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Antitumour Action Of Planar, Organometallic Rhodium(I) Complexes.

T. Giraldi, G. Zassinovich, G. Mestroni
Published 1974 · Chemistry, Medicine

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Abstract Four cis-, square planar rhodium(I) organometallic complexes have been tested for antineoplastic properties. Their activity varies depending on the tumour system employed. They cause little or no effect on the growth of solid S180, and only one of them is effective on LI210 leukemia. Their activity on Ehrlich ascites is more pronounced, with low T/C ratios, two derivatives in particular causing some regressions. This greater activity on ascites carcinoma has been correlated with the oxidability and the lability of the leaving groups of these complexes. The most active compound on Ehrlich ascites, when tested for effects on the incorporation of labelled precursors in macromolecules shows a selective inhibition of leucine incorporation into proteins at therapeutically active doses. It is pointed out that these rhodium derivatives, in contrast to platinum complexes, are characterized by π carbon-metal bonds instead of nitrogen donor ligands for the non-leaving groups.

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