Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Selective Decrease Of Small Sensory Neurons In Lumbar Dorsal Root Ganglia Labeled With Horseradish Peroxidase After Nd:YAG Laser Irradiation Of The Tibial Nerve In The Rat

U. Wesselmann, S. Lin, W. Rymer
Published 1991 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Recent electrophysiological evidence indicates that Q-switched Nd:YAG laser irradiation might have selective effects on neural impulse transmission in small slow conducting sensory nerve fibers as compared to large diameter afferents. In an attempt to clarify the ultimate fate of sensory neurons after laser application to their peripheral axons, we have used horseradish peroxidase (HRP) as a cell marker to retrogradely label sensory neurons innervating the distal hindlimb in the rat. Pulsed Nd:YAG laser light was applied to the tibial nerve at pulse energies of 70 or 80 mJ/pulse for 5 min in experimental rats. Seven days later HRP was applied to the left (laser-treated) and to the contralateral (untreated) tibial nerve proximal to the site of laser irradiation. In control animals the numbers of HRP-labeled dorsal root ganglion cells were not significantly different between the right and the left side. In contrast, after previous laser irradiation labeling was always less on the laser-treated side (2183 +/- 513 cells, mean +/- SEM) as compared to the untreated side (3937 +/- 225). Analysis of the dimensions of labeled cells suggested that the reduction of labeled cells on the laser-treated side was mainly due to a deficit in small sensory neurons. Since the conduction velocity of nerve fibers is related to the size of their somata, our histological data imply that laser light selectively affects retrograde transport mechanisms for HRP in slow conducting sensory nerve fibers.
This paper references
10.1002/CNE.902140303
Cell death and changes in the retrograde transport of horseradish peroxidase in rubrospinal neurons following spinal cord hemisection in the adult rat
H. Goshgarian (1983)
10.3171/JNS.1984.61.5.0841
Pain relief from dorsal root entry zone lesions made with argon and carbon dioxide microsurgical lasers.
S. K. Powers (1984)
10.1002/CNE.900230503
Studies on the regeneration of the peroneal nerve of the albino rat: Number and sectional areas of fibers: Area relation of axis to sheath
M. Greenman (1913)
10.1016/0006-8993(86)90310-0
Cell loss in lumbar dorsal root ganglia and transganglionic degeneration after sciatic nerve resection in the rat
J. Arvidsson (1986)
10.1113/jphysiol.1980.sp013095
Irreverisble differential block of A‐ and C‐fibres following local nerve heating in the cat.
D. Klumpp (1980)
10.1083/JCB.96.1.240
Changes in the amounts of cytoskeletal proteins within the perikarya and axons of regenerating frog motoneurons
D. Sinicropi (1983)
10.1159/000099970
Evaluation of laser- and radiofrequency-generated dorsal root entry zone lesions in the cat.
Z. Elias (1988)
10.1002/CNE.902140202
The cell bodies of origin of sympathetic and sensory axons in some skin and muscle nerves of the cat hindlimb
E. Mclachlan (1983)
10.1002/LSM.1900050202
Temperature rise in biological tissue during Nd:YAG laser irradiation
R. Marchesini (1985)
10.1016/0006-8993(86)90994-7
Differences in horseradish peroxidase labeling of sensory, motor and sympathetic neurons following chronic axotomy of the rat sural nerve
J. Peyronnard (1986)
10.1016/0006-8993(83)90983-6
Decreased horseradish peroxidase labeling in deafferented spinal motoneurons of the rat
J. Peyronnard (1983)
10.1016/0014-4886(86)90144-5
Differential effects of in vitro heating on rat sciatic nerve branches and spinal nerve roots
Sven G. Eliasson (1986)
10.3171/JNS.1983.59.4.0555
The laser in neurological surgery.
M. Edwards (1983)
10.1152/JN.1979.42.4.1134
Studies on sensory neurons of the mouse with intracellular-recording and horseradish peroxidase-injection techniques.
S. Yoshida (1979)
10.1016/0014-4886(84)90190-0
Retrograde and transganglionic degeneration of sensory neurons after a peripheral nerve lesion at birth
Adel A. Bondok (1984)
10.1002/NEU.480060112
Low temperature slowing and cold-block of fast axoplasmic transport in mammalian nerves in vitro.
S. Ochs (1975)
10.1016/0006-8993(85)90590-6
Sciatic nerve transection produces death of dorsal root ganglion cells and reversible loss of substance P in spinal cord
A. Tessler (1985)
10.1083/JCB.34.1.327
STUDIES ON THE MICROTUBULES IN HELIOZOA : II. The Effect of Low Temperature on These Structures in the Formation and Maintenance of the Axopodia
L. Tilney (1967)
10.1016/0306-4522(84)90299-9
The effect of previous transection on quantitative estimates of the preganglionic neurones projecting in the cervical sympathetic trunk of the guinea-pig and the cat made by retrograde labelling of damaged axons by horseradish peroxidase
U. Wesselmann (1984)
10.1002/AR.1092190314
Loss of sensory neurons after sciatic nerve section in the rat
H. Schmalbruch (1987)
Retrograde changes in fibre size following nerve section.
Aitken Jt (1962)
10.1016/0014-4886(75)90192-2
The selective vulnerability of evoked potentials in the trigeminal sensory root to graded thermocoagulation
T. Frigyesi (1975)
10.1126/SCIENCE.6836297
Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation.
R. Anderson (1983)
10.1113/jphysiol.1979.sp012660
Comparison of the temperature‐dependence of rapid axonal transport and microtubules in nerves of the rabbit and bullfrog.
S. Brimijoin (1979)
10.1083/JCB.99.2.705
Control of axonal caliber by neurofilament transport
P. Hoffman (1984)
10.1016/0014-4886(83)90081-X
Effects of sciatic nerve resection on L7 spinal roots and dorsal root ganglia in adult cats
M. Risling (1983)
10.1016/0304-3940(75)90005-1
Stimulation-induced uptake of horseradish peroxidase by rat cortical synapses
C. Cooke (1975)
10.1016/0014-4886(82)90212-6
Intracranial transection of the optic nerve in adult mice: Preliminary observations
B. Grafstein (1982)
10.1016/0304-3940(80)90206-2
The segmental origin of preganglionic axons in the upper thoracic rami of the cat
B. Oldfield (1980)
10.1002/CNE.901160202
The fine structure of neurons of dorsal root ganglia after stimulating or cutting the sciatic nerve
K. R. Smith (1961)
10.1002/CNE.902020306
Asymmetries and symmetries in the number of thoracic dorsal root ganglion cells
J. Ygge (1981)
10.1016/0006-8993(73)90356-9
Uptake and retrograde transport of horseradish peroxidase in frog sartorius nerve in vitro.
W. J. Litchy (1973)
10.1002/CNE.900940203
Quantitative effects of the peripheral innervation area on nerves and spinal ganglion cells
M. W. Cavanaugh (1951)
10.1016/0022-4804(87)90091-6
Sciatic nerve function following hindlimb thermal injury.
W. Monafo (1987)
10.1016/0014-4886(86)90161-5
Motoneurons of the rat sciatic nerve
J. Swett (1986)
10.1016/0006-8993(80)90144-4
Axonal transport of the cytoskeleton in regenerating motor neurons: constancy and change
P. Hoffman (1980)
10.3171/JNS.1981.55.2.0246
Radiofrequency neurolysis in a clinical model. Neuropathological correlation.
H. Smith (1981)
10.1002/CNE.900220203
The structure of the spinal ganglia and of the spinal nerves
S. W. Ranson (1912)
10.1002/CNE.902250213
On the fate of sympathetic and sensory neurons projecting into a neuroma of the superficial peroneal nerve in the cat
W. Jänig (1984)
10.1016/0304-3959(87)90160-6
Human trigeminal root evoked potentials during differential retrogasserian thermal and chemical rhizotomy
J. Macon (1987)
10.1002/NEU.480150204
Fast axonal transport in central nervous system and peripheral nervous system axons following axotomy.
J. Redshaw (1984)
10.1177/26.2.24068
Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents.
M. Mesulam (1978)
10.1002/LSM.1900050110
Thermal effects of the Nd: YAG and carbon dioxide lasers on the central nervous system
L. Burke (1985)
10.3171/JNS.1968.29.1.0042
The effect of radiofrequency current and heat on peripheral nerve action potential in the cat.
F. S. Letcher (1968)
10.1016/0014-4886(81)90194-1
Effect of sciatic neurectomy on neuronal number and size distribution in the L7 ganglion of kittens
H. Aldskogius (1981)
10.1002/CNE.901380306
Changes in nerve cell bodies during the myelination of their axons
A. Julio Martinez (1970)
10.1016/0006-8993(82)90598-4
Primary neurons maintain their central axonal arbors in the spinal dorsal horn following peripheral nerve injury: an anatomical analysis using transganglionic transport of horseradish peroxidase
T. Sugimoto (1982)
10.1002/LSM.1900050607
Thermal and optical properties of living tissue: Application to laser‐induced hyperthermia
L. Svaasand (1985)
10.1113/jphysiol.1985.sp015573
Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones.
A. Harper (1985)
10.1002/CNE.920190106
Alternations in the spinal ganglion cells following neurotomy
S. W. Ranson (1909)
10.1002/AR.1090940210
Estimation of nuclear population from microtome sections
M. Abercrombie (1946)
10.1016/0006-8993(77)90502-9
Decreased peroxidase labeling of lateral geniculate neurons following deafferentation
W. Singer (1977)
10.1126/science.134.3489.1521
Functional Effects of Focused Ultrasound on Mammalian Nerves
R. Young (1961)
10.1016/0006-8993(75)90482-5
A study of the dynamics of retrograde transport and accumulation of horseradish peroxidase in injured neurons
J. Halperin (1975)
10.1007/BF01217921
Nerve cell degeneration and death in the trigeminal ganglion of the adult rat following peripheral nerve transection
H. Aldskogius (1978)
10.1016/0014-4886(83)90389-8
Effects of sciatic nerve crush on the L7 spinal roots and dorsal root ganglia in kittens
M. Risling (1983)
10.1002/CNE.901350203
Cell changes in sensory ganglia following proximal and disal nerve section in the monkey
P. Carmel (1969)
10.1083/JCB.39.2.491
MICROTUBULES IN THE NERVE FIBERS OF THE TOAD BUFO ARENARUM HENSEL
E. L. Echandía (1968)
10.1002/AR.1092190313
The number of neurons in dorsal root ganglia L4–L6 of the rat
H. Schmalbruch (1987)
Regeneration of peripheral unmyelinated nerves. Fate of the axonal sprouts which develop after injury.
G. Bray (1974)
10.3109/07367228509144581
Proliferation of primary sensory neurons in adult rat dorsal root ganglion and the kinetics of retrograde cell loss after sciatic nerve section.
M. Devor (1985)
10.1002/NEU.480090402
Hypothermic decrease in microtubule density and birefringence in unimyelinated axons.
D. Rome-Talbot (1978)



This paper is referenced by
10.1007/s00296-013-2742-z
Is low-level laser therapy in relieving neck pain effective? Systematic review and meta-analysis
Amjed Kadhim-Saleh (2013)
10.1007/s10103-008-0555-1
Relieving pain in minor aphthous stomatitis by a single session of non-thermal carbon dioxide laser irradiation
N. Zand (2008)
10.3109/08990229409051394
Increased number of sciatic sensory neurons in vitamin-E-deficient rats.
T. Cecchini (1994)
10.1111/j.1399-6576.1995.tb04079.x
Long‐term local corticosteroid application does not influence nerve transmission or structure
A. Johansson (1995)
10.1089/PHO.2006.2047
Effects of 904-nm low-level laser therapy in the management of lateral epicondylitis: a randomized controlled trial.
L. Lam (2007)
10.1300/J094v11n03_03
Efficacy of 300 mW, 830 nm Laser in the Treatment of Chronic Neck Pain: A Survey in a General Practice Setting
R. Chow (2003)
10.2174/138161206775193280
Physical therapy modalities in management of fibromyalgia.
A. Gur (2006)
Clinical Evaluation of High and Low-Level Laser Treatment (CO2vsInGaAlP Diode Laser) for Recurrent Aphthous Stomatitis
Nasim Zeini Jahromi (2017)
10.1533/9780857097545.4.573
Lasers in neurology
D. Siposan (2013)
10.1002/9783527632053.CH6
Optical Stimulation of Neurons
S. Rajguru (2010)
10.1002/(SICI)1096-9101(1997)21:2<142::AID-LSM5>3.0.CO;2-Q
Effect of pulsed Nd:YAG laser radiation on action potential conduction in isolated mammalian spinal nerves
R. Orchardson (1997)
10.2147/OARRR.S8040
Advances in diagnostic and treatment options in patients with fibromyalgia syndrome
A. Gur (2009)
10.1007/BF00571951
Changes in sensory neuropeptides in dorsal root ganglion and spinal cord of spontaneously diabetic BB rats
G. Terenghi (2004)
10.1097/00000542-200508000-00020
Distinct Membrane Effects of Spinal Nerve Ligation on Injured and Adjacent Dorsal Root Ganglion Neurons in Rats
D. Sapunar (2005)
10.1300/J094v12n02_09
A Pilot Study of Low-Power Laser Therapy in the Management of Chronic Neck Pain
R. Chow (2004)
10.3171/2019.4.JNS19380
Temporal disconnection between pain relief and trigeminal nerve microstructural changes after Gamma Knife radiosurgery for trigeminal neuralgia.
Peter Shih-Ping Hung (2019)
10.1002/(SICI)1096-9861(20000626)422:2<172::AID-CNE2>3.0.CO;2-H
Delayed loss of small dorsal root ganglion cells after transection of the rat sciatic nerve
T. Tandrup (2000)
10.1097/00006123-200004000-00038
Histological effects of trigeminal nerve radiosurgery in a primate model: implications for trigeminal neuralgia radiosurgery.
D. Kondziolka (2000)
10.1016/S0306-4522(97)00173-5
Loss of dorsal root ganglion cells concomitant with dorsal root axon sprouting following segmental nerve lesions
H. Lekan (1997)
10.1002/LSM.20082
Efficacy of 904 nm gallium arsenide low level laser therapy in the management of chronic myofascial pain in the neck: A double‐blind and randomize‐controlled trial
A. Gur (2004)
Semantic Scholar Logo Some data provided by SemanticScholar