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Characterization Of A Putative Promoter Region Of The Human Poly(ADP-ribose) Polymerase Gene: Structural Similarity To That Of The DNA Polymerase Beta Gene.
T. Ogura, H. Nyunoya, M. Takahashi-Masutani, M. Miwa, T. Sugimura, H. Esumi
Published 1990 · Biology, Medicine
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The 5'-flanking region of the human poly(ADP-ribose) polymerase gene was isolated and characterized. The nucleotide sequence of a part of the poly(ADP-ribose) polymerase gene completely matched that of the cDNA. The transcriptional initiation sites (cap sites) of this gene, located about 166-bp upstream from the translational initiation site, were identified by S1 mapping analysis. Neither CAAT box nor TATA box was found within 500-bp upstream from the cap sites of poly(ADP-ribose) polymerase gene. The 200-bp immediately upstream of the cap site had a high G+C content (76.5%) and contained double repeats of the sequence CCGCCC, putative Sp1 binding sites, and a palindromic structure. The 5'-flanking region of poly(ADP-ribose) polymerase gene also showed promoter activity in chloramphenicol acetyltransferase assay and structural similarity to that of DNA polymerase beta gene.
This paper references
Murine DNA polymerase beta gene: mapping of transcription initiation sites and the nucleotide sequence of the putative promoter region.
M. Yamaguchi (1987)
Stable replication of plasmids derived from Epstein–Barr virus in various mammalian cells
J. Yates (1985)
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
P. Chomczyński (1987)
Induction of poly(ADP-ribose) polymerase gene expression in lectin-stimulated human T lymphocytes is dependent on protein synthesis.
M. Menegazzi (1988)
Genomic clone of hst with transforming activity from a patient with acute leukemia.
T. Yoshida (1987)
CpG-rich islands and the function of DNA methylation
A. Bird (1986)
Primary structure of human poly(ADP-ribose) synthetase as deduced from cDNA sequence.
T. Kurosaki (1987)
The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter
W. Dynan (1983)
Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase.
J. Singer-Sam (1984)
Difference in the expression level of DNA polymerase beta among mouse tissues: high expression in the pachytene spermatocyte.
F. Hirose (1989)
Isolation of putative promoter region for human terminal deoxynucleotidyltransferase gene.
O. Koiwai (1988)
A unidirectional deletion technique for the generation of clones for sequencing
E. Ozkaynak (1987)
Molecular cloning of cDNA for human poly(ADP-ribose) polymerase and expression of its gene during HL-60 cell differentiation.
H. Suzuki (1987)
Human β-polymerase gene. Structure of the 5'-flanking region and active promoter
S. Widen (1988)
Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase.
K. Uchida (1987)
Evidence for phosphorylation of trans-activator p40x of human T-cell leukemia virus type I produced in insect cells with a baculovirus expression vector.
H. Nyunoya (1988)
A cosmid vector for systematic chromosome walking.
S. Cross (1986)
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.
C. Gorman (1982)
Characterization of the promoter region of the human insulin receptor gene. Evidence for promoter activity.
E. Araki (1987)
Reactivity of KB cell deoxyribonucleic acid polymerases alpha and beta with nicked and gapped deoxyribonucleic acid.
T. Wang (1980)
Powerful and versatile enhancer-promoter unit for mammalian expression vectors.
M. K. Foecking (1986)
A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes
J. Banerji (1983)
A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus
M. Boshart (1985)
Adenosine deaminase: characterization and expression of a gene with a remarkable promoter.
D. Valério (1985)
Poly(adenosine diphosphate ribose).
T. Sugimura (1973)
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T. Sugimura (1994)
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Interaction of the transcription factor YY1 with human poly(ADP-ribosyl) transferase.
S. L. Oei (1997)
Striking similarity of the distribution patterns of the poly(ADP-ribose) polymerase and DNA polymerase beta among various mouse organs.
T. Ogura (1990)
PARP alleles within the linked chromosomal region are associated with systemic lupus erythematosus.
B. Tsao (1999)
Transcriptional Repression by Binding of Poly(ADP-ribose) Polymerase to Promoter Sequences*
V. Soldatenkov (2002)
Induction of DNA polymerase beta during proliferation of mitogen-stimulated human lymphocytes.
H. Suzuki (1991)
Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians
M. Muiras (1998)
Regulation of the human poly(ADP-ribosyl) transferase promoter via alternative DNA racket structures.
M. Schweiger (1995)
PARP-1 expression in the mouse is controlled by an autoregulatory loop: PARP-1 binding to an upstream S/MAR element and to a novel recognition motif in its promoter suppresses transcription.
M. Vidaković (2009)
Evaluation of the poly(ADP-ribose) polymerase gene in human stroke.
N. Kato (2000)
Differential expression of poly(ADP-ribose) polymerase and DNA polymerase beta in rat tissues.
M. Menegazzi (1991)
Regulation of the human poly(ADP-ribose) polymerase promoter by the ETS transcription factor
V. Soldatenkov (1999)
The stress-response proteins poly(ADP-ribose) polymerase and NF-κB protect against bile salt-induced apoptosis
C. Payne (1998)
Human poly(ADP-ribose) polymerase gene. Cloning of the promoter region.
Y. Yokoyama (1990)
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T. Sugimura (1992)
Molecular and biochemical features of poly (ADP-ribose) metabolism
D. Lautier (2005)
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