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Inhibition Of Protein Kinase C Induces Differentiation Of Neuroblastoma Cells

M. Miñana, V. Felipo, S. Grisolía
Published 1989 · Biology, Medicine

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It is shown that 1‐(5‐isoquinolinylsulfonyl)‐2‐methylpiperazine (H7), a specific inhibitor of protein kinase C, induces neuritogenesis in neuro 2a cells. The percentage of differentiated cells was 9%, 20%, 59% and 85% at 0, 17, 85 and 500 μM H7, respectively. The number of neurites/cell increased 2‐, 8‐ and 14‐fold over the controls for 17, 85 and 500 μM H7, respectively. These results indicate that protein kinase C plays a key role in the control of differentiation of neural cells and that its specific inhibition may be of basic as well as of practical importance.
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