← Back to Search
Reversible Inhibition Of Cytochrome C Oxidase, The Terminal Enzyme Of The Mitochondrial Respiratory Chain, By Nitric Oxide
M. Cleeter, J. M. Cooper, V. Darley-Usmar, S. Moncada, A. Schapira
Published 1994 · Biology, Medicine
Save to my Library
Download via 🐼 PaperPanda Download via oaDOI Download via OAB Download via LibKey Download via Google Google ScholarAnalyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Incubation of rat skeletal muscle mitochondria with the nitric oxide generator, S‐nitrosoglutathione (GSNO) reversibly inhibited oxygen utilisation with all substrates tested. The visible absorption spectra of the inhibited mitochondria showed that cytochromes c+c 1, b and a+a 3 were reduced, indicating a block at the distal end of the respiratory chain. Analysis of the respiratory chain enzyme activities in the presence of GSNO localised the site of inhibition to cytochrome c oxidase alone. These results indicate that nitric oxide is capable of rapidly and reversibly inhibiting the mitochondrial respiratory chain and may be implicated in the cytotoxic effects of nitric oxide in the CNS and other tissues.
This paper references
Protein measurement with the Folin phenol reagent.
O. H. Lowry (1951)
Reactions of cytochrome oxidase with oxygen and carbon monoxide.
Q. Gibson (1963)
 Cytochrome oxidase from beef heart mitochondria
D. Wharton (1967)
 Preparations of succinate—cytochrome c reductase and the cytochrome b-c1 particle, and reconstitution of succinate-cytochrome c reductase
T. King (1967)
CYTOSTATIC ELIMINATION OF SYNGENEIC RAT TUMOR CELLS IN VITRO BY NONSPECIFICALLY ACTIVATED MACROPHAGES
R. Keller (1973)
The role of activated macrophages in specific and nonspecific cytostasis of tumor cells.
J. Krahenbuhl (1974)
A mitochondrial myopathy characterized by a deficiency in reducible cytochrome b.
J. Morganhughes (1977)
Structure of cytochrome a3-Cua3 couple in cytochrome c oxidase as revealed by nitric oxide binding studies.
T. H. Stevens (1979)
Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria.
J. Turrens (1980)
Biochemical adaptation of mitochondria, muscle, and whole-animal respiration to endurance training.
K. Davies (1981)
 Preparation of derivatives of ferrous and ferric hemoglobin
E. Iorio (1981)
Comparison of carbon monoxide, nitric oxide, and nitrite as inhibitors of the nitrogenase from Clostridium pasteurianum.
J. Meyer (1981)
Sites of inhibition of mitochondrial electron transport in macrophage- injured neoplastic cells
D. Granger (1982)
Nitrite inhibition of Clostridium botulinum: electron spin resonance detection of iron-nitric oxide complexes.
D. Reddy (1983)
The cell biology of macrophage activation.
D. Adams (1984)
Iron depletion: possible cause of tumor cell cytotoxicity induced by activated macrophages.
J. Hibbs (1984)
Mechanisms of Host Resistance to Infective Agents, Tumors and Allografts (Steinman, R.M. and North, R.J., Eds.) pp. 165184
Some observations concerning the S-nitroso and S-phenylsulphonyl derivatives of L-cysteine and glutathione
Hart Terance William (1985)
Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.
J. C. Drapier (1986)
Mitochondria: a practical approach.
V. Darley-Usmar (1987)
Mitochondria: A Practical Approach (Darley-Usmar
C. I. Ragan (1987)
Reaction of S-nitrosoglutathione with sulfhydryl groups in protein.
J. Park (1988)
Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.
J. C. Drapier (1988)
Nitric oxide: a cytotoxic activated macrophage effector molecule.
J. Hibbs (1988)
Mitochondrial iron loss from leukemia cells injured by macrophages. A possible mechanism for electron transport chain defects.
M. Wharton (1988)
Rate of cell death in parkinsonism indicates active neuropathological process
P. Mcgeer (1988)
Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide
D. Stuehr (1989)
Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.
D. Bredt (1989)
Mitochondrial Complex I Deficiency in Parkinson's Disease
A. H. V. Schapira (1989)
Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells
D. Stuehr (1989)
Anatomic and Disease Specificity of NADH CoQ1 Reductase (Complex I) Deficiency in Parkinson's Disease
A. Schapira (1990)
Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat.
Richard Graham Knowles (1990)
Irreversible Inhibition of Mitochondrial Complex I by 1‐Methyl‐4‐Phenylpyridinium: Evidence for Free Radical Involvement
M. Cleeter (1992)
Inhibition of mitochondrial electron transport by peroxynitrite.
R. Radi (1994)
This paper is referenced by
Neuron-Oligodendrocyte Interactions in the Structure and Integrity of Axons
G. J. Duncan (2021)
Network analysis of nitrate-sensitive oral microbiome reveals interactions with cognitive function and cardiovascular health across dietary interventions
A. Vanhatalo (2021)
Possible Effects of Beetroot Supplementation on Physical Performance Through Metabolic, Neuroendocrine, and Antioxidant Mechanisms: A Narrative Review of the Literature
H. Arazi (2021)
Erythropoietin Produces a Dual Effect on Carotid Body Chemoreception in Male Rats
C. Arias-Reyes (2021)
Cellular and Mitochondrial Calcium Communication in Obstructive Lung Disorders.
Shakti Sagar (2021)
Mitochondrial Redox and TCA Cycle Metabolite Signaling in the Heart.
A. Vujic (2021)
Cellular and Exosomal Regulations of Sepsis-Induced Metabolic Alterations
M. G. Appiah (2021)
Metabolic Rewiring in Radiation Oncology Toward Improving the Therapeutic Ratio
M. V. van Gisbergen (2021)
More than just protein building blocks: how amino acids and related metabolic pathways fuel macrophage polarization
M. Kieler (2021)
Mitochondrial Dysfunction Increases Arrhythmic Triggers and Substrates; Potential Anti-arrhythmic Pharmacological Targets
Khalil Saadeh (2021)
Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase
Erika M Palmieri (2020)
The Bioactivity of Neuronal-Derived Nitric Oxide in Aging and Neurodegeneration: Switching Signaling to Degeneration.
A. Ledo (2020)
DIETARY NITRATE AND THE MICROBIOTA-MODULATORS OF METABOLIC FUNCTION
C. Moretti (2020)
Can insulin secreting pancreatic β-cells provide novel insights into the metabolic regulation of the DNA damage response?
Bryndon J. Oleson (2020)
Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight
Erika M Palmieri (2020)
Acetamidine-Based iNOS Inhibitors as Molecular Tools to Counteract Inflammation in BV2 Microglial Cells
S. Grottelli (2020)
Neuroprotection of Rotenone induced Parkinsonism by Ursolic acid in PD mouse model.
W. Zahra (2020)
Modulation of mitochondria and NADPH oxidase function by the nitrate-nitrite-NO pathway in metabolic disease with focus on type 2 diabetes.
T. Schiffer (2020)
Temporal evolution of cardiac mitochondrial dysfunction in a type 1 Diabetes model. Mitochondrial complex I impairment, and H2O2 and NO productions as early subcellular events.
Ivana A. Rukavina-Mikusic (2020)
Inhibition of mitochondrial oxidative metabolism attenuates EMCV replication and protects β-cells from virally mediated lysis
J. Stafford (2020)
ROS-associated immune response and metabolism: a mechanistic approach with implication of various diseases
Sharmistha Banerjee (2020)
An integrative approach to the regulation of mitochondrial respiration during exercise: Focus on high-intensity exercise
J. Calbet (2020)
A neuroglobin-based high-affinity ligand trap reverses carbon monoxide–induced mitochondrial poisoning
J. Rose (2020)
Macrophage activation as an archetype of mitochondrial repurposing.
Anthony E. Jones (2020)
Mitochondria and cellular redox state on the route from ageing to Alzheimer’s disease
G. Abate (2020)
Neuroprotective mechanisms of Ginkgo biloba against oxidative stress
H. Cheung (2020)
Imaging the Landmarks of Vascular Recovery
Jamila Hedhli (2020)
Immunometabolism of Macrophages in Bacterial Infections
G. Galli (2020)
A compendium of G-protein-coupled receptors and cyclic nucleotide regulation of adipose tissue metabolism and energy expenditure.
Ryan P. Ceddia (2020)
Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon
A. Chowdhury (2020)
Mitochondrial Protection by PARP Inhibition
Ferenc Gallyas Jr. (2020)
A Pilot Study of Dietary Nitrate Supplementation in Anaemic Patients.
D. Veale (2020)See more