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Retrograde Transport Of Protein Tracer In The Rabbit Hypoglossal Nerve During Regeneration.

K. Kristensson, J. Sjöstrand
Published 1972 · Biology, Medicine

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Summary Albumin labelled with Evans blue, which forms a red fluorescent complex under ultraviolet irradiation, was injected into the tongues of adult rabbits. Ten to 24 h after the injection there was an accumulation of the red fluorescent tracer in the nerve cell bodies of the hypoglossal neurones, indicating an axonal uptake and retrograde transport of the protein tracer. After crush injury to the right hypoglossal nerve the neuronal uptake of protein tracer was blocked on the ipsilateral side for 26 days. Thirty-five to 48 days after the crush lesion, an increase in the intensity of the fluorescence was seen in hypoglossal neurones on the ipsilateral side relative to the other side. After 80–120 days the difference between the sides could no longer detected. This finding indicates that during nerve regeneration there is a transient stage involving an increase in the neuronal accumulation of macromolecules taken up and transported by the axons from the periphery to the nerve cell bodies; the timing of this stage coincides with the period of maturation of axons reconnected to the muscle.
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