10.1161/01.CIR.52.5.943
Acidification of Plasma by the Red Cell Due to Radiographic Contrast Materials
M. Lichtman (1975)
10.1259/0007-1285-41-483-190
Tendency to acidosis following the injection of radio-opaque contrast material.
M. Marshall (1968)
10.1016/0006-291X(71)90700-5
Biphasic blood oxygen dissociation curves in hemoglobin S hemoglobinopathies. Sickle cell heterozygotes.
B. Cameron (1971)
10.1056/NEJM197307122890209
Electrocardiographic abnormalities associated with intravenous urography.
G. R. Berg (1973)
10.1161/01.CIR.40.5S4.IV-202
Maintenance of Cell Viability
N. Brachfeld (1969)
10.2214/AJR.105.4.777
Effect of angiocardiography on fluid and electrolyte balance.
A. R. Levin (1969)
10.1097/00004424-197307000-00002
Effect of contrast media used in angiocardiography on hemoglobin-oxygen equilibrium.
A. Rosenthal (1973)
Contribution of tissue acidosis to ischemic injury in the perfused rat heart.
J. Williamson (1976)
10.1161/01.CIR.31.5.730
Hemodynamic Consequences of the Injection of Radiopaque Material
G. Friesinger (1965)



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