Online citations, reference lists, and bibliographies.
← Back to Search

Antitumour Action Of Planar, Organometallic Rhodium(I) Complexes.

T. Giraldi, G. Zassinovich, G. Mestroni
Published 1974 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Abstract Four cis-, square planar rhodium(I) organometallic complexes have been tested for antineoplastic properties. Their activity varies depending on the tumour system employed. They cause little or no effect on the growth of solid S180, and only one of them is effective on LI210 leukemia. Their activity on Ehrlich ascites is more pronounced, with low T/C ratios, two derivatives in particular causing some regressions. This greater activity on ascites carcinoma has been correlated with the oxidability and the lability of the leaving groups of these complexes. The most active compound on Ehrlich ascites, when tested for effects on the incorporation of labelled precursors in macromolecules shows a selective inhibition of leucine incorporation into proteins at therapeutically active doses. It is pointed out that these rhodium derivatives, in contrast to platinum complexes, are characterized by π carbon-metal bonds instead of nitrogen donor ligands for the non-leaving groups.



This paper is referenced by
10.1016/S0006-3061(00)82021-9
Morphological effects of chromium and cobalt complexes on bacteria.
A. Theodotou (1976)
Metals and metal compounds in cancer treatment.
B. Desoize (2004)
10.1016/S1040-8428(01)00222-0
Rhodium and its compounds as potential agents in cancer treatment.
N. Katsaros (2002)
10.1007/978-94-011-1252-9_5
Rhodium, iridium and palladium compounds as experimental anticancer drugs
R. G. Buckley (1994)
10.1016/S0031-6989(77)80017-9
Effects of transition metal complexes on human lymphocyte blastogenesis in vitro.
F. Klugmann (1977)
10.1007/978-3-642-74191-3_1
The Role of Non-Platinum Complexes in Cancer Therapy
B. Keppler (1990)
AntitumorActionof Two Rhodiumand RutheniumComplexesin Comparisonwith cis-Diamminedichloroplatinum(ll)1
T. Giraldi (1977)
10.1016/0277-5379(84)90223-2
Antineoplastic activity and toxicity of an organometallic complex of ruthenium(II) in comparison with cis-PDD in mice bearing solid malignant neoplasms.
G. Sava (1984)
10.1016/B978-0-12-013319-2.50008-5
Metal Complexes as Antitumour Agents
B. Keppler (1990)
10.1016/S0020-1693(00)87111-X
Mutagenic effects of rhodium(I) and ruthenium(II) organometallic complexes in bacteria
C. Monti-Bragadin (1987)
10.1007/BF00193472
Complexes of metals other than platinum as antitumour agents
P. Koepf-Maier (2004)
10.1016/0009-2797(83)90037-6
Antitumor effects of rhodium(I), iridium(I) and ruthenium(II) complexes in comparison with cis-dichlorodiammino platinum(II) in mice bearing Lewis lung carcinoma.
G. Sava (1983)
10.1002/AOC.725
Development of organometallic (organo‐transition metal) pharmaceuticals
Claire S. Allardyce (2005)
10.1128/AAC.7.6.825
Effects of cis-Dichlorodiammineplatinum (II) and Related Transition Metal Complexes on Escherichia coli
C. Monti-Bragadin (1975)
10.1016/0009-2797(78)90128-X
Antitumor action of rhodium (I) and iridium (I) complexes.
T. Giraldi (1978)
10.1016/0305-7372(90)90057-M
New tumor-inhibiting metal complexes.
B. K. Keppler (1990)
Antitumor action of two rhodium and ruthenium complexes in comparison with cis-diamminedichloroplatinum(II).
T. Giraldi (1977)
10.1002/EJIC.200501033
Syntheses, Spectroscopic Studies, and Crystal Structures of Chiral [Rh(aminocarboxylato)(η4-cod)] and Chiral [Rh(amino alcohol)(η4-cod)](acetate) Complexes with an Example of a Spontaneous Resolution of a Racemic Mixture into Homochiral Helix-Enantiomers
M. Enamullah (2006)
10.1007/978-3-662-10278-7_5
Medical Use of Cytostatic Platinum Compounds
G. Bernfeld (1985)
10.3109/07357908709020303
Antineoplastic activity of a rhodium trichloride complex of oxalyl homocysteine thiolactone.
K. Mccully (1987)
The effect of metal based complexes on the survival of aerobic and hypoxic chinese hamster ovary cells, in vitro.
N. Falzone (2007)
10.1016/B978-0-444-88189-2.50021-3
Cancer chemotherapy involving platinum and other platinum group complexes.
C. A. Mcauliffe (1991)
10.1007/3418_001
Medicinal properties of organometallic compounds
C. Allardyce (2006)
10.1016/S0020-1693(00)87119-4
Coordination metal complexes of Rh(I), Ir(I) and Ru(II): recent advances on antimetastatic activity on solid mouse tumors
G. Sava (1987)
10.1007/BF02856298
On the reaction of nucleic acid derivatives with rhodium(II) (isobutyrate)4L2
B. S. Yu (1978)
10.1007/BF02989580
Synthesis, Cytostatic, and Antitumor Properties of New Rh(I) Thiazole Complexes
D. Craciunescu (2008)
10.1007/978-94-011-1252-9
Metal Compounds in Cancer Therapy
S. Fricker (1994)
10.1007/BF01396872
Cationic rhodium(I) diolefin complexes
M. A. Garralda (1980)
10.1016/j.bmcl.2013.03.016
A potential rhodium cancer therapy: studies of a cytotoxic organorhodium(I) complex that binds DNA.
Jeanette R. McConnell (2013)
10.1016/S0022-328X(00)89005-1
Diolefinic complexes of rhodium(I) and iridium(I) with nitrogen-containing ligands
G. Zassinovich (1975)
Semantic Scholar Logo Some data provided by SemanticScholar