Online citations, reference lists, and bibliographies.
← Back to Search

Involvement Of Calcitonin Gene-related Peptide (CGRP) And Nitric Oxide (NO) In The Pial Artery Dilatation Elicited By Cortical Spreading Depression

M. Wahl, L. Schilling, A. A. Parsons, A. Kaumann
Published 1994 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The aim of the present study was to examine whether the initial transient arterial dilatation during cortical spreading depression (CSD) was mediated by the release of calcitonin gene-related peptide (CGRP) and/or nitric oxide (NO). This question is of interest as the initial phase of CSD appears to be a model of events occurring during functional hyperemia and during the first period of classic migraine. Using an open cranial window technique, pial arterial diameter in the parietal cortex of cats was recorded with an image splitting method. Employing micropuncture technique, perivascularly applied CGRP8-37 did not alter the resting diameter of pial arteries but antagonized concentration dependently (5 x 10(-9)-10(-6) M) the dilatation (35%) due to 5 x 10(-8) M CGRP. NG-Nitro-L-Arginine (NOLAG, 10(-4) M) also had no effect on resting diameter of pial arteries, indicating that their resting tone is neither mediated by a continuous release of CGRP nor of NO. CSD was triggered by a remote intracortical injection of KCl (150 mM) and recorded by a microelectrode placed adjacent to the artery under investigation. CSD elicited a transient negative DC shift which was accompanied by a peak dilatation of 44 +/- 5.2% (S.E.M.). This dilatation was reduced by approximately 50% during topical application of 10(-7) M CGRP8-37 and 10(-4) M NOLAG each. A 75% inhibition of the CSD-induced dilatation was found during simultaneous application of both compounds. These data indicate that the initial dilatation during CSD is mediated, at least in part, by a release of CGRP and NO.(ABSTRACT TRUNCATED AT 250 WORDS)
This paper references
10.1002/ANA.410280213
Vasoactive peptide release in the extracerebral circulation of humans during migraine headache
P. J. Goadsby (1990)
10.1016/0006-8993(87)90682-2
Change of cerebrovascular reactivity after cortical spreading depression in cats and rats
M. Wahl (1987)
10.1073/PNAS.83.15.5731
Calcitonin gene-related peptide: functional role in cerebrovascular regulation.
J. McCulloch (1986)
10.1152/AJPREGU.1991.261.4.R828
Prostanoids attenuate pial arteriolar dilation induced by cortical spreading depression in rabbits.
M. Shibata (1991)
10.1046/j.1468-2982.1992.1203137.x
Subcortical Cerebral Blood Flow and Metabolic Changes Elicited by Cortical Spreading Depression in Rat
S. Mraovitch (1992)
10.1016/0304-3940(85)90296-4
Innervation of the feline cerebral vasculature by nerve fibers containing calcitonin gene-related peptide: Trigeminal origin and co-existence with substance P
R. Uddman (1985)
10.1046/j.1468-2982.1993.1303180.x
Cortical Spreading Depression Does Not Result in the Release of Calcitonin Gene-Related Peptide into the External Jugular Vein of the Cat: Relevance to Human Migraine
R. D. Piper (1993)
10.1016/0006-8993(88)90620-8
Quisqualate, kainate and NMDA can initiate spreading depression in the turtle cerebellum
M. Lauritzen (1988)
10.1002/ANA.410230214
Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system
P. J. Goadsby (1988)
10.1111/j.1476-5381.1993.tb13454.x
Neurokinin‐induced changes in pial artery diameter in the anaesthetized guinea‐pig
D. Beattie (1993)
10.1016/0006-8993(92)91470-Y
Nitric oxide synthesis couples cerebral blood flow and metabolism
P. Goadsby (1992)
10.1097/00005344-198500073-00005
Local Chemical, Neural, and Humoral Regulation of Cerebrovascular Resistance Vessels
M. Wahl (1985)
10.1016/0304-3940(93)90343-J
Role of nitric oxide in the coupling of cerebral blood flow to neuronal activation in rats
U. Dirnagl (1993)
10.1016/0166-2236(91)90022-M
Glutamate, nitric oxide and cell-cell signalling in the nervous system
J. Garthwaite (1991)
Cerebral and extracranial circulatory disturbances in migraine: pathophysiological implications.
J. Olesen (1991)
10.1073/PNAS.86.22.9030
Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.
D. Bredt (1989)
10.1080/01616412.1993.11740103
Nitric oxide does not act as a mediator coupling cerebral blood flow to neural activity following somatosensory stimuli in rats.
Q. Wang (1993)
Role of nitric oxide in neurally induced cerebroarterial relaxation.
N. Toda (1991)
10.1016/0006-8993(88)90690-7
Evidence for a role of the N-methyl-d-aspartate (NMDA) receptor in cortical spreading depression in the rat
R. Marrannes (1988)
10.1111/j.1476-5381.1992.tb13382.x
l‐Arginine dilates rat pial arterioles by nitric oxide‐dependent mechanisms and increases blood flow during focal cerebral ischaemia
E. Morikawa (1992)
10.1111/j.1526-4610.1991.hed3104213.x
Migraine ‐ Why and How a Cortical Excitatory Wave May Initiate the Aura and Headache
J. E. Hardebo (1991)
10.1016/0006-8993(93)91644-8
Microdialysis of interstitial amino acids during spreading depression and anoxic depolarization in rat neocortex
M. Fabricius (1993)
10.1016/0143-4179(90)90114-E
Stimulation of the superior sagittal sinus in the cat causes release of vasoactive peptides
A. Zagami (1990)
10.1161/01.HYP.16.4.371
Endothelium-derived relaxing factors. A perspective from in vivo data.
J. J. Marshall (1990)
10.1161/01.STR.22.9.1177
Mechanisms of impaired endothelium-dependent cerebral vasodilatation in response to bradykinin in hypertensive rats.
S. T. Yang (1991)
10.1111/j.1471-4159.1990.tb08860.x
Evidence for an Astrocyte‐Derived Vasorelaxing Factor with Properties Similar to Nitric Oxide
S. Murphy (1990)
10.1161/01.RES.70.6.1313
Calcitonin gene-related peptide mediates nitroglycerin and sodium nitroprusside-induced vasodilation in feline cerebral arterioles.
E. P. Wei (1992)
10.1002/NEU.480020103
Glutamate release from the retina during spreading depression.
A. van Harreveld (1970)
10.1002/ANA.410280610
Timing and topography of cerebral blood flow, aura, and headache during migraine attacks
J. Olesen (1990)
10.1016/0006-8993(90)91294-Q
Cerebral hemodynamics during cortical spreading depression in rabbits
M. Shibata (1990)
10.1161/01.RES.72.2.476
Nitric oxide mediates vasodilatation in response to activation of N-methyl-D-aspartate receptors in brain.
F. Faraci (1993)
10.1097/00005344-199117003-00004
Is L-arginine the precursor of an endothelium-derived relaxing factor in the cerebral microcirculation ?
R. Haberl (1991)
10.1016/0304-3940(92)90552-I
Nitric oxide (NO) is involved in increased cerebral cortical blood flow following stimulation of the nucleus basalis of Meynert in anesthetized rats
T. Adachi (1992)
10.1007/BF00195071
NG-nitro-L-arginine (N5-[imino(nitroamino)methyl]-L-ornithine) impairs endothelium-dependent dilations by inhibiting cytosolic nitric oxide synthesis from l-arginine
Alexander Miilsch (2004)
10.1038/jcbfm.1993.9
Possible Origins and Distribution of Immunoreactive Nitric Oxide Synthase-Containing Nerve Fibers in Cerebral Arteries
K. Nozaki (1993)
Cerebral blood flow in migraine and cortical spreading depression.
M. Lauritzen (1987)
10.1161/01.RES.67.6.1374
Mono-L-arginine-containing compounds dilate piglet pial arterioles via an endothelium-derived relaxing factor-like substance.
D. Busija (1990)
10.1152/AJPENDO.1989.256.2.E331
Calcitonin gene-related peptide receptor antagonist human CGRP-(8-37).
T. Chiba (1989)
10.1002/ANA.410090406
Focal hyperemia followed by spreading oligemia and impaired activation of rcbf in classic migraine
J. Olesen (1981)
10.1016/0143-4179(92)90517-Z
Characterization of calcitonin gene-related peptide (CGRP) receptors in guinea pig basilar artery
I. Jansen (1992)
10.1152/AJPHEART.1990.258.5.H1261
Differences in endothelium-dependent cerebral dilation by bradykinin and acetylcholine.
H. Kontos (1990)
10.1002/ANA.410120510
Persistent oligemia of rat cerebral cortex in the wake of spreading depression
Martin Lauritzen (1982)
10.1016/0006-291X(90)92382-A
Regional distribution of EDRF/NO-synthesizing enzyme(s) in rat brain.
U. Foerstermann (1990)
10.1073/PNAS.89.14.6649
Competitive inhibition of nitric oxide synthase prevents the cortical hyperemia associated with peripheral nerve stimulation.
F. Northington (1992)
10.1002/ANA.410130609
Changes in regional cerebral blood flow during the course of classic migraine attacks
Martin Lauritzen (1983)
10.1016/0006-291X(89)91067-X
Enzymatic formation of nitrogen oxides from L-arginine in bovine brain cytosol.
H. Schmidt (1989)
10.1016/0014-4886(92)90137-F
Spreading depression induces prolonged reduction of cortical blood flow reactivity in the rat
P. Lacombe (1992)
10.1152/AJPHEART.1991.261.4.H1038
Role of endothelium-derived relaxing factor in cerebral circulation: large arteries vs. microcirculation.
F. Faraci (1991)
10.1159/000158887
Nitric oxidergic neurogenic vasodilation in the porcine basilar artery.
T. J. Lee (1991)
10.1016/0922-4106(89)90023-0
NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices.
J. Garthwaite (1989)
10.1152/AJPHEART.1991.261.1.H96
Cortical blood flow changes during spreading depression in cats.
R. D. Piper (1991)
10.1161/01.STR.23.11.1623
Effects in Cats of Inhibition of Nitric Oxide Synthesis on Cerebral Vasodilation and Endothelium‐Derived Relaxing Factor From Acetylcholine
E. P. Wei (1992)
10.1038/347768A0
Localization of nitric oxide synthase indicating a neural role for nitric oxide
D. Bredt (1990)
10.1016/0304-3940(89)90437-0
Origins of substance P- and calcitonin gene-related peptide-containing nerves in the internal carotid artery of rat
J. E. Hardebo (1989)



This paper is referenced by
10.1152/ajpheart.1998.274.6.H1979
Perivascular nerves contribute to cortical spreading depression-associated hyperemia in rats.
U. Reuter (1998)
10.1016/S0006-8993(00)03191-7
Cortical spreading depression produces increased cGMP levels in cortex and brain stem that is inhibited by tonabersat (SB-220453) but not sumatriptan
S. J. Read (2001)
10.1007/s11916-012-0255-1
Endogenous Mechanisms Underlying the Activation and Sensitization of Meningeal Nociceptors: The Role of Immuno-Vascular Interactions and Cortical Spreading Depression
D. Levy (2012)
10.1097/01.WCB.0000137057.92786.F3
Pronounced Hypoperfusion during Spreading Depression in Mouse Cortex
C. Ayata (2004)
10.1016/j.pain.2013.07.021
Migraine pathophysiology: Anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain
R. Noseda (2013)
10.1097/00004647-199809000-00007
Nitric Oxide Scavenging by Hemoglobin or Nitric Oxide Synthase Inhibition by N-Nitro-L-Arginine Induces Cortical Spreading Ischemia When K+ Is Increased in the Subarachnoid Space
J. Dreier (1998)
10.1038/sj.bjp.0704842
Nitric oxide synthase inhibitors can antagonize neurogenic and calcitonin gene‐related peptide induced dilation of dural meningeal vessels
S. Akerman (2002)
10.1111/(issn)1743-5013
Headache Currents
D. W. Dodick (2008)
10.1016/0006-8993(95)00833-C
Calcitonin gene-related peptide (CGRP) and the regulation of cerebral parenchymal vessels
M. Kobari (1995)
10.1080/14737175.2016.1200973
Chronic migraine treatment: from OnabotulinumtoxinA onwards
A. Negro (2016)
10.1101/151464
The CGRP receptor antagonist BIBN4096 inhibits prolonged meningeal afferent activation evoked by brief local K+ stimulation but not cortical spreading depression-induced afferent sensitization but not cortical spreading depression-induced afferent sensitization
Jun Zhao (2017)
10.14288/1.0314180
Regulation of cerebral blood flow during transient hypertension in humans
K. W. Wildfong (2016)
Canaux ioniques, douleur et analgésie - Effets analgésiques du blocage d'ASIC1a par la Psalmotoxine 1
M. Mazzuca (2007)
10.1161/01.STR.25.12.2463
Nitric Oxide Promotes Arteriolar Dilation During Cortical Spreading Depression in Rabbits
D. Colonna (1994)
10.1523/JNEUROSCI.0373-15.2015
Migraine: Multiple Processes, Complex Pathophysiology
R. Burstein (2015)
10.1016/S0006-8993(99)01985-X
Effects of sumatriptan on nitric oxide and superoxide balance during glyceryl trinitrate infusion in the rat. Implications for antimigraine mechanisms
S. J. Read (1999)
10.1016/j.pharep.2016.05.001
Involvement of CGRP receptors in retinal spreading depression.
Y. Wang (2016)
10.1152/ajpheart.1998.274.6.H1979
Perivascular nerves contribute to cortical spreading depression-associated hyperemia in rats.
U. Reuter (1998)
10.1007/s001090050130
Inhibition of intercellular adhesion molecule-1 (ICAM-1), soluble ICAM-1 and interleukin-4 by nitric oxide expression in migraine patients
P. Martelletti (1997)
10.1016/S0304-3940(00)01424-5
Capsaicin-sensitive mechanisms are involved in cortical spreading depression-associated cerebral blood flow changes in rats
F. Bari (2000)
10.1155/1996/654071
Pathophysiology of Headaches with a Prominent Vascular Component
J. Pareja (1996)
10.1007/978-88-470-1700-9_16
Mechanisms of Migraine and Its Treatment
L. Edvinsson (2011)
10.1124/PR.55.2.3
The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels
N. Toda (2003)
10.1046/j.1468-2982.2000.00092.x
Repetitive Cortical Spreading Depression in a Gyrencephalic Feline Brain: Inhibition by the Novel Benzoylamino-Benzopyran SB-220453
M. I. Smith (2000)
10.1097/00004647-200205000-00014
Immunohistochemical Localization of Calcitonin Receptor–Like Receptor and Receptor Activity–Modifying Proteins in the Human Cerebral Vasculature
K. Oliver (2002)
10.1179/1743132812Y.0000000113
Preventive effects of AdR-siPTEN through the regulation of NMDA receptor NR2B subunit in trigeminal ganglia of migraine rats
Guangcheng Qin (2012)
10.1016/0143-4179(95)90014-4
The involvement of calcitonin gene-related peptide (CGRP) and substance P in feline pial artery diameter responses evoked by capsaicin
K. J. Escott (1995)
10.1016/0006-8993(95)00737-B
Effects of nitric oxide on the retinal spreading depression
Hans J. Ulmer (1995)
10.1016/S0304-3940(98)00442-X
Nitric oxide does not mediate cerebral blood flow changes during cortical spreading depression in the anaesthetised rat
S. J. Read (1998)
10.1016/S0006-8993(00)02400-8
Sumatriptan modifies cortical free radical release during cortical spreading depression: A novel antimigraine action for sumatriptan?
S. J. Read (2000)
10.1177/0333102418771350
Current understanding of meningeal and cerebral vascular function underlying migraine headache
D. Levy (2018)
10.1186/s10194-019-0983-2
Neuroimaging clues of migraine aura
Nouchine Hadjikhani (2019)
See more
Semantic Scholar Logo Some data provided by SemanticScholar