Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Multiple Gated Cardiac Blood Pool Imaging For Left Ventricular Ejection Fraction: Validation Of The Technique And Assessment Of Variability.

F. Wackers, H. Berger, D. Johnstone, L. Goldman, L. Reduto, R. Langou, A. Gottschalk, B. Zaret
Published 1979 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
The intrinsic variability and accuracy of left ventricular ejection fraction determined by multiple gated cardiac blood pool imaging was evaluated in 83 patients. Ejection fraction by gated studies correlated well with data from first pass radionuclide angiocardiography (r = 0.94) and from contrast angiography (r = 0.84). Intra- and interobserver variabilities of absolute ejection fraction were minimal (mean +/- standard deviation 1.4 +/- 1.2 and 1.6 +/- 1.5 percent, respectively) and were not different for normal (ejection fraction 55 percent or greater) and abnormal patients. Ejection fraction was determined twice in 70 patients: on the same day at intervals separated by 1 to 2 hours (41 patients) and on 2 different days (29 patients). Ejection fraction ranged from 18 to 91 percent and was normal in 37 patients. There was no difference in mean serial variabilities of absolute ejection fraction for all repeat studies performed on the same and separate days (3.3 +/- 3.1 versus 4.3 +/- 3.1 percent (not significantly different). The mean variability of absolute ejection fraction for repeat studies in normal patients was significantly greater than in abnormal patients (5.4 +/- 4.4 versus 2.1 +/- 2.0 percent, P less than 0.01). The incidence rate of absolute interstudy changes of 5 percent or more was significantly higher in normal than in abnormal patients (P less than 0.01). This differential variability should be considered in interpreting sequential changes in left ventricular ejection fraction. To be attributed to nonrandom physiologic alterations, the absolute change in ejection fraction should be 10 percent or more in normal patients and 5 percent or more in abnormal patients.
This paper references
10.1148/120.2.433
Gated blood pool imaging following 99mTc stannous pyrophosphate imaging.
E. Stokely (1976)
Cardiac chamber imaging: a comparison of red blood cells labeled with Tc-99m in vitro and in vivo.
F. Hegge (1978)
10.1161/01.CIR.56.5.820
Assessment of Cardiac Performance with Quantitative Radionuclide Angiocardiography: Sequential Left Ventricular Ejection Fraction, Normalized Left Ventricular Ejection Rate, and Regional Wall Motion
R. Marshall (1977)
10.1161/01.CIR.56.6.1024
Analysis of Left Ventricular Function from Multiple Gated Acquisition Cardiac Blood Pool Imaging Comparison to Contrast Angiography
R. Burow (1977)
10.1016/0033-0620(78)90014-2
Left ventricular ejection fraction--a review of several radionuclide angiographic approaches using the scintillation camera.
W. Ashburn (1978)
Validation of a two minute technique for multiple gated scintigraphic assessment of left ventricular ejection fraction and regional wall motion
J. Maddahi (1978)
10.1056/NEJM197704142961503
Real-time radionuclide cineangiography in the noninvasive evaluation of global and regional left ventricular function at rest and during exercise in patients with coronary-artery disease.
J. Borer (1977)
In vivo labeling of red blood cells with 99mTc: a new approach to blood pool visualization.
D. Pavel (1977)
A real-time system for multi-image gated cardiac studies.
S. Bacharach (1977)
10.1016/0002-9149(66)90192-5
Experiences with a cinefluorographic method for measuring ventricular volume.
C. Chapman (1966)
10.1016/0002-9149(71)90100-7
A scintiphotographic method for measuring left ventricular ejection fraction in man without cardiac catheterization.
H. Strauss (1971)
10.1016/0002-9149(78)90011-5
Variability in sequential measures of left ventricular performance assessed with radionuclide angiocardiography.
R. Marshall (1978)
Noninvasive nuclear kinecardiography.
N. Alpert (1974)
High temporal resolution ECG-gated scintigraphic angiocardiography.
M. Green (1975)
The radionuclide ejection fraction: a comparison of three radionuclide techniques with contrast angiography.
E. Folland (1977)
Ejection fraction by count rate from gated images.
M. Green (1978)



This paper is referenced by
10.1007/BF00252715
Quantitative analysis of left ventricular function from equilibrium gated blood pool scintigrams: an overview of computer methods
J. d (1985)
LEFT VENTRICULAR AND BACKGROUND COUNT DENSITIES AVERAGED OVER ALL STUDIES IN THE THREE DIFFERENT GROUPS LEAP coll
J. C. Reiber (2006)
10.1007/s12410-012-9136-6
Imaging in the Evaluation of the Patient with New-Onset Heart Failure
T. Wong (2012)
10.1016/S0735-1097(98)00533-6
Ejection fraction by radionuclide ventriculography and contrast left ventriculogram. A tale of two techniques. SAVE Investigators. Survival and Ventricular Enlargement.
P. Ureña (1999)
10.1182/BLOOD-2003-08-2841
Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major.
B. Davis (2004)
10.1016/0735-1097(90)92817-L
Silent left ventricular dysfunction during routine activity after thrombolytic therapy for acute myocardial infarction.
D. Kayden (1990)
10.1177/000331979104201102
Reliability of Three Computer Methods in the Analysis of ECG-Gated Radionuclide Left Ventriculography: Interrecording, Interobserver and Intraobserver Variability
F. Jensen (1991)
10.1016/S1071-3581(05)80049-2
Clinical application of radionuclide angiography
S. Port (1995)
10.1136/hrt.57.4.319
How useful are the cold pressor test and sustained isometric handgrip exercise with radionuclide ventriculography in the evaluation of patients with coronary artery disease?
R. J. Northcote (1987)
10.1161/01.CIR.75.1.139
Immediate effect of expiratory loading on left ventricular stroke volume.
T. K. Natarajan (1987)
10.1007/s12350-015-0090-y
Has LVEF changed beyond chance? Limits of agreement of radiotracer-derived LVEF
F. Wackers (2015)
10.1016/0002-8703(86)90467-9
Daily variations of ECG and left ventricular parameters at exercise in patients with anginal attacks but normal coronary arteriograms.
Y. Sugishita (1986)
10.1016/S0735-1097(83)80335-0
Exercise left ventriculography utilizing intravenous digital angiography.
H. Goldberg (1983)
10.1016/S0002-8703(03)00248-5
Reliability of reporting left ventricular systolic function by echocardiography: a systematic review of 3 methods.
J. McGowan (2003)
10.1016/0735-1097(90)90275-T
Natural history of left ventricular thrombi: their appearance and resolution in the posthospitalization period of acute myocardial infarction.
A. Keren (1990)
10.1016/0002-9149(92)90990-G
Effects of the dipyridamole test on left ventricular function in coronary artery disease.
H. Klein (1992)
10.1007/s12350-016-0599-8
The role of nuclear cardiac imaging in risk stratification of sudden cardiac death
D. Juneau (2016)
10.1136/hrt.51.6.631
Measurement of left ventricular ejection fraction after acute myocardial infarction. A serial cross sectional echocardiographic study.
G. Kan (1984)
Ventricular Function After Acute Myocardial
R. Dunn (1982)
Equilibrium radionuclide ventriculography: still a clinically useful method for the assessment of cardiac function?
C. Sachpekidis (2018)
10.1016/J.AMJCARD.2003.09.005
Incidence of recovery of contractile function following revascularization in patients with ischemic left ventricular dysfunction.
A. Schinkel (2004)
10.1097/MNM.0b013e32834bfec4
A prospective comparison of cardiac magnetic resonance imaging and radionuclide ventriculography in the assessment of cardiac function in patients treated with anthracycline-based chemotherapy.
P. Sipola (2012)
10.1042/CS1010601
Neuroendocrine changes during the evolution of doxorubicin-induced left ventricular dysfunction in adult lymphoma patients
T. Nousiainen (2001)
Effects of remote ischaemic preconditioning on peri-operative myocardial injury and clinical outcomes in patients undergoing elective cardiac bypass surgery
L. Candilio (2015)
10.1109/IEMBS.2010.5627864
Factor analysis of ventricular contraction using SPECT-ERNA images
Diana Rojas-Ordus (2010)
10.1093/OXFORDJOURNALS.EURHEARTJ.A061916
Range of normal values for left and right ventricular ejection fraction at rest and during exercise assessed by radionuclide angiocardiography.
M. Pfisterer (1985)
10.1161/01.CIR.62.1.8
Digitalis and Myocardial Infarction in Man
J. Morrison (1980)
10.1161/01.CIR.68.3.576
A randomized prospective trial of intravenous nitroglycerin in patients with acute myocardial infarction.
J. Flaherty (1983)
10.1007/s12350-014-9945-x
Assessment of an intermediate reprojection technique transitioning from planar to SPECT radionuclide ventriculography
J. O’Doherty (2014)
10.1007/978-1-4613-3828-4_20
Radionuclide Techniques for Diagnosing and Sizing of Myocardial Infarction
F. Wackers (1985)
10.1007/s00259-002-0793-6
Accuracy of PET in predicting functional recovery after revascularisation in patients with chronic ischaemic dysfunction: head-to-head comparison between blood flow, glucose utilisation and water-perfusable tissue fraction
J. Bax (2002)
10.1067/MJE.2001.111158
Assessment of left ventricular function by real-time 3-dimensional echocardiography compared with conventional noninvasive methods.
S. Takuma (2001)
See more
Semantic Scholar Logo Some data provided by SemanticScholar