Online citations, reference lists, and bibliographies.
← Back to Search

Effects Of Aging On Nerve Sprouting And Regeneration

A. Pestronk, D. Drachman, J. Griffin
Published 1980 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Abstract We examined the effects of aging on nerve terminal sprouting and regeneration in the peripheral nervous system. Motor end-plates were demonstrated in rat soleus muscles by means of a cholinesterase-silver stain which permitted measurement of end-plate length and nerve terminal branching. Terminal sprouting was elicited by “pharmacological denervation” brough about by botulinum toxin treatment. In the youngest (2-month-old) animals, the end-plates were small, and the terminals had simple branch patterns. Botulinum toxin treatment elicited a striking increase in end-plate length and terminal arborization. In the older (10- and 18-month-old) animals, the end-plate length was greater, and nerve terminal branching patterns were more complex. Botulinum toxin elicited a sprouting response that was less marked than in the youngest animals. In the oldest (28-month-old) animals, the end-plates were shorter and the terminals less complex. Botulinum failed to elicit any significant sprouting response. Regeneration of motor and sensory axons after a crush lesion of the sciatic nerve was measured using radiolabeled proteins carried by axonal transport as a marker of axonal outgrowth. Our results showed that the average rate of regeneration slowed with increasing age, although a small population of axons continued to regenerate rapidly regardless of age. Evidence implicating inherent defects in the ability of nerves to sprout and regenerate with increasing age is presented. Our findings in the peripheral nervous system may shed light on similar functional changes occurring in the central nervous system.
This paper references
10.1001/ARCHNEURPSYC.1958.02340010064005
Intraspinal sprouting of dorsal root axons; development of new collaterals and preterminals following partial denervation of the spinal cord in the cat.
C. N. Liu (1958)
10.1126/SCIENCE.204007
Motor nerve sprouting and acetylcholine receptors.
A. Pestronk (1978)
10.1007/978-1-4684-0925-3_6
Changes in Learning and Memory During Aging
P. Gold (1975)
10.1016/0006-8993(78)90504-8
Regeneration of motor axons in the rat sciatic nerve studied by labeling with axonally transported radioactive proteins
D. Forman (1978)
Growth and degeneration of motor end-plates in normal cat hind limb muscles.
Tuffery Ar (1971)
10.1098/rspb.1977.0085
Ferrier lecture - Functional architecture of macaque monkey visual cortex
D. Hubel (1977)
10.1038/265459a0
Motor neurone sprouting induced by prolonged tetrodotoxin block of nerve action potentials
M. Brown (1977)
10.1002/ANA.410030203
What hope for repair of the brain?
G. Raisman (1978)
10.1038/260352A0
Effect of muscle disuse on acetylcholine receptors
A. Pestronk (1976)
10.1126/SCIENCE.493989
Dendritic growth in the aged human brain and failure of growth in senile dementia.
S. J. Buell (1979)
10.1016/0014-4886(76)90208-9
Brain damage and reorganization of function in old age
D. Stein (1976)
10.1083/JCB.88.1.205
Incorporation of axonally transported glycoproteins into axolemma during nerve regeneration
J. Griffin (1981)
10.1038/209921B0
Motor Unit in Old Age
E. Gutmann (1966)
10.1016/0531-5565(76)90010-3
Some observations on the skeletal musculature of aged rats—III. Abnormalities of terminal axons found in motor end-plates
Koshiro Fujisawa (1976)
10.1016/0014-4886(78)90276-5
Effects of differential environments on plasticity of dendrites of cortical pyramidal neurons in adult rats
H. Uylings (1978)
10.1073/PNAS.75.5.2281
Synapse turnover: a mechanism for acquiring synaptic specificity.
R. Ruffolo (1978)
10.1002/NEU.480070407
Fast axonal transport in motor nerve regeneration.
J. Griffin (1976)
10.1002/NEU.480080407
Impaired axonal regeneration in acrylamide intoxication.
J. Griffin (1977)
The effects of implantation of an extra nerve on axonal sprouting usually induced by botulinum toxin in skeletal muscle of the mouse.
L. Duchen (1977)
10.1056/NEJM197911083011904
Psychotherapy and the single synapse. The impact of psychiatric thought on neurobiologic research.
E. Kandel (1979)
10.1007/978-3-642-45476-9_2
The Anatomy and Pathology of the Neuromuscular Junction
R. Bowden (1976)
10.1016/0014-4886(79)90053-0
Differences in incorporation of axonally transported protein in regenerating motor and sensory axons
M. Bisby (1979)
10.1159/000211462
Age Changes of Motor Endplates in Muscle Fibres of the Rat
E. Gutmann (1965)
10.1093/OXFORDJOURNALS.BMB.A070228
THE RATE OF REGENERATION OF NERVE
E. Gutmann (1942)
10.1016/0006-8993(78)90655-8
Impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats
P. Landfield (1978)
10.1016/0014-4886(79)90188-2
Slowing of the rate of axonal regeneration during growth and maturation
M. Black (1979)
10.1016/0006-8993(74)90941-X
The axonal transport of slowly migrating (3H)leucine labelled proteins and the regeneration rate in regenerating hypoglossal and vagus nerves of the rabbit.
M. Frizell (1974)
10.2307/1418610
Hebb and Senden on the role of learning in perception.
M. Wertheimer (1951)
10.1038/264787A0
Effect of botulinum toxin on trophic regulation of acetycholine receptors
A. Pestronk (1976)
10.1002/CNE.901040102
Age changes in conduction velocity, refractory period, number of fibers, connective tissue space and blood vessels in sciatic nerve of rats
J. Birren (1956)
10.1113/EXPPHYSIOL.1968.SP001948
The effects of botulinum toxin on the pattern of innervation of skeletal muscle in the mouse.
L. Duchen (1968)
10.1073/PNAS.69.1.147
Binding of -bungarotoxin to acetylcholine receptors in mammalian muscle.
Z. Hall (1973)
Muscle biopsy: A modern approach
V. Dubowitz (1973)
10.1002/MUS.880010110
A new stain for quantitative measurement of sprouting at neuromuscular junctions
A. Pestronk (1978)
10.1152/JN.1963.26.6.1003
SINGLE-CELL RESPONSES IN STRIATE CORTEX OF KITTENS DEPRIVED OF VISION IN ONE EYE.
T. Wiesel (1963)
Functional architecture of macaque monkey visual cortex
D. R. Rubel (1977)
10.1126/SCIENCE.715443
Decrease in adrenergic axon sprouting in the senescent rat.
S. Scheff (1978)



This paper is referenced by
10.1002/CNE.903230207
Effects of advancing age on peripheral nerve regeneration
D. W. Vaughan (1992)
10.1002/MUS.880100303
Aging rat neuromuscular junnctions: A morphometric study of cholinesterase‐stained whole mounts and ultrastructure
C. Cardasis (1987)
10.1016/0197-4580(90)90543-9
Age-related decrease in sympathetic sprouting is primarily due to decreased target receptivity: implications for understanding brain aging
K. Crutcher (1990)
10.1016/0306-4522(90)90069-G
Ultraterminal sprouting in innervated and partially denervated adult and aged rat muscle
J. Rosenheimer (1990)
10.1016/S0304-3940(99)00099-3
Flunarizine enhances functional recovery following sciatic nerve crush lesion in rats
Isan K Patro (1999)
10.1097/00005373-199605000-00016
The effect of age on peripheral motor nerve function after crush injury in the rat.
B. Belin (1996)
10.1002/AR.1092370215
Age changes in neuromuscular junctions of masseter muscle
M. K. Elkerdany (1993)
10.1001/ARCHNEUR.1988.00520260077025
Amyotrophic lateral sclerosis. Recent advances in pathogenesis and therapeutic trials.
H. Mitsumoto (1988)
10.3390/cells8080906
Neuromuscular Junction as an Entity of Nerve-Muscle Communication
Elisa Lepore (2019)
10.1002/SYN.890080308
Morphological and electrophysiological study of distal motor nerve fiber degeneration and sprouting after irreversible cholinesterase inhibition
M. Kawabuchi (1991)
10.1016/S0306-4522(02)00762-5
Age, diet and injury affect the survival of facial motoneurons
M. Aperghis (2003)
10.1007/978-1-4471-1871-8_11
Theories of Causation
S. Appel (1995)
10.1002/phy2.235
GDNF content and NMJ morphology are altered in recruited muscles following high‐speed and resistance wheel training
A. Gyorkos (2014)
10.1016/j.expneurol.2011.12.010
Motor nerve terminal destruction and regeneration following anti-ganglioside antibody and complement-mediated injury: An in and ex vivo imaging study in the mouse
A. Rupp (2012)
10.1016/S0306-4522(97)00500-9
Motoneuron survival and expression of neuropeptides and neurotrophic factor receptors following axotomy in adult and ageing rats
I. Johnson (1998)
10.1016/j.neurobiolaging.2008.03.020
Aging impairs collateral sprouting of nociceptive axons in the rat
U. Kovačič (2010)
10.1016/0014-4886(83)90081-X
Effects of sciatic nerve resection on L7 spinal roots and dorsal root ganglia in adult cats
M. Risling (1983)
10.1111/j.1471-4159.1987.tb05744.x
Acetylcholine Receptor Binding Properties at the Rat Neuromuscular Junction During Aging
D. O. Smith (1987)
10.1016/0006-8993(86)91471-X
Effect of age and muscle type on regeneration of neuromuscular synapses in mice
W. G. Hopkins (1986)
10.1111/ejn.12917
Normalized activation in the somatosensory cortex 30 years following nerve repair in children: an fMRI study
A. Chemnitz (2015)
10.1177/1545968311431965
Efficacy of Short-Term FK506 Administration on Accelerating Nerve Regeneration
Y. Yan (2012)
10.1016/0197-4580(87)90069-8
General and strain-specific age changes at mouse limb neuromuscular junctions
N. Anis (1987)
10.1007/s00383-019-04602-1
The incidence of neuropathic pain after intercostal cryoablation during the Nuss procedure
Michael J. Zobel (2019)
Prognostic Factors for Recovery of Walking in Guillain-Barr$\'{e}$syndrome
Sunkuk Kim (2002)
10.1016/S0047-6374(98)00150-X
The effect of age and injury on the expression of inducible nitric oxide synthase in facial motor neurons in F344 rats
J. Jacob (1999)
Median and Ulnar Nerve Injuries in Children and Adolescents- Long-term outcome and Cerebral reorganisation
A. Chemnitz (2013)
10.1515/REVNEURO.2006.17.6.581
Cytoskeletal Transport in the Aging Brain: Focus on the Cholinergic System
G. Niewiadomska (2006)
10.1002/mus.20470
Morphometric analysis of neuromuscular topography in the serratus anterior muscle
S. Potluri (2006)
10.1002/syn.21648
The Effects of Age and Ganglioside Composition on the Rate of Motor Nerve Terminal Regeneration Following Antibody-Mediated Injury in Mice
A. Rupp (2013)
10.1002/MUS.880131105
Time course of sprouting during muscle reinnervation in vitamin E‐deficient rats
R. Cuppini (1990)
10.1142/S0218810417500514
Age-Dependent Schwann Cell Phenotype Regulation Following Peripheral Nerve Injury.
W. A. Chen (2017)
10.1016/j.neuron.2014.06.016
Diminished Schwann Cell Repair Responses Underlie Age-Associated Impaired Axonal Regeneration
Michio W. Painter (2014)
See more
Semantic Scholar Logo Some data provided by SemanticScholar