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Antithrombin III Depression And Thrombin Generation Acceleration In Women Taking Oral Contraceptives

E. V. Kaulla, W. Droegemueller, N. Aoki, K. Kaulla
Published 1971 · Medicine

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Abstract The blood clotting systems of 21 women were studied prior to and modified by steroid contraceptives. The oral contraceptives induced a depression of antithrombin III activity and an acceleration of thrombin generation within the first cycle of therapy. These changes are similar to those observed in patients with chronic thromboembolic disease. It is suggested that of all the clotting changes induced by the oral contraceptives the loss of antithrombin III activity may be the one that is the most clinically significant.
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