Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Effects Of Sciatic Nerve Resection On L7 Spinal Roots And Dorsal Root Ganglia In Adult Cats

M. Risling, H. Aldskogius, C. Hildebrand, S. Remahl
Published 1983 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
The size, distribution, and number of nerve fibers and neuronal perikarya in the L7 spinal roots and ganglia of adult cats were examined 35, 90, and 190 days after ipsilateral sciatic nerve resection. With increasing survival time the size spectra of myelinated ventral root nerve fibers showed a progressive flattening of the alpha peak. In the dorsal roots the myelinated fiber size distribution exhibited a marked shift toward smaller sizes. The reduction in the proportion of large myelinated axons was particularly evident in the dorsal roots. Less clearcut changes were found in the size distribution of spinal ganglion neuronal perikarya. No significant loss of axons could be detected in ventral or dorsal roots. There was, however, a marked reduction in the number of dorsal root ganglion neurons. This discrepancy suggested the possibility that an initial loss of dorsal root axons was concealed by recurrent sprouting of axons from the proximal nerve stump. However, neuroma excision 90 days after nerve resection did not lead to any reduction in dorsal root axon numbers. Thus, any ingrowth of new axons to the dorsal root should occur from levels proximal to the neuroma. In comparison with previous findings in kittens, peripheral nerve resection in adult cats had significantly smaller effects on sizes and numbers of spinal root nerve fibers as well as of dorsal root ganglion neurons. Therefore, the potential for restitution of the peripheral innervation by axon regeneration appeared to be basically greater in mature than in immature animals.
This paper references
A study on the fixation of large mature feline myelinated ventral lumbar spinal-root fibers.
B. Ch (1968)
10.1016/0014-4886(80)90229-0
Structural changes in kittens' ventral and dorsal roots L7 after early postnatal sciatic nerve transection
M. Risling (1980)
10.1113/jphysiol.1982.sp014074
Time course and extent of recovery in reinnervated motor units of cat triceps surae muscles
T. Gordon (1982)
10.1097/00005072-197911000-00002
AXONAL ATROPHY FROM PERMANENT PERIPHERAL AXOTOMY IN ADULT CAT
J. Carlson (1979)
10.1002/CNE.901530105
Unmyelinated axons in the ventral roots of the cat lumbosacral enlargement
R. Coggeshall (1974)
10.1002/CNE.901490207
The organization of the seventh lumbar spinal ganglion of the cat
H. Burton (1973)
10.1016/0006-8993(79)90698-X
Differential atrophy of sensory and motor fibers following section of cat peripheral nerves
J. A. Hoffer (1979)
10.1126/SCIENCE.715443
Decrease in adrenergic axon sprouting in the senescent rat.
S. Scheff (1978)
10.1002/CNE.900940203
Quantitative effects of the peripheral innervation area on nerves and spinal ganglion cells
M. W. Cavanaugh (1951)
10.1152/JN.1979.42.4.1134
Studies on sensory neurons of the mouse with intracellular-recording and horseradish peroxidase-injection techniques.
S. Yoshida (1979)
10.1007/978-3-642-85986-1_14
Methods for counting neurons
B. Konigsmark (1970)
10.1152/PHYSREV.1980.60.3.716
Law of separation of function of the spinal roots.
R. Coggeshall (1980)
Observations on the morphology at the transition between the peripheral and the central nervous system in the cat. II. General organization of the transitional region in S1 dorsal rootlets.
C. Berthold (1977)
10.1016/S0079-6123(08)60685-8
Levels of maturation and reactions to injury during neuronal development.
Arthur Lavelle (1973)
METHODOLOGICAL STUDIES OF THE TECHNIQUE IN MEASURING NERVE FIBRE DIAMETERS.
C. Romero (1965)
10.1016/0014-4886(83)90389-8
Effects of sciatic nerve crush on the L7 spinal roots and dorsal root ganglia in kittens
M. Risling (1983)
10.1016/0014-4886(81)90194-1
Effect of sciatic neurectomy on neuronal number and size distribution in the L7 ganglion of kittens
H. Aldskogius (1981)
10.1002/CNE.901780309
A morphological study of the axons and recurrent axon collaterals of cat sciatic α‐motoneurons after intracellular staining with horseradish peroxidase
S. Cullheim (1978)
10.1007/978-3-642-68074-8_6
Neuronal Plasticity in the Newborn and Adult Feline Red Nucleus
N. Tsukahara (1981)
10.1002/CNE.901840111
Branching of sensory axons in the dorsal root and evidence for the absence of dorsal root efferent fibers
L. Langford (1979)
10.1016/0022-510X(82)90144-7
Occurrence of unmyelinated axon profiles at distal, middle and proximal levels in the ventral root L7 of cats and kittens
M. Risling (1982)
10.1002/AJA.1001070207
Numbers of fibers in regeneration after crushing the motor spinal nerve roots of young, mature and aged cats.
E. Moyer (1960)
10.1152/JN.1979.42.2.618
Chronic paw denervation causes an age-dependent appearance of novel responses from forearm in "paw cortex" of kittens and adult cats.
J. Kalaska (1979)
10.1007/BF01217921
Nerve cell degeneration and death in the trigeminal ganglion of the adult rat following peripheral nerve transection
H. Aldskogius (1978)
10.1097/00005072-197911000-00001
AXONAL UNDERDEVELOPMENT FROM AXOTOMY IN KITTENS
D. Jørgensen (1979)
10.1002/CNE.900940209
The motor cell columns of the lumbo‐sacral spinal cord of the cat
G. J. Romanes (1951)
10.1002/CNE.902010304
Postnatal increase of unmyelinated axon profiles in the feline ventral root L7
M. Risling (1981)
10.1016/0014-4886(84)90048-7
Invasion of the L7 ventral root and spinal pia mater by new axons after sciatic nerve division in kittens
M. Risling (1984)
10.1016/0014-4886(80)90006-0
Effects of aging on nerve sprouting and regeneration
A. Pestronk (1980)
10.1016/0006-8993(83)90042-2
Preferential loss of unmyelinated L7 dorsal root axons following sciatic nerve resection in kittens
H. Aldskogius (1983)
10.1016/0014-4886(82)90117-0
Activation of fibers via experimentally produced stump neuromas of skin nerves: Ephaptic transmission or retrograde sprouting?
H. Blumberg (1982)
10.1016/0006-8993(81)91128-8
Sprouting of dorsal root axons
C. Hulsebosch (1981)
10.1136/jnnp.44.6.485
The effects of axotomy on the conduction of action potentials in peripheral sensory and motor nerve fibres.
Theodore E. Milner (1981)



This paper is referenced by
10.1016/0006-8993(89)91497-2
Neuronal loss in lumbar dorsal root ganglia after proximal compared to distal sciatic nerve resection: a quantitative study in the rat
J. Ygge (1989)
10.3171/JNS.1992.77.3.0457
Effects of different methods of peripheral nerve repair on the number and distribution of muscle afferent neurons in rat dorsal root ganglion.
L. Myles (1992)
10.1016/S0168-0102(00)00153-X
Downregulation of TrkA expression in primary sensory neurons after unilateral lumbar spinal nerve transection and some rescuing effects of nerve growth factor infusion
L. Y. Deng (2000)
10.1088/1741-2560/8/5/056009
A computational model for estimating recruitment of primary afferent fibers by intraneural stimulation in the dorsal root ganglia.
D. Bourbeau (2011)
10.1007/BF02284798
Sciatic nerve injury in the adult rat: comparison of effects on oligosaccharide, CGRP and GAP43 immunoreactivity in primary afferents following two types of trauma
M. Groves (1996)
10.1007/BF00341412
The effect of sciatic nerve transection on myelinated fibers in the L5 dorsal root and lumbar dorsal column
H. Aldskogius (2004)
VENTRAL ROOT OR DORSAL ROOT GANGLION MICROSTIMULATION TO EVOKE HINDLIMB MOTOR RESPONSES
D. Bourbeau (2011)
10.1523/JNEUROSCI.06-12-03706.1986
Functional consequences of neonatal infraorbital nerve section in rat trigeminal ganglion
M. Jacquin (1986)
10.1016/S0306-4522(97)00173-5
Loss of dorsal root ganglion cells concomitant with dorsal root axon sprouting following segmental nerve lesions
H. Lekan (1997)
10.3109/08990229609028912
A stereological analysis of the numerical distribution of neurons in dorsal root ganglia C4-T2 in adult macaque monkeys.
C. Avendaño (1996)
10.1002/CNE.903520212
Birth dates and survival after axotomy of neurochemically defined subsets of trigeminal ganglion cells
F. White (1995)
10.1002/AR.1092190314
Loss of sensory neurons after sciatic nerve section in the rat
H. Schmalbruch (1987)
10.1016/S0079-6123(08)62758-2
Functional properties of spinal visceral afferents supplying abdominal and pelvic organs, with special emphasis on visceral nociception.
W. Jänig (1986)
10.1046/J.1529-8027.2002.02019.X
Enhancing posttraumatic nerve regeneration
G. Lundborg (2002)
10.1054/BJPS.2001.3700
Obstetric brachial plexus palsy: a comparison of the degree of recovery after repair of a C6 ventral root avulsion in newborn and adult sheep.
A. C. Fullarton (2001)
10.1016/0014-4886(91)90013-3
Selective decrease of small sensory neurons in lumbar dorsal root ganglia labeled with horseradish peroxidase after Nd:YAG laser irradiation of the tibial nerve in the rat
U. Wesselmann (1991)
10.1016/0014-4886(89)90145-3
Number of dorsal root ganglion neurons and axons in cats of different ages
H. Aldskogius (1989)
10.1016/0014-4886(92)90186-T
Reinnervation of denervated skeletal muscles by grafted dorsal root ganglion
M. Ochi (1992)
10.1002/CNE.902680402
Anatomical consequences of neonatal infraorbital nerve transection upon the trigeminal ganglion and vibrissa follicle nerves in the adult rat
B. Klein (1988)
MATHEMATICAL AND EXPERIMENTAL MODELS FOR STUDYING SOMATOSENSORY FEEDBACK VIA PRIMARY AFFERENT MICROSTIMULATION
J. Hokanson (2014)
Corneal reinnervation to treat neurotrophic keratopathy
Joseph Catapano (2017)
10.1016/S0014-4886(05)80019-6
End structure and neuropeptide immunoreactivity of axons in sciatic neuromas following nerve section in neonatal rats
K. Fried (1990)
10.1016/0304-3940(90)90383-K
Increased number of unmyelinated fibers in the ventral root after peripheral neurectomy in adult rat
S. C. Nam (1990)
10.3109/07367228509144581
Proliferation of primary sensory neurons in adult rat dorsal root ganglion and the kinetics of retrograde cell loss after sciatic nerve section.
M. Devor (1985)
10.1007/BF00942581
Ultrastructural changes in the gracile nucleus of the rat after sciatic nerve transection
J. Persson (2004)
10.1002/(SICI)1096-9861(19990913)412:1<186::AID-CNE14>3.0.CO;2-H
Effect of nerve crush on perikaryal number and volume of neurons in adult rat dorsal root ganglion
J. Degn (1999)
10.3109/02844319609072397
Loss of neurons in the dorsal root ganglia after transection of a peripheral sensory nerve. An anatomical study in monkeys.
A. Liss (1996)
Progenitor cells in the brainstem and filum terminale
M. Fagerlund (2012)
10.1016/0304-3959(91)90167-V
Receptive properties of pial afferents
W. Jänig (1991)
10.1016/j.neulet.2005.11.024
Increased sensory neuron apoptotic death 2 weeks after peripheral axotomy in C57BL/6J mice compared to A/J mice
Amauri Pierucci (2006)
10.1523/JNEUROSCI.11-07-02157.1991
Axotomy-induced changes in rabbit hindlimb nerves and the effects of chronic electrical stimulation
T. Gordon (1991)
10.1007/BF02830711
Protective effect of interleukin-1β on motor neurons after sciatic nerve injury in rats
Weng Yuxiong (2004)
See more
Semantic Scholar Logo Some data provided by SemanticScholar