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A Study Of Particulate Intestinal Absorption And Hepatocellular Uptake. Use Of Polystyrene Latex Particles.

E. Sanders, C. Ashworth
Published 1961 · Biology, Medicine
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Abstract The object of this study was to elucidate the body mechanisms of absorption, transportation, and disposition of submicroscopic particles. Emulsions of polystyrene latex particles of 2200 A size were administered to rats in food and by stomach tubes. Electron microscopic study of jejunum, liver, and kidney was then carried out. The latex particles were demonstrated to be picked up by intestinal epithelium, to be carried through the cytoplasm within intact vesicles, discharged into the interstices of the lamina propria, and to gain entrance into the lymphatics of the mucosa. The process was identical with that previously shown for lipid particles. The latex particles were also demonstrated in the lumen of glomerular capillaries, in the hepatic sinusoids, in the spaces of Disse of the liver, and in the process of being taken into the liver cells by pinocytotic vesicles at the cell membrane. The value of latex particles of known size in the study of body processes of handling submicroscopic particles was thus demonstrated. Further evidence was gained for the significant role of the liver in removing particles of this general size range from the bloodstream.



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