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Effects Of A Conditioning Lesion On Bullfrog Sciatic Nerve Regeneration: Analysis Of Fast Axonally Transported Proteins

G. Perry, S. Krayanek, D. L. Wilson
Published 1987 · Chemistry, Medicine

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We have shown that bullfrog sciatic nerves respond to a conditioning lesion similarly to goldfish optic nerve and rat or mouse sciatic nerve; that is, following a crush the rate of regeneration is faster in nerves that have received a conditioning lesion compared to nerves that have not. Also, damaged nerve fibres show initial growth or sprouting earlier in a previously conditioned nerve compared to nerves that have not received a prior conditioning lesion. We have not detected changes in the transport of fast axonally transported proteins with the conditioning lesion paradigm, other than those changes seen in regenerating nerves after receiving a single lesion. However, more label was present in a few fast axonally transported proteins at the lesion site in conditioned nerves compared to non-conditioned nerves, and this difference is not apparently due to increased transport. It seems that changes in fast axonally transported proteins probably do not contribute directly to the mechanism underlying the conditioning lesion effect of higher out growth rates, although some of the fast transported proteins may be involved in functions, possibly at the growing tip of damaged fibres, which promote or result from the conditioning effect.
This paper references
10.1136/jnnp.5.3-4.117
FACTORS AFFECTING RECOVERY OF SENSORY FUNCTION AFTER NERVE LESIONS
E. Gutmann (1942)
10.1016/0006-8993(76)90938-0
Neurite outgrowth from explanted Xenopus retina: An effect of prior optic nerve section
B. Agranoff (1976)
10.1016/0006-8993(80)90423-0
Effect of a conditioning lesion on regeneration of goldfish optic axons: ultrastructural evidence of enhanced outgrowth and pinocytosis
H. Lanners (1980)
10.1523/JNEUROSCI.07-03-00792.1987
Fast axonally transported proteins in regenerating goldfish optic axons
G. Perry (1987)
10.1016/B978-0-12-044276-8.50013-8
THE RETINA AS A REGENERATING ORGAN
B. Grafstein (1986)
10.1111/j.1471-4159.1981.tb04671.x
Protein Synthesis and Axonal Transport During Nerve Regeneration
G. Perry (1981)
10.1016/0006-8993(79)90194-X
Explant culture of adult goldfish retina: A model for the study of CNS regeneration
G. Landreth (1979)
10.1083/JCB.89.1.86
Changes in axonally transported proteins during axon regeneration in toad retinal ganglion cells
J. Skene (1981)
10.1111/j.1471-4159.1987.tb13137.x
Destinations of Some Fast‐Transported Proteins in Sensory Neurons of Bullfrog Sciatic Nerve
R. Rulli (1987)
10.1523/JNEUROSCI.05-01-00192.1985
Specific changes in axonally transported proteins during regeneration of the frog (Xenopus laevis) optic nerve
B. G. Szaro (1985)
10.1523/JNEUROSCI.03-02-00243.1983
Correlation of axonal regeneration and slow component B in two branches of a single axon
J. Wujek (1983)
10.1111/j.1471-4159.1983.tb08131.x
Protein Synthesis and Rapid Axonal Transport During Regrowth of Dorsal Root Axons
G. Perry (1983)
10.1007/978-3-642-68074-8_9
Effect of a Conditioning Lesion on Axonal Regeneration and Recovery of Function
D. Forman (1981)
10.1007/978-1-4684-1197-3_12
Effect of a Conditioning Lesion on Axonal Transport During Regeneration
I. Mcquarrie (1984)
10.1016/0006-8993(78)91116-2
The effect of a conditioning lesion on the regeneration of motor axons
I. Mcquarrie (1978)
10.1016/0006-8993(79)90276-2
Accelerated axonal sprouting after nerve transection
I. Mcquarrie (1979)
10.1111/j.1471-4159.1985.tb08736.x
Changes in Protein Content of Goldfish Optic Nerve During Degeneration and Regeneration Following Nerve Crush
G. Perry (1985)
10.1016/0006-8993(78)90614-5
Regeneration of adrenergic axons in rat sciatic nerve: Effect of a conditioning lesion
I. Mcquarrie (1978)
10.1523/JNEUROSCI.01-03-00300.1981
Specific changes in rapidly transported proteins during regeneration of the goldfish optic nerve
L. Benowitz (1981)
10.1111/j.1471-4159.1987.tb04115.x
Subsets of Axonally Transported and Periaxonal Polypeptides Are Released from Regenerating Nerve
B. Tedeschi (1987)
10.1523/JNEUROSCI.01-04-00419.1981
Characteristics of growth-associated polypeptides in regenerating toad retinal ganglion cell axons
J. Skene (1981)
10.1523/JNEUROSCI.03-11-02153.1983
Increased transport of 44,000- to 49,000-dalton acidic proteins during regeneration of the goldfish optic nerve: a two-dimensional gel analysis
L. Benowitz (1983)
10.1002/AJA.1001210312
Fine structure of nerves in the regenerating limb of the newt Triturus.
T. Lentz (1967)
10.1016/0006-8993(77)90193-7
Axonal regeneration in the rat sciatic nerve: Effect of a conditioning lesion and of dbcAMP
I. Mcquarrie (1977)
10.1007/978-1-4684-1197-3_13
The Relationship of Slow Axonal Flow to Nerve Elongation and Degeneration
P. Cancalon (1984)
10.1002/NEU.480110503
Changes in the composition of labeled protein transported in motor axons during their regeneration.
M. Bisby (1980)
10.1016/0006-8993(85)91578-1
Stages of axonal regeneration following optic nerve crush in goldfish: contrasting effects of conditioning nerve lesions and intraocular acetoxycycloheximide injections
I. Mcquarrie (1985)
10.1001/ARCHNEUR.1973.00490250071008
Axon outgrowth enhanced by a previous nerve injury.
I. Mcquarrie (1973)
10.1016/0006-8993(78)90155-5
Two-dimensional gel electrophoresis of proteins in rapid axoplasmic transport
G. Stone (1978)
10.1016/0006-8993(82)91270-7
Protein synthesis and axonal transport in goldfish retinal ganglion cells during regeneration accelerated by a conditioning lesion
I. Mcquarrie (1982)
10.1002/CNE.901680202
Regeneration of retinal axons into the goldfish optic tectum
M. Murray (1976)
10.1016/S0070-2153(08)60518-9
Nerve fiber growth and the cellular response to axotomy.
S. Carbonetto (1982)
10.1016/0006-8993(81)90128-1
Effect of a conditioning lesion on optic nerve regeneration in goldfish
I. Mcquarrie (1981)
10.1523/JNEUROSCI.03-09-01728.1983
Modification of a rapidly transported protein in regenerating nerve
B. Tedeschi (1983)



This paper is referenced by
10.1007/978-94-011-2348-8_6
On retrograde signalling and molecular events associated with nerve damage and regeneration
G. W. Perry (1992)
10.1002/ana.25209
The nerve conditioning lesion: A strategy to enhance nerve regeneration
Jenna-Lynn Senger (2018)
10.1016/0306-4522(93)90168-F
Expression of GAP-43 in normal and regenerating nerves in the frog
J. Golding (1993)
10.3109/02713688908997567
Quantitative analysis of labelled inner retinal proteins in experimental optic neuritis.
J. Guy (1989)
10.1016/0006-8993(90)90676-3
Effects of repetitive conditioning crush lesions on regeneration of the rat sciatic nerve
Jacob Sjo¨berg (1990)
10.1016/0006-8993(90)90812-P
The initial period of peripheral nerve regeneration and the importance of the local environment for the conditioning lesion effect
J. Sjöberg (1990)
10.1016/j.neulet.2012.02.027
Advances in natural biomaterials for nerve tissue repair
Zin Z. Khaing (2012)
10.1002/cne.20297
Conditioning lesions enhance axonal regeneration of descending brain neurons in spinal‐cord‐transected larval lamprey
L. Zhang (2004)
10.1016/0165-3806(95)00135-Z
Alterations in geniculate ganglion proteins following fungiform receptor damage.
P. S. Lasiter (1995)
10.1046/j.1471-4159.1997.68031114.x
Differential Regulation of Fast Axonally Transported Proteins During the Early Response of Rat Retinal Ganglion Cells to Axotomy
L. Wodarczyk (1997)
10.1002/NEU.480220603
Axotomy accelerates slow component b of axonal transport.
J. Jacob (1991)
10.1007/978-94-011-2348-8
Development and Regeneration of the Nervous System
S. Nona (1992)
10.5772/INTECHOPEN.82125
The Impact of Neuroscience on the Evolution of Decision-Making in Brachial Plexus Surgery. Part II: Nerve Grafts Act as Operator Channels (How the New May Meet the Old)
S. Amr (2018)
10.1523/JNEUROSCI.11-11-03412.1991
The major 35S-methionine-labeled rapidly transported protein (superprotein) is identical to SNAP-25, a protein of synaptic terminals
A. Loewy (1991)
10.1007/BF02935585
Nerve growth factor and neuronal cell death
J. Perez-polo (2008)
10.3109/02713688908997568
Axonal transport reductions in acute experimental allergic encephalomyelitis: qualitative analysis of the optic nerve.
J. Guy (1989)
10.1002/JNR.490310308
Effects of protein kinase inhibitors on regeneration in vitro of adult frog sciatic sensory axons
P. Ekström (1992)
10.1016/B978-0-12-802114-9.00013-5
Steroid Hormone Signaling Pathways and Sex Differences in Neuroendocrine and Behavioral Responses to Stress
Mario G Oyola (2016)
10.1111/j.1471-4159.1991.tb06402.x
A Fast Axonally Transported Protein of the Frog Sciatic Sensory Axons Undergoes Similar Qualitative Changes During Regeneration In Vitro and In Vivo
P. Remgård (1991)
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