Online citations, reference lists, and bibliographies.
← Back to Search

Lipoprotein Lipase Activity Of Adipose And Mammary Tissue And Plasma Triglyceride In Pregnant And Lactating Rats.

M. Hamosh, T. R. Clary, S. Chernick, R. Scow
Published 1970 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Abstract 1. 1. The effect of pregnancy and lactation on lipoprotein lipase activity in adipose and mammary tissues and on plasma triglyceride concentration were studied in the rat. 2. 2. Plasma triglyceride concentration, 0.9 mM in control rats, increased 3-fold between the 12th and 20th days of pregnancy to a peak of 3.3 mM, and then decreased 50% during the next 2 days. It increased again at parturition, on the 22nd–23rd days of pregnancy, to 3.0 mM, and then fell sharply and remained below 1.0 mM throughout lactation. 3. 3. Lipoprotein lipase activity in parametrial adipose tissue, 12 units/g in control rats, increased 2-fold between the 9th and 12th days of pregnancy and then decreased slightly during the next 7 days, (1 unit of lipoprotein lipase activity = 1 μmole of triglyceride hydrolyzed per h.) It decreased on the 20th day to 5 units/g, reached 2 units/g at parturition, and remained below 2 units/g throughout lactation. 4. 4. Lipoprotein lipase activity in the inguinal-abdominal mammary glands increased very slowly during the first 20 days of pregnancy, from 0.9 units/g to 7 units/g. It then increased the next day to 21 units/g, decreased sharply at parturition to 6 units/g, and increased after parturition to more than 40 units/g. Lipoprotein lipase activity in mammary gland remained high as long as the mother suckled. 5. 5. Nonsuckling for 9 or more h decreased mammary gland lipoprotein lipase activity to near zero and increased plasma triglyceride concentration to 3 mM. Nonsuckling also increased lipoprotein lipase activity in adipose tissue. 6. 6. Ligation of the lactiferous ducts of the inguinal-abdominal glands on one side markedly reduced the lipoprotein lipase activity in these glands but not that in the contralateral, suckled glands. 7. 7. Plasma triglyceride concentration was inversely related to the lipoprotein lipase activity in mammary tissue during the last 2 days of pregnancy and throughout lactation. 8. 8. It is suggested that the changes in lipoprotein lipase activity of adipose and mammary tissues that occur during late pregnancy and lactation serve to divert dietary lipid from storage in adipose tissue to mammary glands for milk formation.
This paper references
The uptake of doubly labeled chylomicrons by guinea pig mammary gland and liver.
O. Mcbride (1964)
10.1172/JCI104722
Effect of diabetes and insulin on the activity of myocardial and adipose tissue lipoprotein lipase of rats.
J. Kessler (1963)
10.1016/0005-2744(67)90118-0
The effect of nutritional state on lipoprotein lipase activity in isolated rat adipose tissue cells.
N. Pokrajac (1967)
10.1042/BJ0890006
THE UPTAKE FROM THE BLOOD OF TRIGLYCERIDE FATTY ACIDS OF CHYLOMICRA AND LOW-DENSITY LIPOPROTEINS BY THE MAMMARY GLAND OF THE GOAT.
J. M. Barry (1963)
10.1152/AJPLEGACY.1969.217.1.228
Relationship of gastric secretion to food intake in lactating rats.
Long Jf (1969)
10.1042/BJ1050995
Lactogenesis in the rat. Changes in metabolic parameters at parturition.
N. J. Kuhn (1967)
Uptake of free fatty acids and chylomicron glycerides by guinea pig mammary gland in pregnancy and lactation.
O. Mcbride (1964)
10.1002/AJA.1000560204
Cytology of the mammary gland of the albino rat. I. Pregnancy, lactation and involution
K. R. Jeffers (1935)
LOCALIZATION OF LIPOPROTEIN LIPASE IN FAT CELLS OF RAT ADIPOSE TISSUE.
M. Rodbell (1964)
10.1152/AJPLEGACY.1959.197.3.667
Effect of nutrition on activity and release of lipase from rat adipose tissue.
C. Hollenberg (1959)
10.1042/BJ0720027
The fatty acids of human milk from mothers on diets taken ad libitum.
W. Insull (1959)
10.1172/JCI103819
The fatty acids of human milk. II. Alterations produced by manipulation of caloric balance and exchange of dietary fats.
W. Insull (1959)
Photometric determination of fatty acid ester groups in phospholipides.
M. Rapport (1955)
10.1042/BJ1130629
Studies on the origin of milk fat. A further study of bovine serum lipoproteins and an estimation of their contribution to milk fat.
C. Bishop (1969)
10.1042/BJ0990640
Clearing-factor lipase in adipose tissue. A medium in which the enzyme activity of tissue from starved rats increases in vitro.
M. R. Salaman (1966)
10.2337/DIAB.12.2.174
The Effect of Acute Insulin Deficiency in the Rat on Adipose Tissue Lipolytic Activity and Plasma Lipids
Schnatz Jd (1963)
Formation and fate of endogenous triglycerides in blood plasma of rabbits
R. Havel (1962)
10.1152/AJPLEGACY.1964.206.4.796
HYPERLIPEMIA AND KETOSIS IN THE PREGNANT RAT.
R. Scow (1964)
Relation between incorporation of triglyceride fatty acids and heparin-released lipoprotein lipase from adipose tissue slices
A. Bezman (1962)
10.1042/BJ0900271
Interrelationship of carbohydrate and fat metabolism in the involuting mammary gland.
P. Mclean (1964)
Incorporation of dietary lecithin and lysolecithin into lymph chylomicrons in the rat.
R. Scow (1967)
10.1016/0304-4165(69)90079-8
The relationship between milk accumulation and enzyme activities in the involuting rat mammary gland.
E. A. Jones (1969)
10.1042/BJ1020637
The oxidation and utilization of palmitate, stearate, oleate and acetate by the mammary gland of the fed goat in relation to their overall metabolism, and the role of plasma phospholipids and neutral lipids in milk-fat synthesis.
E. Annison (1967)
The liberation of lipoprotein lipase by heparin from adipose tissue incubated in vitro
A. Cherkes (1959)
10.1152/AJPLEGACY.1963.205.2.405
PERFUSION OF RAT ADIPOSE TISSUE.
A. Robert (1963)
10.1172/JCI103259
A relation between non-esterified fatty acids in plasma and the metabolism of glucose.
V. Dole (1956)
10.2307/1438910
Bioenergetics and Growth
L. Walford (1945)
Methods in Enzymology , Vol
S. Colowick (1966)
10.1042/BJ1060677
The significance of changes in tissue clearing-factor lipase activity in relation to the lipaemia of pregnancy.
S. Otway (1968)
10.1042/BJ0980149
An investigation of serum lipoproteins and of their contribution to mild fat in the dairy cow.
R. Glascock (1966)
10.1677/JOE.0.0380351
Growth and obesity in male rats after placement of ventromedial hypothalamic lesions at four different ages.
L. Bernardis (1967)
The lipoprotein lipase of cow's milk
E. Korn (1962)
CHANGES IN THE LIPOLYTIC ACTIVITY OF THE GUINEA PIG MAMMARY GLAND AT PARTURITION.
D. S. Robinson (1963)
10.1042/BJ1120203
Clearing-factor lipase in adipose tissue. Distinction of different states of the enzyme and the possible role of the fat cell in the maintenance of tissue activity.
V. Cunningham (1969)
10.1172/JCI103640
Tissue distribution of C14 after the intravenous injection of labeled chylomicrons and unesterified fatty acids in the rat.
J. H. Bragdon (1958)
THE LIPOPROTEIN LIPASE OF MAMMARY GLAND AND THE CORRELATION OF ITS ACTIVITY TO LACTATION.
O. Mcbride (1963)



This paper is referenced by
10.1016/0018-506X(79)90005-9
Prolactin-induced gain in body weight in relation to caloric intake and energy expenditure in spotted munia
A. Chāndolā (1979)
10.1016/B978-0-408-10857-7.50010-5
Hormonal regulation of biosynthetic activities in white adipose tissue
E. Saggerson (1985)
REGULATION OF LIPID METABOLISM AND MILK LIPID CONTENT IN NORTHERN ELEPHANT SEALS
Melinda Fowler (2012)
10.1016/0005-2760(77)90006-6
Lipoprotein lipase and uptake of triacylglycerol, cholesterol and phosphatidylcholine from chylomicrons by mammary and adipose tissue of lactating rats in vivo.
R. Scow (1977)
10.1007/978-1-4615-9567-0_23
Lipid Metabolic Interactions in the Mother during Pregnancy and their Fetal Repercussions
E. Herrera (1990)
10.2527/JAS1989.67112904X
Effect of suppression of prolactin secretion on adipose lipogenesis in the postpartum beef cow.
S. Mills (1989)
10.1016/0026-0495(91)90237-Q
Circulating metabolite utilization by periuterine adipose tissue in situ in the pregnant rat.
M. Palacín (1991)
10.1152/AJPHEART.2000.279.4.H1813
Effects of mammary engorgement and feed withdrawal on microvascular function in lactating goat mammary glands.
V. Farr (2000)
10.1016/B978-0-323-35214-7.00034-2
34 – Maternal-Fetal Transfer of Lipid Metabolites
E. Herrera (2017)
10.1016/0031-9384(79)90028-3
Gonadal effects on food intake and adiposity: A metabolic hypothesis
G. Wade (1979)
10.1016/0031-9384(94)00342-4
High-fat feeding during pregnancy and lactation affects offspring metabolism in rats
F. Guo (1995)
10.1210/JC.2002-021137
Identification of functional prolactin (PRL) receptor gene expression: PRL inhibits lipoprotein lipase activity in human white adipose tissue.
C. Ling (2003)
10.1093/AJCN/67.2.301
Acute effects of dietary fatty acids on the fatty acids of human milk.
C. A. François (1998)
10.1017/S0022029900014722
The effects of pregnancy, lactation and involution on the metabolism of glucose by rat parametrial adipose tissue.
R. W. Smith (1973)
10.1093/JN/110.4.600
Effect of pregnancy, lactation and a high-fat diet on adipose tissue in Osborne-Mendel rats.
L. Steingrimsdottir (1980)
10.1016/0305-0491(85)90088-4
Adaptations of adipose tissue metabolism and number of insulin receptors in pregnant sheep.
R. Vernon (1985)
10.1007/978-1-4684-0400-5_10
Lipid metabolism in pregnancy.
E. Herrera (1987)
10.1016/0065-2571(88)90011-8
Tumor growth and lipid metabolism during lactation in the rat.
D. Williamson (1988)
10.1093/AJCN/74.6.827
[13C]linoleic acid oxidation and transfer into milk in stunted lactating women with contrasting body mass indexes.
S. Villalpando (2001)
METABOLIC COOPERATIVITY BETWEEN MAMMARY EPITHELIAL CELLS AND ADIPOCYEES OF MICE
J. Bartley (1980)
10.1016/j.smallrumres.2019.106037
Phenotypic relationships between maternal energy metabolism and lamb body weight development during lactation for pure- and crossbred sheep populations in low and high input production systems
J. Reintke (2020)
10.1016/0005-2760(77)90217-X
Effect of albumin on products formed from chylomicron triacylclycerol by lipoprotein lipase in vitro.
R. Scow (1977)
10.1111/j.1651-2227.1978.tb16276.x
LIPOLYTIC ACTIVITY IN MILK FROM MOTHERS OF UNJAUNDICED INFANTS
M. Odiévre (1978)
10.1038/284077A0
Influence of local vascularity on hormone receptors in mammary gland
B. Moore (1980)
10.1016/B978-0-408-10857-7.50023-3
Adipose tissue dysfunction and its consequences
P. Björntorp (1985)
10.1051/RND:19860409
Regulation of metabolism during lactation in the rat.
D. Williamson (1986)
10.3168/JDS.S0022-0302(87)80159-5
Regulation of bovine adipose tissue metabolism during lactation. 3. Adaptations of hormone-sensitive and lipoprotein lipases.
J. Mcnamara (1987)
10.1113/jphysiol.1973.sp010300
The effects of engorgement with milk and of suckling on mammary blood flow in the rat
A. Hanwell (1973)
10.1016/j.envpol.2017.04.100
Diet and metabolic state are the main factors determining concentrations of perfluoroalkyl substances in female polar bears from Svalbard.
Sabrina Tartu (2017)
10.1051/RND:19770809
Lipoprotein lipase activity and composition of omental adipose tissue as related to lipid metabolism of the goat in late pregnancy and early lactation
Y. Chilliard (1977)
Maternal Adaptation to Pregnancy: Altered Circadian Rhythms of Clock Genes in the Hypothalamus and Metabolic Tissues
M. D. Wharfe (2016)
10.1007/BF01921516
Studies on the turn-over of plasma triglycerides using triglyceride14C-labelled chyle in pregnant rats
L. Hummel (2005)
See more
Semantic Scholar Logo Some data provided by SemanticScholar