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Does Dihydrotestosterone Induce Atresia In The Hypophysectomized Immature Female Rat Treated With Pregnant Mare's Serum Gonadotropin?

J. Kohut, J. Jarrell, E. Younglai
Published 1985 · Biology, Medicine

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This study was originally designed to test the hypothesis that the binding of luteinizing hormone in granulosa cells decreases with atresia. The hypophysectomized immature female rat that was primed with pregnant mare's serum gonadotropin and treated with dihydrotestosterone was used as a model for atresia. Histochemical analysis of acid phosphatase was used as a marker for atresia and topical autoradiography with iodine 125-labeled human chorionic gonadotropin for binding of luteinizing hormone. Histologically, there was no significant difference in atresia, acid phosphatase, or 125I-labeled human chorionic gonadotropin binding in antral follicles between control animals given pregnant mare's serum gonadotropin and animals treated with pregnant mare's serum gonadotropin and dihydrotestosterone. Assessment of the total follicular population, however, showed that dihydrotestosterone at dosages of 1 and 5 mg/kg resulted in decreases in atresia of 48% and 58%, respectively. Although these data disprove our hypothesis, they strongly suggest that dihydrotestosterone decreases follicular atresia by increasing the number of small preantral follicles.
This paper references
10.1095/BIOLREPROD20.5.1159
Ovarian follicular development during the rat estrous cycle: gonadotropin receptors and follicular responsiveness.
J. T. Uilenbroek (1979)
10.1095/BIOLREPROD27.4.903
A model for the study of androgen effects on follicular atresia and ovulation.
C. Bagnell (1982)
10.1210/ENDO-108-5-1885
Steroidogenesis in experimentally induced atretic follicles of the hamster: a shift from estradiol to progesterone synthesis.
P. Terranova (1981)
10.1530/JRF.0.0370277
Cell kinetic studies of follicular atresia in the mouse ovary.
A. Byskov (1974)
10.1095/BIOLREPROD21.1.75
Gonadotropin receptors of the ovine ovarian follicle during follicular growth and atresia.
R. Carson (1979)
Dynamics of ovarian function
N. Schwartz (1981)
10.1530/JRF.0.0170555
Proposal for a classification of oocytes and follicles in the mouse ovary.
T. Pedersen (1968)
10.1530/JRF.0.0660197
Autoradiographic analysis of changes in ovarian binding of FSH and HCG during induced follicular atresia in the hamster.
C. Shaha (1982)
10.5694/j.1326-5377.1953.tb85044.x
Histochemistry: Theoretical and Applied
A. G. Pearse (1953)
10.1210/ENDO-68-2-232
Enzymic correlates of physiological regression of follicles and corpora lutea in ovaries of normal rats.
B. Lobel (1961)
10.1530/JRF.0.0490215
Sequential changes associated with the degeneration of preovulatory rat follicles.
J. J. Peluso (1977)
10.1095/BIOLREPROD23.1.219
Atresia of preovulatory follicles: gonadotropin binding and steroidogenic activity.
J. Uilenbroek (1980)
10.1530/JRF.0.0270277
Haemolysis following copulation in male rats.
K. Brown-Grant (1971)
10.1677/JOE.0.0610179
Binding of luteinizing hormone and human chorionic gonadotrophin to ovarian cells and activation of adenylate cyclase.
Y. Koch (1974)
10.1677/JOE.0.0790339
Effects of active immunization of female rabbits against testosterone.
R. W. Armstrong (1978)
10.1210/ENDO-62-3-313
The influence of estrogen and androgen on the ovarian response of hypophysectomized immature rats to gonadotropins.
R. Payne (1958)



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