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Characterization Of A Putative Promoter Region Of The Human Poly(ADP-ribose) Polymerase Gene: Structural Similarity To That Of The DNA Polymerase Beta Gene.

T. Ogura, H. Nyunoya, M. Takahashi-Masutani, M. Miwa, T. Sugimura, H. Esumi
Published 1990 · Biology, Medicine

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The 5'-flanking region of the human poly(ADP-ribose) polymerase gene was isolated and characterized. The nucleotide sequence of a part of the poly(ADP-ribose) polymerase gene completely matched that of the cDNA. The transcriptional initiation sites (cap sites) of this gene, located about 166-bp upstream from the translational initiation site, were identified by S1 mapping analysis. Neither CAAT box nor TATA box was found within 500-bp upstream from the cap sites of poly(ADP-ribose) polymerase gene. The 200-bp immediately upstream of the cap site had a high G+C content (76.5%) and contained double repeats of the sequence CCGCCC, putative Sp1 binding sites, and a palindromic structure. The 5'-flanking region of poly(ADP-ribose) polymerase gene also showed promoter activity in chloramphenicol acetyltransferase assay and structural similarity to that of DNA polymerase beta gene.
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